sb202190 sb (Cayman Chemical)
93
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Name:
SB 202190
Description:
SB 202190 is a selective potent cell permeable inhibitor of p38 MAP kinases inhibiting p38α SAPK2A MAPK14 and p38β SAPK2B MAPK11 with IC values of 50 and 100 nM respectively When tested at 10 μM SB 202190 has negligible effects on a range of other kinases including other MAP kinases ERKs JNKs Pyridinyl imidazole inhibitors including this compound directly bind p38 MAP kinases in the ATP binding pocket Recently SB 202190 has been used to elucidate the roles of p38 MAP kinases in inflammatory cytokine expression nicotine induced receptor expression and HIV mediated depressive disorder
Catalog Number:
10010399
Price:
$29
Purity:
≥98%
Size:
10 mg
Formula:
A crystalline solid
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Structured Review
Cayman Chemical
sb202190 sb
SB 202190 is a selective potent cell permeable inhibitor of p38 MAP kinases inhibiting p38α SAPK2A MAPK14 and p38β SAPK2B MAPK11 with IC values of 50 and 100 nM respectively When tested at 10 μM SB 202190 has negligible effects on a range of other kinases including other MAP kinases ERKs JNKs Pyridinyl imidazole inhibitors including this compound directly bind p38 MAP kinases in the ATP binding pocket Recently SB 202190 has been used to elucidate the roles of p38 MAP kinases in inflammatory cytokine expression nicotine induced receptor expression and HIV mediated depressive disorder
https://www.bioz.com/result/sb202190 sb/product/Cayman Chemical
Average 93 stars, based on 1 article reviews
Price from $9.99 to $1999.99
SB 202190 is a selective potent cell permeable inhibitor of p38 MAP kinases inhibiting p38α SAPK2A MAPK14 and p38β SAPK2B MAPK11 with IC values of 50 and 100 nM respectively When tested at 10 μM SB 202190 has negligible effects on a range of other kinases including other MAP kinases ERKs JNKs Pyridinyl imidazole inhibitors including this compound directly bind p38 MAP kinases in the ATP binding pocket Recently SB 202190 has been used to elucidate the roles of p38 MAP kinases in inflammatory cytokine expression nicotine induced receptor expression and HIV mediated depressive disorder
https://www.bioz.com/result/sb202190 sb/product/Cayman Chemical
Average 93 stars, based on 1 article reviews
Price from $9.99 to $1999.99
sb202190 sb - by Bioz Stars,
2021-04
93/100 stars
Images
1) Product Images from "Cellular aging contributes to failure of cold-induced beige adipocyte formation in old mice and humans"
Article Title: Cellular aging contributes to failure of cold-induced beige adipocyte formation in old mice and humans
Journal: Cell metabolism
doi: 10.1016/j.cmet.2016.10.023
Figure Legend Snippet: Inhibiting p38/MAPK in SMA cells stimulates cold-induced beiging (A-D) Schema- Six month old TM induced SMA-Cre ERT2 ; R26R RFP male mice were administered vehicle or SB202190 (75 μg/mouse/day) for five consecutive days. Mice were randomized to room temperature or cold for seven days (A). (B) H E staining. (C) UCP1 IHC. (D) SMA/RFP fluorescence fate mapping. (E-H) Schema- Six-month-old TM induced SMA-Cre ERT2 and SMA-Cre ERT2 ; PPARγ fl/fl male mice were administered vehicle or SB (75 μg/mouse/day) for five days and subjected to room or cold temperatures for seven days. (G) H E staining. (H) UCP1 IHC. Scale bar = 200 μm.
Techniques Used: Mouse Assay, Staining, Immunohistochemistry, Fluorescence
Figure Legend Snippet: Pharmacologically targeting p38/MAPK in old SMA+ mural cells rejuvenates beige formation (A-C) Total SV cells were isolated from six month old C57/Bl6 male mice (A, B) or SV cells generated from aged human samples. Cells were treated with vehicle or SB202190 (5 μM) for 15 consecutive days. mRNA of senescence markers was examined. *P
Techniques Used: Isolation, Mouse Assay, Generated
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