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src  (Sino Biological)
94
Sino Biological src
a Kinase Library prediction heatmap based on the peptide primary sequence of the SHP2 Y62 phosphosite plotted on human kinome evolutionary tree. TK—Tyrosine kinases, CAMK—calcium calmodulin-dependent kinases, TKL—Tyrosine kinase-like, STE- sterile kinases, CK1—Casein Kinase 1. b SFK multi-kinase and selective inhibitors with targets shown, tested here. c , d Immunoblot analysis of ( c ) U-2 OS cells and ( d ) HCC827 cells treated with dasatinib and SU6656 at indicated concentrations, and DMSO. e , f Immunoblot analysis of HCC827 cells treated with ( e ) saracatinib, CH6953755, and PP2, and ( f ) double and triple combinations at indicated concentrations, and DMSO. g Immunoblot analysis of SYF knock out and wildtype MEFs. h In vitro kinase assays with recombinant <t>SRC,</t> <t>YES1,</t> and FYN kinases and recombinant SHP2 WT and SHP2 Y62F . The SHP2 pY542 antibody demonstrated nonspecific binding in the control conditions. All immunoblots are representative of one of the three independent experiments. The unit of molecular weight markers in Western blots is kDa. Source data are provided as source data file.
Src, supplied by Sino Biological, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/s19/pmc13066003-223-0-15?v=Sino+Biological
Average 94 stars, based on 1 article reviews
src - by Bioz Stars, 2026-07
94/100 stars
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p re ss in vitro kinase assay src  (Sino Biological)
94
Sino Biological p re ss in vitro kinase assay src
a Kinase Library prediction heatmap based on the peptide primary sequence of the SHP2 Y62 phosphosite plotted on human kinome evolutionary tree. TK—Tyrosine kinases, CAMK—calcium calmodulin-dependent kinases, TKL—Tyrosine kinase-like, STE- sterile kinases, CK1—Casein Kinase 1. b SFK multi-kinase and selective inhibitors with targets shown, tested here. c , d Immunoblot analysis of ( c ) U-2 OS cells and ( d ) HCC827 cells treated with dasatinib and SU6656 at indicated concentrations, and DMSO. e , f Immunoblot analysis of HCC827 cells treated with ( e ) saracatinib, CH6953755, and PP2, and ( f ) double and triple combinations at indicated concentrations, and DMSO. g Immunoblot analysis of SYF knock out and wildtype MEFs. h In vitro kinase assays with recombinant <t>SRC,</t> <t>YES1,</t> and FYN kinases and recombinant SHP2 WT and SHP2 Y62F . The SHP2 pY542 antibody demonstrated nonspecific binding in the control conditions. All immunoblots are representative of one of the three independent experiments. The unit of molecular weight markers in Western blots is kDa. Source data are provided as source data file.
P Re Ss In Vitro Kinase Assay Src, supplied by Sino Biological, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/s19/pm41775683-213-5-27?v=Sino+Biological
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p re ss in vitro kinase assay src - by Bioz Stars, 2026-07
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anti p s19 myosin light chain 2  (Cell Signaling Technology Inc)
96
Cell Signaling Technology Inc anti p s19 myosin light chain 2
a Kinase Library prediction heatmap based on the peptide primary sequence of the SHP2 Y62 phosphosite plotted on human kinome evolutionary tree. TK—Tyrosine kinases, CAMK—calcium calmodulin-dependent kinases, TKL—Tyrosine kinase-like, STE- sterile kinases, CK1—Casein Kinase 1. b SFK multi-kinase and selective inhibitors with targets shown, tested here. c , d Immunoblot analysis of ( c ) U-2 OS cells and ( d ) HCC827 cells treated with dasatinib and SU6656 at indicated concentrations, and DMSO. e , f Immunoblot analysis of HCC827 cells treated with ( e ) saracatinib, CH6953755, and PP2, and ( f ) double and triple combinations at indicated concentrations, and DMSO. g Immunoblot analysis of SYF knock out and wildtype MEFs. h In vitro kinase assays with recombinant <t>SRC,</t> <t>YES1,</t> and FYN kinases and recombinant SHP2 WT and SHP2 Y62F . The SHP2 pY542 antibody demonstrated nonspecific binding in the control conditions. All immunoblots are representative of one of the three independent experiments. The unit of molecular weight markers in Western blots is kDa. Source data are provided as source data file.
