mouse monoclonal anti synaptopodin primary antibody  (Abcam)

 
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    Abcam mouse monoclonal anti synaptopodin primary antibody
    Letrozole and Aβ 1–42 reduce synaptic proteins. (a) Representative 3D reconstructions of dendritic segments from sister cultures that were treated with either control, Aβ 1–42 (1 μ M), and letrozole (1 μ m) or Aβ 1–42 + letrozole (1 μ m) for 24 or 72 hours and immunostained for synaptophysin (white) and <t>synaptopodin</t> (red). Scale bar, 2 μ m. (b) Quantification of the densities of synaptopodin-positive puncta following treatments. There is a significant decrease in synaptopodin puncta after 24 and 72 hours of Aβ 1–42 , letrozole or Aβ 1–42 + letrozole treatments compared to control conditions. After 72 hours, the number of synaptopodin puncta was significantly lower in letrozole and Aβ 1–42 + letrozole-treated cultures compared to Aβ 1–42 alone. When synaptopodin puncta densities were compared between 24- and 72-hour treated cultures there was a significant decrease only in letrozole and Aβ 1–42 + letrozole-treated cultures after 72 hours. 24 hours: control, n = total dendritic segment lengths of 1041 μ m from 12 cells in 4 cultures; Aβ 1–42 , n = 633 μ m of dendrite from 8 cells in 4 cultures; letrozole, n = 952 μ m of dendrite from 10 cells in 4 cultures; Aβ 1–42 + letrozole, n = 1007 μ m of dendrite from 10 cells in 4 cultures. 72 hours: control, n = total dendritic segment lengths of 559 μ m from 10 cells in 3 cultures; Aβ 1–42 , n = 472 μ m of dendrite from 9 cells in 4 cultures; letrozole, n = 838 μ m of dendrite from 9 cells in 4 cultures; Aβ 1–42 + letrozole, n = 750 μ m of dendrite from 8 cells in 4 cultures. There is a significant decrease in synaptophysin puncta after 24 and 72 hours of Aβ 1–42 , letrozole, or Aβ 1–42 + letrozole treatments compared to control conditions. After 72 hours, the number of synaptophysin puncta was significantly lower in letrozole and Aβ 1–42 + letrozole-treated cultures compared to Aβ 1–42 alone When synaptophysin puncta densities were compared between 24- and 72-hour treated cultures there was a significant decrease in Aβ 1–42 , letrozole, and Aβ 1–42 + letrozole-treated cultures after 72 hours. 24 hours: control, n = total dendritic segment lengths of 1041 μ m from 12 cells in 4 cultures; Aβ 1–42 , n = 633 μ m of dendrite from 8 cells in 4 cultures; letrozole, n = 952 μ m of dendrite from 10 cells in 4 cultures; Aβ 1–42 + letrozole, n = 1007 μ m of dendrite from 10 cells in 4 cultures. 72 hours: control, n = total dendritic segment lengths of 559 μ m from 10 cells in 3 cultures; Aβ 1–42 , n = 472 μ m of dendrite from 9 cells in 4 cultures; letrozole, n = 838 μ m of dendrite from 9 cells in 4 cultures; Aβ 1–42 + letrozole, n = 750 μ m of dendrite from 8 cells in 4 cultures.
    Mouse Monoclonal Anti Synaptopodin Primary Antibody, supplied by Abcam, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mouse monoclonal anti synaptopodin primary antibody/product/Abcam
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    mouse monoclonal anti synaptopodin primary antibody - by Bioz Stars, 2022-10
    86/100 stars

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    1) Product Images from "Letrozole Potentiates Mitochondrial and Dendritic Spine Impairments Induced by β Amyloid"

    Article Title: Letrozole Potentiates Mitochondrial and Dendritic Spine Impairments Induced by β Amyloid

