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Millipore propionic acid
Propionic Acid, supplied by Millipore, used in various techniques. Bioz Stars score: 97/100, based on 40 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/propionic acid/product/Millipore
Average 97 stars, based on 40 article reviews
Price from $9.99 to $1999.99
propionic acid - by Bioz Stars, 2022-09
97/100 stars

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  • 95
    Millipore 3 trimethylsilyl propionic 2 2 3 3 d4 acid sodium salt
    POMHEX selectively induces energy stress, inhibits proliferation, and triggers apoptosis in ENO1 -deleted glioma cells. ENO1 -deleted (D423, red), ENO1 -isogenically rescued (D423 ENO1, blue), and ENO1 -WT (LN319, grey) glioma cells were treated with the Enolase inhibitor POMHEX for 72 hours. Cells were harvested for protein lysates and polar metabolites. a . ENO1 -deleted cells experience dose-dependent increase in stress response markers (phosphorylated T346 NDRG1, S73 c-Jun), decrease in proliferation (phosphorylated Histone H3, PLK1), and increase in cell death (cleaved caspsase-3), as indicated by western blot. Such effects are exclusive to ENO1 -deleted cells (left, red) and are absent in ENO1 -WT cells (middle, blue; right, grey). b. Lactate levels were measured by 1 H NMR with the integral of 1.34 ppm doublet normalized to <t>3-(trimethylsilyl)propionic-2,2,3,3-d4</t> acid standard and expressed as % of CT [(n=2(CT), mean of n=1 (treated biological replicates)]. A dose-dependent decrease in lactate levels is unique to ENO1 -deleted, but not ENO1 -WT, glioma cells. c. Glycerate levels were used as a marker of Enolase inhibition and were measured by mass spectrometry. Values are expressed as % of CT [(n = 4(CT), mean of n = 2 (treated biological replicates)]. A dose-dependent increase in glycerate levels was observed in ENO1 -deleted but not ENO1 -WT glioma cells. d-e. Phosphocreatine/creatine ratio and pyrophosphate (PPi) levels quantified via mass spectrometry were used as measures of energy stress. The dose-dependent decrease in phosphocreatine to creatine ratio ( d ) and increase in PPi ( e ) in response to POMHEX treatment is specific to ENO1 -deleted glioma cells. Both measurements are expressed as a % of CT [N = 4(CT), mean of N = 2 (treated biological replicates)]. f . Treatment with POMHEX results in depletion of anaplerotic substrates. Top: metabolic map showing relative increases (red) and decreases (blue) of relevant metabolites in glycolysis, hexosamine biosynthesis pathway, non-oxidative pentose phosphate pathway, and TCA cycle in ENO1 -deleted (D423) cells. Bottom: heat map of relevant metabolites in ENO1 -deleted (D423), ENO1 -heterozygous deleted (D502, U343), and ENO1 -WT (LN319) glioma cells. A decrease in TCA metabolites is observed across all cell lines treated with POMHEX, Relative abundance is expressed as area-under-the-curve calculations of metabolite levels obtained from dose-response POMHEX treatment.
    3 Trimethylsilyl Propionic 2 2 3 3 D4 Acid Sodium Salt, supplied by Millipore, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/3 trimethylsilyl propionic 2 2 3 3 d4 acid sodium salt/product/Millipore
    Average 95 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    3 trimethylsilyl propionic 2 2 3 3 d4 acid sodium salt - by Bioz Stars, 2022-09
    95/100 stars
      Buy from Supplier

    97
    Millipore ro3244794 r 3 4 fluoro phenyl 2 5 4 fluoro phenyl benzofuran 2 ylmethoxycarbonylamino propionic acid
    Structures of (a) RO1138452 ((4,5-dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxy-benzyl)-phenyl]-amine), and (b) RO3244794 ( R <t>-3-(4-fluoro-phenyl)-2-[5-(4-fluoro-phenyl)-benzofuran-2-ylmethoxycarbonylamino]-propionic</t> acid).
    Ro3244794 R 3 4 Fluoro Phenyl 2 5 4 Fluoro Phenyl Benzofuran 2 Ylmethoxycarbonylamino Propionic Acid, supplied by Millipore, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ro3244794 r 3 4 fluoro phenyl 2 5 4 fluoro phenyl benzofuran 2 ylmethoxycarbonylamino propionic acid/product/Millipore
    Average 97 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    ro3244794 r 3 4 fluoro phenyl 2 5 4 fluoro phenyl benzofuran 2 ylmethoxycarbonylamino propionic acid - by Bioz Stars, 2022-09
    97/100 stars
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    92
    Millipore monomethoxy poly
    PA imaging of Cy7-labeled MPEG-PCL-g-PEI micelles in enucleated eyes. Notes: The red fluorescence signals might be blood vessels with nonspecific PA signals in the eyes. White and black circles designate the generated PA signal areas of Cy7-labeled amphiphilic micelles. Abbreviations: PA, photoacoustic; Cy, cyanine; MPEG, <t>monomethoxy</t> poly(ethylene glycol); PCL, poly(ε-caprolactone); PEI, polyethylenimine; min, minutes; 2-2-2, MPEG 2000 Da-PCL 2000 Da-PEI 2000 Da; 2-6-2, MPEG 2000 Da-PCL 6000 Da-PEI 2000 Da; 5-2-2; MPEG 5000 Da-PCL 2000 Da-PEI 2000 Da.
    Monomethoxy Poly, supplied by Millipore, used in various techniques. Bioz Stars score: 92/100, based on 11 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/monomethoxy poly/product/Millipore
    Average 92 stars, based on 11 article reviews
    Price from $9.99 to $1999.99
    monomethoxy poly - by Bioz Stars, 2022-09
    92/100 stars
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    Image Search Results


    POMHEX selectively induces energy stress, inhibits proliferation, and triggers apoptosis in ENO1 -deleted glioma cells. ENO1 -deleted (D423, red), ENO1 -isogenically rescued (D423 ENO1, blue), and ENO1 -WT (LN319, grey) glioma cells were treated with the Enolase inhibitor POMHEX for 72 hours. Cells were harvested for protein lysates and polar metabolites. a . ENO1 -deleted cells experience dose-dependent increase in stress response markers (phosphorylated T346 NDRG1, S73 c-Jun), decrease in proliferation (phosphorylated Histone H3, PLK1), and increase in cell death (cleaved caspsase-3), as indicated by western blot. Such effects are exclusive to ENO1 -deleted cells (left, red) and are absent in ENO1 -WT cells (middle, blue; right, grey). b. Lactate levels were measured by 1 H NMR with the integral of 1.34 ppm doublet normalized to 3-(trimethylsilyl)propionic-2,2,3,3-d4 acid standard and expressed as % of CT [(n=2(CT), mean of n=1 (treated biological replicates)]. A dose-dependent decrease in lactate levels is unique to ENO1 -deleted, but not ENO1 -WT, glioma cells. c. Glycerate levels were used as a marker of Enolase inhibition and were measured by mass spectrometry. Values are expressed as % of CT [(n = 4(CT), mean of n = 2 (treated biological replicates)]. A dose-dependent increase in glycerate levels was observed in ENO1 -deleted but not ENO1 -WT glioma cells. d-e. Phosphocreatine/creatine ratio and pyrophosphate (PPi) levels quantified via mass spectrometry were used as measures of energy stress. The dose-dependent decrease in phosphocreatine to creatine ratio ( d ) and increase in PPi ( e ) in response to POMHEX treatment is specific to ENO1 -deleted glioma cells. Both measurements are expressed as a % of CT [N = 4(CT), mean of N = 2 (treated biological replicates)]. f . Treatment with POMHEX results in depletion of anaplerotic substrates. Top: metabolic map showing relative increases (red) and decreases (blue) of relevant metabolites in glycolysis, hexosamine biosynthesis pathway, non-oxidative pentose phosphate pathway, and TCA cycle in ENO1 -deleted (D423) cells. Bottom: heat map of relevant metabolites in ENO1 -deleted (D423), ENO1 -heterozygous deleted (D502, U343), and ENO1 -WT (LN319) glioma cells. A decrease in TCA metabolites is observed across all cell lines treated with POMHEX, Relative abundance is expressed as area-under-the-curve calculations of metabolite levels obtained from dose-response POMHEX treatment.

    Journal: Nature metabolism

    Article Title: An Enolase Inhibitor for the Targeted Treatment of ENO1-Deleted Cancers

    doi: 10.1038/s42255-020-00313-3

    Figure Lengend Snippet: POMHEX selectively induces energy stress, inhibits proliferation, and triggers apoptosis in ENO1 -deleted glioma cells. ENO1 -deleted (D423, red), ENO1 -isogenically rescued (D423 ENO1, blue), and ENO1 -WT (LN319, grey) glioma cells were treated with the Enolase inhibitor POMHEX for 72 hours. Cells were harvested for protein lysates and polar metabolites. a . ENO1 -deleted cells experience dose-dependent increase in stress response markers (phosphorylated T346 NDRG1, S73 c-Jun), decrease in proliferation (phosphorylated Histone H3, PLK1), and increase in cell death (cleaved caspsase-3), as indicated by western blot. Such effects are exclusive to ENO1 -deleted cells (left, red) and are absent in ENO1 -WT cells (middle, blue; right, grey). b. Lactate levels were measured by 1 H NMR with the integral of 1.34 ppm doublet normalized to 3-(trimethylsilyl)propionic-2,2,3,3-d4 acid standard and expressed as % of CT [(n=2(CT), mean of n=1 (treated biological replicates)]. A dose-dependent decrease in lactate levels is unique to ENO1 -deleted, but not ENO1 -WT, glioma cells. c. Glycerate levels were used as a marker of Enolase inhibition and were measured by mass spectrometry. Values are expressed as % of CT [(n = 4(CT), mean of n = 2 (treated biological replicates)]. A dose-dependent increase in glycerate levels was observed in ENO1 -deleted but not ENO1 -WT glioma cells. d-e. Phosphocreatine/creatine ratio and pyrophosphate (PPi) levels quantified via mass spectrometry were used as measures of energy stress. The dose-dependent decrease in phosphocreatine to creatine ratio ( d ) and increase in PPi ( e ) in response to POMHEX treatment is specific to ENO1 -deleted glioma cells. Both measurements are expressed as a % of CT [N = 4(CT), mean of N = 2 (treated biological replicates)]. f . Treatment with POMHEX results in depletion of anaplerotic substrates. Top: metabolic map showing relative increases (red) and decreases (blue) of relevant metabolites in glycolysis, hexosamine biosynthesis pathway, non-oxidative pentose phosphate pathway, and TCA cycle in ENO1 -deleted (D423) cells. Bottom: heat map of relevant metabolites in ENO1 -deleted (D423), ENO1 -heterozygous deleted (D502, U343), and ENO1 -WT (LN319) glioma cells. A decrease in TCA metabolites is observed across all cell lines treated with POMHEX, Relative abundance is expressed as area-under-the-curve calculations of metabolite levels obtained from dose-response POMHEX treatment.

    Article Snippet: Conditioned media was supplemented with 10% D2O for signal lock and 3-(trimethylsilyl)propionic-2,2,3,3-d4 acid standard.

    Techniques: Western Blot, Nuclear Magnetic Resonance, Marker, Inhibition, Mass Spectrometry

    Structures of (a) RO1138452 ((4,5-dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxy-benzyl)-phenyl]-amine), and (b) RO3244794 ( R -3-(4-fluoro-phenyl)-2-[5-(4-fluoro-phenyl)-benzofuran-2-ylmethoxycarbonylamino]-propionic acid).

