primary antibodies against c fos  (Danaher Inc)


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    Danaher Inc primary antibodies against c fos
    Primary Antibodies Against C Fos, supplied by Danaher Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/primary antibodies against c fos/product/Danaher Inc
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    primary antibodies against c fos - by Bioz Stars, 2024-07
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    Proteintech primary antibody against c fos
    Primary Antibody Against C Fos, supplied by Proteintech, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/primary antibody against c fos/product/Proteintech
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
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    rabbit primary antibody against c fos  (Danaher Inc)


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    Danaher Inc rabbit primary antibody against c fos
    Rabbit Primary Antibody Against C Fos, supplied by Danaher Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rabbit primary antibody against c fos/product/Danaher Inc
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    rabbit primary antibody against c fos - by Bioz Stars, 2024-07
    86/100 stars

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    rabbit primary antibody against c fos  (Danaher Inc)


    Bioz Verified Symbol Danaher Inc is a verified supplier
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    Danaher Inc rabbit primary antibody against c fos
    Activating M1 glutamatergic neurons affected heart function and blood pressure. A) Schematic drawing showing viral injection strategy (left), a representative image showing ChR2‐mCherry expression (right top) and the experimental timeline (right bottom), respectively. Scale bar, 500 µm. B) Images showing the overlap between ChR2‐mCherry (red) and vesicular glutamate transporter <t>2</t> <t>(VGlut2)</t> (green) in the M1 (left), and the percentage of ChR2 cells expressing VGlut2 (right, n = 4). Scale bar, 50 µm. C) Representative curve graph of HR over time. D, E) Quantification of HR (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 18) = 25.560, P < 0.001; mCherry off versus on, P = 1.000; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.444; on mCherry versus ChR2, P = 0.707; mCherry = 10, ChR2 = 10), LF/HF power ratio (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 21) = 48.314, P < 0.001; mCherry off versus on, P = 0.406; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.201; on mCherry versus ChR2, P < 0.001;mCherry = 11, ChR2 = 12) in anesthetized mice. F) Examples of echocardiographic images in anesthetized mice. G, H, I, J, K, L, M) Quantification of LVEF (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 18) = 68.023, P < 0.001; mCherry off versus on, P = 0.980; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.933; on mCherry versus ChR2, P < 0.01; mCherry = 10, ChR2 = 10), LVFS (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 18) = 16.221, P < 0.01; mCherry off versus on, P = 0.477; ChR2 off versus on, P < 0.01; off mCherry versus ChR2, P = 0.984; on mCherry versus ChR2, P < 0.01; mCherry = 10, ChR2 = 10), LVIDd (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 18) = 0.137, P = 0.715; mCherry off versus on, P = 0.897; ChR2 off versus on, P = 0.699; off mCherry versus ChR2, P = 0.547; on mCherry versus ChR2, P = 0.682; mCherry = 10, ChR2 = 10), LVIDs (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 18) = 9.309, P < 0.01; mCherry off versus on, P = 0.823; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.929; on mCherry versus ChR2, P = 0.101; mCherry = 10, ChR2 = 10), SBP (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 18) = 6.232, P < 0.05; mCherry off versus on, P = 0.830; ChR2 off versus on, P < 0.01; off mCherry versus ChR2, P = 0.699; on mCherry versus ChR2, P < 0.05; mCherry = 10, ChR2 = 10), DBP (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 18) = 22.638, P < 0.001; mCherry off versus on, P = 0.816; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.699; on mCherry versus ChR2, P < 0.05; mCherry = 10, ChR2 = 10) and MAP (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 18) = 20.249, P < 0.001; mCherry off versus on, P = 0.943; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.521; on mCherry versus ChR2, P < 0.01; mCherry = 10, ChR2 = 10) in anesthetized mice. N) Immunohistochemical images showing overlap of ChR2‐mCherry (red) and <t>c‐Fos</t> (green)‐positive neurons in the M1. Scale bar, 100 µm. O) Quantification of c‐Fos‐positive cells in the M1 (Independent t test. t (4) = −4.311, P < 0.05). Data are mean ± SEM. * P < 0.05; ** P < 0.01, *** P < 0.001.
    Rabbit Primary Antibody Against C Fos, supplied by Danaher Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rabbit primary antibody against c fos/product/Danaher Inc
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    rabbit primary antibody against c fos - by Bioz Stars, 2024-07
    86/100 stars

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    1) Product Images from "Manipulation of Glutamatergic Neuronal Activity in the Primary Motor Cortex Regulates Cardiac Function in Normal and Myocardial Infarction Mice"

    Article Title: Manipulation of Glutamatergic Neuronal Activity in the Primary Motor Cortex Regulates Cardiac Function in Normal and Myocardial Infarction Mice

    Journal: Advanced Science

    doi: 10.1002/advs.202305581

    Activating M1 glutamatergic neurons affected heart function and blood pressure. A) Schematic drawing showing viral injection strategy (left), a representative image showing ChR2‐mCherry expression (right top) and the experimental timeline (right bottom), respectively. Scale bar, 500 µm. B) Images showing the overlap between ChR2‐mCherry (red) and vesicular glutamate transporter 2 (VGlut2) (green) in the M1 (left), and the percentage of ChR2 cells expressing VGlut2 (right, n = 4). Scale bar, 50 µm. C) Representative curve graph of HR over time. D, E) Quantification of HR (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 18) = 25.560, P < 0.001; mCherry off versus on, P = 1.000; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.444; on mCherry versus ChR2, P = 0.707; mCherry = 10, ChR2 = 10), LF/HF power ratio (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 21) = 48.314, P < 0.001; mCherry off versus on, P = 0.406; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.201; on mCherry versus ChR2, P < 0.001;mCherry = 11, ChR2 = 12) in anesthetized mice. F) Examples of echocardiographic images in anesthetized mice. G, H, I, J, K, L, M) Quantification of LVEF (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 18) = 68.023, P < 0.001; mCherry off versus on, P = 0.980; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.933; on mCherry versus ChR2, P < 0.01; mCherry = 10, ChR2 = 10), LVFS (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 18) = 16.221, P < 0.01; mCherry off versus on, P = 0.477; ChR2 off versus on, P < 0.01; off mCherry versus ChR2, P = 0.984; on mCherry versus ChR2, P < 0.01; mCherry = 10, ChR2 = 10), LVIDd (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 18) = 0.137, P = 0.715; mCherry off versus on, P = 0.897; ChR2 off versus on, P = 0.699; off mCherry versus ChR2, P = 0.547; on mCherry versus ChR2, P = 0.682; mCherry = 10, ChR2 = 10), LVIDs (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 18) = 9.309, P < 0.01; mCherry off versus on, P = 0.823; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.929; on mCherry versus ChR2, P = 0.101; mCherry = 10, ChR2 = 10), SBP (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 18) = 6.232, P < 0.05; mCherry off versus on, P = 0.830; ChR2 off versus on, P < 0.01; off mCherry versus ChR2, P = 0.699; on mCherry versus ChR2, P < 0.05; mCherry = 10, ChR2 = 10), DBP (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 18) = 22.638, P < 0.001; mCherry off versus on, P = 0.816; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.699; on mCherry versus ChR2, P < 0.05; mCherry = 10, ChR2 = 10) and MAP (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 18) = 20.249, P < 0.001; mCherry off versus on, P = 0.943; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.521; on mCherry versus ChR2, P < 0.01; mCherry = 10, ChR2 = 10) in anesthetized mice. N) Immunohistochemical images showing overlap of ChR2‐mCherry (red) and c‐Fos (green)‐positive neurons in the M1. Scale bar, 100 µm. O) Quantification of c‐Fos‐positive cells in the M1 (Independent t test. t (4) = −4.311, P < 0.05). Data are mean ± SEM. * P < 0.05; ** P < 0.01, *** P < 0.001.
