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Response to various treatments. Depicts the time course of symptom levels (stress, physical fatigue, and mental fatigue). Dotted arrows indicate changes in dosage. The green line represents the patient’s baseline level. PEM = post-exertional malaise. ( A ) Propranolol, ( B ) moxonidine, ( C ) methyldopa, ( D ) carvedilol, ( E ) carvedilol 2nd trial, and ( F ) baclofen.

Journal: International Journal of Molecular Sciences

Article Title: Stress-Related Chronic Fatigue Syndrome: A Case Report with a Positive Response to Alpha-Methyl-P-Tyrosine (AMPT) Treatment

doi: 10.3390/ijms25147778

Figure Lengend Snippet: Response to various treatments. Depicts the time course of symptom levels (stress, physical fatigue, and mental fatigue). Dotted arrows indicate changes in dosage. The green line represents the patient’s baseline level. PEM = post-exertional malaise. ( A ) Propranolol, ( B ) moxonidine, ( C ) methyldopa, ( D ) carvedilol, ( E ) carvedilol 2nd trial, and ( F ) baclofen.

Article Snippet: Pharmacological treatments reported by the patient included: atenolol (Aliud Pharma, Laichingen, Germany), alpha-methyldopa (Stada, Barcelona, Spain), carvedilol (1A Pharma, Bayern, Germany), moxonidine (Ratiopharm, Ulm, Germany), propranolol (Aliud Pharma, Laichingen, Germany), mirtazapine (1A Pharma Bayern, Germany), zopiclone (Ratiopharm Ulm, Germany), and alpha-methyl-p-tyrosine (AMPT) (Angene International Limited, London, UK).

Techniques:

Molecular pathways affected and drug treatments. ( A ) Propranolol and carvedilol mechanism of action targeting β1 and β2 adrenergic receptors; ( B ) methyldopa, carvedilol, and moxonidine mechanism of action targeting α adrenergic receptors; ( C ) baclofen mechanism of action targeting GABA B receptors; and ( D ) AMPT or metyrosine inhibition of tyrosine hydroxylase, affecting tyrosine metabolism and the related tryptophan pathway. Green (decrease) and red (increase) arrows represent patient´s data (created with Biorender.com, last accessed on 20 June 2024).

Journal: International Journal of Molecular Sciences

Article Title: Stress-Related Chronic Fatigue Syndrome: A Case Report with a Positive Response to Alpha-Methyl-P-Tyrosine (AMPT) Treatment

doi: 10.3390/ijms25147778

Figure Lengend Snippet: Molecular pathways affected and drug treatments. ( A ) Propranolol and carvedilol mechanism of action targeting β1 and β2 adrenergic receptors; ( B ) methyldopa, carvedilol, and moxonidine mechanism of action targeting α adrenergic receptors; ( C ) baclofen mechanism of action targeting GABA B receptors; and ( D ) AMPT or metyrosine inhibition of tyrosine hydroxylase, affecting tyrosine metabolism and the related tryptophan pathway. Green (decrease) and red (increase) arrows represent patient´s data (created with Biorender.com, last accessed on 20 June 2024).

Article Snippet: Pharmacological treatments reported by the patient included: atenolol (Aliud Pharma, Laichingen, Germany), alpha-methyldopa (Stada, Barcelona, Spain), carvedilol (1A Pharma, Bayern, Germany), moxonidine (Ratiopharm, Ulm, Germany), propranolol (Aliud Pharma, Laichingen, Germany), mirtazapine (1A Pharma Bayern, Germany), zopiclone (Ratiopharm Ulm, Germany), and alpha-methyl-p-tyrosine (AMPT) (Angene International Limited, London, UK).

Techniques: Inhibition