microvascular endothelium time cell line  (ATCC)


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    ATCC microvascular endothelium time cell line
    Pharmacologic inhibition of TAK1 by 5Z-7-oxozeaenol suppressed angiogenic activities in vitro and ex vivo by inhibiting cell cycle and DNA replication . (A) Sprouting assay was performed in sectioned mouse aortic rings in the presence or absence of the TAK1 inhibitor, 5Z-7-Oxozeaenol (Oxo), and the sprout area was quantified 3 and 9 days after 5Z-7-oxozeaenol (Oxo) treatment (n = 6 from three independent experiments). Representative images were taken at day 9. Scale bar: 500 ìm. (B) Human telomerase-immortalized human <t>microvascular</t> endothelial (TIMEs) cells were pre-treated with delivery vehicle or 5Z-7-Oxozeaenol (Oxo) at 8, 40, 200 or 1000 nM for 24 or 48 hours, followed by the cell viability assay (n = 16 from four experiments). (C) RNA-Seq was performed for <t>TIME</t> cells treated with 0.2 µM or 1 µM 5Z-7-oxozeaenol (Oxo) or vehicles for 24 hours, followed by bioinformatic analysis (n = 4 independent biological replicates). Volcano plots show that level of gene expression was significantly changed in 0.2 µM or 1µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells. Red dots refer to genes showing a Log 2 (fold change) > 1 or < -1 and False discovery rate (FDR) < 0.05. (D-E) GSEA indicated that several gene sets (Reactome Pathway Database) for canonical pathways were negatively enriched in 0.2 µM- or 1 µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells. (F-G) GSEA plots showing negative association with the 'DNA Replication' and 'Cell Cycle' gene sets in 0.2 µM or 1 µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells compared to controls (vehicles). Statistical analysis was conducted by two-way RM ANOVA and Tukey's multiple comparison test; * P < 0.05, ** P < 0.01, **** P < 0.0001.
    Microvascular Endothelium Time Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    1) Product Images from "Topical application of TAK1 inhibitor encapsulated by gelatin particle alleviates corneal neovascularization"

    Article Title: Topical application of TAK1 inhibitor encapsulated by gelatin particle alleviates corneal neovascularization

    Journal: Theranostics

    doi: 10.7150/thno.65098

    Pharmacologic inhibition of TAK1 by 5Z-7-oxozeaenol suppressed angiogenic activities in vitro and ex vivo by inhibiting cell cycle and DNA replication . (A) Sprouting assay was performed in sectioned mouse aortic rings in the presence or absence of the TAK1 inhibitor, 5Z-7-Oxozeaenol (Oxo), and the sprout area was quantified 3 and 9 days after 5Z-7-oxozeaenol (Oxo) treatment (n = 6 from three independent experiments). Representative images were taken at day 9. Scale bar: 500 ìm. (B) Human telomerase-immortalized human microvascular endothelial (TIMEs) cells were pre-treated with delivery vehicle or 5Z-7-Oxozeaenol (Oxo) at 8, 40, 200 or 1000 nM for 24 or 48 hours, followed by the cell viability assay (n = 16 from four experiments). (C) RNA-Seq was performed for TIME cells treated with 0.2 µM or 1 µM 5Z-7-oxozeaenol (Oxo) or vehicles for 24 hours, followed by bioinformatic analysis (n = 4 independent biological replicates). Volcano plots show that level of gene expression was significantly changed in 0.2 µM or 1µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells. Red dots refer to genes showing a Log 2 (fold change) > 1 or < -1 and False discovery rate (FDR) < 0.05. (D-E) GSEA indicated that several gene sets (Reactome Pathway Database) for canonical pathways were negatively enriched in 0.2 µM- or 1 µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells. (F-G) GSEA plots showing negative association with the 'DNA Replication' and 'Cell Cycle' gene sets in 0.2 µM or 1 µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells compared to controls (vehicles). Statistical analysis was conducted by two-way RM ANOVA and Tukey's multiple comparison test; * P < 0.05, ** P < 0.01, **** P < 0.0001.
    Figure Legend Snippet: Pharmacologic inhibition of TAK1 by 5Z-7-oxozeaenol suppressed angiogenic activities in vitro and ex vivo by inhibiting cell cycle and DNA replication . (A) Sprouting assay was performed in sectioned mouse aortic rings in the presence or absence of the TAK1 inhibitor, 5Z-7-Oxozeaenol (Oxo), and the sprout area was quantified 3 and 9 days after 5Z-7-oxozeaenol (Oxo) treatment (n = 6 from three independent experiments). Representative images were taken at day 9. Scale bar: 500 ìm. (B) Human telomerase-immortalized human microvascular endothelial (TIMEs) cells were pre-treated with delivery vehicle or 5Z-7-Oxozeaenol (Oxo) at 8, 40, 200 or 1000 nM for 24 or 48 hours, followed by the cell viability assay (n = 16 from four experiments). (C) RNA-Seq was performed for TIME cells treated with 0.2 µM or 1 µM 5Z-7-oxozeaenol (Oxo) or vehicles for 24 hours, followed by bioinformatic analysis (n = 4 independent biological replicates). Volcano plots show that level of gene expression was significantly changed in 0.2 µM or 1µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells. Red dots refer to genes showing a Log 2 (fold change) > 1 or < -1 and False discovery rate (FDR) < 0.05. (D-E) GSEA indicated that several gene sets (Reactome Pathway Database) for canonical pathways were negatively enriched in 0.2 µM- or 1 µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells. (F-G) GSEA plots showing negative association with the 'DNA Replication' and 'Cell Cycle' gene sets in 0.2 µM or 1 µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells compared to controls (vehicles). Statistical analysis was conducted by two-way RM ANOVA and Tukey's multiple comparison test; * P < 0.05, ** P < 0.01, **** P < 0.0001.

    Techniques Used: Inhibition, In Vitro, Ex Vivo, Viability Assay, RNA Sequencing Assay, Expressing

    dermal microvascular endothelial cell line ihdmec time  (ATCC)


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    ATCC dermal microvascular endothelial cell line ihdmec time
    ( a ) Tumor growth curves (i – iii) and (iv) summary of relative final tumor volumes of HS-PDXs with the indicate EC/EPC sources. TC + CA-MSC in the absence or presence of human EC (TC + CA-MSC; n = 6) <t>(iHDMEC</t> + iHUVEC) and Pt. EC/EPC (TC + CA-MSC + EC/EPC; n = 7). ( b ) IF evaluation of human tumor vascular antigen CD31 (red) in PDXs with the indicated EC/EPC sources. 4′,6-diamidino-2-phenylindole (DAPI; blue) is used to label cell nuclei. ( c ) IF evaluation of a tumor specific vascular marker EGFL6 (red). Cell nuclei were counterstained with DAPI (blue). ( d ) RNASeq based relative mRNA expression for two patient PDXs without and with the addition of human endothelial cells. (e) Growth curves for standard PDX and HS-PDX, derived from a patient with platinum refractory ovarian cancer, treated with carboplatin (blue arrows indicate timing of carboplatin administration. Abbreviations : CA-MSC, cancer-associated mesenchymal stem cells; EC, endothelial cells; EPC, endothelial progenitor cells; iHDMEC, immortalized human dermal <t>microvascular</t> endothelial cells; iHUVEC, immortalized human umbilical vein endothelial cells; PDX, patient-derived xenograft; P0 and P1, passage 0 and passage 1 (The first generation of PDX is denoted P0, and P0 is subsequently passaged to second generation (P1); Pt., patient; TC, tumor cells. * p < 0.05, ** p < 0.01, *** p < 0.001. Scale bars, 20 µm.
    Dermal Microvascular Endothelial Cell Line Ihdmec Time, supplied by ATCC, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    1) Product Images from "A Novel Humanized Immune Stroma PDX Cancer Model for Therapeutic Studies"

    Article Title: A Novel Humanized Immune Stroma PDX Cancer Model for Therapeutic Studies

    Journal: bioRxiv

    doi: 10.1101/2023.07.03.547206

    ( a ) Tumor growth curves (i – iii) and (iv) summary of relative final tumor volumes of HS-PDXs with the indicate EC/EPC sources. TC + CA-MSC in the absence or presence of human EC (TC + CA-MSC; n = 6) (iHDMEC + iHUVEC) and Pt. EC/EPC (TC + CA-MSC + EC/EPC; n = 7). ( b ) IF evaluation of human tumor vascular antigen CD31 (red) in PDXs with the indicated EC/EPC sources. 4′,6-diamidino-2-phenylindole (DAPI; blue) is used to label cell nuclei. ( c ) IF evaluation of a tumor specific vascular marker EGFL6 (red). Cell nuclei were counterstained with DAPI (blue). ( d ) RNASeq based relative mRNA expression for two patient PDXs without and with the addition of human endothelial cells. (e) Growth curves for standard PDX and HS-PDX, derived from a patient with platinum refractory ovarian cancer, treated with carboplatin (blue arrows indicate timing of carboplatin administration. Abbreviations : CA-MSC, cancer-associated mesenchymal stem cells; EC, endothelial cells; EPC, endothelial progenitor cells; iHDMEC, immortalized human dermal microvascular endothelial cells; iHUVEC, immortalized human umbilical vein endothelial cells; PDX, patient-derived xenograft; P0 and P1, passage 0 and passage 1 (The first generation of PDX is denoted P0, and P0 is subsequently passaged to second generation (P1); Pt., patient; TC, tumor cells. * p < 0.05, ** p < 0.01, *** p < 0.001. Scale bars, 20 µm.
    Figure Legend Snippet: ( a ) Tumor growth curves (i – iii) and (iv) summary of relative final tumor volumes of HS-PDXs with the indicate EC/EPC sources. TC + CA-MSC in the absence or presence of human EC (TC + CA-MSC; n = 6) (iHDMEC + iHUVEC) and Pt. EC/EPC (TC + CA-MSC + EC/EPC; n = 7). ( b ) IF evaluation of human tumor vascular antigen CD31 (red) in PDXs with the indicated EC/EPC sources. 4′,6-diamidino-2-phenylindole (DAPI; blue) is used to label cell nuclei. ( c ) IF evaluation of a tumor specific vascular marker EGFL6 (red). Cell nuclei were counterstained with DAPI (blue). ( d ) RNASeq based relative mRNA expression for two patient PDXs without and with the addition of human endothelial cells. (e) Growth curves for standard PDX and HS-PDX, derived from a patient with platinum refractory ovarian cancer, treated with carboplatin (blue arrows indicate timing of carboplatin administration. Abbreviations : CA-MSC, cancer-associated mesenchymal stem cells; EC, endothelial cells; EPC, endothelial progenitor cells; iHDMEC, immortalized human dermal microvascular endothelial cells; iHUVEC, immortalized human umbilical vein endothelial cells; PDX, patient-derived xenograft; P0 and P1, passage 0 and passage 1 (The first generation of PDX is denoted P0, and P0 is subsequently passaged to second generation (P1); Pt., patient; TC, tumor cells. * p < 0.05, ** p < 0.01, *** p < 0.001. Scale bars, 20 µm.

    Techniques Used: Marker, Expressing, Derivative Assay

    microvascular endothelial cell line time  (ATCC)


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    ATCC microvascular endothelial cell line time
    Microvascular Endothelial Cell Line Time, supplied by ATCC, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    microvascular endothelial cell line time  (ATCC)


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    ATCC microvascular endothelial cell line time
    Microvascular Endothelial Cell Line Time, supplied by ATCC, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    microvascular endothelium time cell line  (ATCC)


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    ATCC microvascular endothelium time cell line
    Pharmacologic inhibition of TAK1 by 5Z-7-oxozeaenol suppressed angiogenic activities in vitro and ex vivo by inhibiting cell cycle and DNA replication . (A) Sprouting assay was performed in sectioned mouse aortic rings in the presence or absence of the TAK1 inhibitor, 5Z-7-Oxozeaenol (Oxo), and the sprout area was quantified 3 and 9 days after 5Z-7-oxozeaenol (Oxo) treatment (n = 6 from three independent experiments). Representative images were taken at day 9. Scale bar: 500 ìm. (B) Human telomerase-immortalized human <t>microvascular</t> endothelial (TIMEs) cells were pre-treated with delivery vehicle or 5Z-7-Oxozeaenol (Oxo) at 8, 40, 200 or 1000 nM for 24 or 48 hours, followed by the cell viability assay (n = 16 from four experiments). (C) RNA-Seq was performed for <t>TIME</t> cells treated with 0.2 µM or 1 µM 5Z-7-oxozeaenol (Oxo) or vehicles for 24 hours, followed by bioinformatic analysis (n = 4 independent biological replicates). Volcano plots show that level of gene expression was significantly changed in 0.2 µM or 1µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells. Red dots refer to genes showing a Log 2 (fold change) > 1 or < -1 and False discovery rate (FDR) < 0.05. (D-E) GSEA indicated that several gene sets (Reactome Pathway Database) for canonical pathways were negatively enriched in 0.2 µM- or 1 µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells. (F-G) GSEA plots showing negative association with the 'DNA Replication' and 'Cell Cycle' gene sets in 0.2 µM or 1 µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells compared to controls (vehicles). Statistical analysis was conducted by two-way RM ANOVA and Tukey's multiple comparison test; * P < 0.05, ** P < 0.01, **** P < 0.0001.
    Microvascular Endothelium Time Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/microvascular endothelium time cell line/product/ATCC
    Average 99 stars, based on 1 article reviews
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    microvascular endothelium time cell line - by Bioz Stars, 2024-04
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    1) Product Images from "Topical application of TAK1 inhibitor encapsulated by gelatin particle alleviates corneal neovascularization"

    Article Title: Topical application of TAK1 inhibitor encapsulated by gelatin particle alleviates corneal neovascularization

    Journal: Theranostics

    doi: 10.7150/thno.65098

    Pharmacologic inhibition of TAK1 by 5Z-7-oxozeaenol suppressed angiogenic activities in vitro and ex vivo by inhibiting cell cycle and DNA replication . (A) Sprouting assay was performed in sectioned mouse aortic rings in the presence or absence of the TAK1 inhibitor, 5Z-7-Oxozeaenol (Oxo), and the sprout area was quantified 3 and 9 days after 5Z-7-oxozeaenol (Oxo) treatment (n = 6 from three independent experiments). Representative images were taken at day 9. Scale bar: 500 ìm. (B) Human telomerase-immortalized human microvascular endothelial (TIMEs) cells were pre-treated with delivery vehicle or 5Z-7-Oxozeaenol (Oxo) at 8, 40, 200 or 1000 nM for 24 or 48 hours, followed by the cell viability assay (n = 16 from four experiments). (C) RNA-Seq was performed for TIME cells treated with 0.2 µM or 1 µM 5Z-7-oxozeaenol (Oxo) or vehicles for 24 hours, followed by bioinformatic analysis (n = 4 independent biological replicates). Volcano plots show that level of gene expression was significantly changed in 0.2 µM or 1µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells. Red dots refer to genes showing a Log 2 (fold change) > 1 or < -1 and False discovery rate (FDR) < 0.05. (D-E) GSEA indicated that several gene sets (Reactome Pathway Database) for canonical pathways were negatively enriched in 0.2 µM- or 1 µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells. (F-G) GSEA plots showing negative association with the 'DNA Replication' and 'Cell Cycle' gene sets in 0.2 µM or 1 µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells compared to controls (vehicles). Statistical analysis was conducted by two-way RM ANOVA and Tukey's multiple comparison test; * P < 0.05, ** P < 0.01, **** P < 0.0001.
    Figure Legend Snippet: Pharmacologic inhibition of TAK1 by 5Z-7-oxozeaenol suppressed angiogenic activities in vitro and ex vivo by inhibiting cell cycle and DNA replication . (A) Sprouting assay was performed in sectioned mouse aortic rings in the presence or absence of the TAK1 inhibitor, 5Z-7-Oxozeaenol (Oxo), and the sprout area was quantified 3 and 9 days after 5Z-7-oxozeaenol (Oxo) treatment (n = 6 from three independent experiments). Representative images were taken at day 9. Scale bar: 500 ìm. (B) Human telomerase-immortalized human microvascular endothelial (TIMEs) cells were pre-treated with delivery vehicle or 5Z-7-Oxozeaenol (Oxo) at 8, 40, 200 or 1000 nM for 24 or 48 hours, followed by the cell viability assay (n = 16 from four experiments). (C) RNA-Seq was performed for TIME cells treated with 0.2 µM or 1 µM 5Z-7-oxozeaenol (Oxo) or vehicles for 24 hours, followed by bioinformatic analysis (n = 4 independent biological replicates). Volcano plots show that level of gene expression was significantly changed in 0.2 µM or 1µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells. Red dots refer to genes showing a Log 2 (fold change) > 1 or < -1 and False discovery rate (FDR) < 0.05. (D-E) GSEA indicated that several gene sets (Reactome Pathway Database) for canonical pathways were negatively enriched in 0.2 µM- or 1 µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells. (F-G) GSEA plots showing negative association with the 'DNA Replication' and 'Cell Cycle' gene sets in 0.2 µM or 1 µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells compared to controls (vehicles). Statistical analysis was conducted by two-way RM ANOVA and Tukey's multiple comparison test; * P < 0.05, ** P < 0.01, **** P < 0.0001.