    Journal:

    Article Title: RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists

    doi: 10.1038/sj.bjp.0706554

    Figure Lengend Snippet: Structures of (a) RO1138452 ((4,5-dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxy-benzyl)-phenyl]-amine), and (b) RO3244794 ( R -3-(4-fluoro-phenyl)-2-[5-(4-fluoro-phenyl)-benzofuran-2-ylmethoxycarbonylamino]-propionic acid).

    Article Snippet: The HCl salts of RO1138452 ((4,5-dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxy-benzyl)-phenyl]-amine), RO3244794 ( R -3-(4-fluoro-phenyl)-2-[5-(4-fluoro-phenyl)-benzofuran-2-ylmethoxycarbonylamino]-propionic acid) and the sodium salt of indomethacin (Sigma-Aldrich Corp. (St Louis, MO, U.S.A.)) were synthesized by the Roche Palo Alto Department of Medicinal Chemistry using methods described in previous publications or patents from our laboratory ( ; ).

    Techniques:

    PA imaging of Cy7-labeled MPEG-PCL-g-PEI micelles in enucleated eyes. Notes: The red fluorescence signals might be blood vessels with nonspecific PA signals in the eyes. White and black circles designate the generated PA signal areas of Cy7-labeled amphiphilic micelles. Abbreviations: PA, photoacoustic; Cy, cyanine; MPEG, monomethoxy poly(ethylene glycol); PCL, poly(ε-caprolactone); PEI, polyethylenimine; min, minutes; 2-2-2, MPEG 2000 Da-PCL 2000 Da-PEI 2000 Da; 2-6-2, MPEG 2000 Da-PCL 6000 Da-PEI 2000 Da; 5-2-2; MPEG 5000 Da-PCL 2000 Da-PEI 2000 Da.

    Journal: International Journal of Nanomedicine

    Article Title: Visual tracing of diffusion and biodistribution for amphiphilic cationic nanoparticles using photoacoustic imaging after ex vivo intravitreal injections

    doi: 10.2147/IJN.S109986

    Figure Lengend Snippet: PA imaging of Cy7-labeled MPEG-PCL-g-PEI micelles in enucleated eyes. Notes: The red fluorescence signals might be blood vessels with nonspecific PA signals in the eyes. White and black circles designate the generated PA signal areas of Cy7-labeled amphiphilic micelles. Abbreviations: PA, photoacoustic; Cy, cyanine; MPEG, monomethoxy poly(ethylene glycol); PCL, poly(ε-caprolactone); PEI, polyethylenimine; min, minutes; 2-2-2, MPEG 2000 Da-PCL 2000 Da-PEI 2000 Da; 2-6-2, MPEG 2000 Da-PCL 6000 Da-PEI 2000 Da; 5-2-2; MPEG 5000 Da-PCL 2000 Da-PEI 2000 Da.

    Article Snippet: Reagents included monomethoxy poly(ethylene glycol) (MPEG, Mn 5,000 and 2,000; Sigma-Aldrich Co., St Louis, MO, USA), ε-caprolactone (ε-CL, MW 114; Alfa Aesar, Ward Hill, MA, USA), polyethylenimine (PEI, MW 2,000; Sigma-Aldrich Co.), stannous octoate (Sn(Oct)2 ; Sigma-Aldrich Co.), amine reactive Cyanine5 (Cy5® , Cy5-NHS) and Cyanine7 (Cy7® , Cy7-NHS) dyes (Lumiprobe, Hannover, Germany), and acryloyl chloride (Sigma-Aldrich Co.).

    Techniques: Imaging, Labeling, Fluorescence, Generated

    Confocal microscopy of the retina at 1 day ( A , E , and I ), 3 days ( B , F , and J ), 5 days ( C , G , and K ), and 7 days ( D , H , and L ) after intravitreal injection of Cy5-labeled micelles in rat. ( A – D ) Eyes injected with Cy5-labeled MPEG2000 Da-PCL2000 Da-g-PEI micelles. ( E – H ) Eyes injected with Cy5-labeled MPEG2000 Da-PCL6000 Da-g-PEI micelles. ( I – L ) A group of MPEG5000 Da-PCL2000 Da-g-PEI micelles. The fluorescent micelles diffused through the retinal layers and were concentrated in the RPE layer. Black arrows indicate this layer. Abbreviations: Cy, cyanine; MPEG, monomethoxy poly(ethylene glycol); PCL, poly(ε-caprolactone); PEI, polyethylenimine; CH, choroid; RPE, retinal pigment epithelium.