    Figure Legend Snippet: Activating M1 glutamatergic neurons affected heart function and blood pressure. A) Schematic drawing showing viral injection strategy (left), a representative image showing ChR2‐mCherry expression (right top) and the experimental timeline (right bottom), respectively. Scale bar, 500 µm. B) Images showing the overlap between ChR2‐mCherry (red) and vesicular glutamate transporter 2 (VGlut2) (green) in the M1 (left), and the percentage of ChR2 cells expressing VGlut2 (right, n = 4). Scale bar, 50 µm. C) Representative curve graph of HR over time. D, E) Quantification of HR (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 18) = 25.560, P < 0.001; mCherry off versus on, P = 1.000; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.444; on mCherry versus ChR2, P = 0.707; mCherry = 10, ChR2 = 10), LF/HF power ratio (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 21) = 48.314, P < 0.001; mCherry off versus on, P = 0.406; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.201; on mCherry versus ChR2, P < 0.001;mCherry = 11, ChR2 = 12) in anesthetized mice. F) Examples of echocardiographic images in anesthetized mice. G, H, I, J, K, L, M) Quantification of LVEF (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 18) = 68.023, P < 0.001; mCherry off versus on, P = 0.980; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.933; on mCherry versus ChR2, P < 0.01; mCherry = 10, ChR2 = 10), LVFS (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 18) = 16.221, P < 0.01; mCherry off versus on, P = 0.477; ChR2 off versus on, P < 0.01; off mCherry versus ChR2, P = 0.984; on mCherry versus ChR2, P < 0.01; mCherry = 10, ChR2 = 10), LVIDd (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 18) = 0.137, P = 0.715; mCherry off versus on, P = 0.897; ChR2 off versus on, P = 0.699; off mCherry versus ChR2, P = 0.547; on mCherry versus ChR2, P = 0.682; mCherry = 10, ChR2 = 10), LVIDs (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 18) = 9.309, P < 0.01; mCherry off versus on, P = 0.823; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.929; on mCherry versus ChR2, P = 0.101; mCherry = 10, ChR2 = 10), SBP (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 18) = 6.232, P < 0.05; mCherry off versus on, P = 0.830; ChR2 off versus on, P < 0.01; off mCherry versus ChR2, P = 0.699; on mCherry versus ChR2, P < 0.05; mCherry = 10, ChR2 = 10), DBP (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 18) = 22.638, P < 0.001; mCherry off versus on, P = 0.816; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.699; on mCherry versus ChR2, P < 0.05; mCherry = 10, ChR2 = 10) and MAP (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 18) = 20.249, P < 0.001; mCherry off versus on, P = 0.943; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.521; on mCherry versus ChR2, P < 0.01; mCherry = 10, ChR2 = 10) in anesthetized mice. N) Immunohistochemical images showing overlap of ChR2‐mCherry (red) and c‐Fos (green)‐positive neurons in the M1. Scale bar, 100 µm. O) Quantification of c‐Fos‐positive cells in the M1 (Independent t test. t (4) = −4.311, P < 0.05). Data are mean ± SEM. * P < 0.05; ** P < 0.01, *** P < 0.001.

