accurotor accelerating rotarod  (Omnitech Electronics)

Journal: Acta Neuropathologica Communications

Article Title: Dual targeting of iNOS and Src tyrosine kinase as a superior therapeutic strategy against soman-induced long-term neurotoxicity: multimodal biomarker, imaging, and neurobehavioral outcome analyses

doi: 10.1186/s40478-025-02220-8

Figure Lengend Snippet: Motor behavioral assessment and its correlation with rsFC of different brain networks post-soman exposure. a A Rotarod (RR) apparatus was used to test the motor behavior of rats at 6 weeks post-soman. The time to fall for each animal is plotted as mean ± SEM in ( b ) and as difference in mean compared to control in ( c ), depicted as a horizontal line. * indicates the soman effect (soman vs control) and # represents treatment effect (vs soman + vehicle). d , e A correlation matrix depicting a correlation coefficient (Pearson correlation, p < 0.05) between time to fall (seconds) in RR (6 weeks post soman) and rsFC of different regional networks (8–9 weeks post soman) is presented, with ‘X’ marks p -value ≥ 0.05 (not significant). f – i Simple linear regression comparing between the time to fall (seconds) and the rsFC (active voxels) with the corresponding correlation coefficient (r) and p -value. Each dot on the graphs represents a data point from each animal. n = 15–30 (7–16/sex), * indicates soman effect (vs control) and # represents effect (vs Soman + vehicle) with corresponding p -values

Article Snippet: Motor learning and coordination in rodents were assessed using an accelerating rotarod apparatus (AccuRotor 4-channel, Omnitech Electronics Inc., and Start Fusion v6.2 AccuRotor Edition Software) as previously described [ ].

Techniques: Control

Journal: Neural Regeneration Research

Article Title: Microglia overexpressing brain-derived neurotrophic factor promote vascular repair and functional recovery in mice after spinal cord injury

doi: 10.4103/NRR.NRR-D-24-00381

Figure Lengend Snippet: BDNF overexpression improves motor function. (A) Experimental timeline of spinal cord injury in CX3:BDNF mice. (B–E) Footprint analysis on day 28 post-spinal cord injury (SL, step length; SW, step width). (F, G) Microglial BDNF overexpression promotes motor function recovery after spinal cord injury, based on BMS scores (*** P < 0.001, sham group vs . SCI group; ## P < 0.01, SCI group vs. SCI-CX3:BDNF group). (H–J) Rotarod analysis on day 28 post-spinal cord injury. One-way analysis of variance with Bonferroni post hoc test (C, D, E, I, J). Two-way repeated-measures analysis of variance with Bonferroni post hoc test (G). ** P < 0.01, *** P < 0.001. In B–J, C57BL/6J mice were used in the Sham group and SCI group, and CX3:BDNF mice were used in SCI-CX3:BDNF group, and there were six mice in each group. BDNF: Brain-derived neurotrophic factor; BMS: Basso mouse scale; D1: day 1; IF: immunofluorescence; r/min: revolutions per minute; SCI: spinal cord injury.

Article Snippet: A UGO basile RotaRod (UGO Basile, Vittorio, Italy, 47650) was used in these experiments, which were designed to test motor function and muscle coordination to analyze the effects of treatment after SCI.

Techniques: Over Expression, Derivative Assay, Immunofluorescence