liquid chromatography tandem mass spectrometry assay  (MicroConstants)

 
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    Structured Review

    MicroConstants liquid chromatography tandem mass spectrometry assay
    Liquid Chromatography Tandem Mass Spectrometry Assay, supplied by MicroConstants, used in various techniques. Bioz Stars score: 88/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/liquid chromatography tandem mass spectrometry assay/product/MicroConstants
    Average 88 stars, based on 7 article reviews
    Price from $9.99 to $1999.99
    liquid chromatography tandem mass spectrometry assay - by Bioz Stars, 2020-07
    88/100 stars

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    Related Articles

    Reversed-phase Chromatography:

    Article Title: Pharmacokinetics and Safety of Intravenous Ceftolozane-Tazobactam in Healthy Adult Subjects following Single and Multiple Ascending Doses
    Article Snippet: .. A liquid chromatography-tandem mass spectrometry assay by Microconstants, Inc., analyzed ceftolozane, tazobactam, and its metabolite M1 (known to be pharmacologically and microbiologically inactive) using solid-phase extraction of plasma and urine, followed by separation with reversed-phase chromatography and detection by tandem mass spectrometry. ..

    Chromatography:

    Article Title: Pharmacokinetics and Safety of Intravenous Ceftolozane-Tazobactam in Healthy Adult Subjects following Single and Multiple Ascending Doses
    Article Snippet: .. A liquid chromatography-tandem mass spectrometry assay by Microconstants, Inc., analyzed ceftolozane, tazobactam, and its metabolite M1 (known to be pharmacologically and microbiologically inactive) using solid-phase extraction of plasma and urine, followed by separation with reversed-phase chromatography and detection by tandem mass spectrometry. ..

    Mass Spectrometry:

    Article Title: Pharmacokinetics and Safety of Intravenous Ceftolozane-Tazobactam in Healthy Adult Subjects following Single and Multiple Ascending Doses
    Article Snippet: .. A liquid chromatography-tandem mass spectrometry assay by Microconstants, Inc., analyzed ceftolozane, tazobactam, and its metabolite M1 (known to be pharmacologically and microbiologically inactive) using solid-phase extraction of plasma and urine, followed by separation with reversed-phase chromatography and detection by tandem mass spectrometry. ..

    Article Title: Population Pharmacokinetics of Ceftolozane/Tazobactam in Healthy Volunteers, Subjects With Varying Degrees of Renal Function and Patients With Bacterial Infections
    Article Snippet: .. Plasma concentrations of ceftolozane and tazobactam were determined by a validated liquid-chromatography-tandem mass spectrometry assay (MicroConstants, Inc., San Diego, CA) described previously. .. Concentrations below the limit of quantitation (BLQ), as defined previously, were considered as missing.

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    MicroConstants solithromycin
    Comparison of levels of middle ear fluid bacterial density in chinchillas treated with <t>solithromycin</t> and challenged with S. pneumoniae 331 (A), CP-645 (B), and CP-712 (C). In panels A and B, triangles represent animals treated with 150 mg of solithromycin/kg/day for 3 days and circles represent animals treated with either amoxicillin or ceftriaxone. In panel C, triangles represent animals treated with 90 mg of solithromycin/kg/day and circles represent animals treated with 150 mg of solithromycin/kg/day.
    Solithromycin, supplied by MicroConstants, used in various techniques. Bioz Stars score: 89/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/solithromycin/product/MicroConstants
    Average 89 stars, based on 3 article reviews
    Price from $9.99 to $1999.99
    solithromycin - by Bioz Stars, 2020-07
    89/100 stars
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    91
    MicroConstants mifepristone
    Mean (SD) plasma trough concentrations of <t>mifepristone</t> ( a ) and its metabolites: RU 42633 ( b ), RU 42698 ( c ), and RU 42848 ( d ) on days 10, 11, and 12 (left portion of graphs), followed by mean plasma concentration–time profiles in the presence (day 17) and absence (day 12) of ketoconazole (right portion of graphs)
    Mifepristone, supplied by MicroConstants, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    mifepristone - by Bioz Stars, 2020-07
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    MicroConstants ketoconazole
    Mean (SD) plasma trough concentrations of mifepristone ( a ) and its metabolites: RU 42633 ( b ), RU 42698 ( c ), and RU 42848 ( d ) on days 10, 11, and 12 (left portion of graphs), followed by mean plasma concentration–time profiles in the presence (day 17) and absence (day 12) of <t>ketoconazole</t> (right portion of graphs)
    Ketoconazole, supplied by MicroConstants, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 91 stars, based on 1 article reviews
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    Comparison of levels of middle ear fluid bacterial density in chinchillas treated with solithromycin and challenged with S. pneumoniae 331 (A), CP-645 (B), and CP-712 (C). In panels A and B, triangles represent animals treated with 150 mg of solithromycin/kg/day for 3 days and circles represent animals treated with either amoxicillin or ceftriaxone. In panel C, triangles represent animals treated with 90 mg of solithromycin/kg/day and circles represent animals treated with 150 mg of solithromycin/kg/day.