    Journal: International Journal of Nanomedicine

    Article Title: Visual tracing of diffusion and biodistribution for amphiphilic cationic nanoparticles using photoacoustic imaging after ex vivo intravitreal injections

    doi: 10.2147/IJN.S109986

    Figure Lengend Snippet: Confocal microscopy of the retina at 1 day ( A , E , and I ), 3 days ( B , F , and J ), 5 days ( C , G , and K ), and 7 days ( D , H , and L ) after intravitreal injection of Cy5-labeled micelles in rat. ( A – D ) Eyes injected with Cy5-labeled MPEG2000 Da-PCL2000 Da-g-PEI micelles. ( E – H ) Eyes injected with Cy5-labeled MPEG2000 Da-PCL6000 Da-g-PEI micelles. ( I – L ) A group of MPEG5000 Da-PCL2000 Da-g-PEI micelles. The fluorescent micelles diffused through the retinal layers and were concentrated in the RPE layer. Black arrows indicate this layer. Abbreviations: Cy, cyanine; MPEG, monomethoxy poly(ethylene glycol); PCL, poly(ε-caprolactone); PEI, polyethylenimine; CH, choroid; RPE, retinal pigment epithelium.

    Article Snippet: Reagents included monomethoxy poly(ethylene glycol) (MPEG, Mn 5,000 and 2,000; Sigma-Aldrich Co., St Louis, MO, USA), ε-caprolactone (ε-CL, MW 114; Alfa Aesar, Ward Hill, MA, USA), polyethylenimine (PEI, MW 2,000; Sigma-Aldrich Co.), stannous octoate (Sn(Oct)2 ; Sigma-Aldrich Co.), amine reactive Cyanine5 (Cy5® , Cy5-NHS) and Cyanine7 (Cy7® , Cy7-NHS) dyes (Lumiprobe, Hannover, Germany), and acryloyl chloride (Sigma-Aldrich Co.).

    Techniques: Confocal Microscopy, Injection, Labeling

    Cytotoxicity of MPEG-PCL-g-PEI micelles of various compositions on ARPE cells and cell viability were determined by MTT assay (n=6). Abbreviations: MPEG, monomethoxy poly(ethylene glycol); PCL, poly(ε-caprolactone); PEI, polyethylenimine; MTT, 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyl-tetrazolium bromide; 2-2-2, MPEG 2000 Da-PCL 2000 Da-PEI 2000 Da; 2-6-2, MPEG 2000 Da-PCL 6000 Da-PEI 2000 Da; 5-2-2; MPEG 5000 Da-PCL 2000 Da-PEI 2000 Da.

    Journal: International Journal of Nanomedicine

    Article Title: Visual tracing of diffusion and biodistribution for amphiphilic cationic nanoparticles using photoacoustic imaging after ex vivo intravitreal injections

    doi: 10.2147/IJN.S109986

    Figure Lengend Snippet: Cytotoxicity of MPEG-PCL-g-PEI micelles of various compositions on ARPE cells and cell viability were determined by MTT assay (n=6). Abbreviations: MPEG, monomethoxy poly(ethylene glycol); PCL, poly(ε-caprolactone); PEI, polyethylenimine; MTT, 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyl-tetrazolium bromide; 2-2-2, MPEG 2000 Da-PCL 2000 Da-PEI 2000 Da; 2-6-2, MPEG 2000 Da-PCL 6000 Da-PEI 2000 Da; 5-2-2; MPEG 5000 Da-PCL 2000 Da-PEI 2000 Da.