    Journal: Journal of Aging Research

    doi: 10.1155/2013/538979

    Letrozole and Aβ 1–42 reduce synaptic proteins. (a) Representative 3D reconstructions of dendritic segments from sister cultures that were treated with either control, Aβ 1–42 (1 μ M), and letrozole (1 μ m) or Aβ 1–42 + letrozole (1 μ m) for 24 or 72 hours and immunostained for synaptophysin (white) and synaptopodin (red). Scale bar, 2 μ m. (b) Quantification of the densities of synaptopodin-positive puncta following treatments. There is a significant decrease in synaptopodin puncta after 24 and 72 hours of Aβ 1–42 , letrozole or Aβ 1–42 + letrozole treatments compared to control conditions. After 72 hours, the number of synaptopodin puncta was significantly lower in letrozole and Aβ 1–42 + letrozole-treated cultures compared to Aβ 1–42 alone. When synaptopodin puncta densities were compared between 24- and 72-hour treated cultures there was a significant decrease only in letrozole and Aβ 1–42 + letrozole-treated cultures after 72 hours. 24 hours: control, n = total dendritic segment lengths of 1041 μ m from 12 cells in 4 cultures; Aβ 1–42 , n = 633 μ m of dendrite from 8 cells in 4 cultures; letrozole, n = 952 μ m of dendrite from 10 cells in 4 cultures; Aβ 1–42 + letrozole, n = 1007 μ m of dendrite from 10 cells in 4 cultures. 72 hours: control, n = total dendritic segment lengths of 559 μ m from 10 cells in 3 cultures; Aβ 1–42 , n = 472 μ m of dendrite from 9 cells in 4 cultures; letrozole, n = 838 μ m of dendrite from 9 cells in 4 cultures; Aβ 1–42 + letrozole, n = 750 μ m of dendrite from 8 cells in 4 cultures. There is a significant decrease in synaptophysin puncta after 24 and 72 hours of Aβ 1–42 , letrozole, or Aβ 1–42 + letrozole treatments compared to control conditions. After 72 hours, the number of synaptophysin puncta was significantly lower in letrozole and Aβ 1–42 + letrozole-treated cultures compared to Aβ 1–42 alone When synaptophysin puncta densities were compared between 24- and 72-hour treated cultures there was a significant decrease in Aβ 1–42 , letrozole, and Aβ 1–42 + letrozole-treated cultures after 72 hours. 24 hours: control, n = total dendritic segment lengths of 1041 μ m from 12 cells in 4 cultures; Aβ 1–42 , n = 633 μ m of dendrite from 8 cells in 4 cultures; letrozole, n = 952 μ m of dendrite from 10 cells in 4 cultures; Aβ 1–42 + letrozole, n = 1007 μ m of dendrite from 10 cells in 4 cultures. 72 hours: control, n = total dendritic segment lengths of 559 μ m from 10 cells in 3 cultures; Aβ 1–42 , n = 472 μ m of dendrite from 9 cells in 4 cultures; letrozole, n = 838 μ m of dendrite from 9 cells in 4 cultures; Aβ 1–42 + letrozole, n = 750 μ m of dendrite from 8 cells in 4 cultures.
    Figure Legend Snippet: Letrozole and Aβ 1–42 reduce synaptic proteins. (a) Representative 3D reconstructions of dendritic segments from sister cultures that were treated with either control, Aβ 1–42 (1 μ M), and letrozole (1 μ m) or Aβ 1–42 + letrozole (1 μ m) for 24 or 72 hours and immunostained for synaptophysin (white) and synaptopodin (red). Scale bar, 2 μ m. (b) Quantification of the densities of synaptopodin-positive puncta following treatments. There is a significant decrease in synaptopodin puncta after 24 and 72 hours of Aβ 1–42 , letrozole or Aβ 1–42 + letrozole treatments compared to control conditions. After 72 hours, the number of synaptopodin puncta was significantly lower in letrozole and Aβ 1–42 + letrozole-treated cultures compared to Aβ 1–42 alone. When synaptopodin puncta densities were compared between 24- and 72-hour treated cultures there was a significant decrease only in letrozole and Aβ 1–42 + letrozole-treated cultures after 72 hours. 24 hours: control, n = total dendritic segment lengths of 1041 μ m from 12 cells in 4 cultures; Aβ 1–42 , n = 633 μ m of dendrite from 8 cells in 4 cultures; letrozole, n = 952 μ m of dendrite from 10 cells in 4 cultures; Aβ 1–42 + letrozole, n = 1007 μ m of dendrite from 10 cells in 4 cultures. 72 hours: control, n = total dendritic segment lengths of 559 μ m from 10 cells in 3 cultures; Aβ 1–42 , n = 472 μ m of dendrite from 9 cells in 4 cultures; letrozole, n = 838 μ m of dendrite from 9 cells in 4 cultures; Aβ 1–42 + letrozole, n = 750 μ m of dendrite from 8 cells in 4 cultures. There is a significant decrease in synaptophysin puncta after 24 and 72 hours of Aβ 1–42 , letrozole, or Aβ 1–42 + letrozole treatments compared to control conditions. After 72 hours, the number of synaptophysin puncta was significantly lower in letrozole and Aβ 1–42 + letrozole-treated cultures compared to Aβ 1–42 alone When synaptophysin puncta densities were compared between 24- and 72-hour treated cultures there was a significant decrease in Aβ 1–42 , letrozole, and Aβ 1–42 + letrozole-treated cultures after 72 hours. 24 hours: control, n = total dendritic segment lengths of 1041 μ m from 12 cells in 4 cultures; Aβ 1–42 , n = 633 μ m of dendrite from 8 cells in 4 cultures; letrozole, n = 952 μ m of dendrite from 10 cells in 4 cultures; Aβ 1–42 + letrozole, n = 1007 μ m of dendrite from 10 cells in 4 cultures. 72 hours: control, n = total dendritic segment lengths of 559 μ m from 10 cells in 3 cultures; Aβ 1–42 , n = 472 μ m of dendrite from 9 cells in 4 cultures; letrozole, n = 838 μ m of dendrite from 9 cells in 4 cultures; Aβ 1–42 + letrozole, n = 750 μ m of dendrite from 8 cells in 4 cultures.

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    Abcam mouse monoclonal anti synaptopodin primary antibody
    Letrozole and Aβ 1–42 reduce synaptic proteins. (a) Representative 3D reconstructions of dendritic segments from sister cultures that were treated with either control, Aβ 1–42 (1 μ M), and letrozole (1 μ m) or Aβ 1–42 + letrozole (1 μ m) for 24 or 72 hours and immunostained for synaptophysin (white) and <t>synaptopodin</t> (red). Scale bar, 2 μ m. (b) Quantification of the densities of synaptopodin-positive puncta following treatments. There is a significant decrease in synaptopodin puncta after 24 and 72 hours of Aβ 1–42 , letrozole or Aβ 1–42 + letrozole treatments compared to control conditions. After 72 hours, the number of synaptopodin puncta was significantly lower in letrozole and Aβ 1–42 + letrozole-treated cultures compared to Aβ 1–42 alone. When synaptopodin puncta densities were compared between 24- and 72-hour treated cultures there was a significant decrease only in letrozole and Aβ 1–42 + letrozole-treated cultures after 72 hours. 24 hours: control, n = total dendritic segment lengths of 1041 μ m from 12 cells in 4 cultures; Aβ 1–42 , n = 633 μ m of dendrite from 8 cells in 4 cultures; letrozole, n = 952 μ m of dendrite from 10 cells in 4 cultures; Aβ 1–42 + letrozole, n = 1007 μ m of dendrite from 10 cells in 4 cultures. 72 hours: control, n = total dendritic segment lengths of 559 μ m from 10 cells in 3 cultures; Aβ 1–42 , n = 472 μ m of dendrite from 9 cells in 4 cultures; letrozole, n = 838 μ m of dendrite from 9 cells in 4 cultures; Aβ 1–42 + letrozole, n = 750 μ m of dendrite from 8 cells in 4 cultures. There is a significant decrease in synaptophysin puncta after 24 and 72 hours of Aβ 1–42 , letrozole, or Aβ 1–42 + letrozole treatments compared to control conditions. After 72 hours, the number of synaptophysin puncta was significantly lower in letrozole and Aβ 1–42 + letrozole-treated cultures compared to Aβ 1–42 alone When synaptophysin puncta densities were compared between 24- and 72-hour treated cultures there was a significant decrease in Aβ 1–42 , letrozole, and Aβ 1–42 + letrozole-treated cultures after 72 hours. 24 hours: control, n = total dendritic segment lengths of 1041 μ m from 12 cells in 4 cultures; Aβ 1–42 , n = 633 μ m of dendrite from 8 cells in 4 cultures; letrozole, n = 952 μ m of dendrite from 10 cells in 4 cultures; Aβ 1–42 + letrozole, n = 1007 μ m of dendrite from 10 cells in 4 cultures. 72 hours: control, n = total dendritic segment lengths of 559 μ m from 10 cells in 3 cultures; Aβ 1–42 , n = 472 μ m of dendrite from 9 cells in 4 cultures; letrozole, n = 838 μ m of dendrite from 9 cells in 4 cultures; Aβ 1–42 + letrozole, n = 750 μ m of dendrite from 8 cells in 4 cultures.
    Mouse Monoclonal Anti Synaptopodin Primary Antibody, supplied by Abcam, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mouse monoclonal anti synaptopodin primary antibody/product/Abcam
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    mouse monoclonal anti synaptopodin primary antibody - by Bioz Stars, 2022-10
    86/100 stars
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    Letrozole and Aβ 1–42 reduce synaptic proteins. (a) Representative 3D reconstructions of dendritic segments from sister cultures that were treated with either control, Aβ 1–42 (1 μ M), and letrozole (1 μ m) or Aβ 1–42 + letrozole (1 μ m) for 24 or 72 hours and immunostained for synaptophysin (white) and synaptopodin (red). Scale bar, 2 μ m. (b) Quantification of the densities of synaptopodin-positive puncta following treatments. There is a significant decrease in synaptopodin puncta after 24 and 72 hours of Aβ 1–42 , letrozole or Aβ 1–42 + letrozole treatments compared to control conditions. After 72 hours, the number of synaptopodin puncta was significantly lower in letrozole and Aβ 1–42 + letrozole-treated cultures compared to Aβ 1–42 alone. When synaptopodin puncta densities were compared between 24- and 72-hour treated cultures there was a significant decrease only in letrozole and Aβ 1–42 + letrozole-treated cultures after 72 hours. 24 hours: control, n = total dendritic segment lengths of 1041 μ m from 12 cells in 4 cultures; Aβ 1–42 , n = 633 μ m of dendrite from 8 cells in 4 cultures; letrozole, n = 952 μ m of dendrite from 10 cells in 4 cultures; Aβ 1–42 + letrozole, n = 1007 μ m of dendrite from 10 cells in 4 cultures. 72 hours: control, n = total dendritic segment lengths of 559 μ m from 10 cells in 3 cultures; Aβ 1–42 , n = 472 μ m of dendrite from 9 cells in 4 cultures; letrozole, n = 838 μ m of dendrite from 9 cells in 4 cultures; Aβ 1–42 + letrozole, n = 750 μ m of dendrite from 8 cells in 4 cultures. There is a significant decrease in synaptophysin puncta after 24 and 72 hours of Aβ 1–42 , letrozole, or Aβ 1–42 + letrozole treatments compared to control conditions. After 72 hours, the number of synaptophysin puncta was significantly lower in letrozole and Aβ 1–42 + letrozole-treated cultures compared to Aβ 1–42 alone When synaptophysin puncta densities were compared between 24- and 72-hour treated cultures there was a significant decrease in Aβ 1–42 , letrozole, and Aβ 1–42 + letrozole-treated cultures after 72 hours. 24 hours: control, n = total dendritic segment lengths of 1041 μ m from 12 cells in 4 cultures; Aβ 1–42 , n = 633 μ m of dendrite from 8 cells in 4 cultures; letrozole, n = 952 μ m of dendrite from 10 cells in 4 cultures; Aβ 1–42 + letrozole, n = 1007 μ m of dendrite from 10 cells in 4 cultures. 72 hours: control, n = total dendritic segment lengths of 559 μ m from 10 cells in 3 cultures; Aβ 1–42 , n = 472 μ m of dendrite from 9 cells in 4 cultures; letrozole, n = 838 μ m of dendrite from 9 cells in 4 cultures; Aβ 1–42 + letrozole, n = 750 μ m of dendrite from 8 cells in 4 cultures.

    Journal: Journal of Aging Research

    Article Title: Letrozole Potentiates Mitochondrial and Dendritic Spine Impairments Induced by β Amyloid

    doi: 10.1155/2013/538979

    Figure Lengend Snippet: Letrozole and Aβ 1–42 reduce synaptic proteins. (a) Representative 3D reconstructions of dendritic segments from sister cultures that were treated with either control, Aβ 1–42 (1 μ M), and letrozole (1 μ m) or Aβ 1–42 + letrozole (1 μ m) for 24 or 72 hours and immunostained for synaptophysin (white) and synaptopodin (red). Scale bar, 2 μ m. (b) Quantification of the densities of synaptopodin-positive puncta following treatments. There is a significant decrease in synaptopodin puncta after 24 and 72 hours of Aβ 1–42 , letrozole or Aβ 1–42 + letrozole treatments compared to control conditions. After 72 hours, the number of synaptopodin puncta was significantly lower in letrozole and Aβ 1–42 + letrozole-treated cultures compared to Aβ 1–42 alone. When synaptopodin puncta densities were compared between 24- and 72-hour treated cultures there was a significant decrease only in letrozole and Aβ 1–42 + letrozole-treated cultures after 72 hours. 24 hours: control, n = total dendritic segment lengths of 1041 μ m from 12 cells in 4 cultures; Aβ 1–42 , n = 633 μ m of dendrite from 8 cells in 4 cultures; letrozole, n = 952 μ m of dendrite from 10 cells in 4 cultures; Aβ 1–42 + letrozole, n = 1007 μ m of dendrite from 10 cells in 4 cultures. 72 hours: control, n = total dendritic segment lengths of 559 μ m from 10 cells in 3 cultures; Aβ 1–42 , n = 472 μ m of dendrite from 9 cells in 4 cultures; letrozole, n = 838 μ m of dendrite from 9 cells in 4 cultures; Aβ 1–42 + letrozole, n = 750 μ m of dendrite from 8 cells in 4 cultures. There is a significant decrease in synaptophysin puncta after 24 and 72 hours of Aβ 1–42 , letrozole, or Aβ 1–42 + letrozole treatments compared to control conditions. After 72 hours, the number of synaptophysin puncta was significantly lower in letrozole and Aβ 1–42 + letrozole-treated cultures compared to Aβ 1–42 alone When synaptophysin puncta densities were compared between 24- and 72-hour treated cultures there was a significant decrease in Aβ 1–42 , letrozole, and Aβ 1–42 + letrozole-treated cultures after 72 hours. 24 hours: control, n = total dendritic segment lengths of 1041 μ m from 12 cells in 4 cultures; Aβ 1–42 , n = 633 μ m of dendrite from 8 cells in 4 cultures; letrozole, n = 952 μ m of dendrite from 10 cells in 4 cultures; Aβ 1–42 + letrozole, n = 1007 μ m of dendrite from 10 cells in 4 cultures. 72 hours: control, n = total dendritic segment lengths of 559 μ m from 10 cells in 3 cultures; Aβ 1–42 , n = 472 μ m of dendrite from 9 cells in 4 cultures; letrozole, n = 838 μ m of dendrite from 9 cells in 4 cultures; Aβ 1–42 + letrozole, n = 750 μ m of dendrite from 8 cells in 4 cultures.

    Article Snippet: Rabbit monoclonal anti-synaptophysin primary antibody was used at 1 : 400 dilution (Zymed, CA, USA) and mouse monoclonal anti-synaptopodin primary antibody was used at 1 : 400 dilution (Abcam, MA, USA), as well.

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