Anti P S19 Myosin Light Chain 2, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/s19/pm41353402-249-25-29?v=Cell+Signaling+Technology+Inc
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anti p s19 myosin light chain 2 - by Bioz Stars, 2026-07
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p mlc s19 rabbit cell signaling technology 3671  (Cell Signaling Technology Inc)
96
Cell Signaling Technology Inc p mlc s19 rabbit cell signaling technology 3671
a Kinase Library prediction heatmap based on the peptide primary sequence of the SHP2 Y62 phosphosite plotted on human kinome evolutionary tree. TK—Tyrosine kinases, CAMK—calcium calmodulin-dependent kinases, TKL—Tyrosine kinase-like, STE- sterile kinases, CK1—Casein Kinase 1. b SFK multi-kinase and selective inhibitors with targets shown, tested here. c , d Immunoblot analysis of ( c ) U-2 OS cells and ( d ) HCC827 cells treated with dasatinib and SU6656 at indicated concentrations, and DMSO. e , f Immunoblot analysis of HCC827 cells treated with ( e ) saracatinib, CH6953755, and PP2, and ( f ) double and triple combinations at indicated concentrations, and DMSO. g Immunoblot analysis of SYF knock out and wildtype MEFs. h In vitro kinase assays with recombinant <t>SRC,</t> <t>YES1,</t> and FYN kinases and recombinant SHP2 WT and SHP2 Y62F . The SHP2 pY542 antibody demonstrated nonspecific binding in the control conditions. All immunoblots are representative of one of the three independent experiments. The unit of molecular weight markers in Western blots is kDa. Source data are provided as source data file.
P Mlc S19 Rabbit Cell Signaling Technology 3671, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/s19/pmc12581665__jciinsight-10-196350-s105-36-104-107?v=Cell+Signaling+Technology+Inc
Average 96 stars, based on 1 article reviews
p mlc s19 rabbit cell signaling technology 3671 - by Bioz Stars, 2026-07
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p mlct18 s19 rabbit cell signaling technology 3674  (Cell Signaling Technology Inc)
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Cell Signaling Technology Inc p mlct18 s19 rabbit cell signaling technology 3674
a Kinase Library prediction heatmap based on the peptide primary sequence of the SHP2 Y62 phosphosite plotted on human kinome evolutionary tree. TK—Tyrosine kinases, CAMK—calcium calmodulin-dependent kinases, TKL—Tyrosine kinase-like, STE- sterile kinases, CK1—Casein Kinase 1. b SFK multi-kinase and selective inhibitors with targets shown, tested here. c , d Immunoblot analysis of ( c ) U-2 OS cells and ( d ) HCC827 cells treated with dasatinib and SU6656 at indicated concentrations, and DMSO. e , f Immunoblot analysis of HCC827 cells treated with ( e ) saracatinib, CH6953755, and PP2, and ( f ) double and triple combinations at indicated concentrations, and DMSO. g Immunoblot analysis of SYF knock out and wildtype MEFs. h In vitro kinase assays with recombinant <t>SRC,</t> <t>YES1,</t> and FYN kinases and recombinant SHP2 WT and SHP2 Y62F . The SHP2 pY542 antibody demonstrated nonspecific binding in the control conditions. All immunoblots are representative of one of the three independent experiments. The unit of molecular weight markers in Western blots is kDa. Source data are provided as source data file.
P Mlct18 S19 Rabbit Cell Signaling Technology 3674, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/s19/pmc12581665__jciinsight-10-196350-s105-36-96-98?v=Cell+Signaling+Technology+Inc
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p mlct18 s19 rabbit cell signaling technology 3674 - by Bioz Stars, 2026-07
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recombinant active src kinase  (Sino Biological)
93
Sino Biological recombinant active src kinase