    Article Snippet: Reagents included monomethoxy poly(ethylene glycol) (MPEG, Mn 5,000 and 2,000; Sigma-Aldrich Co., St Louis, MO, USA), ε-caprolactone (ε-CL, MW 114; Alfa Aesar, Ward Hill, MA, USA), polyethylenimine (PEI, MW 2,000; Sigma-Aldrich Co.), stannous octoate (Sn(Oct)2 ; Sigma-Aldrich Co.), amine reactive Cyanine5 (Cy5® , Cy5-NHS) and Cyanine7 (Cy7® , Cy7-NHS) dyes (Lumiprobe, Hannover, Germany), and acryloyl chloride (Sigma-Aldrich Co.).

    Techniques: MTT Assay

    Biodistribution of MPEG-PCL-g-PEI NPs after intravitreal injection at each time point ( A ) 1 day, ( B ) 3 days, ( C ) 5 days, and ( D ) 7 days. Note: The bar graphs were obtained from confocal microscopic images of whole eye cryosections. Abbreviations: MPEG, monomethoxy poly(ethylene glycol); PCL, poly(ε-caprolactone); PEI, polyethylenimine; NPs, nanoparticles; RPE, retinal pigment epithelium; INL, inner nuclear layer; IPL, inner plexiform layer; OPL, outer plexiform layer; ONL, outer nuclear layer; NFL, nerve fiber layer; GCL, ganglion cell layer; IO/IS, inner segment of photoreceptor/outer segment of photoreceptor; 2-2-2, MPEG 2000 Da-PCL 2000 Da-PEI 2000 Da; 2-6-2, MPEG 2000 Da-PCL 6000 Da-PEI 2000 Da; 5-2-2; MPEG 5000 Da-PCL 2000 Da-PEI 2000 Da.

    Journal: International Journal of Nanomedicine

    Article Title: Visual tracing of diffusion and biodistribution for amphiphilic cationic nanoparticles using photoacoustic imaging after ex vivo intravitreal injections

    doi: 10.2147/IJN.S109986

    Figure Lengend Snippet: Biodistribution of MPEG-PCL-g-PEI NPs after intravitreal injection at each time point ( A ) 1 day, ( B ) 3 days, ( C ) 5 days, and ( D ) 7 days. Note: The bar graphs were obtained from confocal microscopic images of whole eye cryosections. Abbreviations: MPEG, monomethoxy poly(ethylene glycol); PCL, poly(ε-caprolactone); PEI, polyethylenimine; NPs, nanoparticles; RPE, retinal pigment epithelium; INL, inner nuclear layer; IPL, inner plexiform layer; OPL, outer plexiform layer; ONL, outer nuclear layer; NFL, nerve fiber layer; GCL, ganglion cell layer; IO/IS, inner segment of photoreceptor/outer segment of photoreceptor; 2-2-2, MPEG 2000 Da-PCL 2000 Da-PEI 2000 Da; 2-6-2, MPEG 2000 Da-PCL 6000 Da-PEI 2000 Da; 5-2-2; MPEG 5000 Da-PCL 2000 Da-PEI 2000 Da.

    Article Snippet: Reagents included monomethoxy poly(ethylene glycol) (MPEG, Mn 5,000 and 2,000; Sigma-Aldrich Co., St Louis, MO, USA), ε-caprolactone (ε-CL, MW 114; Alfa Aesar, Ward Hill, MA, USA), polyethylenimine (PEI, MW 2,000; Sigma-Aldrich Co.), stannous octoate (Sn(Oct)2 ; Sigma-Aldrich Co.), amine reactive Cyanine5 (Cy5® , Cy5-NHS) and Cyanine7 (Cy7® , Cy7-NHS) dyes (Lumiprobe, Hannover, Germany), and acryloyl chloride (Sigma-Aldrich Co.).

    Techniques: Injection

    TGA curves: PNS (dashed curve) ; PNS-SS-ADA (double dashed dotted curve) ; PNS-SS-ADA@CD-mPEG (solid curve) .

