mefloquine mq (Millipore)
Structured Review

Mefloquine Mq, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 8 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mefloquine mq/product/Millipore
Average 86 stars, based on 8 article reviews
Price from $9.99 to $1999.99
Images
1) Product Images from "Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum"
Article Title: Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum
Journal: ACS Infectious Diseases
doi: 10.1021/acsinfecdis.7b00217

Figure Legend Snippet: Identification of 3D7-E182D mutant active, equally potent, and wild-type active DHODH inhibitors. (a) A high-throughput screen of select GSK libraries using wild-type and E182D recombinant Pf DHODH identified 118 primary hits. On the basis of the IC 50 ratio of E182D/WT, compounds were classified as E182D mutant active ( n = 18), equally potent ( n = 21), or wild-type active ( n = 69). Control compounds are indicated on the plot: IDI-6273 (blue), mutant active control; DSM74 (red), wild-type active control. (b) Cell-based validation of 85 active compounds. Compounds were classified into three groups based on the EC 50 ratio of E182D/WT: equally potent ( n = 17), mutant active ( n = 7), or wild-type active ( n = 59). Control compounds are indicated on the plot: IDI-6273 (blue), mutant active control; DSM74 and Genz-669178 (red), wild-type active controls; dihydroartemisinin (DHA) and mefloquine (MQ) (white), non-DHODH inhibitor controls.
Techniques Used: Mutagenesis, High Throughput Screening Assay, Recombinant
2) Product Images from "Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum"
Article Title: Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum
Journal: ACS Infectious Diseases
doi: 10.1021/acsinfecdis.7b00217

Figure Legend Snippet: Identification of 3D7-E182D mutant active, equally potent, and wild-type active DHODH inhibitors. (a) A high-throughput screen of select GSK libraries using wild-type and E182D recombinant Pf DHODH identified 118 primary hits. On the basis of the IC 50 ratio of E182D/WT, compounds were classified as E182D mutant active ( n = 18), equally potent ( n = 21), or wild-type active ( n = 69). Control compounds are indicated on the plot: IDI-6273 (blue), mutant active control; DSM74 (red), wild-type active control. (b) Cell-based validation of 85 active compounds. Compounds were classified into three groups based on the EC 50 ratio of E182D/WT: equally potent ( n = 17), mutant active ( n = 7), or wild-type active ( n = 59). Control compounds are indicated on the plot: IDI-6273 (blue), mutant active control; DSM74 and Genz-669178 (red), wild-type active controls; dihydroartemisinin (DHA) and mefloquine (MQ) (white), non-DHODH inhibitor controls.
Techniques Used: Mutagenesis, High Throughput Screening Assay, Recombinant