n 6 cyclopentyladenosine  (Tocris)

 
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  • 94
    Name:
    N6 Cyclopentyladenosine
    Description:
    Potent and selective A1 agonist
    Catalog Number:
    1702
    Product Aliases:
    CPA
    Price:
    None
    Purity:
    ≥99% (HPLC)
    Category:
    Adenosine A1 Receptor Agonists Adenosine A1 Receptors Adenosine Receptors 7 TM Receptors Pharmacology
    Formula:
    N-Cyclopentyladenosine
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    Structured Review

    Tocris n 6 cyclopentyladenosine
    N6 Cyclopentyladenosine
    Potent and selective A1 agonist
    https://www.bioz.com/result/n 6 cyclopentyladenosine/product/Tocris
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    n 6 cyclopentyladenosine - by Bioz Stars, 2020-09
    94/100 stars

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    Conditioned Place Preference:

    Article Title: Presynaptically-expressed long-term potentiation increases multivesicular release at parallel fiber synapses
    Article Snippet: .. R -CPP and N6 -Cyclopentyladenosine (CPA) (Tocris) were dissolved in ACSF. γ-DGG (Tocris) was dissolved in 10 μM NaOH and ACSF. .. Picrotoxin (Sigma) and forskolin (Tocris) were dissolved in DMSO, at 500 and 50 mM, respectively.

    other:

    Article Title: Regulation of Hippocampal Cannabinoid CB1 Receptor Actions by Adenosine A1 Receptors and Chronic Caffeine Administration: Implications for the Effects of ?9-Tetrahydrocannabinol on Spatial Memory
    Article Snippet: 1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride (SKF89976A), N6 -cyclopentyladenosine (CPA), 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), 8-[4-[(2-aminoethyl) amino]carbonylmethyloxyphenyl] xanthine (XAC), ( R )-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl) pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenyl-methanone mesylate (WIN55,212-2), (3 S )-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenyl-methanone monomethanesulfonate (WIN55,212-3), and N -(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1 H -pyrazole-3-carboxamide (AM251) were from Tocris Bioscience. ( RS )-4-amino-3-(4-chlorophenyl)butanoic acid (baclofen) was from Ascent Scientific (Bristol, UK).

    Article Title: The Role of cGMP on Adenosine A1 Receptor-mediated Inhibition of Synaptic Transmission at the Hippocampus
    Article Snippet: Drugs N6-cyclopentyladenosine (CPA) was purchased from Tocris, (9S ,10R ,12R )-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimet-hyl-1-oxo-9,12-epoxy-1H -diindolo[1,2,3-fg :3′,2′,1′-kl ]pyrrolo[3,4-i ][1,6]benzodiazocine-10-carboxylic acid methylester (KT5823) was from Santa Cruz Biotecnology, 1H-[1,2,4]oxadiazole[4,3-a]quinoxalin-1-one (ODQ) and NG-nitro-L -arginine methylester (L-NAME) were from Sigma and Adenosine deaminase (ADA) was from Roche.

    Article Title: Modulation of Adenosine Receptors and Antioxidative Effect of Beer Extracts in in Vitro Models
    Article Snippet: CPA (N6 -Cyclopentyladenosine) was obtained from Tocris (Madrid, Spain).

    Article Title: Characterization of Spontaneous, Transient Adenosine Release in the Caudate-Putamen and Prefrontal Cortex
    Article Snippet: CPA (N6 -cyclopentyladenosine) was purchased from Tocris Bioscience (Ellisville, MO, USA), dissolved in saline, and administered at 1 mg/kg.

    Article Title: Adenosine A1 receptors modulate high voltage-activated Ca2+ currents and motor pattern generation in the Xenopus embryo
    Article Snippet: Adenosine (RBI, Poole, UK), adenosine monophosphate (AMP, Sigma, Poole, UK), N 6 -cyclopentyladenosine (CPA, RBI), 5′-( N -cyclopropyl)-carboxamidoadenosine (CPCA, RBI), 2- p- (2-carboxethyl)phenethylamino-5′- N -ethylcarboxamidoadenosine hydrochloride (CGS 21680, Tocris Cookson, Bristol, UK), 1-deoxy-1-[6-[[(3-iodophenyl)methyl]amino]-9H - purin-9-yl]- N- methyl-β-D-ribofuranuronamide (IB-MECA, Tocris Cookson), 8-cyclopentyl-1,3-dipropylxanthine (DPCPX, RBI), 4-(2-[7-amino-2-(2-furyl)[1,2, 4]triazolo[2,3-a][1,3,5]triazin-5-ylamino]ethyl)phenol (ZM241385, Tocris Cookson), alloxazine (benzo[g]pteridine-2,4(1H,3H)-dione, RBI), 8-(3-chlorostyrl)caffeine (CSC, RBI).

    Article Title: A2B adenosine receptors mediate relaxation of the pig intravesical ureter: adenosine modulation of non adrenergic non cholinergic excitatory neurotransmission
    Article Snippet: N6 -cyclopentyladenosine (CPA), 5′-(N-cyclopropyl)-carboxamidoadenosine (CPCA), 2-chloroadenosine (2-CA), 2-[p-(carboxyethyl)-phenylethylamino]-5′-N-ethylcarboxamidoadenosine , 1,3-dipropyl-8-cyclopentyl xanthine (DPCPX), N6 -(3-iodobenzyl)-adenosine-5′- N -methylcarboxamide (IB-MECA), nitrobenzylthioinosine (NBTI), 5′-N-ethylcarboxamidoadenosine (NECA), 8-phenyl-theophylline (8-PT) (RBI, U.S.A), 4-(2-[7-amino-2-(2-furyl) [1,2,4]-triazolo[2,3-a][1,3,5]triazin-5-ylamino]ethyl)phenol (ZM 241385) (Tocris Cookson, U.S.A.).

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  • ccpa  (Tocris)
    94
    Tocris ccpa
    Saturation binding assays at ARs stably expressed in recombinant CHO cells: a mA 1 AR using [ 3 <t>H]CCPA;</t> b mA 1 AR using [ 3 H]DPCPX; c mA 2A AR using [ 3 <t>H]CGS-21680;</t> d mA 2A AR using [ 3 H]MSX-2. Data are means of three independent saturation assays each performed in
    Ccpa, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 15 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ccpa/product/Tocris
    Average 94 stars, based on 15 article reviews
    Price from $9.99 to $1999.99
    ccpa - by Bioz Stars, 2020-09
    94/100 stars
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    Saturation binding assays at ARs stably expressed in recombinant CHO cells: a mA 1 AR using [ 3 H]CCPA; b mA 1 AR using [ 3 H]DPCPX; c mA 2A AR using [ 3 H]CGS-21680; d mA 2A AR using [ 3 H]MSX-2. Data are means of three independent saturation assays each performed in

    Journal: Purinergic Signalling

    Article Title: Selectivity is species-dependent: Characterization of standard agonists and antagonists at human, rat, and mouse adenosine receptors

    doi: 10.1007/s11302-015-9460-9

    Figure Lengend Snippet: Saturation binding assays at ARs stably expressed in recombinant CHO cells: a mA 1 AR using [ 3 H]CCPA; b mA 1 AR using [ 3 H]DPCPX; c mA 2A AR using [ 3 H]CGS-21680; d mA 2A AR using [ 3 H]MSX-2. Data are means of three independent saturation assays each performed in

    Article Snippet: CCPA, CGS-21680, Cl-IB-MECA, IB-MECA, DPCPX, ZM-241835, and MRS-1745 were commercially available from TOCRIS.

    Techniques: Binding Assay, Stable Transfection, Recombinant

    Stimulation of adenosine receptors sensitizes the mechanical response of esophageal nociceptors. Nodose nociceptive fibers are sensitized via the adenosine A 1 receptor and/or A 2A receptor, whereas jugular nociceptive fibers are sensitized only via the adenosine A 1 receptor. The response to esophageal distention with intraluminal pressure 60 mmHg (20 s) was quantified in the absence and in the presence of the indicated agonist. Control response (100%) averaged 45 and 29 action potentials/20 s in nodose and jugular nociceptors, respectively. The effect on mechanical response was tested with CCPA (0.1 μM) and CGS-21680 (0.1 μM,) in nodose nociceptors and CCPA (0.3 μM) and CGS-21680 (0.3 μM) in jugular nociceptors. * P

    Journal: American Journal of Physiology - Gastrointestinal and Liver Physiology

    Article Title: Adenosine-induced activation of esophageal nociceptors

    doi: 10.1152/ajpgi.00361.2010

    Figure Lengend Snippet: Stimulation of adenosine receptors sensitizes the mechanical response of esophageal nociceptors. Nodose nociceptive fibers are sensitized via the adenosine A 1 receptor and/or A 2A receptor, whereas jugular nociceptive fibers are sensitized only via the adenosine A 1 receptor. The response to esophageal distention with intraluminal pressure 60 mmHg (20 s) was quantified in the absence and in the presence of the indicated agonist. Control response (100%) averaged 45 and 29 action potentials/20 s in nodose and jugular nociceptors, respectively. The effect on mechanical response was tested with CCPA (0.1 μM) and CGS-21680 (0.1 μM,) in nodose nociceptors and CCPA (0.3 μM) and CGS-21680 (0.3 μM) in jugular nociceptors. * P

    Article Snippet: CCPA (Tocris) and CGS-21680 (Tocris) were dissolved in DMSO (stock solutions 10 mM).