    Journal: Antimicrobial Agents and Chemotherapy

    Article Title: Efficacy of Solithromycin (CEM-101) for Experimental Otitis Media Caused by Nontypeable Haemophilus influenzae and Streptococcus pneumoniae

    doi: 10.1128/AAC.00863-16

    Figure Lengend Snippet: Comparison of levels of middle ear fluid bacterial density in chinchillas treated with solithromycin and challenged with S. pneumoniae 331 (A), CP-645 (B), and CP-712 (C). In panels A and B, triangles represent animals treated with 150 mg of solithromycin/kg/day for 3 days and circles represent animals treated with either amoxicillin or ceftriaxone. In panel C, triangles represent animals treated with 90 mg of solithromycin/kg/day and circles represent animals treated with 150 mg of solithromycin/kg/day.

    Article Snippet: Plasma, middle ear pellet, and extracellular fluid concentrations of solithromycin were measured at MicroConstants, Inc. (San Diego, CA), with a previously developed method using liquid chromatography coupled to tandem mass spectrometry (LC-MS-MS) (analytical method MN08060) for the analysis of solithromycin in animal and human plasma ( ).The method was applied directly to the matrices generated from this study without modification.

    Techniques:

    Time-kill assessment of solithromycin versus S. pneumoniae CP-645 ermB resistance was performed at 0.5× MIC, 1× MIC, and 2× MIC (A) and versus S. pneumoniae CP-712 mefA subclass mefA resistance was performed at 0.5× MIC, 1× MIC, 2× MIC, and 4× MIC (B).

    Journal: Antimicrobial Agents and Chemotherapy

    Article Title: Efficacy of Solithromycin (CEM-101) for Experimental Otitis Media Caused by Nontypeable Haemophilus influenzae and Streptococcus pneumoniae

    doi: 10.1128/AAC.00863-16

    Figure Lengend Snippet: Time-kill assessment of solithromycin versus S. pneumoniae CP-645 ermB resistance was performed at 0.5× MIC, 1× MIC, and 2× MIC (A) and versus S. pneumoniae CP-712 mefA subclass mefA resistance was performed at 0.5× MIC, 1× MIC, 2× MIC, and 4× MIC (B).

    Article Snippet: Plasma, middle ear pellet, and extracellular fluid concentrations of solithromycin were measured at MicroConstants, Inc. (San Diego, CA), with a previously developed method using liquid chromatography coupled to tandem mass spectrometry (LC-MS-MS) (analytical method MN08060) for the analysis of solithromycin in animal and human plasma ( ).The method was applied directly to the matrices generated from this study without modification.

    Techniques:

    Comparison of levels of middle ear fluid bacterial density in chinchillas treated with solithromycin challenged with NTHi BCH1 (A), BMC1247C (B), and BMC1213C (C). Triangles represent animals treated with 150 mg/kg/day of solithromycin for 3 days and circles represent untreated animals.

    Journal: Antimicrobial Agents and Chemotherapy

    Article Title: Efficacy of Solithromycin (CEM-101) for Experimental Otitis Media Caused by Nontypeable Haemophilus influenzae and Streptococcus pneumoniae

    doi: 10.1128/AAC.00863-16

    Figure Lengend Snippet: Comparison of levels of middle ear fluid bacterial density in chinchillas treated with solithromycin challenged with NTHi BCH1 (A), BMC1247C (B), and BMC1213C (C). Triangles represent animals treated with 150 mg/kg/day of solithromycin for 3 days and circles represent untreated animals.

    Article Snippet: Plasma, middle ear pellet, and extracellular fluid concentrations of solithromycin were measured at MicroConstants, Inc. (San Diego, CA), with a previously developed method using liquid chromatography coupled to tandem mass spectrometry (LC-MS-MS) (analytical method MN08060) for the analysis of solithromycin in animal and human plasma ( ).The method was applied directly to the matrices generated from this study without modification.