    Journal: International Journal of Biomaterials

    Article Title: Efficient Self-Assembly of mPEG End-Capped Porous Silica as a Redox-Sensitive Nanocarrier for Controlled Doxorubicin Delivery

    doi: 10.1155/2018/1575438

    Figure Lengend Snippet: TGA curves: PNS (dashed curve) ; PNS-SS-ADA (double dashed dotted curve) ; PNS-SS-ADA@CD-mPEG (solid curve) .

    Article Snippet: Tetraethyl orthosilicate (TEOS, 98%), p -toluenesulfonyl chloride (TsCl), ADA, doxorubicin (DOX, 99%), mPEG (Mw 5000), DTT, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC, 97%), N,N-dimethyl formamide (DMF), and ethylenediamine (EDA, 99%) were purchased from Sigma-Aldrich (St. Louis, MO, USA).

    Techniques:

    N 2 adsorption-desorption isotherms: PNS (a); PNS-SS-ADA (b); PNS-SS-ADA@CD-mPEG (c).

    Journal: International Journal of Biomaterials

    Article Title: Efficient Self-Assembly of mPEG End-Capped Porous Silica as a Redox-Sensitive Nanocarrier for Controlled Doxorubicin Delivery

    doi: 10.1155/2018/1575438

    Figure Lengend Snippet: N 2 adsorption-desorption isotherms: PNS (a); PNS-SS-ADA (b); PNS-SS-ADA@CD-mPEG (c).

    Article Snippet: Tetraethyl orthosilicate (TEOS, 98%), p -toluenesulfonyl chloride (TsCl), ADA, doxorubicin (DOX, 99%), mPEG (Mw 5000), DTT, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC, 97%), N,N-dimethyl formamide (DMF), and ethylenediamine (EDA, 99%) were purchased from Sigma-Aldrich (St. Louis, MO, USA).

    Techniques: Adsorption

    1 H NMR spectra: PNS-SS-ADA (a); CD-mPEG (b).

    Journal: International Journal of Biomaterials

    Article Title: Efficient Self-Assembly of mPEG End-Capped Porous Silica as a Redox-Sensitive Nanocarrier for Controlled Doxorubicin Delivery

    doi: 10.1155/2018/1575438

    Figure Lengend Snippet: 1 H NMR spectra: PNS-SS-ADA (a); CD-mPEG (b).

    Article Snippet: Tetraethyl orthosilicate (TEOS, 98%), p -toluenesulfonyl chloride (TsCl), ADA, doxorubicin (DOX, 99%), mPEG (Mw 5000), DTT, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC, 97%), N,N-dimethyl formamide (DMF), and ethylenediamine (EDA, 99%) were purchased from Sigma-Aldrich (St. Louis, MO, USA).

    Techniques: Nuclear Magnetic Resonance

    In vitro release profiles of DOX from PNS-SS-ADA@CD-mPEG in PBS (pH 7.4) with and without DTT (5 mM).

    Journal: International Journal of Biomaterials

    Article Title: Efficient Self-Assembly of mPEG End-Capped Porous Silica as a Redox-Sensitive Nanocarrier for Controlled Doxorubicin Delivery

    doi: 10.1155/2018/1575438

    Figure Lengend Snippet: In vitro release profiles of DOX from PNS-SS-ADA@CD-mPEG in PBS (pH 7.4) with and without DTT (5 mM).

    Article Snippet: Tetraethyl orthosilicate (TEOS, 98%), p -toluenesulfonyl chloride (TsCl), ADA, doxorubicin (DOX, 99%), mPEG (Mw 5000), DTT, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC, 97%), N,N-dimethyl formamide (DMF), and ethylenediamine (EDA, 99%) were purchased from Sigma-Aldrich (St. Louis, MO, USA).

    Techniques: In Vitro

    Viability of HeLa cells incubated with PNS-SS-ADA@CD-mPEG (100 μ g/mL), free DOX (5 μ g/mL), and DOX/PNS-SS-ADA@CD-mPEG (eq. DOX conc.) for 24, 48, and 96 h. The cells were exposed to the samples for the indicated times. The data represent the mean values ± the standard deviation (SD) ( n = 4).

    Journal: International Journal of Biomaterials

    Article Title: Efficient Self-Assembly of mPEG End-Capped Porous Silica as a Redox-Sensitive Nanocarrier for Controlled Doxorubicin Delivery

    doi: 10.1155/2018/1575438

    Figure Lengend Snippet: Viability of HeLa cells incubated with PNS-SS-ADA@CD-mPEG (100 μ g/mL), free DOX (5 μ g/mL), and DOX/PNS-SS-ADA@CD-mPEG (eq. DOX conc.) for 24, 48, and 96 h. The cells were exposed to the samples for the indicated times. The data represent the mean values ± the standard deviation (SD) ( n = 4).

    Article Snippet: Tetraethyl orthosilicate (TEOS, 98%), p -toluenesulfonyl chloride (TsCl), ADA, doxorubicin (DOX, 99%), mPEG (Mw 5000), DTT, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC, 97%), N,N-dimethyl formamide (DMF), and ethylenediamine (EDA, 99%) were purchased from Sigma-Aldrich (St. Louis, MO, USA).

    Techniques: Incubation, Standard Deviation

    ]; PNS-SS-ADA@CD-mPEG (c).

    Journal: International Journal of Biomaterials

    Article Title: Efficient Self-Assembly of mPEG End-Capped Porous Silica as a Redox-Sensitive Nanocarrier for Controlled Doxorubicin Delivery

    doi: 10.1155/2018/1575438

    Figure Lengend Snippet: ]; PNS-SS-ADA@CD-mPEG (c).

    Article Snippet: Tetraethyl orthosilicate (TEOS, 98%), p -toluenesulfonyl chloride (TsCl), ADA, doxorubicin (DOX, 99%), mPEG (Mw 5000), DTT, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC, 97%), N,N-dimethyl formamide (DMF), and ethylenediamine (EDA, 99%) were purchased from Sigma-Aldrich (St. Louis, MO, USA).

    Techniques:

    Schematic showing the formation of redox-responsive DOX/PNS-SS-ADA@CD-mPEG nanocarriers.

    Journal: International Journal of Biomaterials

    Article Title: Efficient Self-Assembly of mPEG End-Capped Porous Silica as a Redox-Sensitive Nanocarrier for Controlled Doxorubicin Delivery

    doi: 10.1155/2018/1575438

    Figure Lengend Snippet: Schematic showing the formation of redox-responsive DOX/PNS-SS-ADA@CD-mPEG nanocarriers.

    Article Snippet: Tetraethyl orthosilicate (TEOS, 98%), p -toluenesulfonyl chloride (TsCl), ADA, doxorubicin (DOX, 99%), mPEG (Mw 5000), DTT, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC, 97%), N,N-dimethyl formamide (DMF), and ethylenediamine (EDA, 99%) were purchased from Sigma-Aldrich (St. Louis, MO, USA).

    Techniques:

    TEM images and particle size histograms: PNS (a, b); PNS-SS-ADA@CD-mPEG (c, d) fitted by log-normal distribution function, respectively.

    Journal: International Journal of Biomaterials

    Article Title: Efficient Self-Assembly of mPEG End-Capped Porous Silica as a Redox-Sensitive Nanocarrier for Controlled Doxorubicin Delivery

    doi: 10.1155/2018/1575438

    Figure Lengend Snippet: TEM images and particle size histograms: PNS (a, b); PNS-SS-ADA@CD-mPEG (c, d) fitted by log-normal distribution function, respectively.

    Article Snippet: Tetraethyl orthosilicate (TEOS, 98%), p -toluenesulfonyl chloride (TsCl), ADA, doxorubicin (DOX, 99%), mPEG (Mw 5000), DTT, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC, 97%), N,N-dimethyl formamide (DMF), and ethylenediamine (EDA, 99%) were purchased from Sigma-Aldrich (St. Louis, MO, USA).

    Techniques: Transmission Electron Microscopy