    Techniques Used: Injection, Expressing, Immunohistochemical staining

    Chemogenetic inhibition of M1 glutamatergic neurons suppressed heart function and blood pressure. A) Experimental schematics (left), a representative image showing hM4Di–mCherry expression in the M1 (right top) and the image of experimental timeline (right bottom), respectively. Scale bar, 500 µm. B) Images showing the overlap between VGlut2 (green) and hM4Di‐mCherry (red) in the M1 (left), and the percentage of hM4Di cells expressing VGlut2 (right, n = 4). Scale bar, 25 µm. C) Examples of echocardiographic images in anesthetized mice. D, E, F, G, H, I) Quantification of LVEF (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 22) = 52.169, P < 0.001; mCherry Saline versus CNO, P = 0.876; hM4Di Saline versus CNO, P < 0.001; Saline mCherry versus hM4Di, P = 0.161; CNO mCherry versus hM4Di, P < 0.001, mCherry = 12, hM4Di = 12), HR (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 22) = 5.931, P < 0.05; mCherry Saline versus CNO, P = 0.267; hM4Di Saline versus CNO, P < 0.05; Saline mCherry versus hM4Di, P = 0.286; CNO mCherry versus hM4Di, P = 0.740; mCherry = 12, hM4Di = 12), LVFS (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 22) = 8.603, P < 0.01; mCherry Saline versus CNO, P = 0.452; hM4Di Saline versus CNO, P < 0.01; Saline mCherry versus hM4Di, P = 0.341; CNO mCherry versus hM4Di, P < 0.01; mCherry = 12, hM4Di = 12), LVIDd (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 22) = 2.420, P = 0.134; mCherry Saline versus CNO, P = 0.819; hM4Di Saline versus CNO, P = 0.062; Saline mCherry versus hM4Di, P = 0.245; CNO mCherry versus hM4Di, P < 0.05; mCherry = 12, hM4Di = 12), LVIDs (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 22) = 13.221, P < 0.01; mCherry Saline versus CNO, P = 0.552; hM4Di Saline versus CNO, P < 0.001; Saline mCherry versus hM4Di, P = 0.155; CNO mCherry versus hM4Di, P < 0.001; mCherry = 12, hM4Di = 12) and LF/HF (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 25) = 95.277, P < 0.001; mCherry Saline versus CNO, P = 0.392; hM4Di Saline versus CNO, P < 0.001; Saline mCherry versus hM4Di, P = 0.691; CNO mCherry versus hM4Di, P < 0.001, mCherry = 13, hM4Di = 14) in anesthetized mice. J, K, L) Quantification of SBP (Two‐way repeated‐measures ANOVA‐Interaction: mCherry Saline versus CNO, P = 0.528; hM4Di Saline versus CNO, P < 0.05; Wilcoxon rank sum test; Saline mCherry versus hM4Di, P = 0.366; CNO mCherry versus hM4Di, P < 0.01; two‐sided Mann–Whitney test. mCherry = 6, hM4Di = 7), DBP (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 11) = 7.796, P < 0.01; mCherry Saline versus CNO, P = 0.578; hM4Di Saline versus CNO, P < 0.001; Saline mCherry versus hM4Di, P = 0.174; CNO mCherry versus hM4Di, P < 0.05, mCherry = 6, hM4Di = 7) and MAP (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 11) = 11.536, P < 0.01; mCherry Saline versus CNO, P = 0.764; hM4Di Saline versus CNO, P < 0.001; Saline mCherry versus hM4Di, P = 0.261; CNO mCherry versus hM4Di, P < 0.01, mCherry = 6, hM4Di = 7) in conscious mice. M) Immunohistochemical images showing overlap of hM4Di (red) and c‐Fos (green) neurons in the M1 expressing mCherry or hM4Di mice. Scale bar, 100 µm. N) Quantification of c‐Fos‐positive cells in the M1 (Independent t test. t (4) = 24.356, P < 0.001). Data are mean ± SEM. * P < 0.05; ** P < 0.01, *** P < 0.001.
