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Stabilizers and destabilizers of rG4 structures affect ribosomal frameshifting of HDAC1 . The effect of a G4-stabilizing ligand <t>(PhenDC3,</t> A ) or a G4 destabilizer (TMPyP4, B ) on the HDAC1 frameshifting ratio. The red arrows and numbers indicate the decreased percentage. Data in this figure represent the mean ± SD ( n ≥ 3 biological replicates; * P < 0.05, ** P < 0.01, Student’s t- test). n.s . indicates not significant.
Phendc3, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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phen dc3  (MedChemExpress)
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Stabilizers and destabilizers of rG4 structures affect ribosomal frameshifting of HDAC1 . The effect of a G4-stabilizing ligand <t>(PhenDC3,</t> A ) or a G4 destabilizer (TMPyP4, B ) on the HDAC1 frameshifting ratio. The red arrows and numbers indicate the decreased percentage. Data in this figure represent the mean ± SD ( n ≥ 3 biological replicates; * P < 0.05, ** P < 0.01, Student’s t- test). n.s . indicates not significant.
Phen Dc3, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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phen-dc3 trifluoromethanesulfonate  (MedChemExpress)
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Stabilizers and destabilizers of rG4 structures affect ribosomal frameshifting of HDAC1 . The effect of a G4-stabilizing ligand <t>(PhenDC3,</t> A ) or a G4 destabilizer (TMPyP4, B ) on the HDAC1 frameshifting ratio. The red arrows and numbers indicate the decreased percentage. Data in this figure represent the mean ± SD ( n ≥ 3 biological replicates; * P < 0.05, ** P < 0.01, Student’s t- test). n.s . indicates not significant.
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13c-labelled phen-dc3  (Institut Curie)
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Institut Curie 13c-labelled phen-dc3
Stabilizers and destabilizers of rG4 structures affect ribosomal frameshifting of HDAC1 . The effect of a G4-stabilizing ligand <t>(PhenDC3,</t> A ) or a G4 destabilizer (TMPyP4, B ) on the HDAC1 frameshifting ratio. The red arrows and numbers indicate the decreased percentage. Data in this figure represent the mean ± SD ( n ≥ 3 biological replicates; * P < 0.05, ** P < 0.01, Student’s t- test). n.s . indicates not significant.
13c Labelled Phen Dc3, supplied by Institut Curie, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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hy 15594a  (MedChemExpress)
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MedChemExpress hy 15594a
Stabilizers and destabilizers of rG4 structures affect ribosomal frameshifting of HDAC1 . The effect of a G4-stabilizing ligand <t>(PhenDC3,</t> A ) or a G4 destabilizer (TMPyP4, B ) on the HDAC1 frameshifting ratio. The red arrows and numbers indicate the decreased percentage. Data in this figure represent the mean ± SD ( n ≥ 3 biological replicates; * P < 0.05, ** P < 0.01, Student’s t- test). n.s . indicates not significant.
Hy 15594a, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ala hyn0305  (MedChemExpress)
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MedChemExpress ala hyn0305
Stabilizers and destabilizers of rG4 structures affect ribosomal frameshifting of HDAC1 . The effect of a G4-stabilizing ligand <t>(PhenDC3,</t> A ) or a G4 destabilizer (TMPyP4, B ) on the HDAC1 frameshifting ratio. The red arrows and numbers indicate the decreased percentage. Data in this figure represent the mean ± SD ( n ≥ 3 biological replicates; * P < 0.05, ** P < 0.01, Student’s t- test). n.s . indicates not significant.
Ala Hyn0305, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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phen dc3 triflate  (MedChemExpress)
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MedChemExpress phen dc3 triflate
Stabilizers and destabilizers of rG4 structures affect ribosomal frameshifting of HDAC1 . The effect of a G4-stabilizing ligand <t>(PhenDC3,</t> A ) or a G4 destabilizer (TMPyP4, B ) on the HDAC1 frameshifting ratio. The red arrows and numbers indicate the decreased percentage. Data in this figure represent the mean ± SD ( n ≥ 3 biological replicates; * P < 0.05, ** P < 0.01, Student’s t- test). n.s . indicates not significant.
Phen Dc3 Triflate, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Stabilizers and destabilizers of rG4 structures affect ribosomal frameshifting of HDAC1 . The effect of a G4-stabilizing ligand (PhenDC3, A ) or a G4 destabilizer (TMPyP4, B ) on the HDAC1 frameshifting ratio. The red arrows and numbers indicate the decreased percentage. Data in this figure represent the mean ± SD ( n ≥ 3 biological replicates; * P < 0.05, ** P < 0.01, Student’s t- test). n.s . indicates not significant.

Journal: Nucleic Acids Research

Article Title: RNA G-quadruplexes promote codon repeat-associated ribosomal frameshifting in human genes

doi: 10.1093/nar/gkaf1481

Figure Lengend Snippet: Stabilizers and destabilizers of rG4 structures affect ribosomal frameshifting of HDAC1 . The effect of a G4-stabilizing ligand (PhenDC3, A ) or a G4 destabilizer (TMPyP4, B ) on the HDAC1 frameshifting ratio. The red arrows and numbers indicate the decreased percentage. Data in this figure represent the mean ± SD ( n ≥ 3 biological replicates; * P < 0.05, ** P < 0.01, Student’s t- test). n.s . indicates not significant.

Article Snippet: Immediately after dropwise addition of the DNA–PEI mixture, cells were treated with 2 μM PhenDC3 (MedChemExpress, HY-15594A) or 2 μM TMPyP4 (MedChemExpress, HY-108477), with dimethylsulfoxide (DMSO) serving as the vehicle control.

Techniques: