liquid chromatography mass spectrometry lc ms analysis  (Agilent technologies)

 
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    Structured Review

    Agilent technologies liquid chromatography mass spectrometry lc ms analysis
    <t>Liquid</t> <t>chromatography</t> <t>mass-spectrometry-based</t> <t>analysis</t> of mycolic acid extracts. Abbreviation: MTB, Mycobacterium tuberculosis.
    Liquid Chromatography Mass Spectrometry Lc Ms Analysis, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 94/100, based on 27 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 94 stars, based on 27 article reviews
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    1) Product Images from "Identification of mycolic acid forms using surface-enhanced Raman scattering as a fast detection method for tuberculosis"

    Article Title: Identification of mycolic acid forms using surface-enhanced Raman scattering as a fast detection method for tuberculosis

    Journal: International Journal of Nanomedicine

    doi: 10.2147/IJN.S171400

    Liquid chromatography mass-spectrometry-based analysis of mycolic acid extracts. Abbreviation: MTB, Mycobacterium tuberculosis.
    Figure Legend Snippet: Liquid chromatography mass-spectrometry-based analysis of mycolic acid extracts. Abbreviation: MTB, Mycobacterium tuberculosis.

    Techniques Used: Liquid Chromatography, Mass Spectrometry

    2) Product Images from "Excess ω-6 fatty acids influx in aging drives metabolic dysregulation, electrocardiographic alterations, and low-grade chronic inflammation"

    Article Title: Excess ω-6 fatty acids influx in aging drives metabolic dysregulation, electrocardiographic alterations, and low-grade chronic inflammation

    Journal: American Journal of Physiology - Heart and Circulatory Physiology

    doi: 10.1152/ajpheart.00297.2017

    ω-6 supplementation increases proinflammatory lipid mediators with no structural changes in the left ventricle (LV). A : schematic representation of targeted liquid chromatography-mass spectrometry analyses (LC/MS) analysis. B : quantitative analysis of 12( S )-HETE, 15( S )-HETE, leukotriene B 4 (LTB 4 ), PGE 2 , and thromboxane B 2 (TXB 2 ) in young and aging mice fed with standard laboratory chow (LC) or excess ω-6 diet. Red, young-LC group; black, young-safflower oil (SO) group; purple, aging-LC group; green, aging-SO group. C : multiple reaction monitoring (MRM) peaks of 12( S )-HETE in young and aging mice with and without ω-6 supplementation. D : structure of 12( S )-HETE. E : representative wheat germ agglutinin (WGA) membrane and Hoechst nuclear-stained images showing LV cardiomyocytes from young and aging mice fed with LC or ω-6-enriched diets. F : 5-lipoxygenase (5-LOX) methylation in aging by bisulphite PCR. Values are means ± SE; n = 5 mice/group. * P
    Figure Legend Snippet: ω-6 supplementation increases proinflammatory lipid mediators with no structural changes in the left ventricle (LV). A : schematic representation of targeted liquid chromatography-mass spectrometry analyses (LC/MS) analysis. B : quantitative analysis of 12( S )-HETE, 15( S )-HETE, leukotriene B 4 (LTB 4 ), PGE 2 , and thromboxane B 2 (TXB 2 ) in young and aging mice fed with standard laboratory chow (LC) or excess ω-6 diet. Red, young-LC group; black, young-safflower oil (SO) group; purple, aging-LC group; green, aging-SO group. C : multiple reaction monitoring (MRM) peaks of 12( S )-HETE in young and aging mice with and without ω-6 supplementation. D : structure of 12( S )-HETE. E : representative wheat germ agglutinin (WGA) membrane and Hoechst nuclear-stained images showing LV cardiomyocytes from young and aging mice fed with LC or ω-6-enriched diets. F : 5-lipoxygenase (5-LOX) methylation in aging by bisulphite PCR. Values are means ± SE; n = 5 mice/group. * P

    Techniques Used: Liquid Chromatography, Mass Spectrometry, Liquid Chromatography with Mass Spectroscopy, Mouse Assay, Whole Genome Amplification, Staining, Methylation, Polymerase Chain Reaction

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    Liquid Chromatography with Mass Spectroscopy:

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    Spectroscopy:

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    Liquid Chromatography:

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    Agilent technologies lc uv ms ms based reverse phase chiral analysis
    <t>LC-UV-MS-MS</t> <t>based</t> <t>chiral</t> <t>analysis</t> shows incubation of porcine 12-LOX with DHA generated product with > 98% S-configuration. The incubation was reduced with NaBH 4 before analysis. The assignment was confirmed by co-eluting (retention time), online UV and diagnostic ions of ms/ms spectrum with authentic synthetic standards. The spectrum of 14-HDHA is shown on the right.
    Lc Uv Ms Ms Based Reverse Phase Chiral Analysis, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Agilent technologies mass spectrometry nano lc chip q tof
    Mean relative quantities of various classes of released N -glycans from bovine colostrum whey proteins determined by <t>nano-LC</t> Chip <t>Q-ToF</t> MS/MS by free and immobilized Endo BI-1. Error bars represent one standard deviation. * Represents significant differences within the same class of N -glycans at p
    Mass Spectrometry Nano Lc Chip Q Tof, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Agilent technologies lc esi ms ms analysis ethanolic extract
    <t>LC-ESI-MS/MS</t> analysis of <t>ethanolic</t> extract of T. paniculata. a) Ellagic acid, b) 2’,4’,5,7, Tetramethoxy−8-methylflavanone, c) 3,3’di-O-Methyl Ellagic acid, d) Arjunolic acid, e) Galloylarjunolic acid, f) Termilignan, g) Betulinic acid.
    Lc Esi Ms Ms Analysis Ethanolic Extract, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 88/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Agilent technologies lc ms ms analysis eurycomanone detection
    Pharmacokinetic profile of ( a ) standardized water extract (SWE) of E. longifolia and ( b ) <t>eurycomanone</t> compound, respectively, in rats. (IV = intravenous route, PO = oral route).
    Lc Ms Ms Analysis Eurycomanone Detection, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/lc ms ms analysis eurycomanone detection/product/Agilent technologies
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    Image Search Results


    LC-UV-MS-MS based chiral analysis shows incubation of porcine 12-LOX with DHA generated product with > 98% S-configuration. The incubation was reduced with NaBH 4 before analysis. The assignment was confirmed by co-eluting (retention time), online UV and diagnostic ions of ms/ms spectrum with authentic synthetic standards. The spectrum of 14-HDHA is shown on the right.

    Journal: Current Protocols in Immunology

    Article Title: Metabolomics-Lipidomics of Eicosanoids and Docosanoids Generated By Phagocytes

    doi: 10.1002/0471142735.im1426s95

    Figure Lengend Snippet: LC-UV-MS-MS based chiral analysis shows incubation of porcine 12-LOX with DHA generated product with > 98% S-configuration. The incubation was reduced with NaBH 4 before analysis. The assignment was confirmed by co-eluting (retention time), online UV and diagnostic ions of ms/ms spectrum with authentic synthetic standards. The spectrum of 14-HDHA is shown on the right.

    Article Snippet: LC-UV-MS-MS based reverse phase chiral analysis is carried out using ABI 3200 Qtrap mass spectrometer coupled with an Agilent 1100 series HPLC with a ChiralPak AD-RH reverse phase chiral column (Chiral Technology, West Chester, PA) (15).

    Techniques: Mass Spectrometry, Incubation, Generated, Diagnostic Assay

    LC-UV-MS-MS based chiral analysis of racemic 4-HDHA, 7-HDHA, and 14-HDHA mixture. Chiralities are determined by marching retention time with optical pure compounds. Total Ion Chromatogram (TIC) of racemic 4-HDHA, 7-HDHA, and 14-HDHA mixture is shown in brown color. Chromatogram of precursor/product ion pair m/z 343 > 101 for racemic 4-HDHA is shown in blue, m/z 343 > 141 for 7-HDHA in orange, and m/z 343 > 205 for 14-HDHA in green.

    Journal: Current Protocols in Immunology

    Article Title: Metabolomics-Lipidomics of Eicosanoids and Docosanoids Generated By Phagocytes

    doi: 10.1002/0471142735.im1426s95

    Figure Lengend Snippet: LC-UV-MS-MS based chiral analysis of racemic 4-HDHA, 7-HDHA, and 14-HDHA mixture. Chiralities are determined by marching retention time with optical pure compounds. Total Ion Chromatogram (TIC) of racemic 4-HDHA, 7-HDHA, and 14-HDHA mixture is shown in brown color. Chromatogram of precursor/product ion pair m/z 343 > 101 for racemic 4-HDHA is shown in blue, m/z 343 > 141 for 7-HDHA in orange, and m/z 343 > 205 for 14-HDHA in green.

    Article Snippet: LC-UV-MS-MS based reverse phase chiral analysis is carried out using ABI 3200 Qtrap mass spectrometer coupled with an Agilent 1100 series HPLC with a ChiralPak AD-RH reverse phase chiral column (Chiral Technology, West Chester, PA) (15).