    Figure Legend Snippet: Chemogenetic inhibition of M1 glutamatergic neurons suppressed heart function and blood pressure. A) Experimental schematics (left), a representative image showing hM4Di–mCherry expression in the M1 (right top) and the image of experimental timeline (right bottom), respectively. Scale bar, 500 µm. B) Images showing the overlap between VGlut2 (green) and hM4Di‐mCherry (red) in the M1 (left), and the percentage of hM4Di cells expressing VGlut2 (right, n = 4). Scale bar, 25 µm. C) Examples of echocardiographic images in anesthetized mice. D, E, F, G, H, I) Quantification of LVEF (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 22) = 52.169, P < 0.001; mCherry Saline versus CNO, P = 0.876; hM4Di Saline versus CNO, P < 0.001; Saline mCherry versus hM4Di, P = 0.161; CNO mCherry versus hM4Di, P < 0.001, mCherry = 12, hM4Di = 12), HR (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 22) = 5.931, P < 0.05; mCherry Saline versus CNO, P = 0.267; hM4Di Saline versus CNO, P < 0.05; Saline mCherry versus hM4Di, P = 0.286; CNO mCherry versus hM4Di, P = 0.740; mCherry = 12, hM4Di = 12), LVFS (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 22) = 8.603, P < 0.01; mCherry Saline versus CNO, P = 0.452; hM4Di Saline versus CNO, P < 0.01; Saline mCherry versus hM4Di, P = 0.341; CNO mCherry versus hM4Di, P < 0.01; mCherry = 12, hM4Di = 12), LVIDd (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 22) = 2.420, P = 0.134; mCherry Saline versus CNO, P = 0.819; hM4Di Saline versus CNO, P = 0.062; Saline mCherry versus hM4Di, P = 0.245; CNO mCherry versus hM4Di, P < 0.05; mCherry = 12, hM4Di = 12), LVIDs (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 22) = 13.221, P < 0.01; mCherry Saline versus CNO, P = 0.552; hM4Di Saline versus CNO, P < 0.001; Saline mCherry versus hM4Di, P = 0.155; CNO mCherry versus hM4Di, P < 0.001; mCherry = 12, hM4Di = 12) and LF/HF (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 25) = 95.277, P < 0.001; mCherry Saline versus CNO, P = 0.392; hM4Di Saline versus CNO, P < 0.001; Saline mCherry versus hM4Di, P = 0.691; CNO mCherry versus hM4Di, P < 0.001, mCherry = 13, hM4Di = 14) in anesthetized mice. J, K, L) Quantification of SBP (Two‐way repeated‐measures ANOVA‐Interaction: mCherry Saline versus CNO, P = 0.528; hM4Di Saline versus CNO, P < 0.05; Wilcoxon rank sum test; Saline mCherry versus hM4Di, P = 0.366; CNO mCherry versus hM4Di, P < 0.01; two‐sided Mann–Whitney test. mCherry = 6, hM4Di = 7), DBP (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 11) = 7.796, P < 0.01; mCherry Saline versus CNO, P = 0.578; hM4Di Saline versus CNO, P < 0.001; Saline mCherry versus hM4Di, P = 0.174; CNO mCherry versus hM4Di, P < 0.05, mCherry = 6, hM4Di = 7) and MAP (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 11) = 11.536, P < 0.01; mCherry Saline versus CNO, P = 0.764; hM4Di Saline versus CNO, P < 0.001; Saline mCherry versus hM4Di, P = 0.261; CNO mCherry versus hM4Di, P < 0.01, mCherry = 6, hM4Di = 7) in conscious mice. M) Immunohistochemical images showing overlap of hM4Di (red) and c‐Fos (green) neurons in the M1 expressing mCherry or hM4Di mice. Scale bar, 100 µm. N) Quantification of c‐Fos‐positive cells in the M1 (Independent t test. t (4) = 24.356, P < 0.001). Data are mean ± SEM. * P < 0.05; ** P < 0.01, *** P < 0.001.

    Techniques Used: Inhibition, Expressing, Saline, MANN-WHITNEY, Immunohistochemical staining

    Optogenetic activating the M1 excitatory neurons weakened heart function in MI mice. A) Experimental operation diagram (left), a representative image showing ChR2–mCherry expression (right top), and image of experimental timeline (right bottom). Scale bar, 500 µm. B) Colocalization of ChR2‐mCherry expression (red) and VGlut2 staining (green) (left) and the percentage of ChR2 cells expressing VGlut2 (right, n = 4). Scale bar, 50 µm. C) Representative curve graph of HR over time. D, E) Quantification of HR (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 14) = 11.503, P < 0.01; mCherry off versus on, P = 0.693; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.929; on mCherry versus ChR2, P = 0.649; mCherry = 8, ChR2 = 8), LF/HF (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 14) = 30.469, P <0.05, mCherry off versus on, P = 0.685; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.621; on mCherry versus ChR2, P < 0.001; mCherry = 8, ChR2 = 8). F) Examples of echocardiographic images in anesthetized mice. G, H, I, J, K, L, M,) Quantification of LVEF (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 14) = 71.675, P < 0.01; mCherry off versus on, P = 0.943; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.576; on mCherry versus ChR2, P < 0.05; mCherry = 8, ChR2 = 8), LVFS (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 14) = 37.954, P < 0.001; mCherry off versus on, P = 0.496; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.664; on mCherry versus ChR2, P < 0.05; mCherry = 8, ChR2 = 8), LVIDd (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 14) = 0.533; mCherry off versus on, P = 1; ChR2 off versus on, P = 0.319; off mCherry versus ChR2, P = 0.447; on mCherry versus ChR2, P = 0.376; mCherry = 8, ChR2 = 8), LVIDs (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 14) = 5.316, P < 0.05; mCherry off versus on, P = 0.898; ChR2 off versus on, P < 0.01; off mCherry versus ChR2, P = 0.565; on mCherry versus ChR2, P = 0.261; mCherry = 8, ChR2 = 8), SBP (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 14) = 15.154, P < 0.01; mCherry off versus on, P = 0.239; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.052; on mCherry versus ChR2, P = 0.213; mCherry = 8, ChR2 = 8), DBP (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 14) = 39.035, P < 0.01; mCherry off versus on, P = 0.581; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.595; on mCherry versus ChR2, P <0.01; mCherry = 8, ChR2 = 8), MAP (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 14) = 19.982, P < 0.01; mCherry off versus on, P = 0.066; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.591; on mCherry versus ChR2, P <0.05; mCherry = 8, ChR2 = 8) in anesthetized mice. N). Immunohistochemical images showing overlap of ChR2‐mCherry (red) and c‐Fos (green)‐positive neurons in the M1. Scale bar, 100 µm. O) Quantification of c‐Fos‐positive cells in the M1 (Independent t test. t (4) = −9.282, P < 0.01). Data are mean ± SEM. * P < 0.05; ** P < 0.01, *** P < 0.001.
    Figure Legend Snippet: Optogenetic activating the M1 excitatory neurons weakened heart function in MI mice. A) Experimental operation diagram (left), a representative image showing ChR2–mCherry expression (right top), and image of experimental timeline (right bottom). Scale bar, 500 µm. B) Colocalization of ChR2‐mCherry expression (red) and VGlut2 staining (green) (left) and the percentage of ChR2 cells expressing VGlut2 (right, n = 4). Scale bar, 50 µm. C) Representative curve graph of HR over time. D, E) Quantification of HR (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 14) = 11.503, P < 0.01; mCherry off versus on, P = 0.693; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.929; on mCherry versus ChR2, P = 0.649; mCherry = 8, ChR2 = 8), LF/HF (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 14) = 30.469, P <0.05, mCherry off versus on, P = 0.685; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.621; on mCherry versus ChR2, P < 0.001; mCherry = 8, ChR2 = 8). F) Examples of echocardiographic images in anesthetized mice. G, H, I, J, K, L, M,) Quantification of LVEF (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 14) = 71.675, P < 0.01; mCherry off versus on, P = 0.943; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.576; on mCherry versus ChR2, P < 0.05; mCherry = 8, ChR2 = 8), LVFS (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 14) = 37.954, P < 0.001; mCherry off versus on, P = 0.496; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.664; on mCherry versus ChR2, P < 0.05; mCherry = 8, ChR2 = 8), LVIDd (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 14) = 0.533; mCherry off versus on, P = 1; ChR2 off versus on, P = 0.319; off mCherry versus ChR2, P = 0.447; on mCherry versus ChR2, P = 0.376; mCherry = 8, ChR2 = 8), LVIDs (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 14) = 5.316, P < 0.05; mCherry off versus on, P = 0.898; ChR2 off versus on, P < 0.01; off mCherry versus ChR2, P = 0.565; on mCherry versus ChR2, P = 0.261; mCherry = 8, ChR2 = 8), SBP (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 14) = 15.154, P < 0.01; mCherry off versus on, P = 0.239; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.052; on mCherry versus ChR2, P = 0.213; mCherry = 8, ChR2 = 8), DBP (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 14) = 39.035, P < 0.01; mCherry off versus on, P = 0.581; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.595; on mCherry versus ChR2, P <0.01; mCherry = 8, ChR2 = 8), MAP (Two‐way repeated‐measures ANOVA‐Interaction: F (1, 14) = 19.982, P < 0.01; mCherry off versus on, P = 0.066; ChR2 off versus on, P < 0.001; off mCherry versus ChR2, P = 0.591; on mCherry versus ChR2, P <0.05; mCherry = 8, ChR2 = 8) in anesthetized mice. N). Immunohistochemical images showing overlap of ChR2‐mCherry (red) and c‐Fos (green)‐positive neurons in the M1. Scale bar, 100 µm. O) Quantification of c‐Fos‐positive cells in the M1 (Independent t test. t (4) = −9.282, P < 0.01). Data are mean ± SEM. * P < 0.05; ** P < 0.01, *** P < 0.001.

    Techniques Used: Expressing, Staining, Immunohistochemical staining

    rabbit primary antibody against c fos  (Synaptic Systems)


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    Santa Cruz Biotechnology rabbit primary antibody against c fos
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    primary antibodies against c fos  (Cell Signaling Technology Inc)


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    Cell Signaling Technology Inc primary antibodies against c fos
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    primary antibodies against c fos  (Cell Signaling Technology Inc)


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    Cell Signaling Technology Inc primary antibodies against c fos
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