    Techniques:

    Plasma PK parameters ( C max and AUC 0–24 ) and MEF concentrations were determined on day 1 and day 3 after administration of 150 mg of solithromycin/kg of body weight once per day. Open circles and open triangles represent plasma and MEF concentrations, respectively, after the first dose of solithromycin, and filled circles and filled triangles represent plasma and MEF concentrations, respectively, after the third dose of solithromycin.

    Journal: Antimicrobial Agents and Chemotherapy

    Article Title: Efficacy of Solithromycin (CEM-101) for Experimental Otitis Media Caused by Nontypeable Haemophilus influenzae and Streptococcus pneumoniae

    doi: 10.1128/AAC.00863-16

    Figure Lengend Snippet: Plasma PK parameters ( C max and AUC 0–24 ) and MEF concentrations were determined on day 1 and day 3 after administration of 150 mg of solithromycin/kg of body weight once per day. Open circles and open triangles represent plasma and MEF concentrations, respectively, after the first dose of solithromycin, and filled circles and filled triangles represent plasma and MEF concentrations, respectively, after the third dose of solithromycin.

    Article Snippet: Plasma, middle ear pellet, and extracellular fluid concentrations of solithromycin were measured at MicroConstants, Inc. (San Diego, CA), with a previously developed method using liquid chromatography coupled to tandem mass spectrometry (LC-MS-MS) (analytical method MN08060) for the analysis of solithromycin in animal and human plasma ( ).The method was applied directly to the matrices generated from this study without modification.

    Techniques:

    Mean (SD) plasma trough concentrations of mifepristone ( a ) and its metabolites: RU 42633 ( b ), RU 42698 ( c ), and RU 42848 ( d ) on days 10, 11, and 12 (left portion of graphs), followed by mean plasma concentration–time profiles in the presence (day 17) and absence (day 12) of ketoconazole (right portion of graphs)

    Journal: Advances in Therapy

    Article Title: Effects of Ketoconazole on the Pharmacokinetics of Mifepristone, a Competitive Glucocorticoid Receptor Antagonist, in Healthy Men

    doi: 10.1007/s12325-017-0621-9

    Figure Lengend Snippet: Mean (SD) plasma trough concentrations of mifepristone ( a ) and its metabolites: RU 42633 ( b ), RU 42698 ( c ), and RU 42848 ( d ) on days 10, 11, and 12 (left portion of graphs), followed by mean plasma concentration–time profiles in the presence (day 17) and absence (day 12) of ketoconazole (right portion of graphs)

    Article Snippet: Bioanalytical Procedures Plasma concentrations of mifepristone, its metabolites, and ketoconazole were assessed by MicroConstants (San Diego, California) using validated high-performance liquid chromatography (HPLC) methods with mass spectrometric (MS) detection.

    Techniques: Concentration Assay

    Mifepristone and its three major metabolites

    Journal: Advances in Therapy

    Article Title: Effects of Ketoconazole on the Pharmacokinetics of Mifepristone, a Competitive Glucocorticoid Receptor Antagonist, in Healthy Men

    doi: 10.1007/s12325-017-0621-9

    Figure Lengend Snippet: Mifepristone and its three major metabolites

    Article Snippet: Bioanalytical Procedures Plasma concentrations of mifepristone, its metabolites, and ketoconazole were assessed by MicroConstants (San Diego, California) using validated high-performance liquid chromatography (HPLC) methods with mass spectrometric (MS) detection.

    Techniques:

    Mean (SD) plasma trough concentrations of mifepristone ( a ) and its metabolites: RU 42633 ( b ), RU 42698 ( c ), and RU 42848 ( d ) on days 10, 11, and 12 (left portion of graphs), followed by mean plasma concentration–time profiles in the presence (day 17) and absence (day 12) of ketoconazole (right portion of graphs)

    Journal: Advances in Therapy

    Article Title: Effects of Ketoconazole on the Pharmacokinetics of Mifepristone, a Competitive Glucocorticoid Receptor Antagonist, in Healthy Men

    doi: 10.1007/s12325-017-0621-9

    Figure Lengend Snippet: Mean (SD) plasma trough concentrations of mifepristone ( a ) and its metabolites: RU 42633 ( b ), RU 42698 ( c ), and RU 42848 ( d ) on days 10, 11, and 12 (left portion of graphs), followed by mean plasma concentration–time profiles in the presence (day 17) and absence (day 12) of ketoconazole (right portion of graphs)

    Article Snippet: Bioanalytical Procedures Plasma concentrations of mifepristone, its metabolites, and ketoconazole were assessed by MicroConstants (San Diego, California) using validated high-performance liquid chromatography (HPLC) methods with mass spectrometric (MS) detection.

    Techniques: Concentration Assay