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Journal: bioRxiv
Article Title: Systematic Infectome–Phenome Profiling Reveals Cryptococcal Infection-Associated Proteins Driving Immune System Remodeling and Immunization Potential
doi: 10.64898/2026.01.30.702846
Figure Lengend Snippet: A ) Venn diagram of unique proteins identified in the in vitro cellular proteome (purple; 2767 proteins) and secretome (blue; 18 proteins) with 25 proteins commonly detected. B) Egg diagram of proteins identified from the host, Mus musculus (4,952 after valid value filtering), and pathogen, Cryptococcus neoformans (874 after valid value filtering) from infectome analysis. C) Principal component analysis of infectome experiment. D) Volcano plot for comparison of host proteins with significant differences in abundance between infected (teal) and uninfected (grey) conditions. Student’s t test, P < 0.05; FDR = 0.05; S 0 = 1. E) Comparison of significantly different fungal proteins identified from the in vitro cellular proteome compared to the infectome. F) Comparison of significantly different fungal proteins identified from the in vitro secretome compared to the infectome. Red lines represent 0-, 4-, and 16-fold change in protein abundance. G) Pie chart based on GOBP for 53 fungal infection-associated protein (percentage of each category represented). Experiment completed in biological triplicate.
Article Snippet: The derived peak list was incorporated with the Andromeda search engine against the reference C. neoformans var. grubii serotype A (strain
Techniques: In Vitro, Comparison, Infection, Quantitative Proteomics