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triphosphate echelon  (Echelon Biosciences)


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    Structured Review

    Echelon Biosciences triphosphate echelon
    Triphosphate Echelon, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/triphosphate echelon/product/Echelon Biosciences
    Average 91 stars, based on 1 article reviews
    triphosphate echelon - by Bioz Stars, 2025-04
    91/100 stars

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    ( A ) Schematic representation of SPR experiments with the immobilised lipid headgroup as the ligand and the PH domain as the analyte. ( B ) SPR measurements of the kindlin-3 PH domain WT and mutants with immobilised PtdIns(4,5)P 2 and <t>PtdIns(3,4,5)P</t> 3 , respectively. On the left in each case, we show the background-subtracted raw sensogram data for the WT protein, while on the right we show binding saturation curves for WT, K363A K367A and IPRR insertion mutants. The highest concentration used is given on each set of sensogram curves; subsequent binding profiles derive from a series of twofold dilutions.
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    Image Search Results


    ( A ) Schematic representation of SPR experiments with the immobilised lipid headgroup as the ligand and the PH domain as the analyte. ( B ) SPR measurements of the kindlin-3 PH domain WT and mutants with immobilised PtdIns(4,5)P 2 and PtdIns(3,4,5)P 3 , respectively. On the left in each case, we show the background-subtracted raw sensogram data for the WT protein, while on the right we show binding saturation curves for WT, K363A K367A and IPRR insertion mutants. The highest concentration used is given on each set of sensogram curves; subsequent binding profiles derive from a series of twofold dilutions.

    Journal: Biochemical Journal

    Article Title: Structure and lipid-binding properties of the kindlin-3 pleckstrin homology domain

    doi: 10.1042/BCJ20160791

    Figure Lengend Snippet: ( A ) Schematic representation of SPR experiments with the immobilised lipid headgroup as the ligand and the PH domain as the analyte. ( B ) SPR measurements of the kindlin-3 PH domain WT and mutants with immobilised PtdIns(4,5)P 2 and PtdIns(3,4,5)P 3 , respectively. On the left in each case, we show the background-subtracted raw sensogram data for the WT protein, while on the right we show binding saturation curves for WT, K363A K367A and IPRR insertion mutants. The highest concentration used is given on each set of sensogram curves; subsequent binding profiles derive from a series of twofold dilutions.

    Article Snippet: POPC and POPE (1-palmitoyl-2-oleoyl- sn -glycero-3-phosphoethanolamine) were purchased from Avanti Polar Lipids, and PtdIns(4,5)P 2 (P-4516), PtdIns(3,4,5)P 3 (P-3924), and Ins(1,3,4,5)P 4 (Q-1345) were purchased from Echelon Biosciences.

    Techniques: Binding Assay, Concentration Assay

    ( A ) Schematic representation of SPR experiments with the immobilised PH domain as the ligand and lipid nanodiscs as the analyte in solution. ( B ) SPR measurement between the WT kindlin-3 PH domain and nanodiscs with 5% PtdIns(3,4,5)P 3 . The background-subtracted raw sensogram data for the WT protein are shown on the left and the resulting binding saturation curve on the right. The highest concentration used is given on the sensogram graph; subsequent binding profiles derive from a series of twofold dilutions. See Materials and Methods for experimental details.

    Journal: Biochemical Journal

    Article Title: Structure and lipid-binding properties of the kindlin-3 pleckstrin homology domain

    doi: 10.1042/BCJ20160791

    Figure Lengend Snippet: ( A ) Schematic representation of SPR experiments with the immobilised PH domain as the ligand and lipid nanodiscs as the analyte in solution. ( B ) SPR measurement between the WT kindlin-3 PH domain and nanodiscs with 5% PtdIns(3,4,5)P 3 . The background-subtracted raw sensogram data for the WT protein are shown on the left and the resulting binding saturation curve on the right. The highest concentration used is given on the sensogram graph; subsequent binding profiles derive from a series of twofold dilutions. See Materials and Methods for experimental details.

    Article Snippet: POPC and POPE (1-palmitoyl-2-oleoyl- sn -glycero-3-phosphoethanolamine) were purchased from Avanti Polar Lipids, and PtdIns(4,5)P 2 (P-4516), PtdIns(3,4,5)P 3 (P-3924), and Ins(1,3,4,5)P 4 (Q-1345) were purchased from Echelon Biosciences.

    Techniques: Binding Assay, Concentration Assay

    ( A ) Immobilised PtdIns(3,4,5)P 3 headgroup as the ligand and the PH domain as the analyte. ( B ) Immobilised Grp1PH domain as the ligand and lipid nanodiscs as the analyte. The upper panel in each case gives the background-subtracted raw sensogram data and the lower panel gives the resulting binding saturation curve. The highest concentration used is given on the sensogram graphs (83 µM Grp1 PH domain in A ; 3.4 µM nanodiscs in B ); subsequent binding profiles derive from a series of twofold dilutions. See Materials and Methods for experimental details.

    Journal: Biochemical Journal

    Article Title: Structure and lipid-binding properties of the kindlin-3 pleckstrin homology domain

    doi: 10.1042/BCJ20160791

    Figure Lengend Snippet: ( A ) Immobilised PtdIns(3,4,5)P 3 headgroup as the ligand and the PH domain as the analyte. ( B ) Immobilised Grp1PH domain as the ligand and lipid nanodiscs as the analyte. The upper panel in each case gives the background-subtracted raw sensogram data and the lower panel gives the resulting binding saturation curve. The highest concentration used is given on the sensogram graphs (83 µM Grp1 PH domain in A ; 3.4 µM nanodiscs in B ); subsequent binding profiles derive from a series of twofold dilutions. See Materials and Methods for experimental details.

    Article Snippet: POPC and POPE (1-palmitoyl-2-oleoyl- sn -glycero-3-phosphoethanolamine) were purchased from Avanti Polar Lipids, and PtdIns(4,5)P 2 (P-4516), PtdIns(3,4,5)P 3 (P-3924), and Ins(1,3,4,5)P 4 (Q-1345) were purchased from Echelon Biosciences.

    Techniques: Binding Assay, Concentration Assay

    The activating conversion of integrins to an upright conformation is promoted by the binding of talin to the membrane-proximal NPxY and of kindlin to the membrane-distal NPxY on an integrin β-subunit cytoplasmic tail. Clustered PtdIns(3,4,5)P 3 interacts with and recruits kindlin-3 from the cytosol to the membrane, thus facilitating the formation of an integrin–talin–kindlin ternary complex.

    Journal: Biochemical Journal

    Article Title: Structure and lipid-binding properties of the kindlin-3 pleckstrin homology domain

    doi: 10.1042/BCJ20160791

    Figure Lengend Snippet: The activating conversion of integrins to an upright conformation is promoted by the binding of talin to the membrane-proximal NPxY and of kindlin to the membrane-distal NPxY on an integrin β-subunit cytoplasmic tail. Clustered PtdIns(3,4,5)P 3 interacts with and recruits kindlin-3 from the cytosol to the membrane, thus facilitating the formation of an integrin–talin–kindlin ternary complex.

    Article Snippet: POPC and POPE (1-palmitoyl-2-oleoyl- sn -glycero-3-phosphoethanolamine) were purchased from Avanti Polar Lipids, and PtdIns(4,5)P 2 (P-4516), PtdIns(3,4,5)P 3 (P-3924), and Ins(1,3,4,5)P 4 (Q-1345) were purchased from Echelon Biosciences.

    Techniques: Binding Assay