    Techniques: Mass Spectrometry

    Mean relative quantities of various classes of released N -glycans from bovine colostrum whey proteins determined by nano-LC Chip Q-ToF MS/MS by free and immobilized Endo BI-1. Error bars represent one standard deviation. * Represents significant differences within the same class of N -glycans at p

    Journal: Catalysts (Basel, Switzerland)

    Article Title: Immobilization of an Endo-β-N-acetylglucosaminidase for the Release of Bioactive N-glycans

    doi: 10.3390/catal8070278

    Figure Lengend Snippet: Mean relative quantities of various classes of released N -glycans from bovine colostrum whey proteins determined by nano-LC Chip Q-ToF MS/MS by free and immobilized Endo BI-1. Error bars represent one standard deviation. * Represents significant differences within the same class of N -glycans at p

    Article Snippet: N-glycan Analysis by Mass Spectrometry Nano-LC-Chip Q ToF Samples were transferred to polypropylene vials and 6 μL were injected into an Agilent 6520 nano-LC-Chip quadrupole time-of-flight mass spectrometer (Q-ToF MS, Agilent Technologies, Santa Clara, CA, USA).

    Techniques: Chromatin Immunoprecipitation, Mass Spectrometry, Standard Deviation

    LC-ESI-MS/MS analysis of ethanolic extract of T. paniculata. a) Ellagic acid, b) 2’,4’,5,7, Tetramethoxy−8-methylflavanone, c) 3,3’di-O-Methyl Ellagic acid, d) Arjunolic acid, e) Galloylarjunolic acid, f) Termilignan, g) Betulinic acid.

    Journal: BMC Complementary and Alternative Medicine

    Article Title: Evaluation of anti-obesity activities of ethanolic extract of Terminalia paniculata bark on high fat diet-induced obese rats

    doi: 10.1186/s12906-015-0598-3

    Figure Lengend Snippet: LC-ESI-MS/MS analysis of ethanolic extract of T. paniculata. a) Ellagic acid, b) 2’,4’,5,7, Tetramethoxy−8-methylflavanone, c) 3,3’di-O-Methyl Ellagic acid, d) Arjunolic acid, e) Galloylarjunolic acid, f) Termilignan, g) Betulinic acid.

    Article Snippet: LC-ESI-MS/MS analysis ethanolic extract of TPEE LC-ESI-MS/MS analysis of ethanolic extract of T. paniculata was carried out on 6520 Accurate Q-TOF (Agilent Santa Clara, CA) mass spectrometer coupled to HPLC equipped with a UV–vis detector.

    Techniques: Mass Spectrometry

    Pharmacokinetic profile of ( a ) standardized water extract (SWE) of E. longifolia and ( b ) eurycomanone compound, respectively, in rats. (IV = intravenous route, PO = oral route).

    Journal: Pharmaceutics

    Article Title: Bioavailability of Eurycomanone in Its Pure Form and in a Standardised Eurycoma longifolia Water Extract

    doi: 10.3390/pharmaceutics10030090

    Figure Lengend Snippet: Pharmacokinetic profile of ( a ) standardized water extract (SWE) of E. longifolia and ( b ) eurycomanone compound, respectively, in rats. (IV = intravenous route, PO = oral route).

    Article Snippet: LC-MS/MS Analysis Eurycomanone detection in the pure eurycomanone experiments was done via the LC-MS/MS system consisting of an Agilent 1260 Infinity HPLC system and an AB SCIEX API 4000™ Triple-Quadrupole mass spectrometer equipped with TurboIonSpray® probe and atmospheric pressure chemical ionization (APCI) (AB Sciex LLC, Framingham, MA, USA).

    Techniques:

    Aqueous solubility of eurycomanone, propranolol, estriol, and tamoxifen at pH 7.4 and pH 5.4. The values were plotted based on the mean ± standard deviation. **** denotes significant difference when compared to eurycomanone ( p ≤ 0.0001) at the two pH values. * denotes significance difference between propranolol and eurycomanone at pH 5.4 ( p ≤ 0.05). Line over bars indicates no significant difference when compared to eurycomanone ( p ≥ 0.05).

    Journal: Pharmaceutics

    Article Title: Bioavailability of Eurycomanone in Its Pure Form and in a Standardised Eurycoma longifolia Water Extract

    doi: 10.3390/pharmaceutics10030090

    Figure Lengend Snippet: Aqueous solubility of eurycomanone, propranolol, estriol, and tamoxifen at pH 7.4 and pH 5.4. The values were plotted based on the mean ± standard deviation. **** denotes significant difference when compared to eurycomanone ( p ≤ 0.0001) at the two pH values. * denotes significance difference between propranolol and eurycomanone at pH 5.4 ( p ≤ 0.05). Line over bars indicates no significant difference when compared to eurycomanone ( p ≥ 0.05).

    Article Snippet: LC-MS/MS Analysis Eurycomanone detection in the pure eurycomanone experiments was done via the LC-MS/MS system consisting of an Agilent 1260 Infinity HPLC system and an AB SCIEX API 4000™ Triple-Quadrupole mass spectrometer equipped with TurboIonSpray® probe and atmospheric pressure chemical ionization (APCI) (AB Sciex LLC, Framingham, MA, USA).

    Techniques: Solubility, Standard Deviation

    Eurycomanone showed high stability at pH 2, pH 5, and pH 6.5 and is comparable to the stability of propranolol. The values were plotted based on the mean ± standard deviation. There were no significant differences between propranolol and eurycomanone at all the pH levels tested. Line over bars indicates no significant difference when compared to eurycomanone ( p ≥ 0.05).

    Journal: Pharmaceutics

    Article Title: Bioavailability of Eurycomanone in Its Pure Form and in a Standardised Eurycoma longifolia Water Extract

    doi: 10.3390/pharmaceutics10030090

    Figure Lengend Snippet: Eurycomanone showed high stability at pH 2, pH 5, and pH 6.5 and is comparable to the stability of propranolol. The values were plotted based on the mean ± standard deviation. There were no significant differences between propranolol and eurycomanone at all the pH levels tested. Line over bars indicates no significant difference when compared to eurycomanone ( p ≥ 0.05).

    Article Snippet: LC-MS/MS Analysis Eurycomanone detection in the pure eurycomanone experiments was done via the LC-MS/MS system consisting of an Agilent 1260 Infinity HPLC system and an AB SCIEX API 4000™ Triple-Quadrupole mass spectrometer equipped with TurboIonSpray® probe and atmospheric pressure chemical ionization (APCI) (AB Sciex LLC, Framingham, MA, USA).

    Techniques: Standard Deviation

    Eurycomanone plasma protein binding in rat, monkey, mice, human, and dog plasma. The values were plotted based on the mean ± standard deviation. ** and * denote significant difference when compared to across species ( p ≤ 0.01) and ( p ≤ 0.05) respectively. No significant difference was found between the rest of the species tested ( p ≥ 0.05) (not indicated on graph).

    Journal: Pharmaceutics

    Article Title: Bioavailability of Eurycomanone in Its Pure Form and in a Standardised Eurycoma longifolia Water Extract

    doi: 10.3390/pharmaceutics10030090

    Figure Lengend Snippet: Eurycomanone plasma protein binding in rat, monkey, mice, human, and dog plasma. The values were plotted based on the mean ± standard deviation. ** and * denote significant difference when compared to across species ( p ≤ 0.01) and ( p ≤ 0.05) respectively. No significant difference was found between the rest of the species tested ( p ≥ 0.05) (not indicated on graph).

    Article Snippet: LC-MS/MS Analysis Eurycomanone detection in the pure eurycomanone experiments was done via the LC-MS/MS system consisting of an Agilent 1260 Infinity HPLC system and an AB SCIEX API 4000™ Triple-Quadrupole mass spectrometer equipped with TurboIonSpray® probe and atmospheric pressure chemical ionization (APCI) (AB Sciex LLC, Framingham, MA, USA).

    Techniques: Protein Binding, Mouse Assay, Standard Deviation

    Eurycomanone showed low permeability as compared to propranolol and carbamazepine when assayed using the parallel artificial membrane permeability assay (PAMPA). The values were plotted based on the mean ± standard deviation. **** denotes significant difference when compared to eurycomanone ( p ≤ 0.0001). Line over bars indicates no significant difference between atenolol and eurycomanone ( p ≥ 0.05).

    Journal: Pharmaceutics

    Article Title: Bioavailability of Eurycomanone in Its Pure Form and in a Standardised Eurycoma longifolia Water Extract

    doi: 10.3390/pharmaceutics10030090

    Figure Lengend Snippet: Eurycomanone showed low permeability as compared to propranolol and carbamazepine when assayed using the parallel artificial membrane permeability assay (PAMPA). The values were plotted based on the mean ± standard deviation. **** denotes significant difference when compared to eurycomanone ( p ≤ 0.0001). Line over bars indicates no significant difference between atenolol and eurycomanone ( p ≥ 0.05).

    Article Snippet: LC-MS/MS Analysis Eurycomanone detection in the pure eurycomanone experiments was done via the LC-MS/MS system consisting of an Agilent 1260 Infinity HPLC system and an AB SCIEX API 4000™ Triple-Quadrupole mass spectrometer equipped with TurboIonSpray® probe and atmospheric pressure chemical ionization (APCI) (AB Sciex LLC, Framingham, MA, USA).

    Techniques: Permeability, PAMPA Assay, Standard Deviation

    Eurycomanone’s stability in rat, monkey, mice, human, and dog plasma as compared to propantheline bromide and enalapril. The values were plotted based on the mean ± standard deviation. **** denotes significant difference when compared to eurycomanone ( p ≤ 0.0001) in the five species tested. *** denotes significance difference ( p ≤ 0.001) in eurycomanone’s stability between species monkey and human. Line over bars indicates no significant difference when compared to eurycomanone in species monkey and dog for enalapril ( p ≥ 0.05).

    Journal: Pharmaceutics

    Article Title: Bioavailability of Eurycomanone in Its Pure Form and in a Standardised Eurycoma longifolia Water Extract

    doi: 10.3390/pharmaceutics10030090

    Figure Lengend Snippet: Eurycomanone’s stability in rat, monkey, mice, human, and dog plasma as compared to propantheline bromide and enalapril. The values were plotted based on the mean ± standard deviation. **** denotes significant difference when compared to eurycomanone ( p ≤ 0.0001) in the five species tested. *** denotes significance difference ( p ≤ 0.001) in eurycomanone’s stability between species monkey and human. Line over bars indicates no significant difference when compared to eurycomanone in species monkey and dog for enalapril ( p ≥ 0.05).

    Article Snippet: LC-MS/MS Analysis Eurycomanone detection in the pure eurycomanone experiments was done via the LC-MS/MS system consisting of an Agilent 1260 Infinity HPLC system and an AB SCIEX API 4000™ Triple-Quadrupole mass spectrometer equipped with TurboIonSpray® probe and atmospheric pressure chemical ionization (APCI) (AB Sciex LLC, Framingham, MA, USA).

    Techniques: Mouse Assay, Standard Deviation

    Lipophilicity properties of eurycomanone, propranolol, estriol, metoprolol, and diesthylstilbestrol. The distribution coefficient (log D) value for eurycomanone was −0.35. All standards showed acceptable log D values, respectively. The values were plotted based on the mean ± standard deviation. **** denotes significant difference when compared to eurycomanone ( p ≤ 0.0001). The log D value of eurycomanone is comparable to that of metoprolol. Line over bars indicates no significant difference between metoprolol and eurycomanone ( p ≥ 0.05).

    Journal: Pharmaceutics

    Article Title: Bioavailability of Eurycomanone in Its Pure Form and in a Standardised Eurycoma longifolia Water Extract

    doi: 10.3390/pharmaceutics10030090

    Figure Lengend Snippet: Lipophilicity properties of eurycomanone, propranolol, estriol, metoprolol, and diesthylstilbestrol. The distribution coefficient (log D) value for eurycomanone was −0.35. All standards showed acceptable log D values, respectively. The values were plotted based on the mean ± standard deviation. **** denotes significant difference when compared to eurycomanone ( p ≤ 0.0001). The log D value of eurycomanone is comparable to that of metoprolol. Line over bars indicates no significant difference between metoprolol and eurycomanone ( p ≥ 0.05).

    Article Snippet: LC-MS/MS Analysis Eurycomanone detection in the pure eurycomanone experiments was done via the LC-MS/MS system consisting of an Agilent 1260 Infinity HPLC system and an AB SCIEX API 4000™ Triple-Quadrupole mass spectrometer equipped with TurboIonSpray® probe and atmospheric pressure chemical ionization (APCI) (AB Sciex LLC, Framingham, MA, USA).

    Techniques: Standard Deviation

    Pharmacokinetic profile of eurycomanone when administered as its pure compound in mice. (IV = intravenous route, PO = oral route)

    Journal: Pharmaceutics

    Article Title: Bioavailability of Eurycomanone in Its Pure Form and in a Standardised Eurycoma longifolia Water Extract

    doi: 10.3390/pharmaceutics10030090

    Figure Lengend Snippet: Pharmacokinetic profile of eurycomanone when administered as its pure compound in mice. (IV = intravenous route, PO = oral route)

    Article Snippet: LC-MS/MS Analysis Eurycomanone detection in the pure eurycomanone experiments was done via the LC-MS/MS system consisting of an Agilent 1260 Infinity HPLC system and an AB SCIEX API 4000™ Triple-Quadrupole mass spectrometer equipped with TurboIonSpray® probe and atmospheric pressure chemical ionization (APCI) (AB Sciex LLC, Framingham, MA, USA).

    Techniques: Mouse Assay