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Linear arithmetic mean insulin aspart plasma time profiles ( A ), mean smoothed <t>LOESS</t> fits of body weight standardized GIR versus time profiles (GIR values less than 0 at baseline are results of the LOESS smoothing) ( B ). The horizontal line in ( A ) is the lower level of quantification (100 pg/mL). GIR glucose infusion rate, LOESS locally weighted <t>scatterplot</t> smoothing.
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Linear arithmetic mean insulin aspart plasma time profiles ( A ), mean smoothed <t>LOESS</t> fits of body weight standardized GIR versus time profiles (GIR values less than 0 at baseline are results of the LOESS smoothing) ( B ). The horizontal line in ( A ) is the lower level of quantification (100 pg/mL). GIR glucose infusion rate, LOESS locally weighted <t>scatterplot</t> smoothing.
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Linear arithmetic mean insulin aspart plasma time profiles ( A ), mean smoothed <t>LOESS</t> fits of body weight standardized GIR versus time profiles (GIR values less than 0 at baseline are results of the LOESS smoothing) ( B ). The horizontal line in ( A ) is the lower level of quantification (100 pg/mL). GIR glucose infusion rate, LOESS locally weighted <t>scatterplot</t> smoothing.
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Linear arithmetic mean insulin aspart plasma time profiles ( A ), mean smoothed <t>LOESS</t> fits of body weight standardized GIR versus time profiles (GIR values less than 0 at baseline are results of the LOESS smoothing) ( B ). The horizontal line in ( A ) is the lower level of quantification (100 pg/mL). GIR glucose infusion rate, LOESS locally weighted <t>scatterplot</t> smoothing.
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Linear arithmetic mean insulin aspart plasma time profiles ( A ), mean smoothed <t>LOESS</t> fits of body weight standardized GIR versus time profiles (GIR values less than 0 at baseline are results of the LOESS smoothing) ( B ). The horizontal line in ( A ) is the lower level of quantification (100 pg/mL). GIR glucose infusion rate, LOESS locally weighted <t>scatterplot</t> smoothing.
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Linear arithmetic mean insulin aspart plasma time profiles ( A ), mean smoothed <t>LOESS</t> fits of body weight standardized GIR versus time profiles (GIR values less than 0 at baseline are results of the LOESS smoothing) ( B ). The horizontal line in ( A ) is the lower level of quantification (100 pg/mL). GIR glucose infusion rate, LOESS locally weighted <t>scatterplot</t> smoothing.
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Linear arithmetic mean insulin aspart plasma time profiles ( A ), mean smoothed LOESS fits of body weight standardized GIR versus time profiles (GIR values less than 0 at baseline are results of the LOESS smoothing) ( B ). The horizontal line in ( A ) is the lower level of quantification (100 pg/mL). GIR glucose infusion rate, LOESS locally weighted scatterplot smoothing.

Journal: Scientific Reports

Article Title: Pharmacokinetic and pharmacodynamic similarity between SAR341402 insulin aspart and Japan-approved NovoRapid in healthy Japanese subjects

doi: 10.1038/s41598-021-02410-z

Figure Lengend Snippet: Linear arithmetic mean insulin aspart plasma time profiles ( A ), mean smoothed LOESS fits of body weight standardized GIR versus time profiles (GIR values less than 0 at baseline are results of the LOESS smoothing) ( B ). The horizontal line in ( A ) is the lower level of quantification (100 pg/mL). GIR glucose infusion rate, LOESS locally weighted scatterplot smoothing.

Article Snippet: Individual GIR values in each treatment group were standardized for body weight and subjected to a smoothing procedure using a locally weighted scatterplot smoothing (LOESS) function (SAS, PROC LOESS, factor 0.06).

Techniques: Clinical Proteomics