    Techniques:

    Nodose nociceptive nerve terminals are activated via the adenosine A 1 receptor and/or A 2A receptor, whereas jugular nociceptive nerve terminals are activated via the adenosine A 1 receptor. A : example of a nodose fiber responsive to both the selective adenosine A 1 receptor agonist CCPA and the selective adenosine A 2A receptor agonist CGS-21680. B : example of a jugular fiber responsive to CCPA but not CGS-21680. In jugular traces, several units were simultaneously recorded, but only the unit with indicated large-amplitude action potential waveform had a mechanosensitive nerve terminal in the esophagus. The trivial activity seen in the presence of CGS-21680 in the jugular fiber was similar to the control activity before the drug (

    Journal: American Journal of Physiology - Gastrointestinal and Liver Physiology

    Article Title: Adenosine-induced activation of esophageal nociceptors

    doi: 10.1152/ajpgi.00361.2010

    Figure Lengend Snippet: Nodose nociceptive nerve terminals are activated via the adenosine A 1 receptor and/or A 2A receptor, whereas jugular nociceptive nerve terminals are activated via the adenosine A 1 receptor. A : example of a nodose fiber responsive to both the selective adenosine A 1 receptor agonist CCPA and the selective adenosine A 2A receptor agonist CGS-21680. B : example of a jugular fiber responsive to CCPA but not CGS-21680. In jugular traces, several units were simultaneously recorded, but only the unit with indicated large-amplitude action potential waveform had a mechanosensitive nerve terminal in the esophagus. The trivial activity seen in the presence of CGS-21680 in the jugular fiber was similar to the control activity before the drug (

    Article Snippet: CCPA (Tocris) and CGS-21680 (Tocris) were dissolved in DMSO (stock solutions 10 mM).

    Techniques: Activity Assay

    Effects of NECA, a non-selective adenosine receptor agonist; CCPA, an A 1 receptor agonist; and AB-MECA, an A 3 receptor agonist, on the production of TNF-α by LPS-stimulated human lung macrophages. Values are means ± SEM of five experiments. * P

    Journal: British Journal of Pharmacology

    Article Title: The role of adenosine receptors in regulating production of tumour necrosis factor-? and chemokines by human lung macrophages

    doi: 10.1111/j.1476-5381.2009.00614.x

    Figure Lengend Snippet: Effects of NECA, a non-selective adenosine receptor agonist; CCPA, an A 1 receptor agonist; and AB-MECA, an A 3 receptor agonist, on the production of TNF-α by LPS-stimulated human lung macrophages. Values are means ± SEM of five experiments. * P

    Article Snippet: NECA (5′- N -ethyl-carboxamidoadenosine), CCPA (2-chloro- N 6 -cyclopentyladenosine), ZM 241385 (4-(2-[7-amino-2-(2-furyl)[1,2,4]triazolo-[2,3- a ][1,3,5]triazin-5-yl-amino]ethyl)phenol), MRS 1754 ( N -(4-cyano-phenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-2,3,4,5,6,7-hexahydro-1 H -purin-8-yl)-phenoxy]acetamide) and MRS 1220 (9-chloro-2-(2-furanyl)-5-[(phenylacetyl)amino][1,2,4]-triazolo[1,5- c ]quinazoline) were purchased from Tocris Bioscience (Bristol, UK).

    Techniques:

    Differential cardiovascular effects of PD-81723 and CCPA. We compared the effects of a selective A 1 AR allosteric enhancer (PD-81723) and a selective A 1 AR agonist [2-chloro- N 6 -cyclopentyladenosine (CCPA)] on mouse heart rate ( A ) and systolic blood pressure ( B ). We measured systolic blood pressure as well as heart rate via an indwelling carotid artery catheter. PD-81723 (3 and 6 mg/kg ip) did not significantly change heart or systolic blood pressure in mice ( n = 4). In contrast, CCPA (0.1 and 0.5mg/kg ip, n = 4) caused dose-dependent decreases in heart rate and systolic blood pressure in mice. Arrows indicate the time of drug injection. * P

    Journal: American Journal of Physiology - Renal Physiology

    Article Title: A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury

    doi: 10.1152/ajprenal.00157.2012

    Figure Lengend Snippet: Differential cardiovascular effects of PD-81723 and CCPA. We compared the effects of a selective A 1 AR allosteric enhancer (PD-81723) and a selective A 1 AR agonist [2-chloro- N 6 -cyclopentyladenosine (CCPA)] on mouse heart rate ( A ) and systolic blood pressure ( B ). We measured systolic blood pressure as well as heart rate via an indwelling carotid artery catheter. PD-81723 (3 and 6 mg/kg ip) did not significantly change heart or systolic blood pressure in mice ( n = 4). In contrast, CCPA (0.1 and 0.5mg/kg ip, n = 4) caused dose-dependent decreases in heart rate and systolic blood pressure in mice. Arrows indicate the time of drug injection. * P

    Article Snippet: 2-Amino-4,5-dimethyl-3-thienyl-[3-(trifluoromethyl)phenyl] methanone (PD-81723; a selective allosteric enhancer for the A1 AR; ), 2-chloro- N 6 -cyclopentyladenosine (CCPA; a selective A1 AR agonist), 8-cyclopentyl-1,3-dipropylxanthine (DPCPX; a selective antagonist for the A1 AR) and 4-{[4-(4-chlorophenyl)-2-thiazolyl]amino}phenol [SKI-II, a selective nonlipid inhibitor of sphingosine kinase (SK)] were purchased from Tocris (Minneapolis, MN).

    Techniques: Mouse Assay, Injection