a Kinase Library prediction heatmap based on the peptide primary sequence of the SHP2 Y62 phosphosite plotted on human kinome evolutionary tree. TK—Tyrosine kinases, CAMK—calcium calmodulin-dependent kinases, TKL—Tyrosine kinase-like, STE- sterile kinases, CK1—Casein Kinase 1. b SFK multi-kinase and selective inhibitors with targets shown, tested here. c , d Immunoblot analysis of ( c ) U-2 OS cells and ( d ) HCC827 cells treated with dasatinib and SU6656 at indicated concentrations, and DMSO. e , f Immunoblot analysis of HCC827 cells treated with ( e ) saracatinib, CH6953755, and PP2, and ( f ) double and triple combinations at indicated concentrations, and DMSO. g Immunoblot analysis of SYF knock out and wildtype MEFs. h In vitro kinase assays with recombinant <t>SRC,</t> <t>YES1,</t> and FYN kinases and recombinant SHP2 WT and SHP2 Y62F . The SHP2 pY542 antibody demonstrated nonspecific binding in the control conditions. All immunoblots are representative of one of the three independent experiments. The unit of molecular weight markers in Western blots is kDa. Source data are provided as source data file.
Recombinant Active Src Kinase, supplied by Sino Biological, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/s19/pm41068561-55-0-4?v=Sino+Biological
Average 93 stars, based on 1 article reviews
recombinant active src kinase - by Bioz Stars, 2026-07
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s19 data collection pdb id xxxx ligand a 515259 space group p2 1 cell dimensions  (Global Phasing Ltd)
86
Global Phasing Ltd s19 data collection pdb id xxxx ligand a 515259 space group p2 1 cell dimensions
a Kinase Library prediction heatmap based on the peptide primary sequence of the SHP2 Y62 phosphosite plotted on human kinome evolutionary tree. TK—Tyrosine kinases, CAMK—calcium calmodulin-dependent kinases, TKL—Tyrosine kinase-like, STE- sterile kinases, CK1—Casein Kinase 1. b SFK multi-kinase and selective inhibitors with targets shown, tested here. c , d Immunoblot analysis of ( c ) U-2 OS cells and ( d ) HCC827 cells treated with dasatinib and SU6656 at indicated concentrations, and DMSO. e , f Immunoblot analysis of HCC827 cells treated with ( e ) saracatinib, CH6953755, and PP2, and ( f ) double and triple combinations at indicated concentrations, and DMSO. g Immunoblot analysis of SYF knock out and wildtype MEFs. h In vitro kinase assays with recombinant <t>SRC,</t> <t>YES1,</t> and FYN kinases and recombinant SHP2 WT and SHP2 Y62F . The SHP2 pY542 antibody demonstrated nonspecific binding in the control conditions. All immunoblots are representative of one of the three independent experiments. The unit of molecular weight markers in Western blots is kDa. Source data are provided as source data file.
S19 Data Collection Pdb Id Xxxx Ligand A 515259 Space Group P2 1 Cell Dimensions, supplied by Global Phasing Ltd, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/s19/pm24900801__ml400496h_si_001-151-6-3?v=Global+Phasing+Ltd
Average 86 stars, based on 1 article reviews
s19 data collection pdb id xxxx ligand a 515259 space group p2 1 cell dimensions - by Bioz Stars, 2026-07
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pyridyltrifluoroborates s18 references s19 1h  (Thermo Fisher)
99
Thermo Fisher pyridyltrifluoroborates s18 references s19 1h
a Kinase Library prediction heatmap based on the peptide primary sequence of the SHP2 Y62 phosphosite plotted on human kinome evolutionary tree. TK—Tyrosine kinases, CAMK—calcium calmodulin-dependent kinases, TKL—Tyrosine kinase-like, STE- sterile kinases, CK1—Casein Kinase 1. b SFK multi-kinase and selective inhibitors with targets shown, tested here. c , d Immunoblot analysis of ( c ) U-2 OS cells and ( d ) HCC827 cells treated with dasatinib and SU6656 at indicated concentrations, and DMSO. e , f Immunoblot analysis of HCC827 cells treated with ( e ) saracatinib, CH6953755, and PP2, and ( f ) double and triple combinations at indicated concentrations, and DMSO. g Immunoblot analysis of SYF knock out and wildtype MEFs. h In vitro kinase assays with recombinant <t>SRC,</t> <t>YES1,</t> and FYN kinases and recombinant SHP2 WT and SHP2 Y62F . The SHP2 pY542 antibody demonstrated nonspecific binding in the control conditions. All immunoblots are representative of one of the three independent experiments. The unit of molecular weight markers in Western blots is kDa. Source data are provided as source data file.
Pyridyltrifluoroborates S18 References S19 1h, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/s19/pm19067651__ja806681z_si_001-3-29-45?v=Thermo+Fisher
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pyridyltrifluoroborates s18 references s19 1h - by Bioz Stars, 2026-07
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Image Search Results


