Journal: Bioactive Materials

Article Title: Screening of a quinonoid compounds library identifies decylubiquinone as an antioxidant and anti-apoptotic agent against glucocorticoid-induced osteoporosis via CD39/CD73/adenosine axis

doi: 10.1016/j.bioactmat.2026.03.062

Figure Lengend Snippet: Establishment of DUB-loaded bone-targeted liposomal delivery system. ( A ) Representative images and quantitative analysis of mineralized nodule formation via Alizarin Red S (ARS) staining in primary BMSCs for the effect of DUB@Lip on osteogenesis differentiation under conditions of 10 μM Dex. ( B ) RT-qPCR for the expression of osteogenesis-related genes in primary BMSCs of different groups. ( C-D ) In vitro cellular uptake assay of IR-780-labeled DUB@Lip liposomes in primary BMSCs by confocal microscopy and flow cytometry. ( E-F ) Evaluation of bone-targeting capacity and pharmacokinetic analysis of DUB@Lip and DUB@TLip via ex vivo fluorescence imaging. ( G-H ) Representative reconstructed images and quantification for Tb.BV/TV, Tb.N, Tb.Th, Tb.Sp, and Ct.Th in femora in mice of different groups by Micro-CT. ( I ) H&E staining and quantification for trabecular bone area in distal femora in mice of different groups. ( J ) Masson staining and quantification for collagen deposition fraction (collagen area/trabecular bone area) in distal femora in mice of different groups. n = 4 independent repeats by using different biological samples in each group for in vitro experiments, or 8 mice per group for in vivo assays. Data were means ± s.e.m. ns p > 0.05, ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001 by one-way ANOVA. Scale bars: 200 μm (A-B), 2 mm (G left & right bottom), 1 mm (G right top), and 100 μm (I-J).

Article Snippet: To prepare non-targeted DUB-loaded liposomes, DSPE-PEG2000-ALN was substituted with an equimolar amount of DSPE-mPEG2000 (HY-142978, MedChemExpress, Shanghai, China) using the same preparation procedure.

Techniques: Staining, Quantitative RT-PCR, Expressing, In Vitro, Labeling, Liposomes, Confocal Microscopy, Flow Cytometry, Ex Vivo, Fluorescence, Imaging, Micro-CT, In Vivo

Journal: Materials Today Bio

Article Title: The mechanistic study of injectable hydrogel loaded with BMSC-exosomes in regulating the TGF-β/MMP axis to inhibit experimental myopia model

doi: 10.1016/j.mtbio.2026.103051

Figure Lengend Snippet: The mechanism of injectable exosome-loaded hydrogel for sclera remodeling to prevent development of myopia.

Article Snippet: Exosome-loaded AlgMA-MGs (Exos-AlgMA-MGs) enhanced fibroblast proliferation and migration, downregulated MMP-2, and upregulated collagen I synthesis via modulation of the TGF-β/MMP axis.

Techniques:

Journal: Materials Today Bio

Article Title: The mechanistic study of injectable hydrogel loaded with BMSC-exosomes in regulating the TGF-β/MMP axis to inhibit experimental myopia model

doi: 10.1016/j.mtbio.2026.103051

Figure Lengend Snippet: Characterization of injectability and biosafety of AlgMA-MGs. (A) Schematic of the injection process of AlgMA-MGs. (B) Microscopic photograph of AlgMA-MGs. Scale bar: 300 μm. (C) Temperature sweep of G′ and G″ for AlgMA and AlgMA-MGs from 20 °C to 50 °C. (D) Frequency dependence of G′ and G″ between 1 and 50 Hz. (E) Strain amplitude sweep from 0.1% to 100% strain. (F) Viscosity as a function of shear rate (0.1–1000 s −1 ). (G, H) Evolution of G′, G″, and viscosity during the oscillatory strain sweep (1%-10%-1%-50%-1%-100%-1%). (I) Subcutaneous implantation of AlgMA-MGs hydrogel within 4 weeks in vivo. (J) H&E-stained tissue section of the implantation site and normal tissue at week 4. Scale bars: 200 μm.

Article Snippet: Exosome-loaded AlgMA-MGs (Exos-AlgMA-MGs) enhanced fibroblast proliferation and migration, downregulated MMP-2, and upregulated collagen I synthesis via modulation of the TGF-β/MMP axis.

Techniques: Injection, Viscosity, Shear, In Vivo, Staining

Journal: Materials Today Bio

Article Title: The mechanistic study of injectable hydrogel loaded with BMSC-exosomes in regulating the TGF-β/MMP axis to inhibit experimental myopia model

doi: 10.1016/j.mtbio.2026.103051

Figure Lengend Snippet: Hydrogel implantation procedure and longitudinal ocular parameters of the different treatment groups. (A) Sub-Tenon's implantation of the injectable exosome-loaded hydrogel at the posterior pole. (B) Temporal changes in intraocular pressure across the different treatment groups. (C) Temporal changes in axial length across the different treatment groups. (D) Axial length at each time point for the different treatment groups. (E) Axial length of each treatment group at different time points. (n ≥ 3; ns: no significance, ∗: p < 0.05, ∗∗: p < 0.01, ∗∗∗: p < 0.001).

Article Snippet: Exosome-loaded AlgMA-MGs (Exos-AlgMA-MGs) enhanced fibroblast proliferation and migration, downregulated MMP-2, and upregulated collagen I synthesis via modulation of the TGF-β/MMP axis.

Techniques: