Journal: Neural Regeneration Research

Article Title: A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury

doi: 10.4103/NRR.NRR-D-23-01322

Figure Lengend Snippet: Animal behavior testing for rotarod test, grip strength test, and open field test at 7 and 14 days in cerebral ischemia/reperfusion after self-assembling nanofiber hydrogel PA-TIMP-QK injection. (A) Statistical analysis of latency during the rotarod test ( n = 6). (B) Statistical analysis of speed during the rotarod test ( n = 6). (C) Statistical analysis of grip strength test ( n = 6). (D) Representative paths of rats in the open field test, tracked by the SMART 3.0 system. The total distances of the PA-TIMP-QK group at 7 days were longer than those in the PBS and VEGF165 groups. The total distances of the PA-TIMP-QK group at 14 days were longer than those in the PBS, VEGF165 and PA-QK groups. There was no significant difference in anxiety assessment after 7 days. On the 14 th day, the PA-TIMP-QK group spent significantly longer time in the central zone of the open field compared with the PBS, PA-QK groups. (E) Statistical analysis of total distance at 7 and 14 days ( n = 6). (F) Statistical analysis of time in the center zone at 7 and 14 days ( n = 6). Data are expressed as the mean ± SD. * P < 0.05, ** P < 0.01, *** P < 0.001 (one-way analysis of variance followed by Tukey’s post hoc test). PA: Peptide amphiphilic molecule; PBS: phosphate buffered saline; QK: vascular endothelial growth factor mimic peptide-KLTWQELYQLKYKGI; TIMP: matrix metalloproteinase-2 cleaved peptide-PLGLAG; VEGF165: vascular endothelial growth factor 165.

Article Snippet: Before cerebral I/R (CI/R), Sprague-Dawley rats were trained on the rotarod apparatus (LE8505, Panlab, Madrid, Spain) for 5 consecutive days.

Techniques: Injection, Saline

Journal: Neuropsychopharmacology Reports

Article Title: Co‐Expression of Tardive Dyskinesia and Drug‐Induced Parkinsonism in Rats Chronically Treated With Haloperidol

doi: 10.1002/npr2.12524

Figure Lengend Snippet: Behavioral analyses in chronic haloperidol‐treated rats. (A) Vacuous chewing movements (VCMs) per 2 min gradually increased with repeated haloperidol treatment in the severe TD group. (B) The frequency of exploratory behavior decreased after treatment initiation. (C) Performance in the rotarod test deteriorated with haloperidol treatment. Statistical analysis was performed only for week 27. (D) There was a positive correlation between the number of VCMs and the frequency of exploratory behaviors in haloperidol‐treated rats. (E) There was no association between the number of VCMs and rotarod test performance in haloperidol‐treated rats. * p < 0.05 and ** p < 0.01 compared with the control group; + p < 0.05 and ++ p < 0.01 compared with mild TD group via Kruskal–Wallis and post hoc Steel–Dwass tests. Error bars represent the standard error of the mean. TD, tardive dyskinesia.

Article Snippet: In the rotarod test using an MK‐630B single‐lane rotor rod (Muromachi Machinery Co., Tokyo, Japan), the time to drop was measured with a rotation speed that started at 4 rpm and increased to 40 rpm after 5 min. Rotarod test trials were performed six times at 20–30‐min intervals.

Techniques: Control

Journal: Neuropsychopharmacology Reports

Article Title: Co‐Expression of Tardive Dyskinesia and Drug‐Induced Parkinsonism in Rats Chronically Treated With Haloperidol

doi: 10.1002/npr2.12524

Figure Lengend Snippet: Behavioral analyses in chronic haloperidol‐treated rats. (A) Vacuous chewing movements (VCMs) per 2 min gradually increased with repeated haloperidol treatment in the severe TD group. (B) The frequency of exploratory behavior decreased after treatment initiation. (C) Performance in the rotarod test deteriorated with haloperidol treatment. Statistical analysis was performed only for week 27. (D) There was a positive correlation between the number of VCMs and the frequency of exploratory behaviors in haloperidol‐treated rats. (E) There was no association between the number of VCMs and rotarod test performance in haloperidol‐treated rats. * p < 0.05 and ** p < 0.01 compared with the control group; + p < 0.05 and ++ p < 0.01 compared with mild TD group via Kruskal–Wallis and post hoc Steel–Dwass tests. Error bars represent the standard error of the mean. TD, tardive dyskinesia.

Article Snippet: In the rotarod test using an MK‐630B single‐lane rotor rod (Muromachi Machinery Co., Tokyo, Japan), the time to drop was measured with a rotation speed that started at 4 rpm and increased to 40 rpm after 5 min. Rotarod test trials were performed six times at 20–30‐min intervals.

Techniques: Control