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ICN Biomedicals nifedipine
Effect on the inward current of the dihydropyridine compound <t>nifedipine</t> and of a substitution of Ba 2 + for Ca 2 + . (A) Currents were obtained on the same cell in response to a voltage pulse to +10 mV from a holding potential of –70 mV. The star indicates the current evoked after addition of 1 μM nifedipine in the external solution. (B) Currents were evoked on the same cell in response to a voltage pulse to +10 mV from a holding potential of –70 mV. The star indicates the current evoked after substitution of 6 mM Ba 2+ for 6 mM Ca 2+ in the external solution.
Nifedipine, supplied by ICN Biomedicals, used in various techniques. Bioz Stars score: 92/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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1) Product Images from "The L-type voltage-dependent Ca2+ channel EGL-19 controls body wall muscle function in Caenorhabditis elegans"

Article Title: The L-type voltage-dependent Ca2+ channel EGL-19 controls body wall muscle function in Caenorhabditis elegans

Journal: The Journal of Cell Biology

doi: 10.1083/jcb.200203055

Effect on the inward current of the dihydropyridine compound nifedipine and of a substitution of Ba 2 + for Ca 2 + . (A) Currents were obtained on the same cell in response to a voltage pulse to +10 mV from a holding potential of –70 mV. The star indicates the current evoked after addition of 1 μM nifedipine in the external solution. (B) Currents were evoked on the same cell in response to a voltage pulse to +10 mV from a holding potential of –70 mV. The star indicates the current evoked after substitution of 6 mM Ba 2+ for 6 mM Ca 2+ in the external solution.
Figure Legend Snippet: Effect on the inward current of the dihydropyridine compound nifedipine and of a substitution of Ba 2 + for Ca 2 + . (A) Currents were obtained on the same cell in response to a voltage pulse to +10 mV from a holding potential of –70 mV. The star indicates the current evoked after addition of 1 μM nifedipine in the external solution. (B) Currents were evoked on the same cell in response to a voltage pulse to +10 mV from a holding potential of –70 mV. The star indicates the current evoked after substitution of 6 mM Ba 2+ for 6 mM Ca 2+ in the external solution.

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Article Title: The L-type voltage-dependent Ca2+ channel EGL-19 controls body wall muscle function in Caenorhabditis elegans
Article Snippet: .. Nifedipine (ICN Biomedicals) was dissolved in DMSO at a concentration of 10 mM. ..

other:

Article Title: Hepatic microsomal metabolism of indole to indoxyl, a precursor of indoxyl sulfate
Article Snippet: Haloperidol, nifedipine and tolbutamide were obtained from ICN Biomedicals Inc. (Aurora, OH, USA).

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  • 92
    ICN Biomedicals nifedipine
    Effect on the inward current of the dihydropyridine compound <t>nifedipine</t> and of a substitution of Ba 2 + for Ca 2 + . (A) Currents were obtained on the same cell in response to a voltage pulse to +10 mV from a holding potential of –70 mV. The star indicates the current evoked after addition of 1 μM nifedipine in the external solution. (B) Currents were evoked on the same cell in response to a voltage pulse to +10 mV from a holding potential of –70 mV. The star indicates the current evoked after substitution of 6 mM Ba 2+ for 6 mM Ca 2+ in the external solution.
    Nifedipine, supplied by ICN Biomedicals, used in various techniques. Bioz Stars score: 92/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/nifedipine/product/ICN Biomedicals
    Average 92 stars, based on 2 article reviews
    Price from $9.99 to $1999.99
    nifedipine - by Bioz Stars, 2020-09
    92/100 stars
      Buy from Supplier

    86
    ICN Biomedicals cm nifedipine
    Microinjections of L-MEN1 rescue excitatory nAChR expression in vitro . All vertical (voltage) scale bars represent 20 mV. All horizontal (time) scale bars represent 2 s. ( a ) Single, postsynaptic LPeD1 neurons were cultured in CM+DMSO (vehicle control; n = 8 for U0126 experiment; n = 16 for <t>nifedipine</t> experiment) and impaled with intracellular electrodes. Exogenous application of ACh (10 −6 M) triggered an excitatory response. ( b ) Exogenous application of ACh to LPeD1 somata induced an inhibitory response in the presence the MEK1/2 inhibitor U0126 (n = 11) (40 µM). ( bi ) The deficit in excitatory nAChR expression due to inhibition of the MAPK/ERK cascade in LPeD1 neurons was rescued by microinjections of synthetic L-MEN1 (n = 12). ( bii ) Summary of the percentage of cells that functionally exhibited excitatory nAChRs with a significance of P
    Cm Nifedipine, supplied by ICN Biomedicals, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cm nifedipine/product/ICN Biomedicals
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    cm nifedipine - by Bioz Stars, 2020-09
    86/100 stars
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    Effect on the inward current of the dihydropyridine compound nifedipine and of a substitution of Ba 2 + for Ca 2 + . (A) Currents were obtained on the same cell in response to a voltage pulse to +10 mV from a holding potential of –70 mV. The star indicates the current evoked after addition of 1 μM nifedipine in the external solution. (B) Currents were evoked on the same cell in response to a voltage pulse to +10 mV from a holding potential of –70 mV. The star indicates the current evoked after substitution of 6 mM Ba 2+ for 6 mM Ca 2+ in the external solution.

    Journal: The Journal of Cell Biology

    Article Title: The L-type voltage-dependent Ca2+ channel EGL-19 controls body wall muscle function in Caenorhabditis elegans

    doi: 10.1083/jcb.200203055

    Figure Lengend Snippet: Effect on the inward current of the dihydropyridine compound nifedipine and of a substitution of Ba 2 + for Ca 2 + . (A) Currents were obtained on the same cell in response to a voltage pulse to +10 mV from a holding potential of –70 mV. The star indicates the current evoked after addition of 1 μM nifedipine in the external solution. (B) Currents were evoked on the same cell in response to a voltage pulse to +10 mV from a holding potential of –70 mV. The star indicates the current evoked after substitution of 6 mM Ba 2+ for 6 mM Ca 2+ in the external solution.

    Article Snippet: Nifedipine (ICN Biomedicals) was dissolved in DMSO at a concentration of 10 mM.

    Techniques:

    Microinjections of L-MEN1 rescue excitatory nAChR expression in vitro . All vertical (voltage) scale bars represent 20 mV. All horizontal (time) scale bars represent 2 s. ( a ) Single, postsynaptic LPeD1 neurons were cultured in CM+DMSO (vehicle control; n = 8 for U0126 experiment; n = 16 for nifedipine experiment) and impaled with intracellular electrodes. Exogenous application of ACh (10 −6 M) triggered an excitatory response. ( b ) Exogenous application of ACh to LPeD1 somata induced an inhibitory response in the presence the MEK1/2 inhibitor U0126 (n = 11) (40 µM). ( bi ) The deficit in excitatory nAChR expression due to inhibition of the MAPK/ERK cascade in LPeD1 neurons was rescued by microinjections of synthetic L-MEN1 (n = 12). ( bii ) Summary of the percentage of cells that functionally exhibited excitatory nAChRs with a significance of P

    Journal: PLoS ONE

    Article Title: Menin: A Tumor Suppressor That Mediates Postsynaptic Receptor Expression and Synaptogenesis between Central Neurons of Lymnaea stagnalis

    doi: 10.1371/journal.pone.0111103

    Figure Lengend Snippet: Microinjections of L-MEN1 rescue excitatory nAChR expression in vitro . All vertical (voltage) scale bars represent 20 mV. All horizontal (time) scale bars represent 2 s. ( a ) Single, postsynaptic LPeD1 neurons were cultured in CM+DMSO (vehicle control; n = 8 for U0126 experiment; n = 16 for nifedipine experiment) and impaled with intracellular electrodes. Exogenous application of ACh (10 −6 M) triggered an excitatory response. ( b ) Exogenous application of ACh to LPeD1 somata induced an inhibitory response in the presence the MEK1/2 inhibitor U0126 (n = 11) (40 µM). ( bi ) The deficit in excitatory nAChR expression due to inhibition of the MAPK/ERK cascade in LPeD1 neurons was rescued by microinjections of synthetic L-MEN1 (n = 12). ( bii ) Summary of the percentage of cells that functionally exhibited excitatory nAChRs with a significance of P

    Article Snippet: For the drug-treated conditions, neurons were cultured overnight in DM+L-EGF (400 ng/ml), CM+PD153035 (EGFR inhibitor; 200 nM; 234490; EMD Millipore), CM+Nifedipine (L-type voltage-gated calcium channel inhibitor; 10 µM; 151743; ICN Biomedicals), CM+U0126 (MEK1/2 inhibitor; 40 µM; V1121; Promega), or the appropriate vehicle controls.

    Techniques: Expressing, In Vitro, Cell Culture, Inhibition

    Calcium influx through L-type VGCCs and MAPK/ERK are required for the expression of excitatory nAChRs. ( a ) Single LPeD1 neurons were cultured in CM and impaled with intracellular electrodes. Exogenous application of ACh (10 −6 M) triggered an excitatory response in the postsynaptic neuron, LPeD1 (n = 30). ( ai ) Exogenous application of ACh to LPeD1 somata induced an inhibitory response in the presence the L-type VGCC blocker nifedipine (n = 9) (10 µM). ( aii ) The expression of excitatory nAChRs was also prevented by the MEK1/2 inhibitor, U0126 (40 µM) n = 9. ( b ) Summary of the percentage of cells that functionally exhibited excitatory nAChRs with a significance of P

    Journal: PLoS ONE

    Article Title: Menin: A Tumor Suppressor That Mediates Postsynaptic Receptor Expression and Synaptogenesis between Central Neurons of Lymnaea stagnalis

    doi: 10.1371/journal.pone.0111103

    Figure Lengend Snippet: Calcium influx through L-type VGCCs and MAPK/ERK are required for the expression of excitatory nAChRs. ( a ) Single LPeD1 neurons were cultured in CM and impaled with intracellular electrodes. Exogenous application of ACh (10 −6 M) triggered an excitatory response in the postsynaptic neuron, LPeD1 (n = 30). ( ai ) Exogenous application of ACh to LPeD1 somata induced an inhibitory response in the presence the L-type VGCC blocker nifedipine (n = 9) (10 µM). ( aii ) The expression of excitatory nAChRs was also prevented by the MEK1/2 inhibitor, U0126 (40 µM) n = 9. ( b ) Summary of the percentage of cells that functionally exhibited excitatory nAChRs with a significance of P

    Article Snippet: For the drug-treated conditions, neurons were cultured overnight in DM+L-EGF (400 ng/ml), CM+PD153035 (EGFR inhibitor; 200 nM; 234490; EMD Millipore), CM+Nifedipine (L-type voltage-gated calcium channel inhibitor; 10 µM; 151743; ICN Biomedicals), CM+U0126 (MEK1/2 inhibitor; 40 µM; V1121; Promega), or the appropriate vehicle controls.

    Techniques: Expressing, Cell Culture