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Strategies and characterisation of nanoparticle-mediated delivery for mitigating ferroptosis in IVDD. (A) Schematic illustration of the synthesis of mPEG-PSA NPs from SA and its mechanism for mitigating IVDD as a therapeutic agent and the characterisation of mPEG-PSA NPs . Copyright 2025 Elsevier; (B) Schematic illustration of the mechanism by which NCH acts inside <t>NPCs</t> and characterization and preparation of PGA-Cu@SS08 . Copyright 2025 Wiley; (C) Schematic illustration of fullerol suppressing ferroptosis of NPCs to delay the process of IVDD and characterization of fullerol . Copyright 2025 Elsevier.
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Strategies and characterisation of nanoparticle-mediated delivery for mitigating ferroptosis in IVDD. (A) Schematic illustration of the synthesis of mPEG-PSA NPs from SA and its mechanism for mitigating IVDD as a therapeutic agent and the characterisation of mPEG-PSA NPs . Copyright 2025 Elsevier; (B) Schematic illustration of the mechanism by which NCH acts inside <t>NPCs</t> and characterization and preparation of PGA-Cu@SS08 . Copyright 2025 Wiley; (C) Schematic illustration of fullerol suppressing ferroptosis of NPCs to delay the process of IVDD and characterization of fullerol . Copyright 2025 Elsevier.
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Strategies and characterisation of nanoparticle-mediated delivery for mitigating ferroptosis in IVDD. (A) Schematic illustration of the synthesis of mPEG-PSA NPs from SA and its mechanism for mitigating IVDD as a therapeutic agent and the characterisation of mPEG-PSA NPs . Copyright 2025 Elsevier; (B) Schematic illustration of the mechanism by which NCH acts inside <t>NPCs</t> and characterization and preparation of PGA-Cu@SS08 . Copyright 2025 Wiley; (C) Schematic illustration of fullerol suppressing ferroptosis of NPCs to delay the process of IVDD and characterization of fullerol . Copyright 2025 Elsevier.
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Strategies and characterisation of nanoparticle-mediated delivery for mitigating ferroptosis in IVDD. (A) Schematic illustration of the synthesis of mPEG-PSA NPs from SA and its mechanism for mitigating IVDD as a therapeutic agent and the characterisation of mPEG-PSA NPs . Copyright 2025 Elsevier; (B) Schematic illustration of the mechanism by which NCH acts inside <t>NPCs</t> and characterization and preparation of PGA-Cu@SS08 . Copyright 2025 Wiley; (C) Schematic illustration of fullerol suppressing ferroptosis of NPCs to delay the process of IVDD and characterization of fullerol . Copyright 2025 Elsevier.
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Strategies and characterisation of nanoparticle-mediated delivery for mitigating ferroptosis in IVDD. (A) Schematic illustration of the synthesis of mPEG-PSA NPs from SA and its mechanism for mitigating IVDD as a therapeutic agent and the characterisation of mPEG-PSA NPs . Copyright 2025 Elsevier; (B) Schematic illustration of the mechanism by which NCH acts inside <t>NPCs</t> and characterization and preparation of PGA-Cu@SS08 . Copyright 2025 Wiley; (C) Schematic illustration of fullerol suppressing ferroptosis of NPCs to delay the process of IVDD and characterization of fullerol . Copyright 2025 Elsevier.
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Strategies and characterisation of nanoparticle-mediated delivery for mitigating ferroptosis in IVDD. (A) Schematic illustration of the synthesis of mPEG-PSA NPs from SA and its mechanism for mitigating IVDD as a therapeutic agent and the characterisation of mPEG-PSA NPs . Copyright 2025 Elsevier; (B) Schematic illustration of the mechanism by which NCH acts inside <t>NPCs</t> and characterization and preparation of PGA-Cu@SS08 . Copyright 2025 Wiley; (C) Schematic illustration of fullerol suppressing ferroptosis of NPCs to delay the process of IVDD and characterization of fullerol . Copyright 2025 Elsevier.
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Strategies and characterisation of nanoparticle-mediated delivery for mitigating ferroptosis in IVDD. (A) Schematic illustration of the synthesis of mPEG-PSA NPs from SA and its mechanism for mitigating IVDD as a therapeutic agent and the characterisation of mPEG-PSA NPs . Copyright 2025 Elsevier; (B) Schematic illustration of the mechanism by which NCH acts inside <t>NPCs</t> and characterization and preparation of PGA-Cu@SS08 . Copyright 2025 Wiley; (C) Schematic illustration of fullerol suppressing ferroptosis of NPCs to delay the process of IVDD and characterization of fullerol . Copyright 2025 Elsevier.
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Strategies and characterisation of nanoparticle-mediated delivery for mitigating ferroptosis in IVDD. (A) Schematic illustration of the synthesis of mPEG-PSA NPs from SA and its mechanism for mitigating IVDD as a therapeutic agent and the characterisation of mPEG-PSA NPs . Copyright 2025 Elsevier; (B) Schematic illustration of the mechanism by which NCH acts inside NPCs and characterization and preparation of PGA-Cu@SS08 . Copyright 2025 Wiley; (C) Schematic illustration of fullerol suppressing ferroptosis of NPCs to delay the process of IVDD and characterization of fullerol . Copyright 2025 Elsevier.

Journal: Journal of Orthopaedic Translation

Article Title: Biomaterial-based strategies targeting ferroptosis for alleviating intervertebral disc degeneration: Advances and perspectives

doi: 10.1016/j.jot.2026.101148

Figure Lengend Snippet: Strategies and characterisation of nanoparticle-mediated delivery for mitigating ferroptosis in IVDD. (A) Schematic illustration of the synthesis of mPEG-PSA NPs from SA and its mechanism for mitigating IVDD as a therapeutic agent and the characterisation of mPEG-PSA NPs . Copyright 2025 Elsevier; (B) Schematic illustration of the mechanism by which NCH acts inside NPCs and characterization and preparation of PGA-Cu@SS08 . Copyright 2025 Wiley; (C) Schematic illustration of fullerol suppressing ferroptosis of NPCs to delay the process of IVDD and characterization of fullerol . Copyright 2025 Elsevier.

Article Snippet: Dynamic hydrogel , NPCs Sprague–Dawley rats , Oridonin Differentiation factor 5 , Nrf2 pathway↑ BMP pathway↑ , Ferroptosis↓ Inflammation↓ ECM synthesis↑ , Needle-puncture-induced disc degeneration model Intradiscally injection , Wang et al., 2023 [ ] .

Techniques: