micafungin  (Astellas)

 
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    Astellas micafungin
    Micafungin, supplied by Astellas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/micafungin/product/Astellas
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    micafungin - by Bioz Stars, 2023-02
    86/100 stars

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    micafungin  (Astellas)

     
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    Structured Review

    Astellas micafungin
    Micafungin, supplied by Astellas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/micafungin/product/Astellas
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    micafungin - by Bioz Stars, 2023-02
    86/100 stars

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    micafungin  (Astellas)

     
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    Astellas micafungin
    Data in all panels represents mice treated 3 times per week for 3 weeks with anidulafungin (green bars), caspofungin (yellow bars), <t>micafungin</t> (blue bars) at the doses noted and trimethoprim-sulfamethoxazole at 50/200 mg/kg (pink bars, T/S) or untreated (red bars, C/S). Bars indicate log 10 mean cysts±standard deviation (SD) per lung. Panel A: High dose echinocandin treatment, cyst burdens. All groups were significantly different than the untreated control mice (C/S), P<0.001. Panel B: Low dose echinocandin treatment, cyst burdens. Cyst burdens were compared to untreated controls (C/S) and P values for each group are listed on the graph; (*) indicates P<0.001. Panel C: High dose echinocandin treatment, trophic burdens *P<0.001 treated vs untreated control mice (C/S). Panel D: Low dose echinocandin treatment, trophic burdens. *P<0.001 treated vs untreated control mice.
    Micafungin, supplied by Astellas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/micafungin/product/Astellas
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    micafungin - by Bioz Stars, 2023-02
    86/100 stars

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    1) Product Images from "Echinocandin Treatment of Pneumocystis Pneumonia in Rodent Models Depletes Cysts Leaving Trophic Burdens That Cannot Transmit the Infection"

    Article Title: Echinocandin Treatment of Pneumocystis Pneumonia in Rodent Models Depletes Cysts Leaving Trophic Burdens That Cannot Transmit the Infection

    Journal: PLoS ONE

    doi: 10.1371/journal.pone.0008524

    Data in all panels represents mice treated 3 times per week for 3 weeks with anidulafungin (green bars), caspofungin (yellow bars), micafungin (blue bars) at the doses noted and trimethoprim-sulfamethoxazole at 50/200 mg/kg (pink bars, T/S) or untreated (red bars, C/S). Bars indicate log 10 mean cysts±standard deviation (SD) per lung. Panel A: High dose echinocandin treatment, cyst burdens. All groups were significantly different than the untreated control mice (C/S), P<0.001. Panel B: Low dose echinocandin treatment, cyst burdens. Cyst burdens were compared to untreated controls (C/S) and P values for each group are listed on the graph; (*) indicates P<0.001. Panel C: High dose echinocandin treatment, trophic burdens *P<0.001 treated vs untreated control mice (C/S). Panel D: Low dose echinocandin treatment, trophic burdens. *P<0.001 treated vs untreated control mice.
    Figure Legend Snippet: Data in all panels represents mice treated 3 times per week for 3 weeks with anidulafungin (green bars), caspofungin (yellow bars), micafungin (blue bars) at the doses noted and trimethoprim-sulfamethoxazole at 50/200 mg/kg (pink bars, T/S) or untreated (red bars, C/S). Bars indicate log 10 mean cysts±standard deviation (SD) per lung. Panel A: High dose echinocandin treatment, cyst burdens. All groups were significantly different than the untreated control mice (C/S), P<0.001. Panel B: Low dose echinocandin treatment, cyst burdens. Cyst burdens were compared to untreated controls (C/S) and P values for each group are listed on the graph; (*) indicates P<0.001. Panel C: High dose echinocandin treatment, trophic burdens *P<0.001 treated vs untreated control mice (C/S). Panel D: Low dose echinocandin treatment, trophic burdens. *P<0.001 treated vs untreated control mice.

