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Image Search Results
Journal: Cancer Science
Article Title: SLAMF6 Enhances the Efficacy of Anti‐ PD ‐ L1 Immunotherapy in CRC Through the STAT1 / CXCL10 Signaling Axis
doi: 10.1111/cas.70530
Figure Lengend Snippet: SLAMF6 enhances anti‐PD‐L1 immunotherapy in CRC via the STAT1/CXCL10 axis. SLAMF6 activates STAT1 to upregulate CXCL10, promoting CD8 + T‐cell recruitment into CRC tumor microenvironment. Together with anti‐PD‐L1, this enhances ICI efficacy.
Article Snippet: The primary antibodies used in this study were as follows: anti‐SLAMF6 (1:100, Abcam, ab213690), anti‐CD3 (1:100, Abcam, ab16669), anti‐CD8 (1:500, Cell Signaling Technology, #98941, Danvers, MA, USA), anti‐Ki67 (1:200, Proteintech, 27309‐1‐AP), anti‐CXCL10 (1:100, absin, abs135937), anti‐IFN‐γ (1:300, Proteintech, 15365‐1‐AP), and
Techniques: