piperidine  (Millipore)


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    Piperidine
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    Structured Review

    Millipore piperidine
    Piperidine

    https://www.bioz.com/result/piperidine/product/Millipore
    Average 99 stars, based on 42 article reviews
    Price from $9.99 to $1999.99
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    Injection:

    Article Title: ERG Responses in Mice with Deletion of the Synaptic Ribbon Component RIBEYE
    Article Snippet: .. All drugs were dissolved in sterile PBS, and a volume of 2 µl containing 20-mM l -2 amino-4-phosphonobutyric acid (APB), 40-mM cis-2,3 piperidine dicarboxylic acid (PDA), and 20-µM tetrodotoxin (TTX) (all from Sigma-Aldrich, St. Louis, MO, USA) or PBS alone was injected. .. Recordings were performed after a 60-minute recovery time, during which time the mice were dark adapted, and they were completed within 90 minutes following injections.

    other:

    Article Title: Cholesterol at the Endoplasmic Reticulum: Roles of the Sigma-1 Receptor Chaperone and Implications thereof in Human Diseases
    Article Snippet: [ ] Goyagi T, Goto S, Bhardwaj A, Dawson VL, Hurn PD, Kirsch JR. Neuroprotective effect of sigma(1)-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) is linked to reduced neuronal nitric oxide production.

    Article Title: Investigation of nitrite alternatives for the color stabilization of heme–iron hydrolysates
    Article Snippet: Hemin, sodium hydroxide (NaOH), sodium ascorbate, sodium nitrite (SN), 4-methylimidazole (4-MeI), methyl nicotinate (MeN), pyrrolidine (Pyrl), piperidine (PipD) and pyrazine (PyrZ) were purchased from Sigma-Aldrich.

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  • 92
    Millipore gdf15
    Efficient clonal selection of p53KO hESCs and evaluation of their stemness. A) Experimental strategy of isolation of hESCs p53KO clones from p53 Low hESCs population. B, C) Isolated p53KO clones were analyzed by Western Blot for p53 expression, beta-actin antibody was used to verify equal loading. D) MOCK and p53 KO hESCs (clone #A11) were grown on MEFs and examined for the morphology of colonies (left) or the expression of pluripotency markers Oct4 (green) and Nanog (red) by microscopy. DAPI was used to visualize cell nuclei (blue). Scale bars = 100µm. E) MOCK and p53 KO hESCs (clone #A11) were treated either by 3.4 μM Etoposide to induce DNA damage or DMSO. After 8 hrs, cells were harvested and analyzed by Western blot for p53 protein stabilization, and the expression of p53 downstream genes – MDM2 and <t>GDF15.</t> DNA damage induction is shown by the increase in phospho γ-H2A.X. F) Bright field microscopy images of MOCK and p53 KO hESCs (clone#A11) following differentiation into EBs. Scale bars = 200µm. G) EBs derived from p53 KO hESCs (clone#A11) were analyzed for the expression of the differentiation markers by antibody staining and confocal microscopy. DAPI (blue) was used to visualize cell nuclei. Ectoderm markers are represented by TUJ (green) and SOX2 (red), mesoderm is represented here by Brachyury (green), and endoderm is represented here by GATA6 (green). Scale bars = 200µm. H) Hematoxylin and eosin staining of teratoma tissue from SCID mouse injected with p53KO hESCs (representative data shown for clone #A9). Tissue sections show morphological structures typical for neuroectoderm, mesoderm, and endoderm. Scale bars = 200µm.
    Gdf15, supplied by Millipore, used in various techniques. Bioz Stars score: 92/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    94
    Millipore 1 1 4 7 phenyl 1h imidazo 4 5 g quinoxalin 6 yl benzyl piperidin 4 yl 1 3 dihydro benzoimidazol 2 one
    The structures of chemical compounds used in this study. The compounds 1 – 6 are CQ and its analogs, and 7 – 10 are P3IK-Akt inhibitors used in this work. The compounds 1 – 10 (left to right) are as follows: 1 , Chloroquine diphosphate (CQ); 2 , Butyl-(7-chloro-quinolin-4-yl)-amine; 3 , Butyl-(7-fluoro-quinolin-4-yl)-amine; 4 , N ′-(7-Chloro-quinolin-4-yl)- N , N -dimethyl-ethane-1,2-diamine; 5 , N ′-(7-Fluoro-quinolin-4-yl)- N , N -dimethyl-ethane-1,2-diamine; 6 , N ′-(7-Methoxy-quinolin-4-yl)- N , N -dimethyl-ethane-1,2-diamine; 7 , 6-Benzothiazol-2-yl-1-ethyl-2-[2-(methyl-phenyl-amino)-vinyl]-3-phenyl-3 H -benzoimidazol-1-ium Iodide (Calbiochem catalog #124011); 8 , 1-{1-[4-(7-Phenyl-1 H -imidazo[4,5- g <t>]quinoxalin-6-yl)-benzyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one</t> (Calbiochem catalog #124018); 9 , [4-(2-chloro-4 a ,10 a -dihydro-phenoxazin-10-yl)-butyl]-diethyl-amine hydrochloride (Calbiochem catalog #124020); 10 , 2-Morpholin-4-yl-8-phenyl-chromen-4-one (LY294002).
    1 1 4 7 Phenyl 1h Imidazo 4 5 G Quinoxalin 6 Yl Benzyl Piperidin 4 Yl 1 3 Dihydro Benzoimidazol 2 One, supplied by Millipore, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/1 1 4 7 phenyl 1h imidazo 4 5 g quinoxalin 6 yl benzyl piperidin 4 yl 1 3 dihydro benzoimidazol 2 one/product/Millipore
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    85
    Millipore 4 4 fluorophenyl 1 4 piperidinyl imidazole
    The structures of chemical compounds used in this study. The compounds 1 – 6 are CQ and its analogs, and 7 – 10 are P3IK-Akt inhibitors used in this work. The compounds 1 – 10 (left to right) are as follows: 1 , Chloroquine diphosphate (CQ); 2 , Butyl-(7-chloro-quinolin-4-yl)-amine; 3 , Butyl-(7-fluoro-quinolin-4-yl)-amine; 4 , N ′-(7-Chloro-quinolin-4-yl)- N , N -dimethyl-ethane-1,2-diamine; 5 , N ′-(7-Fluoro-quinolin-4-yl)- N , N -dimethyl-ethane-1,2-diamine; 6 , N ′-(7-Methoxy-quinolin-4-yl)- N , N -dimethyl-ethane-1,2-diamine; 7 , 6-Benzothiazol-2-yl-1-ethyl-2-[2-(methyl-phenyl-amino)-vinyl]-3-phenyl-3 H -benzoimidazol-1-ium Iodide (Calbiochem catalog #124011); 8 , 1-{1-[4-(7-Phenyl-1 H -imidazo[4,5- g <t>]quinoxalin-6-yl)-benzyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one</t> (Calbiochem catalog #124018); 9 , [4-(2-chloro-4 a ,10 a -dihydro-phenoxazin-10-yl)-butyl]-diethyl-amine hydrochloride (Calbiochem catalog #124020); 10 , 2-Morpholin-4-yl-8-phenyl-chromen-4-one (LY294002).
    4 4 Fluorophenyl 1 4 Piperidinyl Imidazole, supplied by Millipore, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/4 4 fluorophenyl 1 4 piperidinyl imidazole/product/Millipore
    Average 85 stars, based on 1 article reviews
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    Efficient clonal selection of p53KO hESCs and evaluation of their stemness. A) Experimental strategy of isolation of hESCs p53KO clones from p53 Low hESCs population. B, C) Isolated p53KO clones were analyzed by Western Blot for p53 expression, beta-actin antibody was used to verify equal loading. D) MOCK and p53 KO hESCs (clone #A11) were grown on MEFs and examined for the morphology of colonies (left) or the expression of pluripotency markers Oct4 (green) and Nanog (red) by microscopy. DAPI was used to visualize cell nuclei (blue). Scale bars = 100µm. E) MOCK and p53 KO hESCs (clone #A11) were treated either by 3.4 μM Etoposide to induce DNA damage or DMSO. After 8 hrs, cells were harvested and analyzed by Western blot for p53 protein stabilization, and the expression of p53 downstream genes – MDM2 and GDF15. DNA damage induction is shown by the increase in phospho γ-H2A.X. F) Bright field microscopy images of MOCK and p53 KO hESCs (clone#A11) following differentiation into EBs. Scale bars = 200µm. G) EBs derived from p53 KO hESCs (clone#A11) were analyzed for the expression of the differentiation markers by antibody staining and confocal microscopy. DAPI (blue) was used to visualize cell nuclei. Ectoderm markers are represented by TUJ (green) and SOX2 (red), mesoderm is represented here by Brachyury (green), and endoderm is represented here by GATA6 (green). Scale bars = 200µm. H) Hematoxylin and eosin staining of teratoma tissue from SCID mouse injected with p53KO hESCs (representative data shown for clone #A9). Tissue sections show morphological structures typical for neuroectoderm, mesoderm, and endoderm. Scale bars = 200µm.

    Journal: Stem cells and development

    Article Title: An efficient method for generation of Knock-out human embryonic stem cells using CRISPR/Cas9 system

    doi: 10.1089/scd.2017.0058

    Figure Lengend Snippet: Efficient clonal selection of p53KO hESCs and evaluation of their stemness. A) Experimental strategy of isolation of hESCs p53KO clones from p53 Low hESCs population. B, C) Isolated p53KO clones were analyzed by Western Blot for p53 expression, beta-actin antibody was used to verify equal loading. D) MOCK and p53 KO hESCs (clone #A11) were grown on MEFs and examined for the morphology of colonies (left) or the expression of pluripotency markers Oct4 (green) and Nanog (red) by microscopy. DAPI was used to visualize cell nuclei (blue). Scale bars = 100µm. E) MOCK and p53 KO hESCs (clone #A11) were treated either by 3.4 μM Etoposide to induce DNA damage or DMSO. After 8 hrs, cells were harvested and analyzed by Western blot for p53 protein stabilization, and the expression of p53 downstream genes – MDM2 and GDF15. DNA damage induction is shown by the increase in phospho γ-H2A.X. F) Bright field microscopy images of MOCK and p53 KO hESCs (clone#A11) following differentiation into EBs. Scale bars = 200µm. G) EBs derived from p53 KO hESCs (clone#A11) were analyzed for the expression of the differentiation markers by antibody staining and confocal microscopy. DAPI (blue) was used to visualize cell nuclei. Ectoderm markers are represented by TUJ (green) and SOX2 (red), mesoderm is represented here by Brachyury (green), and endoderm is represented here by GATA6 (green). Scale bars = 200µm. H) Hematoxylin and eosin staining of teratoma tissue from SCID mouse injected with p53KO hESCs (representative data shown for clone #A9). Tissue sections show morphological structures typical for neuroectoderm, mesoderm, and endoderm. Scale bars = 200µm.

    Article Snippet: The following primary antibodies were used in western blot analysis: Oct-4 (sc-5279; Santa Cruz Biotechnology); GATA6 (#5851), Brachyury (#81694), Nanog (#3580), phospho γ-H2A.X (#9718), and β-actin (#3700; all from Cell Signaling); GDF15 (07-217; Millipore); α-tubulin (11-250-C100; Exbio); mouse monoclonal antibody against p53 (DO-1) and mouse monoclonal antibody against MDM2 (2A9) were generously provided by Bořivoj Vojtěšek (Masaryk Memorial Cancer Institute, Brno, Czech Republic) and Stjepan Uldrijan (Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic), respectively.

    Techniques: Selection, Isolation, Clone Assay, Western Blot, Expressing, Microscopy, Derivative Assay, Staining, Confocal Microscopy, Injection

    Analysis of GDF-15 in follicular fluid, serum, and granulosa cell lines: Follicular fluid (FF) and serum (S) of two subjects electrophoresed under a reduced or b non-reduced conditions (seminal plasma [SP] serving as positive control); conditioned media harvested from c control and e , f nutlin-3- or AraC-treated granulosa cell lines, quantification by ELISA; d expression of GDF-15 in granulosa cell lines as determined by western blotting under reduced condition (β-actin serves as loading control). *~ p

    Journal: Journal of Assisted Reproduction and Genetics

    Article Title: Presence of growth/differentiation factor-15 cytokine in human follicular fluid, granulosa cells, and oocytes

    doi: 10.1007/s10815-018-1230-5

    Figure Lengend Snippet: Analysis of GDF-15 in follicular fluid, serum, and granulosa cell lines: Follicular fluid (FF) and serum (S) of two subjects electrophoresed under a reduced or b non-reduced conditions (seminal plasma [SP] serving as positive control); conditioned media harvested from c control and e , f nutlin-3- or AraC-treated granulosa cell lines, quantification by ELISA; d expression of GDF-15 in granulosa cell lines as determined by western blotting under reduced condition (β-actin serves as loading control). *~ p

    Article Snippet: To detect GDF-15, membranes were incubated for overnight at 4 °C with primary antibody against GDF-15 (07-217, 1:250 dilution; EMD Millipore [Merck], Billerica, MA, USA,), washed once in TBS-Tween, and then incubated for 1 h at room temperature with HRP-conjugated secondary antibody (NA934V, 1:6000 dilution; GE Healthcare Bioscience, Chicago, IL, USA).

    Techniques: Positive Control, Enzyme-linked Immunosorbent Assay, Expressing, Western Blot

    Quantitative RT-PCR and western blot analysis of GDF-15 expression in fully grown human oocytes: a amplification curves re-constructed using data exported from LightCycler 480 to SigmaPlot software, presented as an average of all amplified curves obtained for particular sample (from all replicates) and gene (LNCaP cells sorted in set numbers serving as positive and calibration controls); b calculated Cp values (by LightCycler 480 software [absolute quantification 2nd derivative maximum analysis]). $ ~ 5 replicates; § ~ 2 replicates; and c expression of GDF-15 in oocytes (OO, 17 oocytes) analyzed by western blot under reduced condition (LNCaP cells and seminal plasma [SP] samples serving as positive controls)

    Journal: Journal of Assisted Reproduction and Genetics

    Article Title: Presence of growth/differentiation factor-15 cytokine in human follicular fluid, granulosa cells, and oocytes

    doi: 10.1007/s10815-018-1230-5

    Figure Lengend Snippet: Quantitative RT-PCR and western blot analysis of GDF-15 expression in fully grown human oocytes: a amplification curves re-constructed using data exported from LightCycler 480 to SigmaPlot software, presented as an average of all amplified curves obtained for particular sample (from all replicates) and gene (LNCaP cells sorted in set numbers serving as positive and calibration controls); b calculated Cp values (by LightCycler 480 software [absolute quantification 2nd derivative maximum analysis]). $ ~ 5 replicates; § ~ 2 replicates; and c expression of GDF-15 in oocytes (OO, 17 oocytes) analyzed by western blot under reduced condition (LNCaP cells and seminal plasma [SP] samples serving as positive controls)

    Article Snippet: To detect GDF-15, membranes were incubated for overnight at 4 °C with primary antibody against GDF-15 (07-217, 1:250 dilution; EMD Millipore [Merck], Billerica, MA, USA,), washed once in TBS-Tween, and then incubated for 1 h at room temperature with HRP-conjugated secondary antibody (NA934V, 1:6000 dilution; GE Healthcare Bioscience, Chicago, IL, USA).

    Techniques: Quantitative RT-PCR, Western Blot, Expressing, Amplification, Construct, Software

    a Cytoplasmic expression of GDF-15 in primary oocytes of preterm newborn ovaries as determined by immunohistochemistry. b Expression of HIF-1α in somatic ovarian cells as determined by immunohistochemistry. c Negative control, processed without primary antibody. Gestational age of the preterm newborn 1 was 29 weeks and lived for 65 days. Preterm newborn 2 (24 weeks of gestation) died the second day after cesarean. Magnification × 400 for all pictures, scale bars represent 20 μm

    Journal: Journal of Assisted Reproduction and Genetics

    Article Title: Presence of growth/differentiation factor-15 cytokine in human follicular fluid, granulosa cells, and oocytes

    doi: 10.1007/s10815-018-1230-5

    Figure Lengend Snippet: a Cytoplasmic expression of GDF-15 in primary oocytes of preterm newborn ovaries as determined by immunohistochemistry. b Expression of HIF-1α in somatic ovarian cells as determined by immunohistochemistry. c Negative control, processed without primary antibody. Gestational age of the preterm newborn 1 was 29 weeks and lived for 65 days. Preterm newborn 2 (24 weeks of gestation) died the second day after cesarean. Magnification × 400 for all pictures, scale bars represent 20 μm

    Article Snippet: To detect GDF-15, membranes were incubated for overnight at 4 °C with primary antibody against GDF-15 (07-217, 1:250 dilution; EMD Millipore [Merck], Billerica, MA, USA,), washed once in TBS-Tween, and then incubated for 1 h at room temperature with HRP-conjugated secondary antibody (NA934V, 1:6000 dilution; GE Healthcare Bioscience, Chicago, IL, USA).

    Techniques: Expressing, Immunohistochemistry, Negative Control

    a Donor and patient characteristics; b GDF-15 concentrations (ng/mL) in follicular fluid (FF), comparing/correlating healthy donors and patients; c relation between concentrations of GDF-15 in FF and serum; d – g relation between GDF-15 concentration in FF and average follicular size, number of follicles, subject age, and BMI; and (H) BMI vs. concentrations of GDF-15 in serum (Pearson’s correlations calculated)

