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The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior 
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Impact of the lack of wfikkn1 on the 48-h postfertilization zebrafish transcriptome. A, Top 10 <t>MetaCore</t> process network enrichments of human orthologs of differentially expressed genes between WT_DMSO and mut_DMSO. Significant processes (FDR-adjusted p < .05) are bolded and italicized. The interaction size is the number of observed genes from each cluster that belongs to the process network, and enrichment ratio is the ratio of the number of observed genes to the expected genes from each network. The top 2 processes are skeletal muscle development and muscle contraction. B, MetaCore interactome of genes enriched in the top 2 biological process networks (gray). AHR and WFIKKN1 were manually added to the network. Proteins predicted by MetaCore that interact with AHR or WFIKKN1, and the gray genes are depicted in other colors (BMP4, CTNNB1, AR, NANOG, SOX17, RUNX1, BMP2, and BMP4). Thicker colored lines show the direct interactions with WFIKKN1. Abbreviations: WT, wild type; DMSO, dimethyl sulfoxide; FDR, false discovery rate. AHR, aryl hydrocarbon receptor. A color version of this figure appears in the online version of this article.
The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior 
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Functional enrichment of genes differently differentially expressed in wild-type and wfikkn1 mutant zebrafish upon exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Top 20 <t>MetaCore</t> process network enrichments of genes in Cluster 2. Significant processes (false discovery rate-adjusted p < .05) bolded and italicized. The interaction size is the number of observed genes from each cluster that belongs to the process network, and enrichment ratio is the ratio of the number of observed genes to the expected genes from each network.
The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior 
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Whole-animal proteomic comparison between wild-type (WT) and wfikkn1 mutant zebrafish at 48 hpf. A, PCA plot of 6 biological replicates of the wild-type (wt) and wfikkn1 (mut) significant peptides (false discovery rate [FDR] p < .05). B, Comparison between genes of proteins predicted from significant peptides (FDR p < .05; proteomics) and significant differentially expressed genes (FDR p < .05; transcriptomics). C, Heatmap showing <t>MetaCore</t> process networks (significant processes are bolded) on the y-axis, and proteins from proteomic and transcriptomic (*) datasets on the x-axis. Blue boxes represent proteins expressed in at least 3 biological replicates of WT or mutants and absent in all replicates of the other genotype.
The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior Toxicological Sciences, 2022 Apr 04
"Impact of the lack of wfikkn1 on the 48-h postfertilization zebrafish transcriptome. A, Top 10 <t>MetaCore</t> process network enrichments of human orthologs of differentially expressed genes between WT_DMSO and mut_DMSO. Significant processes (FDR-adjusted p < .05) are bolded and italicized. The interaction size is the number of observed genes from each cluster that belongs to the process network, and enrichment ratio is the ratio of the number of observed genes to the expected genes from each network. The top 2 processes are skeletal muscle development and muscle contraction. B, MetaCore interactome of genes enriched in the top 2 biological process networks (gray). AHR and WFIKKN1 were manually added to the network. Proteins predicted by MetaCore that interact with AHR or WFIKKN1, and the gray genes are depicted in other colors (BMP4, CTNNB1, AR, NANOG, SOX17, RUNX1, BMP2, and BMP4). Thicker colored lines show the direct interactions with WFIKKN1. Abbreviations: WT, wild type; DMSO, dimethyl sulfoxide; FDR, false discovery rate. AHR, aryl hydrocarbon receptor. A color version of this figure appears in the online version of this article. "
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