rabbit polyclonal anti cdk1 (Proteintech)
Structured Review
Rabbit Polyclonal Anti Cdk1, supplied by Proteintech, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rabbit polyclonal anti cdk1/product/Proteintech
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
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rabbit polyclonal anti phospho cdk1 (Thermo Fisher)
Thermo Fisher is a verified supplier
Thermo Fisher manufactures this product
Structured Review
Rabbit Polyclonal Anti Phospho Cdk1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rabbit polyclonal anti phospho cdk1/product/Thermo Fisher
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
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rabbit polyclonal anti cdk1 (Millipore)
Structured Review
Rabbit Polyclonal Anti Cdk1, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rabbit polyclonal anti cdk1/product/Millipore
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
Images
1) Product Images from "Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis"
Article Title: Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis
Journal: Cell reports
doi: 10.1016/j.celrep.2024.114431
Figure Legend Snippet: KEY RESOURCES TABLE
Techniques Used: Virus, Plasmid Preparation, Recombinant, Magnetic Beads, Mutagenesis, Proximity Ligation Assay, Reverse Transcription, SYBR Green Assay, Software
rabbit polyclonal anti cdk1 (Proteintech)
Structured Review
Rabbit Polyclonal Anti Cdk1, supplied by Proteintech, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rabbit polyclonal anti cdk1/product/Proteintech
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
Images
1) Product Images from "Reduced dynamicity and increased high-order protein assemblies in dense fibrillar component of the nucleolus under cellular senescence"
Article Title: Reduced dynamicity and increased high-order protein assemblies in dense fibrillar component of the nucleolus under cellular senescence
Journal: Redox Biology
doi: 10.1016/j.redox.2024.103279
Figure Legend Snippet: Changes in formation of nuclear foci and protein solubility under cellular senescence. ( A) Top panel: Congo red staining images showing amyloids during cellular senescence induced by treatment with etoposide, decitabine, or H 2 O 2 . Scale bar: 20 μm. Middle panel: Bright-field images showing nucleoli. Bottom panel: Quantification of Congo red fluorescence intensity along the dashed line in the top panels. (B) Immunofluorescence with anti-CDK1 antibody in U2OS GFP-NPM1 cells during etoposide-induced cellular senescence. Scale bar: 20 μm. (C) Immunofluorescence with anti-VHL (left) and anti-DDX39B (right) antibodies in U2OS GFP-NPM1 cells during etoposide-induced cellular senescence. Scale bar: 20 μm. (D) Quantification of nuclear foci by the number and size of three biological replicates. (Upper left panel) The number of VHL foci per cell. (upper right panel) Size of VHL foci (vehicle n = 103, etoposide n = 48). Lower left panel: number of DDX39B foci per cell. Lower right panel: size of DDX39B foci (vehicle, n = 45; etoposide, n = 39). Error bars indicate SD. * P < 0.05, **** P < 0.0001 (unpaired t -test). (E) Quantification of foci localization during etoposide-induced cellular senescence based on the percentage of nuclear foci per total foci in a cell. The total number of foci was counted with a minimum of 200 per group. ( F and G) Western blot images detecting changes in protein solubility dependent on recovery in heat shock (HS)-exposed U2OS cells (F) and U2OS cells with cellular senescence induced by etoposide (G) . ( H and I) Quantification of the changes in the solubility of VHL and FIB under HS (H) and cellular senescence induced by etoposide treatment (I) . Each dot represents biological replicates. Error bars indicate SEM. * P < 0.05, ** P < 0.01, ns, non-significant (ordinary one-way ANOV(A) followed by correction for multiple comparison by controlling the FDR). Immunofluorescence images against an anti-TDP43 antibody (J) and quantification of colocalization between TDP-43 and NPM1 by Pearson's colocalization coefficient (K) . U2OS cells expressing GFP-NPM1 were treated with sodium arsenite or etoposide. U2OS cells expressing GFP-NPM1 recovered after one and three days of treatment with sodium arsenite and etoposide, respectively. D, day s (sodium arsenite: n = 13; sodium arsenite and recovery: n = 15; etoposide: n = 18; etoposide and washout: n = 20). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Techniques Used: Solubility, Staining, Fluorescence, Immunofluorescence, Western Blot, Comparison, Expressing
rabbit anti cdk1 polyclonal antibody (ABclonal Biotechnology)
Structured Review
Rabbit Anti Cdk1 Polyclonal Antibody, supplied by ABclonal Biotechnology, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rabbit anti cdk1 polyclonal antibody/product/ABclonal Biotechnology
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
Images
1) Product Images from "A systematic study on the treatment of hepatitis B-related hepatocellular carcinoma with drugs based on bioinformatics and key target reverse network pharmacology and experimental verification"
Article Title: A systematic study on the treatment of hepatitis B-related hepatocellular carcinoma with drugs based on bioinformatics and key target reverse network pharmacology and experimental verification
Journal: Infectious Agents and Cancer
doi: 10.1186/s13027-023-00520-z
Figure Legend Snippet: Abnormal expression of 6 key genes in HBV-related HCC. A. 6 key genes were more highly expressed in liver cancer tissues compared with those in the normal tissues in GEPIA database. The red and gray boxes represent cancer and normal tissues, respectively. B. The stage of (a) AURKA, (b) BIRC5, (c) CCNB1, (d) CDK1, (e) CDKN3 and (f) TYMS using UALCAN database. C. The immunohistochemical images of (a) AURKA, (b) BIRC5, (c) CCNB1, (d) CDK1, (e) TYMS in liver and HCC tissues using the HPA database
Techniques Used: Expressing, Immunohistochemical staining
Figure Legend Snippet: Survival analysis of 6 key genes (A) AURKA, (B) BIRC5, (C) CCNB1, (D) CDK1, (E) CDKN3 and (F) TYMS
Techniques Used:
Figure Legend Snippet: The drug-gene interaction network of chemotherapeutic drugs and 6 key genes, (A) AURKA, (B) BIRC5, (C) CCNB1, (D) CDK1, (E) CDKN3 and (F) TYMS, was constructed using CTD database
Techniques Used: Construct
Figure Legend Snippet: In the Herb database, the components corresponding to key targets
Techniques Used:
Figure Legend Snippet: Molecular docking binding energy results (kcal/mol)
Techniques Used: Binding Assay
Figure Legend Snippet: Effects of quercetin, celastrol and cantharidin on the expression of CDK1 and CCNB1. A. Effects of quercetin, celastrol and cantharidin on the expression of CDK1 and CCNB1 in HepG2215 cells. B. Effects of quercetin, celastrol and cantharidin on the expression of CDK1 and CCNB1 in Hep3B cells
Techniques Used: Expressing
rabbit anti cdk1 polyclonal antibody (ABclonal Biotechnology)
Structured Review
Rabbit Anti Cdk1 Polyclonal Antibody, supplied by ABclonal Biotechnology, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rabbit anti cdk1 polyclonal antibody/product/ABclonal Biotechnology
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
Images
rabbit anti cdk1 polyclonal antibody (ABclonal Biotechnology)
Structured Review
Rabbit Anti Cdk1 Polyclonal Antibody, supplied by ABclonal Biotechnology, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rabbit anti cdk1 polyclonal antibody/product/ABclonal Biotechnology
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
Images
1) Product Images from "AURKA, TOP2A and MELK are the key genes identified by WGCNA for the pathogenesis of lung adenocarcinoma"
Article Title: AURKA, TOP2A and MELK are the key genes identified by WGCNA for the pathogenesis of lung adenocarcinoma
Journal: Oncology Letters
doi: 10.3892/ol.2023.13824
Figure Legend Snippet: Oligonucleotide primers used in the present study.
