beclin 1  (Abcam)

 
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    Name:
    Beclin 1 peptide
    Description:

    Catalog Number:
    ab39729
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    Structured Review

    Abcam beclin 1
    Representative illustrations of the immunohistochemistry analysis of c-Met, PI3K, <t>Beclin-1</t> and CagA in normal gastric mucosae and GC tissues (magnification, ×40). (A) c-Met expression in normal gastric mucosae. (B) c-Met expression in GC tissue. (C) PI3K expression in normal gastric mucosae. (D) PI3K expression in GC tissue. (E) Beclin-1 expression in normal gastric mucosae. (F) Beclin-1 expression in GC tissue. (G) CagA expression in normal gastric mucosae. (H) CagA expression in GC tissue. PI3K, phosphatidylinositol-4,5-bisphosphate 3-kinase; CagA, cytotoxin-associated gene A; GC, gastric cancer.

    https://www.bioz.com/result/beclin 1/product/Abcam
    Average 99 stars, based on 757 article reviews
    Price from $9.99 to $1999.99
    beclin 1 - by Bioz Stars, 2020-09
    99/100 stars

    Images

    1) Product Images from "Clinical value of CagA, c-Met, PI3K and Beclin-1 expressed in gastric cancer and their association with prognosis"

    Article Title: Clinical value of CagA, c-Met, PI3K and Beclin-1 expressed in gastric cancer and their association with prognosis

    Journal: Oncology Letters

    doi: 10.3892/ol.2017.7394

    Representative illustrations of the immunohistochemistry analysis of c-Met, PI3K, Beclin-1 and CagA in normal gastric mucosae and GC tissues (magnification, ×40). (A) c-Met expression in normal gastric mucosae. (B) c-Met expression in GC tissue. (C) PI3K expression in normal gastric mucosae. (D) PI3K expression in GC tissue. (E) Beclin-1 expression in normal gastric mucosae. (F) Beclin-1 expression in GC tissue. (G) CagA expression in normal gastric mucosae. (H) CagA expression in GC tissue. PI3K, phosphatidylinositol-4,5-bisphosphate 3-kinase; CagA, cytotoxin-associated gene A; GC, gastric cancer.
    Figure Legend Snippet: Representative illustrations of the immunohistochemistry analysis of c-Met, PI3K, Beclin-1 and CagA in normal gastric mucosae and GC tissues (magnification, ×40). (A) c-Met expression in normal gastric mucosae. (B) c-Met expression in GC tissue. (C) PI3K expression in normal gastric mucosae. (D) PI3K expression in GC tissue. (E) Beclin-1 expression in normal gastric mucosae. (F) Beclin-1 expression in GC tissue. (G) CagA expression in normal gastric mucosae. (H) CagA expression in GC tissue. PI3K, phosphatidylinositol-4,5-bisphosphate 3-kinase; CagA, cytotoxin-associated gene A; GC, gastric cancer.

    Techniques Used: Immunohistochemistry, Expressing

    Kaplan-Meier survival curves for the DFS and OS of 121 patients with GC according to the expression status of c-Met, PI3K, Beclin-1 and CagA. The log-rank test was used to determine the significance of associations between survival and expression. (A) The expression of c-Met in GC tissue was associated with a poor DFS rate (P=0.010). (B) The expression of CagA in GC tissue was associated with a poor DFS rate (P=0.020). (C) The expression of c-Met in GC tissue was associated with a poor OS rate (P=0.003). (D) The expression of PI3K in GC tissue was associated with a poor OS rate (P=0.035). (E) The negative expression of Beclin-1 in GC tissue was associated with a poor DFS rate (P
    Figure Legend Snippet: Kaplan-Meier survival curves for the DFS and OS of 121 patients with GC according to the expression status of c-Met, PI3K, Beclin-1 and CagA. The log-rank test was used to determine the significance of associations between survival and expression. (A) The expression of c-Met in GC tissue was associated with a poor DFS rate (P=0.010). (B) The expression of CagA in GC tissue was associated with a poor DFS rate (P=0.020). (C) The expression of c-Met in GC tissue was associated with a poor OS rate (P=0.003). (D) The expression of PI3K in GC tissue was associated with a poor OS rate (P=0.035). (E) The negative expression of Beclin-1 in GC tissue was associated with a poor DFS rate (P

    Techniques Used: Expressing

    2) Product Images from "Clinical value of CagA, c-Met, PI3K and Beclin-1 expressed in gastric cancer and their association with prognosis"

    Article Title: Clinical value of CagA, c-Met, PI3K and Beclin-1 expressed in gastric cancer and their association with prognosis