    Techniques Used: Inhibition, In Vitro, Ex Vivo, Viability Assay, RNA Sequencing Assay, Expressing

    microvascular endothelial cell line time  (ATCC)


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    ATCC microvascular endothelial cell line time
    Microvascular Endothelial Cell Line Time, supplied by ATCC, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    microvascular endothelial cell line time  (ATCC)


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    ATCC microvascular endothelial cell line time
    Microvascular Endothelial Cell Line Time, supplied by ATCC, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    microvascular endothelial cell line time  (ATCC)


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    ATCC microvascular endothelial cell line time
    Microvascular Endothelial Cell Line Time, supplied by ATCC, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    human time immortalized microvascular endothelial cell ec line  (ATCC)


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    ATCC human time immortalized microvascular endothelial cell ec line
    Human Time Immortalized Microvascular Endothelial Cell Ec Line, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    microvascular endothelial cell line time gfp  (ATCC)


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    ATCC microvascular endothelial cell line time gfp
    Microvascular Endothelial Cell Line Time Gfp, supplied by ATCC, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    microvascular endothelium time cell line  (ATCC)


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    ATCC microvascular endothelium time cell line
    Microvascular Endothelium Time Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/microvascular endothelium time cell line/product/ATCC
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    ATCC microvascular endothelium time cell line
    Pharmacologic inhibition of TAK1 by 5Z-7-oxozeaenol suppressed angiogenic activities in vitro and ex vivo by inhibiting cell cycle and DNA replication . (A) Sprouting assay was performed in sectioned mouse aortic rings in the presence or absence of the TAK1 inhibitor, 5Z-7-Oxozeaenol (Oxo), and the sprout area was quantified 3 and 9 days after 5Z-7-oxozeaenol (Oxo) treatment (n = 6 from three independent experiments). Representative images were taken at day 9. Scale bar: 500 ìm. (B) Human telomerase-immortalized human <t>microvascular</t> endothelial (TIMEs) cells were pre-treated with delivery vehicle or 5Z-7-Oxozeaenol (Oxo) at 8, 40, 200 or 1000 nM for 24 or 48 hours, followed by the cell viability assay (n = 16 from four experiments). (C) RNA-Seq was performed for <t>TIME</t> cells treated with 0.2 µM or 1 µM 5Z-7-oxozeaenol (Oxo) or vehicles for 24 hours, followed by bioinformatic analysis (n = 4 independent biological replicates). Volcano plots show that level of gene expression was significantly changed in 0.2 µM or 1µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells. Red dots refer to genes showing a Log 2 (fold change) > 1 or < -1 and False discovery rate (FDR) < 0.05. (D-E) GSEA indicated that several gene sets (Reactome Pathway Database) for canonical pathways were negatively enriched in 0.2 µM- or 1 µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells. (F-G) GSEA plots showing negative association with the 'DNA Replication' and 'Cell Cycle' gene sets in 0.2 µM or 1 µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells compared to controls (vehicles). Statistical analysis was conducted by two-way RM ANOVA and Tukey's multiple comparison test; * P < 0.05, ** P < 0.01, **** P < 0.0001.
    Microvascular Endothelium Time Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    86
    ATCC dermal microvascular endothelial cell line ihdmec time
    ( a ) Tumor growth curves (i – iii) and (iv) summary of relative final tumor volumes of HS-PDXs with the indicate EC/EPC sources. TC + CA-MSC in the absence or presence of human EC (TC + CA-MSC; n = 6) <t>(iHDMEC</t> + iHUVEC) and Pt. EC/EPC (TC + CA-MSC + EC/EPC; n = 7). ( b ) IF evaluation of human tumor vascular antigen CD31 (red) in PDXs with the indicated EC/EPC sources. 4′,6-diamidino-2-phenylindole (DAPI; blue) is used to label cell nuclei. ( c ) IF evaluation of a tumor specific vascular marker EGFL6 (red). Cell nuclei were counterstained with DAPI (blue). ( d ) RNASeq based relative mRNA expression for two patient PDXs without and with the addition of human endothelial cells. (e) Growth curves for standard PDX and HS-PDX, derived from a patient with platinum refractory ovarian cancer, treated with carboplatin (blue arrows indicate timing of carboplatin administration. Abbreviations : CA-MSC, cancer-associated mesenchymal stem cells; EC, endothelial cells; EPC, endothelial progenitor cells; iHDMEC, immortalized human dermal <t>microvascular</t> endothelial cells; iHUVEC, immortalized human umbilical vein endothelial cells; PDX, patient-derived xenograft; P0 and P1, passage 0 and passage 1 (The first generation of PDX is denoted P0, and P0 is subsequently passaged to second generation (P1); Pt., patient; TC, tumor cells. * p < 0.05, ** p < 0.01, *** p < 0.001. Scale bars, 20 µm.
    Dermal Microvascular Endothelial Cell Line Ihdmec Time, supplied by ATCC, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/dermal microvascular endothelial cell line ihdmec time/product/ATCC