Techniques Used: Sequencing
Figure Legend Snippet: In total, 59 control samples and 504 cancer samples were derived from TCGA database for verification. From the 10 genes selected from the two modules, a total of 20 genes were verified. A total of 19 of these changes were verified, and the other one (CXCR4) was excluded. (A) The expression of AURKA, BUB1, CCNB1, CDC45, CDK1, MELK, NUSAP1, PBK, TOP2A and TTK genes in normal lung tissues and lung adenocarcinoma tissues, where red indicates normal lung tissues and green indicates lung adenocarcinoma tissues. (B) The expression of BDKRB2, CCL19, CX3CR1, CXCL13, CXCL9, CXCR4, CXCR5, GNAI1, GNG11 and NMUR1 genes in normal lung tissues and lung adenocarcinoma tissues, with red indicating normal lung tissues and green indicating lung adenocarcinoma tissues. t-test of normal lung tissue and lung adenocarcinoma tissue. *P<0.05, **P<0.01 and ****P<0.0001.
Techniques Used: Derivative Assay, Expressing
Figure Legend Snippet: ROC curve analysis of 20 genes. AUCs >0.9 were included in the subsequent analysis. A total of 13 genes ( AURKA, CDC45, TTK, TOP2A, CCNB1, NUSAP1, MELK, PBK, BUB1, CDK1, CXCL13, GNG11 and NMUR1 ) were included, and seven genes were excluded. (A) ROC curve analysis was performed for the AURKA, CDC45, TTK, TOP2A and CCNB1 genes sequentially. (B) ROC curve analysis was performed for the NUSAP1, MELK, PBK, BPKPB2 and BUB1 genes sequentially. (C) ROC curve analysis was performed for the CDK1, CCL19, CXCR5, CXCL13 and CXCL9 genes sequentially. (D) ROC curve analysis was performed for the CXCR4, GNG11, GNAL1 and NMUR1, CX3CR1 genes sequentially. ROC, receiver operating characteristic; AUC, area under the curve.
Techniques Used:
Figure Legend Snippet: Survival analysis was performed and survival curves were obtained using GEPIA database. According to the P-values, there were eight genes with P<0.05 ( AURKA, TOP2A, CCNB1, NUSAP1, MELK, PBK, BUB1 and CDK1). (A-H) The survival curves of CDK1, BUB1, CCNB1, TOP2A, PBK, NUSAP1, AURKA and MELK genes in TCGA database are presented in order. TCGA, The Cancer Genome Atlas.
Techniques Used:
Figure Legend Snippet: mRNA expression of eight genes screened using WGCNA in clinical tissue samples. Clinical samples are divided into lung adenocarcinoma adjacent tissues and lung adenocarcinoma tissue samples. (A-H) In each graph, the left bar represents the lung adenocarcinoma adjacent tissues, and the right bar the lung adenocarcinoma tissues. The mRNA expression levels of AURKA, BUB1, CCNB1, CDK1, MELK, NUSAP1 and TOP2A genes in lung adenocarcinoma were higher than those in paired adjacent normal tissues. WGCNA, weighted gene co-expression network analysis.
Techniques Used: Expressing
Figure Legend Snippet: Protein expression of seven genes screened using WGCNA in clinical tissue samples. (A) Representative western blots of AURKA, BUB1, CCNB1, CDK1, MELK, NUSAP1 and TOP2A protein expression in adjacent lung adenocarcinoma tissues and lung adenocarcinoma tissue samples. (B) The quantitative analysis of the data in panel A, in which the protein levels of AURKA, TOP2A and MELK in lung adenocarcinoma tissues were higher than those in matched adjacent lung adenocarcinoma tissues. WGCNA, weighted gene co-expression network analysis.
Techniques Used: Expressing, Western Blot
rabbit polyclonal anti cdk1 p34 (Santa Cruz Biotechnology)
Structured Review
Rabbit Polyclonal Anti Cdk1 P34, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rabbit polyclonal anti cdk1 p34/product/Santa Cruz Biotechnology
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
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polyclonal anti rabbit cdc2 p34 (Santa Cruz Biotechnology)
Structured Review
Polyclonal Anti Rabbit Cdc2 P34, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/polyclonal anti rabbit cdc2 p34/product/Santa Cruz Biotechnology
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
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rabbit polyclonal anti phospho cdk1 thr161 (Beyotime)
Structured Review
Rabbit Polyclonal Anti Phospho Cdk1 Thr161, supplied by Beyotime, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rabbit polyclonal anti phospho cdk1 thr161/product/Beyotime
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99