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Normal and impaired glymphatic system. In a normal glymphatic system, CSF flows in from the arterial (red vessels) <t>PVS</t> and out through the venous (blue vessels) PVS, effectively removing metabolic wastes (purple blobs) from the brain. However, in a damaged glymphatic system, the CSF-ISF exchange is impaired, which hinders the removal of metabolic wastes from the brain. AQP4: Aquaporin-4; CSF: cerebrospinal fluid; EPVS: enlarged perivascular space; ISF: interstitial fluid; PVS: perivascular space.
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Normal and impaired glymphatic system. In a normal glymphatic system, CSF flows in from the arterial (red vessels) <t>PVS</t> and out through the venous (blue vessels) PVS, effectively removing metabolic wastes (purple blobs) from the brain. However, in a damaged glymphatic system, the CSF-ISF exchange is impaired, which hinders the removal of metabolic wastes from the brain. AQP4: Aquaporin-4; CSF: cerebrospinal fluid; EPVS: enlarged perivascular space; ISF: interstitial fluid; PVS: perivascular space.
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Normal and impaired glymphatic system. In a normal glymphatic system, CSF flows in from the arterial (red vessels) <t>PVS</t> and out through the venous (blue vessels) PVS, effectively removing metabolic wastes (purple blobs) from the brain. However, in a damaged glymphatic system, the CSF-ISF exchange is impaired, which hinders the removal of metabolic wastes from the brain. AQP4: Aquaporin-4; CSF: cerebrospinal fluid; EPVS: enlarged perivascular space; ISF: interstitial fluid; PVS: perivascular space.
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Normal and impaired glymphatic system. In a normal glymphatic system, CSF flows in from the arterial (red vessels) <t>PVS</t> and out through the venous (blue vessels) PVS, effectively removing metabolic wastes (purple blobs) from the brain. However, in a damaged glymphatic system, the CSF-ISF exchange is impaired, which hinders the removal of metabolic wastes from the brain. AQP4: Aquaporin-4; CSF: cerebrospinal fluid; EPVS: enlarged perivascular space; ISF: interstitial fluid; PVS: perivascular space.
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Normal and impaired glymphatic system. In a normal glymphatic system, CSF flows in from the arterial (red vessels) <t>PVS</t> and out through the venous (blue vessels) PVS, effectively removing metabolic wastes (purple blobs) from the brain. However, in a damaged glymphatic system, the CSF-ISF exchange is impaired, which hinders the removal of metabolic wastes from the brain. AQP4: Aquaporin-4; CSF: cerebrospinal fluid; EPVS: enlarged perivascular space; ISF: interstitial fluid; PVS: perivascular space.
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Normal and impaired glymphatic system. In a normal glymphatic system, CSF flows in from the arterial (red vessels) <t>PVS</t> and out through the venous (blue vessels) PVS, effectively removing metabolic wastes (purple blobs) from the brain. However, in a damaged glymphatic system, the CSF-ISF exchange is impaired, which hinders the removal of metabolic wastes from the brain. AQP4: Aquaporin-4; CSF: cerebrospinal fluid; EPVS: enlarged perivascular space; ISF: interstitial fluid; PVS: perivascular space.
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Normal and impaired glymphatic system. In a normal glymphatic system, CSF flows in from the arterial (red vessels) <t>PVS</t> and out through the venous (blue vessels) PVS, effectively removing metabolic wastes (purple blobs) from the brain. However, in a damaged glymphatic system, the CSF-ISF exchange is impaired, which hinders the removal of metabolic wastes from the brain. AQP4: Aquaporin-4; CSF: cerebrospinal fluid; EPVS: enlarged perivascular space; ISF: interstitial fluid; PVS: perivascular space.
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Image Search Results


Normal and impaired glymphatic system. In a normal glymphatic system, CSF flows in from the arterial (red vessels) PVS and out through the venous (blue vessels) PVS, effectively removing metabolic wastes (purple blobs) from the brain. However, in a damaged glymphatic system, the CSF-ISF exchange is impaired, which hinders the removal of metabolic wastes from the brain. AQP4: Aquaporin-4; CSF: cerebrospinal fluid; EPVS: enlarged perivascular space; ISF: interstitial fluid; PVS: perivascular space.

Journal: Neural Regeneration Research

Article Title: Targeting the brain’s glymphatic pathway: A novel therapeutic approach for cerebral small vessel disease

doi: 10.4103/NRR.NRR-D-24-00821

Figure Lengend Snippet: Normal and impaired glymphatic system. In a normal glymphatic system, CSF flows in from the arterial (red vessels) PVS and out through the venous (blue vessels) PVS, effectively removing metabolic wastes (purple blobs) from the brain. However, in a damaged glymphatic system, the CSF-ISF exchange is impaired, which hinders the removal of metabolic wastes from the brain. AQP4: Aquaporin-4; CSF: cerebrospinal fluid; EPVS: enlarged perivascular space; ISF: interstitial fluid; PVS: perivascular space.

Article Snippet: A recent clinical study utilized ex vivo MRI and validated models to quantify the relationship between enlarged EPVS and other pathological changes in brains with CAA, finding that PVS enlargement was positively correlated with Aβ accumulation in the vessel walls of the overlying cortex (Perosa et al., 2022).

Techniques:

In vivo imaging techniques for the detection of glymphatic pathway. CSF: Cerebrospinal fluid; DCE-MRI: dynamic contrast enhanced-magnetic resonance imaging; DTI-ALPS: diffusion tensor image-along the perivascular space; PET-CT: positron emission tomography-computed tomography.

Journal: Neural Regeneration Research

Article Title: Targeting the brain’s glymphatic pathway: A novel therapeutic approach for cerebral small vessel disease

doi: 10.4103/NRR.NRR-D-24-00821

Figure Lengend Snippet: In vivo imaging techniques for the detection of glymphatic pathway. CSF: Cerebrospinal fluid; DCE-MRI: dynamic contrast enhanced-magnetic resonance imaging; DTI-ALPS: diffusion tensor image-along the perivascular space; PET-CT: positron emission tomography-computed tomography.

Article Snippet: A recent clinical study utilized ex vivo MRI and validated models to quantify the relationship between enlarged EPVS and other pathological changes in brains with CAA, finding that PVS enlargement was positively correlated with Aβ accumulation in the vessel walls of the overlying cortex (Perosa et al., 2022).

Techniques: In Vivo Imaging, Magnetic Resonance Imaging, Diffusion-based Assay, Positron Emission Tomography-Computed Tomography, Positron Emission Tomography, Computed Tomography