    Journal: Oncology Letters

    doi: 10.3892/ol.2017.7394

    Representative illustrations of the immunohistochemistry analysis of c-Met, PI3K, Beclin-1 and CagA in normal gastric mucosae and GC tissues (magnification, ×40). (A) c-Met expression in normal gastric mucosae. (B) c-Met expression in GC tissue. (C) PI3K expression in normal gastric mucosae. (D) PI3K expression in GC tissue. (E) Beclin-1 expression in normal gastric mucosae. (F) Beclin-1 expression in GC tissue. (G) CagA expression in normal gastric mucosae. (H) CagA expression in GC tissue. PI3K, phosphatidylinositol-4,5-bisphosphate 3-kinase; CagA, cytotoxin-associated gene A; GC, gastric cancer.
    Figure Legend Snippet: Representative illustrations of the immunohistochemistry analysis of c-Met, PI3K, Beclin-1 and CagA in normal gastric mucosae and GC tissues (magnification, ×40). (A) c-Met expression in normal gastric mucosae. (B) c-Met expression in GC tissue. (C) PI3K expression in normal gastric mucosae. (D) PI3K expression in GC tissue. (E) Beclin-1 expression in normal gastric mucosae. (F) Beclin-1 expression in GC tissue. (G) CagA expression in normal gastric mucosae. (H) CagA expression in GC tissue. PI3K, phosphatidylinositol-4,5-bisphosphate 3-kinase; CagA, cytotoxin-associated gene A; GC, gastric cancer.

    Techniques Used: Immunohistochemistry, Expressing

    Kaplan-Meier survival curves for the DFS and OS of 121 patients with GC according to the expression status of c-Met, PI3K, Beclin-1 and CagA. The log-rank test was used to determine the significance of associations between survival and expression. (A) The expression of c-Met in GC tissue was associated with a poor DFS rate (P=0.010). (B) The expression of CagA in GC tissue was associated with a poor DFS rate (P=0.020). (C) The expression of c-Met in GC tissue was associated with a poor OS rate (P=0.003). (D) The expression of PI3K in GC tissue was associated with a poor OS rate (P=0.035). (E) The negative expression of Beclin-1 in GC tissue was associated with a poor DFS rate (P
    Figure Legend Snippet: Kaplan-Meier survival curves for the DFS and OS of 121 patients with GC according to the expression status of c-Met, PI3K, Beclin-1 and CagA. The log-rank test was used to determine the significance of associations between survival and expression. (A) The expression of c-Met in GC tissue was associated with a poor DFS rate (P=0.010). (B) The expression of CagA in GC tissue was associated with a poor DFS rate (P=0.020). (C) The expression of c-Met in GC tissue was associated with a poor OS rate (P=0.003). (D) The expression of PI3K in GC tissue was associated with a poor OS rate (P=0.035). (E) The negative expression of Beclin-1 in GC tissue was associated with a poor DFS rate (P

    Techniques Used: Expressing

    3) Product Images from "Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA"

    Article Title: Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA

    Journal: Scientific Reports

    doi: 10.1038/srep18346

    CagA-positive exosomes induced morphological changes in AGS cells. ( A ) Detection of tyrosine-phosphorylated CagA in whole cell lysates and exosomes by western blotting using an anti-phosphotyrosine antibody. The same membrane blot was stripped and reprobed with anti-CagA antibody. ( B ) AGS-derived exosomes, WT-A10-derived CagA-negative exosomes, and WT-A10-derived CagA-positive exosomes were added to AGS cells (5 μg protein/ 3.5 × 10 4 cells), and cell morphologies were observed by light microscopy. Arrows indicate the hummingbird phenotype. Scale bar = 50 μm. ( C ) The percentages of hummingbird cells induced by CagA-negative and CagA-positive exosomes were calculated. Error bars indicate the mean ± SD (n = 3); * p
    Figure Legend Snippet: CagA-positive exosomes induced morphological changes in AGS cells. ( A ) Detection of tyrosine-phosphorylated CagA in whole cell lysates and exosomes by western blotting using an anti-phosphotyrosine antibody. The same membrane blot was stripped and reprobed with anti-CagA antibody. ( B ) AGS-derived exosomes, WT-A10-derived CagA-negative exosomes, and WT-A10-derived CagA-positive exosomes were added to AGS cells (5 μg protein/ 3.5 × 10 4 cells), and cell morphologies were observed by light microscopy. Arrows indicate the hummingbird phenotype. Scale bar = 50 μm. ( C ) The percentages of hummingbird cells induced by CagA-negative and CagA-positive exosomes were calculated. Error bars indicate the mean ± SD (n = 3); * p

    Techniques Used: Western Blot, Derivative Assay, Light Microscopy

    Related Articles

    Blocking Assay:

    Article Title: Dexmedetomidine Protects Against Oxygen–Glucose Deprivation-Induced Injury Through Inducing Astrocytes Autophagy via TSC2/mTOR Pathway
    Article Snippet: .. After blocking with 5% fat free milk, the membranes were incubated with a TSC2 (Cell Signaling, AB_564043), and p62 (Cell Signaling, AB_2085095), and LC3 (Santa Cruz Biotechnology, AB_1962479), and Beclin 1 (Abcam, AB_1641491), and 4EBP1, p-4EBP1 (SIGMA, AB_2097980, AB_10557439), and mTOR, p-mTOR (SIGMA, AB_2231882, AB_2231882), and S6K1, p-S6K1 (SIGMA, AB_2569704, AB_1620652), and β-actin (Santa Cruz Biotechnology, AB_626632). .. Blots were visualized using an Odyssey infrared imaging system (LI-COR Biosciences, USA) and analyzed using Image J.

    Incubation:

    Article Title: Dexmedetomidine Protects Against Oxygen–Glucose Deprivation-Induced Injury Through Inducing Astrocytes Autophagy via TSC2/mTOR Pathway
    Article Snippet: .. After blocking with 5% fat free milk, the membranes were incubated with a TSC2 (Cell Signaling, AB_564043), and p62 (Cell Signaling, AB_2085095), and LC3 (Santa Cruz Biotechnology, AB_1962479), and Beclin 1 (Abcam, AB_1641491), and 4EBP1, p-4EBP1 (SIGMA, AB_2097980, AB_10557439), and mTOR, p-mTOR (SIGMA, AB_2231882, AB_2231882), and S6K1, p-S6K1 (SIGMA, AB_2569704, AB_1620652), and β-actin (Santa Cruz Biotechnology, AB_626632). .. Blots were visualized using an Odyssey infrared imaging system (LI-COR Biosciences, USA) and analyzed using Image J.

    Article Title: The Role of Autophagy in Kidney Inflammatory Injury via the NF-κB Route Induced by LPS
    Article Snippet: .. The nitrocellulose membranes were blocked with 5% non-fat dry milk in TBST buffer (10 mmol/l Tris-HCl, 0.15 mol/l NaCl and 0.05% Tween 20, pH 7.2) for 1 h and then incubated with antibodies against LC3 (Sigma), Beclin-1 (Abcam, Cambridge, UK); phosphorylated p65 (Abcam), p52(Cell Signaling), and IL-1β (Santa Cruz Biotechnology), respectively, at 4o C overnight, washed and then incubated with the corresponding goat anti-rabbit or anti-mouse IgG conjugated to horseradish peroxidase (Santa Cruz Biotechnology) in 1:3,000-5,000 (in PBST) for 60 min. .. Protein bands were developed and detected using the ECL Super Signal reagent (Pierce, Rockford, IL, USA).

    Article Title: Long non-coding RNA PlncRNA-1 regulates cell proliferation, apoptosis, and autophagy in septic acute kidney injury by regulating BCL2
    Article Snippet: .. After being blocked in 5% skim milk for 2 h at room temperature, the membranes were incubated for overnight at 4°C with primary antibodies against caspase-3, cleaved caspase-3, LC-3, Beclin-1, or BCL2 (1:1000, Abcam, Cambridge, UK). ..

    other:

    Article Title: HIF-1α/Beclin1-Mediated Autophagy Is Involved in Neuroprotection Induced by Hypoxic Preconditioning
    Article Snippet: Compared with the control, the levels of HIF-1α, BNIP3, and Beclin1 (defined as 100%) and the ratio of LC3-II to LC3-I under HPC were 675.8 ± 22.5, 408.4 ± 26.7, 525.0 ± 43.3%, and 1.1 ± 0.1, respectively, demonstrating that HPC robustly increased the levels of HIF-1α, BNIP3, and Beclin1 and the ratio of LC3-II/LC3-I.

    Activity Assay:

    Article Title: Hydrogen Sulfide Protects Human Cardiac Fibroblasts Against H2O2-induced Injury Through Regulating Autophagy-Related Proteins
    Article Snippet: .. H2 S Regulates the Expression of LC3-II, Beclin1, and P62 During Autophagy The expression levels of LC3-I/II, Beclin1, and P62 play vital roles for autophagic activity – . ..

    Expressing:

    Article Title: Hydrogen Sulfide Protects Human Cardiac Fibroblasts Against H2O2-induced Injury Through Regulating Autophagy-Related Proteins
    Article Snippet: .. H2 S Regulates the Expression of LC3-II, Beclin1, and P62 During Autophagy The expression levels of LC3-I/II, Beclin1, and P62 play vital roles for autophagic activity – . ..

    Article Title: Expression and clinical significances of Beclin1, LC3 and mTOR in colorectal cancer
    Article Snippet: .. The expression of Beclin1 also decreases in malignant epithelial ovarian cancers compared with that in benign and borderline ovarian tumors [ ]. .. In our present study, the expression of Beclin1 significantly increased in CRC tissues compared with that in the counterpart noncancerous tissues in the mRNA and proteins levels.

    Article Title: Expression of autophagy-related proteins in phyllodes tumor
    Article Snippet: .. Thus, we cannot determine whether the expression of beclin-1 is associated with prognosis in cancer patients unless further study on the correlation of the expression and the localization of beclin-1 and prognosis of tumors is performed. .. Otherwise, the expression of LC3B and p62 is known to be associated with poor prognosis in tumors of other organs, consistent with our results [ , ].

    Over Expression:

    Article Title: Expression and clinical significances of Beclin1, LC3 and mTOR in colorectal cancer
    Article Snippet: .. The overexpression of Beclin1 could be interpreted in several ways. ..

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