a Kinase Library prediction heatmap based on the peptide primary sequence of the SHP2 Y62 phosphosite plotted on human kinome evolutionary tree. TK—Tyrosine kinases, CAMK—calcium calmodulin-dependent kinases, TKL—Tyrosine kinase-like, STE- sterile kinases, CK1—Casein Kinase 1. b SFK multi-kinase and selective inhibitors with targets shown, tested here. c , d Immunoblot analysis of ( c ) U-2 OS cells and ( d ) HCC827 cells treated with dasatinib and SU6656 at indicated concentrations, and DMSO. e , f Immunoblot analysis of HCC827 cells treated with ( e ) saracatinib, CH6953755, and PP2, and ( f ) double and triple combinations at indicated concentrations, and DMSO. g Immunoblot analysis of SYF knock out and wildtype MEFs. h In vitro kinase assays with recombinant SRC, YES1, and FYN kinases and recombinant SHP2 WT and SHP2 Y62F . The SHP2 pY542 antibody demonstrated nonspecific binding in the control conditions. All immunoblots are representative of one of the three independent experiments. The unit of molecular weight markers in Western blots is kDa. Source data are provided as source data file.

Journal: Nature Communications

Article Title: A hotspot phosphorylation site on SHP2 drives oncoprotein activation and drug resistance

doi: 10.1038/s41467-026-70060-8

Figure Lengend Snippet: a Kinase Library prediction heatmap based on the peptide primary sequence of the SHP2 Y62 phosphosite plotted on human kinome evolutionary tree. TK—Tyrosine kinases, CAMK—calcium calmodulin-dependent kinases, TKL—Tyrosine kinase-like, STE- sterile kinases, CK1—Casein Kinase 1. b SFK multi-kinase and selective inhibitors with targets shown, tested here. c , d Immunoblot analysis of ( c ) U-2 OS cells and ( d ) HCC827 cells treated with dasatinib and SU6656 at indicated concentrations, and DMSO. e , f Immunoblot analysis of HCC827 cells treated with ( e ) saracatinib, CH6953755, and PP2, and ( f ) double and triple combinations at indicated concentrations, and DMSO. g Immunoblot analysis of SYF knock out and wildtype MEFs. h In vitro kinase assays with recombinant SRC, YES1, and FYN kinases and recombinant SHP2 WT and SHP2 Y62F . The SHP2 pY542 antibody demonstrated nonspecific binding in the control conditions. All immunoblots are representative of one of the three independent experiments. The unit of molecular weight markers in Western blots is kDa. Source data are provided as source data file.

Article Snippet: SRC (Cat# S19-18G), YES1 (Cat# Y01-10G), and FYN (Cat# F15-10G) kinase proteins were purchased from SinoBiological.

Techniques: Sequencing, Phospho-proteomics, Sterility, Western Blot, Knock-Out, In Vitro, Recombinant, Binding Assay, Control, Molecular Weight