Journal: International Journal of Molecular Sciences
Article Title: Salivary Immunoglobulin Gamma-3 Chain C Is a Promising Noninvasive Biomarker for Systemic Lupus Erythematosus
doi: 10.3390/ijms22031374
Figure Lengend Snippet: Receiver operating characteristic (ROC) curves for the salivary immunoglobulin gamma-3 chain C region (IGHG3) and lactoferrin (LTF) for the diagnosis of systemic lupus erythematosus (SLE). The area under the curve (AUC), sensitivity, and specificity of sIGHG3 were 0.75, 78%, and 64.6%, respectively, with a cut-off value of 2.26 pg/mL for the diagnosis of SLE compared to healthy controls (HCs). The AUC, sensitivity, and specificity of salivary LTF were 0.84, 91.9%, and 60.6%, respectively, with a cut-off value of 4.36 pg/mL for the diagnosis of SLE.
Article Snippet: IGHG3, IGHA1, S100A8, lactoferrin, and OGG1 were analyzed by Western blotting using a rabbit anti-human IGHG3 polyclonal (MBS248789; MyBioSource, San Diego, CA, USA), rabbit anti-human IGHA1 polyclonal (MBS9206028; MyBioSource), rabbit anti-human rat S100A8 polyclonal (MBS127619; MyBioSource), mouse anti-human lactoferrin monoclonal (ab10110; Abcam, Cambridge, UK), and rabbit anti-human OGG1 polyclonal (NB100-106; Novus Biologicals, Centennial, CO, USA) antibodies, respectively.
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