    Techniques Used: Standard Deviation

    Percent survival for treated vs untreated mice was calculated for the 21 day treatment period using GraphPad Prism v.4. Asterisks indicate a significant difference from untreated controls (C/S). Line colors reflect the treatment and regimen as shown on the figure legend. Panel A: 10 mg/kg treatment regimen: anidulafungin: P = 0.02; caspofungin: P = 0.006; micafungin: P = 0.0006; T/S: 0.002. Panel B: 5 mg/kg treatment regimen: anidulafungin: P = 0.002; T/S: P = 0.02; Panel C: 2.5 mg/kg regimen: anidulafungin: P = 0.004; T/S: P = 0.002; Panel D: 1.0 mg/kg regimen: anidulafungin: P = 0.0049; caspofungin: P = 0.002; T/S: P = 0.002; Panel E: 0.5 mg/kg regimen: anidulafungin: P = 0.002; caspofungin:P = 0.007; T/S: P = 0.002; Panel F: 0.1 mg/kg regimen: anidulafungin: P = 0.004; T/S: P = 0.002.
    Figure Legend Snippet: Percent survival for treated vs untreated mice was calculated for the 21 day treatment period using GraphPad Prism v.4. Asterisks indicate a significant difference from untreated controls (C/S). Line colors reflect the treatment and regimen as shown on the figure legend. Panel A: 10 mg/kg treatment regimen: anidulafungin: P = 0.02; caspofungin: P = 0.006; micafungin: P = 0.0006; T/S: 0.002. Panel B: 5 mg/kg treatment regimen: anidulafungin: P = 0.002; T/S: P = 0.02; Panel C: 2.5 mg/kg regimen: anidulafungin: P = 0.004; T/S: P = 0.002; Panel D: 1.0 mg/kg regimen: anidulafungin: P = 0.0049; caspofungin: P = 0.002; T/S: P = 0.002; Panel E: 0.5 mg/kg regimen: anidulafungin: P = 0.002; caspofungin:P = 0.007; T/S: P = 0.002; Panel F: 0.1 mg/kg regimen: anidulafungin: P = 0.004; T/S: P = 0.002.

    Techniques Used:

    Grocott's methenamine silver-stained sections of lungs from: untreated mice (Panels A–C); representative sections from mice treated with 10-, 5- and 1 mg/kg caspofungin (Panels D–F;) representative sections from mice treated with 10-, 5- and 1 mg/kg micafungin (Panels G–I); and 10-, 5- and 1 mg/kg anidulafungin (Panels J–L). 1,250× magnification; 10 um bars in Panels A–C are the same for Panels D–L. Arrows indicate morphologies discussed in the text.
    Figure Legend Snippet: Grocott's methenamine silver-stained sections of lungs from: untreated mice (Panels A–C); representative sections from mice treated with 10-, 5- and 1 mg/kg caspofungin (Panels D–F;) representative sections from mice treated with 10-, 5- and 1 mg/kg micafungin (Panels G–I); and 10-, 5- and 1 mg/kg anidulafungin (Panels J–L). 1,250× magnification; 10 um bars in Panels A–C are the same for Panels D–L. Arrows indicate morphologies discussed in the text.

    Techniques Used: Staining

    micafungin  (Astellas)

     
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    Astellas micafungin
    Micafungin, supplied by Astellas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/micafungin/product/Astellas
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    micafungin - by Bioz Stars, 2023-02
    86/100 stars

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    micafungin  (Astellas)

     
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    Astellas micafungin
    Micafungin, supplied by Astellas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/micafungin/product/Astellas
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    micafungin - by Bioz Stars, 2023-02
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    mycamine  (Astellas)

     
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    Astellas mycamine
    Mycamine, supplied by Astellas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 86 stars, based on 1 article reviews
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    mycamine - by Bioz Stars, 2023-02
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    micafungin  (Astellas)

     
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    Astellas micafungin
    Micafungin, supplied by Astellas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/micafungin/product/Astellas
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    micafungin - by Bioz Stars, 2023-02
    86/100 stars

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    micafungin  (Astellas)

     
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    Astellas micafungin
    Tornado diagram. The solid vertical line represents the total incremental lifetime costs per quality-adjusted life year (QALY) for survivors using <t>micafungin</t> compared with fluconazole as empiric treatment of suspected intensive care unit (ICU)-acquired candidemia as calculated in the base case scenario. The horizontal bars represent the range of this difference when the corresponding single input is varied across its designated range with all other input parameters held constant. All costs inflated to 2008 $US using medical component of the consumer product index; a 3% annual discount applied. BSI = blood stream infection; C&S = culture and sensitivity; CG = Candida glabrata ; CK = Candida krusei , MYC = micafungin.
    Micafungin, supplied by Astellas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/micafungin/product/Astellas
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    micafungin - by Bioz Stars, 2023-02
    86/100 stars

    Images

    1) Product Images from "Cost-effectiveness of micafungin as an alternative to fluconazole empiric treatment of suspected ICU-acquired candidemia among patients with sepsis: a model simulation"

    Article Title: Cost-effectiveness of micafungin as an alternative to fluconazole empiric treatment of suspected ICU-acquired candidemia among patients with sepsis: a model simulation

    Journal: Critical Care

    doi: 10.1186/cc7924

    Tornado diagram. The solid vertical line represents the total incremental lifetime costs per quality-adjusted life year (QALY) for survivors using micafungin compared with fluconazole as empiric treatment of suspected intensive care unit (ICU)-acquired candidemia as calculated in the base case scenario. The horizontal bars represent the range of this difference when the corresponding single input is varied across its designated range with all other input parameters held constant. All costs inflated to 2008 $US using medical component of the consumer product index; a 3% annual discount applied. BSI = blood stream infection; C&S = culture and sensitivity; CG = Candida glabrata ; CK = Candida krusei , MYC = micafungin.
    Figure Legend Snippet: Tornado diagram. The solid vertical line represents the total incremental lifetime costs per quality-adjusted life year (QALY) for survivors using micafungin compared with fluconazole as empiric treatment of suspected intensive care unit (ICU)-acquired candidemia as calculated in the base case scenario. The horizontal bars represent the range of this difference when the corresponding single input is varied across its designated range with all other input parameters held constant. All costs inflated to 2008 $US using medical component of the consumer product index; a 3% annual discount applied. BSI = blood stream infection; C&S = culture and sensitivity; CG = Candida glabrata ; CK = Candida krusei , MYC = micafungin.

    Techniques Used: Infection

    micafungin  (Astellas)

     
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    Astellas micafungin
    Tornado diagram. The solid vertical line represents the total incremental lifetime costs per quality-adjusted life year (QALY) for survivors using <t>micafungin</t> compared with fluconazole as empiric treatment of suspected intensive care unit (ICU)-acquired candidemia as calculated in the base case scenario. The horizontal bars represent the range of this difference when the corresponding single input is varied across its designated range with all other input parameters held constant. All costs inflated to 2008 $US using medical component of the consumer product index; a 3% annual discount applied. BSI = blood stream infection; C&S = culture and sensitivity; CG = Candida glabrata ; CK = Candida krusei , MYC = micafungin.
    Micafungin, supplied by Astellas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/micafungin/product/Astellas
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    micafungin - by Bioz Stars, 2023-02
    86/100 stars

    Images

    1) Product Images from "Cost-effectiveness of micafungin as an alternative to fluconazole empiric treatment of suspected ICU-acquired candidemia among patients with sepsis: a model simulation"

    Article Title: Cost-effectiveness of micafungin as an alternative to fluconazole empiric treatment of suspected ICU-acquired candidemia among patients with sepsis: a model simulation

    Journal: Critical Care

    doi: 10.1186/cc7924

    Tornado diagram. The solid vertical line represents the total incremental lifetime costs per quality-adjusted life year (QALY) for survivors using micafungin compared with fluconazole as empiric treatment of suspected intensive care unit (ICU)-acquired candidemia as calculated in the base case scenario. The horizontal bars represent the range of this difference when the corresponding single input is varied across its designated range with all other input parameters held constant. All costs inflated to 2008 $US using medical component of the consumer product index; a 3% annual discount applied. BSI = blood stream infection; C&S = culture and sensitivity; CG = Candida glabrata ; CK = Candida krusei , MYC = micafungin.
    Figure Legend Snippet: Tornado diagram. The solid vertical line represents the total incremental lifetime costs per quality-adjusted life year (QALY) for survivors using micafungin compared with fluconazole as empiric treatment of suspected intensive care unit (ICU)-acquired candidemia as calculated in the base case scenario. The horizontal bars represent the range of this difference when the corresponding single input is varied across its designated range with all other input parameters held constant. All costs inflated to 2008 $US using medical component of the consumer product index; a 3% annual discount applied. BSI = blood stream infection; C&S = culture and sensitivity; CG = Candida glabrata ; CK = Candida krusei , MYC = micafungin.

    Techniques Used: Infection

    micafungin  (Astellas)

     
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    Structured Review

    Astellas micafungin
    Tornado diagram. The solid vertical line represents the total incremental lifetime costs per quality-adjusted life year (QALY) for survivors using <t>micafungin</t> compared with fluconazole as empiric treatment of suspected intensive care unit (ICU)-acquired candidemia as calculated in the base case scenario. The horizontal bars represent the range of this difference when the corresponding single input is varied across its designated range with all other input parameters held constant. All costs inflated to 2008 $US using medical component of the consumer product index; a 3% annual discount applied. BSI = blood stream infection; C&S = culture and sensitivity; CG = Candida glabrata ; CK = Candida krusei , MYC = micafungin.
    Micafungin, supplied by Astellas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/micafungin/product/Astellas
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    micafungin - by Bioz Stars, 2023-02
    86/100 stars

    Images

    1) Product Images from "Cost-effectiveness of micafungin as an alternative to fluconazole empiric treatment of suspected ICU-acquired candidemia among patients with sepsis: a model simulation"

    Article Title: Cost-effectiveness of micafungin as an alternative to fluconazole empiric treatment of suspected ICU-acquired candidemia among patients with sepsis: a model simulation

    Journal: Critical Care

    doi: 10.1186/cc7924

    Tornado diagram. The solid vertical line represents the total incremental lifetime costs per quality-adjusted life year (QALY) for survivors using micafungin compared with fluconazole as empiric treatment of suspected intensive care unit (ICU)-acquired candidemia as calculated in the base case scenario. The horizontal bars represent the range of this difference when the corresponding single input is varied across its designated range with all other input parameters held constant. All costs inflated to 2008 $US using medical component of the consumer product index; a 3% annual discount applied. BSI = blood stream infection; C&S = culture and sensitivity; CG = Candida glabrata ; CK = Candida krusei , MYC = micafungin.
    Figure Legend Snippet: Tornado diagram. The solid vertical line represents the total incremental lifetime costs per quality-adjusted life year (QALY) for survivors using micafungin compared with fluconazole as empiric treatment of suspected intensive care unit (ICU)-acquired candidemia as calculated in the base case scenario. The horizontal bars represent the range of this difference when the corresponding single input is varied across its designated range with all other input parameters held constant. All costs inflated to 2008 $US using medical component of the consumer product index; a 3% annual discount applied. BSI = blood stream infection; C&S = culture and sensitivity; CG = Candida glabrata ; CK = Candida krusei , MYC = micafungin.

    Techniques Used: Infection

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    • micafungin  (Astellas)
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    Astellas micafungin
    Micafungin, supplied by Astellas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Mycamine, supplied by Astellas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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