Mouse Specific Ph2ax Rabbit Mab, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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1) Product Images from "A platinum(IV) prodrug strategy to overcome glutathione-based oxaliplatin resistance"
Article Title: A platinum(IV) prodrug strategy to overcome glutathione-based oxaliplatin resistance
Journal: Communications Chemistry
Figure Legend Snippet: Cancer proliferative activity ( a ) and GSH content ( b ) as well as DNA damage in tumor ( c ) and kidney ( d ) tissues. Mice bearing CT26 allografts ( n = 4 per group) were treated twice a week with equimolar concentrations of BSO-OxMal (23.5 mg/kg) or oxaliplatin (9 mg/kg) and sacrificed 24 h after the last drug dosing. Immunohistochemical staining of Ki-67 ( a ) and the DNA damage parameter pH2AX ( c ) were quantified in 8–10 regions of interest (ROI) per tumor within random non-necrotic, viable cancer regions by ImageJ software. In ( d ) cells stained positively for pH2AX in the kidney were counted within 5 ROI per kidney section. Representative images are shown for tumor sections in Supplementary Fig. and for organ sections in Supplementary Fig. . In ( b ) tumor GSH content of the respective cancer samples was quantified by a calorimetric method as described in the methods section. Data in ( b , d ) are depicted as mean ± SEM (standard error of mean). Statistical significance was tested using one-way ANOVA ( a , c ) or Student´s t test ( b , d ). In all cases: * p < 0.05; ** p < 0.01; *** p < 0.001.
Techniques Used: Activity Assay, Immunohistochemical staining, Staining, Software