    Average 86 stars, based on 1 article reviews
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    86
    ATCC microvascular endothelial cell line time
    ( a ) Tumor growth curves (i – iii) and (iv) summary of relative final tumor volumes of HS-PDXs with the indicate EC/EPC sources. TC + CA-MSC in the absence or presence of human EC (TC + CA-MSC; n = 6) <t>(iHDMEC</t> + iHUVEC) and Pt. EC/EPC (TC + CA-MSC + EC/EPC; n = 7). ( b ) IF evaluation of human tumor vascular antigen CD31 (red) in PDXs with the indicated EC/EPC sources. 4′,6-diamidino-2-phenylindole (DAPI; blue) is used to label cell nuclei. ( c ) IF evaluation of a tumor specific vascular marker EGFL6 (red). Cell nuclei were counterstained with DAPI (blue). ( d ) RNASeq based relative mRNA expression for two patient PDXs without and with the addition of human endothelial cells. (e) Growth curves for standard PDX and HS-PDX, derived from a patient with platinum refractory ovarian cancer, treated with carboplatin (blue arrows indicate timing of carboplatin administration. Abbreviations : CA-MSC, cancer-associated mesenchymal stem cells; EC, endothelial cells; EPC, endothelial progenitor cells; iHDMEC, immortalized human dermal <t>microvascular</t> endothelial cells; iHUVEC, immortalized human umbilical vein endothelial cells; PDX, patient-derived xenograft; P0 and P1, passage 0 and passage 1 (The first generation of PDX is denoted P0, and P0 is subsequently passaged to second generation (P1); Pt., patient; TC, tumor cells. * p < 0.05, ** p < 0.01, *** p < 0.001. Scale bars, 20 µm.
    Microvascular Endothelial Cell Line Time, supplied by ATCC, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/microvascular endothelial cell line time/product/ATCC
    Average 86 stars, based on 1 article reviews
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    99
    ATCC human time immortalized microvascular endothelial cell ec line
    ( a ) Tumor growth curves (i – iii) and (iv) summary of relative final tumor volumes of HS-PDXs with the indicate EC/EPC sources. TC + CA-MSC in the absence or presence of human EC (TC + CA-MSC; n = 6) <t>(iHDMEC</t> + iHUVEC) and Pt. EC/EPC (TC + CA-MSC + EC/EPC; n = 7). ( b ) IF evaluation of human tumor vascular antigen CD31 (red) in PDXs with the indicated EC/EPC sources. 4′,6-diamidino-2-phenylindole (DAPI; blue) is used to label cell nuclei. ( c ) IF evaluation of a tumor specific vascular marker EGFL6 (red). Cell nuclei were counterstained with DAPI (blue). ( d ) RNASeq based relative mRNA expression for two patient PDXs without and with the addition of human endothelial cells. (e) Growth curves for standard PDX and HS-PDX, derived from a patient with platinum refractory ovarian cancer, treated with carboplatin (blue arrows indicate timing of carboplatin administration. Abbreviations : CA-MSC, cancer-associated mesenchymal stem cells; EC, endothelial cells; EPC, endothelial progenitor cells; iHDMEC, immortalized human dermal <t>microvascular</t> endothelial cells; iHUVEC, immortalized human umbilical vein endothelial cells; PDX, patient-derived xenograft; P0 and P1, passage 0 and passage 1 (The first generation of PDX is denoted P0, and P0 is subsequently passaged to second generation (P1); Pt., patient; TC, tumor cells. * p < 0.05, ** p < 0.01, *** p < 0.001. Scale bars, 20 µm.
    Human Time Immortalized Microvascular Endothelial Cell Ec Line, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/human time immortalized microvascular endothelial cell ec line/product/ATCC
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    86
    ATCC microvascular endothelial cell line time gfp
    ( a ) Tumor growth curves (i – iii) and (iv) summary of relative final tumor volumes of HS-PDXs with the indicate EC/EPC sources. TC + CA-MSC in the absence or presence of human EC (TC + CA-MSC; n = 6) <t>(iHDMEC</t> + iHUVEC) and Pt. EC/EPC (TC + CA-MSC + EC/EPC; n = 7). ( b ) IF evaluation of human tumor vascular antigen CD31 (red) in PDXs with the indicated EC/EPC sources. 4′,6-diamidino-2-phenylindole (DAPI; blue) is used to label cell nuclei. ( c ) IF evaluation of a tumor specific vascular marker EGFL6 (red). Cell nuclei were counterstained with DAPI (blue). ( d ) RNASeq based relative mRNA expression for two patient PDXs without and with the addition of human endothelial cells. (e) Growth curves for standard PDX and HS-PDX, derived from a patient with platinum refractory ovarian cancer, treated with carboplatin (blue arrows indicate timing of carboplatin administration. Abbreviations : CA-MSC, cancer-associated mesenchymal stem cells; EC, endothelial cells; EPC, endothelial progenitor cells; iHDMEC, immortalized human dermal <t>microvascular</t> endothelial cells; iHUVEC, immortalized human umbilical vein endothelial cells; PDX, patient-derived xenograft; P0 and P1, passage 0 and passage 1 (The first generation of PDX is denoted P0, and P0 is subsequently passaged to second generation (P1); Pt., patient; TC, tumor cells. * p < 0.05, ** p < 0.01, *** p < 0.001. Scale bars, 20 µm.
    Microvascular Endothelial Cell Line Time Gfp, supplied by ATCC, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/microvascular endothelial cell line time gfp/product/ATCC
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    Image Search Results


    Pharmacologic inhibition of TAK1 by 5Z-7-oxozeaenol suppressed angiogenic activities in vitro and ex vivo by inhibiting cell cycle and DNA replication . (A) Sprouting assay was performed in sectioned mouse aortic rings in the presence or absence of the TAK1 inhibitor, 5Z-7-Oxozeaenol (Oxo), and the sprout area was quantified 3 and 9 days after 5Z-7-oxozeaenol (Oxo) treatment (n = 6 from three independent experiments). Representative images were taken at day 9. Scale bar: 500 ìm. (B) Human telomerase-immortalized human microvascular endothelial (TIMEs) cells were pre-treated with delivery vehicle or 5Z-7-Oxozeaenol (Oxo) at 8, 40, 200 or 1000 nM for 24 or 48 hours, followed by the cell viability assay (n = 16 from four experiments). (C) RNA-Seq was performed for TIME cells treated with 0.2 µM or 1 µM 5Z-7-oxozeaenol (Oxo) or vehicles for 24 hours, followed by bioinformatic analysis (n = 4 independent biological replicates). Volcano plots show that level of gene expression was significantly changed in 0.2 µM or 1µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells. Red dots refer to genes showing a Log 2 (fold change) > 1 or < -1 and False discovery rate (FDR) < 0.05. (D-E) GSEA indicated that several gene sets (Reactome Pathway Database) for canonical pathways were negatively enriched in 0.2 µM- or 1 µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells. (F-G) GSEA plots showing negative association with the 'DNA Replication' and 'Cell Cycle' gene sets in 0.2 µM or 1 µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells compared to controls (vehicles). Statistical analysis was conducted by two-way RM ANOVA and Tukey's multiple comparison test; * P < 0.05, ** P < 0.01, **** P < 0.0001.

    Journal: Theranostics

    Article Title: Topical application of TAK1 inhibitor encapsulated by gelatin particle alleviates corneal neovascularization

    doi: 10.7150/thno.65098

    Figure Lengend Snippet: Pharmacologic inhibition of TAK1 by 5Z-7-oxozeaenol suppressed angiogenic activities in vitro and ex vivo by inhibiting cell cycle and DNA replication . (A) Sprouting assay was performed in sectioned mouse aortic rings in the presence or absence of the TAK1 inhibitor, 5Z-7-Oxozeaenol (Oxo), and the sprout area was quantified 3 and 9 days after 5Z-7-oxozeaenol (Oxo) treatment (n = 6 from three independent experiments). Representative images were taken at day 9. Scale bar: 500 ìm. (B) Human telomerase-immortalized human microvascular endothelial (TIMEs) cells were pre-treated with delivery vehicle or 5Z-7-Oxozeaenol (Oxo) at 8, 40, 200 or 1000 nM for 24 or 48 hours, followed by the cell viability assay (n = 16 from four experiments). (C) RNA-Seq was performed for TIME cells treated with 0.2 µM or 1 µM 5Z-7-oxozeaenol (Oxo) or vehicles for 24 hours, followed by bioinformatic analysis (n = 4 independent biological replicates). Volcano plots show that level of gene expression was significantly changed in 0.2 µM or 1µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells. Red dots refer to genes showing a Log 2 (fold change) > 1 or < -1 and False discovery rate (FDR) < 0.05. (D-E) GSEA indicated that several gene sets (Reactome Pathway Database) for canonical pathways were negatively enriched in 0.2 µM- or 1 µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells. (F-G) GSEA plots showing negative association with the 'DNA Replication' and 'Cell Cycle' gene sets in 0.2 µM or 1 µM 5Z-7-oxozeaenol (Oxo)-treated TIME cells compared to controls (vehicles). Statistical analysis was conducted by two-way RM ANOVA and Tukey's multiple comparison test; * P < 0.05, ** P < 0.01, **** P < 0.0001.

    Article Snippet: The telomerase-immortalized human microvascular endothelium (TIME) cell line was purchased from American Type Culture Collection (CRL-4025; ATCC, Manassas, VA).

    Techniques: Inhibition, In Vitro, Ex Vivo, Viability Assay, RNA Sequencing Assay, Expressing

    ( a ) Tumor growth curves (i – iii) and (iv) summary of relative final tumor volumes of HS-PDXs with the indicate EC/EPC sources. TC + CA-MSC in the absence or presence of human EC (TC + CA-MSC; n = 6) (iHDMEC + iHUVEC) and Pt. EC/EPC (TC + CA-MSC + EC/EPC; n = 7). ( b ) IF evaluation of human tumor vascular antigen CD31 (red) in PDXs with the indicated EC/EPC sources. 4′,6-diamidino-2-phenylindole (DAPI; blue) is used to label cell nuclei. ( c ) IF evaluation of a tumor specific vascular marker EGFL6 (red). Cell nuclei were counterstained with DAPI (blue). ( d ) RNASeq based relative mRNA expression for two patient PDXs without and with the addition of human endothelial cells. (e) Growth curves for standard PDX and HS-PDX, derived from a patient with platinum refractory ovarian cancer, treated with carboplatin (blue arrows indicate timing of carboplatin administration. Abbreviations : CA-MSC, cancer-associated mesenchymal stem cells; EC, endothelial cells; EPC, endothelial progenitor cells; iHDMEC, immortalized human dermal microvascular endothelial cells; iHUVEC, immortalized human umbilical vein endothelial cells; PDX, patient-derived xenograft; P0 and P1, passage 0 and passage 1 (The first generation of PDX is denoted P0, and P0 is subsequently passaged to second generation (P1); Pt., patient; TC, tumor cells. * p < 0.05, ** p < 0.01, *** p < 0.001. Scale bars, 20 µm.

    Journal: bioRxiv

    Article Title: A Novel Humanized Immune Stroma PDX Cancer Model for Therapeutic Studies

    doi: 10.1101/2023.07.03.547206

    Figure Lengend Snippet: ( a ) Tumor growth curves (i – iii) and (iv) summary of relative final tumor volumes of HS-PDXs with the indicate EC/EPC sources. TC + CA-MSC in the absence or presence of human EC (TC + CA-MSC; n = 6) (iHDMEC + iHUVEC) and Pt. EC/EPC (TC + CA-MSC + EC/EPC; n = 7). ( b ) IF evaluation of human tumor vascular antigen CD31 (red) in PDXs with the indicated EC/EPC sources. 4′,6-diamidino-2-phenylindole (DAPI; blue) is used to label cell nuclei. ( c ) IF evaluation of a tumor specific vascular marker EGFL6 (red). Cell nuclei were counterstained with DAPI (blue). ( d ) RNASeq based relative mRNA expression for two patient PDXs without and with the addition of human endothelial cells. (e) Growth curves for standard PDX and HS-PDX, derived from a patient with platinum refractory ovarian cancer, treated with carboplatin (blue arrows indicate timing of carboplatin administration. Abbreviations : CA-MSC, cancer-associated mesenchymal stem cells; EC, endothelial cells; EPC, endothelial progenitor cells; iHDMEC, immortalized human dermal microvascular endothelial cells; iHUVEC, immortalized human umbilical vein endothelial cells; PDX, patient-derived xenograft; P0 and P1, passage 0 and passage 1 (The first generation of PDX is denoted P0, and P0 is subsequently passaged to second generation (P1); Pt., patient; TC, tumor cells. * p < 0.05, ** p < 0.01, *** p < 0.001. Scale bars, 20 µm.

    Article Snippet: Immortalized human dermal microvascular endothelial cell line (iHDMEC) TIME (ATCC ® CRL-4025™), and immortalized human umbilical vein endothelial cell line (iHUVEC) HUVEC/TERT 2 (ATCC ® CRL-4053) were purchased from ATCC (Manassas, VA, USA).

    Techniques: Marker, Expressing, Derivative Assay