    Journal: Journal of Assisted Reproduction and Genetics

    Article Title: Presence of growth/differentiation factor-15 cytokine in human follicular fluid, granulosa cells, and oocytes

    doi: 10.1007/s10815-018-1230-5

    Figure Lengend Snippet: a Donor and patient characteristics; b GDF-15 concentrations (ng/mL) in follicular fluid (FF), comparing/correlating healthy donors and patients; c relation between concentrations of GDF-15 in FF and serum; d – g relation between GDF-15 concentration in FF and average follicular size, number of follicles, subject age, and BMI; and (H) BMI vs. concentrations of GDF-15 in serum (Pearson’s correlations calculated)

    Article Snippet: To detect GDF-15, membranes were incubated for overnight at 4 °C with primary antibody against GDF-15 (07-217, 1:250 dilution; EMD Millipore [Merck], Billerica, MA, USA,), washed once in TBS-Tween, and then incubated for 1 h at room temperature with HRP-conjugated secondary antibody (NA934V, 1:6000 dilution; GE Healthcare Bioscience, Chicago, IL, USA).

    Techniques: Concentration Assay

    The structures of chemical compounds used in this study. The compounds 1 – 6 are CQ and its analogs, and 7 – 10 are P3IK-Akt inhibitors used in this work. The compounds 1 – 10 (left to right) are as follows: 1 , Chloroquine diphosphate (CQ); 2 , Butyl-(7-chloro-quinolin-4-yl)-amine; 3 , Butyl-(7-fluoro-quinolin-4-yl)-amine; 4 , N ′-(7-Chloro-quinolin-4-yl)- N , N -dimethyl-ethane-1,2-diamine; 5 , N ′-(7-Fluoro-quinolin-4-yl)- N , N -dimethyl-ethane-1,2-diamine; 6 , N ′-(7-Methoxy-quinolin-4-yl)- N , N -dimethyl-ethane-1,2-diamine; 7 , 6-Benzothiazol-2-yl-1-ethyl-2-[2-(methyl-phenyl-amino)-vinyl]-3-phenyl-3 H -benzoimidazol-1-ium Iodide (Calbiochem catalog #124011); 8 , 1-{1-[4-(7-Phenyl-1 H -imidazo[4,5- g ]quinoxalin-6-yl)-benzyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one (Calbiochem catalog #124018); 9 , [4-(2-chloro-4 a ,10 a -dihydro-phenoxazin-10-yl)-butyl]-diethyl-amine hydrochloride (Calbiochem catalog #124020); 10 , 2-Morpholin-4-yl-8-phenyl-chromen-4-one (LY294002).

    Journal: European Journal of Medicinal Chemistry

    Article Title: A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to non-cancer cells

    doi: 10.1016/j.ejmech.2009.11.017

    Figure Lengend Snippet: The structures of chemical compounds used in this study. The compounds 1 – 6 are CQ and its analogs, and 7 – 10 are P3IK-Akt inhibitors used in this work. The compounds 1 – 10 (left to right) are as follows: 1 , Chloroquine diphosphate (CQ); 2 , Butyl-(7-chloro-quinolin-4-yl)-amine; 3 , Butyl-(7-fluoro-quinolin-4-yl)-amine; 4 , N ′-(7-Chloro-quinolin-4-yl)- N , N -dimethyl-ethane-1,2-diamine; 5 , N ′-(7-Fluoro-quinolin-4-yl)- N , N -dimethyl-ethane-1,2-diamine; 6 , N ′-(7-Methoxy-quinolin-4-yl)- N , N -dimethyl-ethane-1,2-diamine; 7 , 6-Benzothiazol-2-yl-1-ethyl-2-[2-(methyl-phenyl-amino)-vinyl]-3-phenyl-3 H -benzoimidazol-1-ium Iodide (Calbiochem catalog #124011); 8 , 1-{1-[4-(7-Phenyl-1 H -imidazo[4,5- g ]quinoxalin-6-yl)-benzyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one (Calbiochem catalog #124018); 9 , [4-(2-chloro-4 a ,10 a -dihydro-phenoxazin-10-yl)-butyl]-diethyl-amine hydrochloride (Calbiochem catalog #124020); 10 , 2-Morpholin-4-yl-8-phenyl-chromen-4-one (LY294002).

    Article Snippet: In particular, the CQ analog compound 5 (N ′-(7-Fluoro-quinolin-4-yl)-N ,N -dimethyl-ethane-1,2-diamine) showed a substantial increase in cell killing by Akt inhibitors 8 and 9 (1-{1-[4-(7-Phenyl-1H-imidazo[4,5-g ]quinoxalin-6-yl)-benzyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one [Calbiochem #124018] and [4-(2-Chloro-4a ,10a -dihydro-phenoxazin-10-yl)-butyl]-diethyl-amine hydrochloride [Calbiochem #124020], respectively).

    Techniques: