m picrotoxin  (Millipore)


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  • 99
    Name:
    Picrotoxin
    Description:
    Picrotoxin is isolated from moonseed family Menispermaceae It is a stimulant and may cause convulsions It is an allosteric modulator of γ aminobutyric acid GABAA receptor
    Catalog Number:
    p1675
    Price:
    None
    Applications:
    Picrotoxin has been used:. as non-competitive antagonist for the γ-aminobutyric acid (GABAA) for studying synchronized burst (SB) dynamics. as a component of extracellular saline for blocking glutamate and acetylcholine receptors in neurons. as a component of artificial cerebrospinal fluid (ACSF) for voltage-clamp recordings studies in dissociated cortical neurons
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    Structured Review

    Millipore m picrotoxin
    Picrotoxin
    Picrotoxin is isolated from moonseed family Menispermaceae It is a stimulant and may cause convulsions It is an allosteric modulator of γ aminobutyric acid GABAA receptor
    https://www.bioz.com/result/m picrotoxin/product/Millipore
    Average 99 stars, based on 6 article reviews
    Price from $9.99 to $1999.99
    m picrotoxin - by Bioz Stars, 2020-09
    99/100 stars

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    other:

    Article Title: Synaptic Contributions to Focal and Widespread Spatiotemporal Dynamics in the Isolated Rat Subiculum In Vitro
    Article Snippet: Picrotoxin (PTX), 2,3-dioxo-6-nitro-1,2,3,4-tetrahydro-benzo[f]quinoxaline-7-sulfonamide (NBQX), CNQX, AP-5, atropine, mecamylamine, and salts were purchased from Sigma (St. Louis, MO).

    Article Title: Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice
    Article Snippet: Drugs and antibodies Kainate (KA) was purchased from Tocris Cookson (Bristol, UK), Picrotoxin (PTX), D-2-amino-5-phosphono-pentanoic acid (AP-5), 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy- 5H-2,3-benzodiazepine (GYKI53655), 6-cyano-7-nitroquinoxalene-2,3-dione (CNQX), phosphatase inhibitor cocktail 2 and 3 were obtained from Sigma-Aldrich (St. Louis, MO).

    Article Title: Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice
    Article Snippet: Kainate (KA) was purchased from Tocris Cookson (Bristol, UK), Picrotoxin (PTX), D-2-amino-5-phosphono-pentanoic acid (AP-5), 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy- 5H-2,3-benzodiazepine (GYKI53655), 6-cyano-7-nitroquinoxalene-2,3-dione (CNQX), phosphatase inhibitor cocktail 2 and 3 were obtained from Sigma-Aldrich (St. Louis, MO).

    Article Title: Inactivation of GABAA receptor is related to heat shock stress response in organism model Caenorhabditis elegans
    Article Snippet: Picrotoxin (PTX) hydrogen peroxide and GABA were purchased from Sigma-Aldrich (St. Louis, MO, USA).

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  • 99
    Millipore mg132
    Effect of proteasomal inhibition on mEPSC amplitudes and frequencies in normal active and silenced cultures. A–H , Example traces ( A–D ) and averaged mEPSC slopes ( E–H ) recorded from neurons in the control situation ( A , E ), after activity silencing ( B , F ), and upon <t>MG132</t> treatment of control ( C , G ) and silenced ( D , H ) cultures. I , K , Cumulative distribution of averaged mEPSC amplitudes ( I ) and interevent intervals ( K ) were plotted for all treatments. J , L , Quantification of 200 mEPSC amplitudes ( J ) and interevent intervals ( L ) for all treatments. Mean values are shown; whiskers indicate SEM. Significance was tested with one-way ANOVA with Bonferroni post hoc test; ** p
    Mg132, supplied by Millipore, used in various techniques. Bioz Stars score: 99/100, based on 1367 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mg132/product/Millipore
    Average 99 stars, based on 1367 article reviews
    Price from $9.99 to $1999.99
    mg132 - by Bioz Stars, 2020-09
    99/100 stars
      Buy from Supplier

    94
    Millipore kn 62
    Effect of proteasomal inhibition on mEPSC amplitudes and frequencies in normal active and silenced cultures. A–H , Example traces ( A–D ) and averaged mEPSC slopes ( E–H ) recorded from neurons in the control situation ( A , E ), after activity silencing ( B , F ), and upon <t>MG132</t> treatment of control ( C , G ) and silenced ( D , H ) cultures. I , K , Cumulative distribution of averaged mEPSC amplitudes ( I ) and interevent intervals ( K ) were plotted for all treatments. J , L , Quantification of 200 mEPSC amplitudes ( J ) and interevent intervals ( L ) for all treatments. Mean values are shown; whiskers indicate SEM. Significance was tested with one-way ANOVA with Bonferroni post hoc test; ** p
    Kn 62, supplied by Millipore, used in various techniques. Bioz Stars score: 94/100, based on 11 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/kn 62/product/Millipore
    Average 94 stars, based on 11 article reviews
    Price from $9.99 to $1999.99
    kn 62 - by Bioz Stars, 2020-09
    94/100 stars
      Buy from Supplier

    99
    Millipore picrotoxin
    Effect of proteasomal inhibition on mEPSC amplitudes and frequencies in normal active and silenced cultures. A–H , Example traces ( A–D ) and averaged mEPSC slopes ( E–H ) recorded from neurons in the control situation ( A , E ), after activity silencing ( B , F ), and upon <t>MG132</t> treatment of control ( C , G ) and silenced ( D , H ) cultures. I , K , Cumulative distribution of averaged mEPSC amplitudes ( I ) and interevent intervals ( K ) were plotted for all treatments. J , L , Quantification of 200 mEPSC amplitudes ( J ) and interevent intervals ( L ) for all treatments. Mean values are shown; whiskers indicate SEM. Significance was tested with one-way ANOVA with Bonferroni post hoc test; ** p
    Picrotoxin, supplied by Millipore, used in various techniques. Bioz Stars score: 99/100, based on 194 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/picrotoxin/product/Millipore
    Average 99 stars, based on 194 article reviews
    Price from $9.99 to $1999.99
    picrotoxin - by Bioz Stars, 2020-09
    99/100 stars
      Buy from Supplier

    Image Search Results


    Effect of proteasomal inhibition on mEPSC amplitudes and frequencies in normal active and silenced cultures. A–H , Example traces ( A–D ) and averaged mEPSC slopes ( E–H ) recorded from neurons in the control situation ( A , E ), after activity silencing ( B , F ), and upon MG132 treatment of control ( C , G ) and silenced ( D , H ) cultures. I , K , Cumulative distribution of averaged mEPSC amplitudes ( I ) and interevent intervals ( K ) were plotted for all treatments. J , L , Quantification of 200 mEPSC amplitudes ( J ) and interevent intervals ( L ) for all treatments. Mean values are shown; whiskers indicate SEM. Significance was tested with one-way ANOVA with Bonferroni post hoc test; ** p

    Journal: The Journal of Neuroscience

    Article Title: Extensive Remodeling of the Presynaptic Cytomatrix upon Homeostatic Adaptation to Network Activity Silencing

    doi: 10.1523/JNEUROSCI.2088-11.2011

    Figure Lengend Snippet: Effect of proteasomal inhibition on mEPSC amplitudes and frequencies in normal active and silenced cultures. A–H , Example traces ( A–D ) and averaged mEPSC slopes ( E–H ) recorded from neurons in the control situation ( A , E ), after activity silencing ( B , F ), and upon MG132 treatment of control ( C , G ) and silenced ( D , H ) cultures. I , K , Cumulative distribution of averaged mEPSC amplitudes ( I ) and interevent intervals ( K ) were plotted for all treatments. J , L , Quantification of 200 mEPSC amplitudes ( J ) and interevent intervals ( L ) for all treatments. Mean values are shown; whiskers indicate SEM. Significance was tested with one-way ANOVA with Bonferroni post hoc test; ** p

    Article Snippet: Pharmaceutics were used in the following concentrations (in μ m ): 50 d -(−)-2-amino-5-phosphonopentanoic acid ( d -AP5) (Tocris Bioscience) and 10 6-cyano-7-nitroquinoxaline-2,3-dione disodium (CNQX) (Tocris Bioscience), 50 picrotoxin (PTX) (Tocris Bioscience), 2 tetrodotoxin (TTX) (Tocris Bioscience), and 10 MG132 (Calbiochem).

    Techniques: Inhibition, Activity Assay

    Effect of proteasome inhibition on expression of synaptic scaffolds in normal active and silenced cultures. A , Timing of treatments for all experimental groups. Neurons were harvested at DIV 23, activity blockers were added for the last 48 h, and proteasome inhibitor MG132 was added 6 h before harvesting. B , Representative immunoblots of analyzed proteins for all treatments. C , Quantification of expression levels for all treatments. The numerical OD values were normalized to mean values of control. D , MG132-induced changes in expression levels normalized to levels under the same activity condition with non-manipulated proteasome activity. In both plots the bars represent means of six to nine analyzed sets of values (numbers indicated in C ) obtained in one of three experiments performed, all yielding comparable results. Whiskers indicate SEM. The statistical significance was assessed using a t test comparing MG132-treated and nontreated samples for each activity level in C and using one-way ANOVA with Bonferroni post hoc test in D . * p

    Journal: The Journal of Neuroscience

    Article Title: Extensive Remodeling of the Presynaptic Cytomatrix upon Homeostatic Adaptation to Network Activity Silencing

    doi: 10.1523/JNEUROSCI.2088-11.2011

    Figure Lengend Snippet: Effect of proteasome inhibition on expression of synaptic scaffolds in normal active and silenced cultures. A , Timing of treatments for all experimental groups. Neurons were harvested at DIV 23, activity blockers were added for the last 48 h, and proteasome inhibitor MG132 was added 6 h before harvesting. B , Representative immunoblots of analyzed proteins for all treatments. C , Quantification of expression levels for all treatments. The numerical OD values were normalized to mean values of control. D , MG132-induced changes in expression levels normalized to levels under the same activity condition with non-manipulated proteasome activity. In both plots the bars represent means of six to nine analyzed sets of values (numbers indicated in C ) obtained in one of three experiments performed, all yielding comparable results. Whiskers indicate SEM. The statistical significance was assessed using a t test comparing MG132-treated and nontreated samples for each activity level in C and using one-way ANOVA with Bonferroni post hoc test in D . * p

    Article Snippet: Pharmaceutics were used in the following concentrations (in μ m ): 50 d -(−)-2-amino-5-phosphonopentanoic acid ( d -AP5) (Tocris Bioscience) and 10 6-cyano-7-nitroquinoxaline-2,3-dione disodium (CNQX) (Tocris Bioscience), 50 picrotoxin (PTX) (Tocris Bioscience), 2 tetrodotoxin (TTX) (Tocris Bioscience), and 10 MG132 (Calbiochem).

    Techniques: Inhibition, Expressing, Activity Assay, Western Blot