lipid analogs  (Echelon Biosciences)


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    Echelon Biosciences lipid analogs
    Lipid Analogs, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    lipid analogs  (Echelon Biosciences)


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    Echelon Biosciences lipid analogs
    Lipid Analogs, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 91 stars, based on 1 article reviews
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    lipid analogs  (Echelon Biosciences)


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    Echelon Biosciences lipid analogs
    Lipid Analogs, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 91 stars, based on 1 article reviews
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    lysophosphatic acid  (Echelon Biosciences)


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    Echelon Biosciences lysophosphatic acid
    Lysophosphatic Acid, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/lysophosphatic acid/product/Echelon Biosciences
    Average 91 stars, based on 1 article reviews
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    lysophosphatic acid - by Bioz Stars, 2023-02
    91/100 stars

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    lysophosphatic acid beads  (Echelon Biosciences)


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    Echelon Biosciences lysophosphatic acid beads
    ( a ) Pull-down of Hb by <t>lysophosphatic</t> acid, sphingosine and S1P beads from normal human RBC lysates. ( b ) Membrane heme concentrations in isolated Sphk1 −/− mouse erythrocyte pretreated with DMSO, 2 and 6 μmol l −1 S1P in normoxia and hypoxia (4% O 2 ) for 6 h. ( c ) Schematic drawing illustrates functional experiments to monitor translocalization of GAPDH from membrane isolated from human erythrocytes. Hb binding to membrane ( d ) and GAPDH release from membrane to the cytosol ( e ) in human erythrocyte membrane ghost treated with Hb and different concentrations of S1P under normoxia and hypoxia. Hb binding to membrane ( f ) and GAPDH release from membrane to the cytosol ( g ) in human erythrocyte membrane ghost treated with Hb-CO and different concentrations of S1P under normoxia and hypoxia. ( h ) Working model: hypoxia-mediated elevation of erythrocyte Sphk1 activity increases the level of S1P, which binds to deoxy-Hb and facilitates binding of deoxy-Hb to membrane and release of GAPDH; increased cytosolic GAPDH accelerates glycolysis and shifts glucose metabolism in favour of 2,3-BPG production, which in turn leads to more O 2 release to counteract tissue hypoxia. Mean±s.e.m; n =6 per group, * P <0.05 versus normoxia, ** P <0.05 versus 2 μmol l −1 or 100 nmol l −1 , Student's t -test and one-way ANOVA.
    Lysophosphatic Acid Beads, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/lysophosphatic acid beads/product/Echelon Biosciences
    Average 91 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    lysophosphatic acid beads - by Bioz Stars, 2023-02
    91/100 stars

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    1) Product Images from "Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia"

    Article Title: Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia

    Journal: Nature Communications

    doi: 10.1038/ncomms12086

    ( a ) Pull-down of Hb by lysophosphatic acid, sphingosine and S1P beads from normal human RBC lysates. ( b ) Membrane heme concentrations in isolated Sphk1 −/− mouse erythrocyte pretreated with DMSO, 2 and 6 μmol l −1 S1P in normoxia and hypoxia (4% O 2 ) for 6 h. ( c ) Schematic drawing illustrates functional experiments to monitor translocalization of GAPDH from membrane isolated from human erythrocytes. Hb binding to membrane ( d ) and GAPDH release from membrane to the cytosol ( e ) in human erythrocyte membrane ghost treated with Hb and different concentrations of S1P under normoxia and hypoxia. Hb binding to membrane ( f ) and GAPDH release from membrane to the cytosol ( g ) in human erythrocyte membrane ghost treated with Hb-CO and different concentrations of S1P under normoxia and hypoxia. ( h ) Working model: hypoxia-mediated elevation of erythrocyte Sphk1 activity increases the level of S1P, which binds to deoxy-Hb and facilitates binding of deoxy-Hb to membrane and release of GAPDH; increased cytosolic GAPDH accelerates glycolysis and shifts glucose metabolism in favour of 2,3-BPG production, which in turn leads to more O 2 release to counteract tissue hypoxia. Mean±s.e.m; n =6 per group, * P <0.05 versus normoxia, ** P <0.05 versus 2 μmol l −1 or 100 nmol l −1 , Student's t -test and one-way ANOVA.
    Figure Legend Snippet: ( a ) Pull-down of Hb by lysophosphatic acid, sphingosine and S1P beads from normal human RBC lysates. ( b ) Membrane heme concentrations in isolated Sphk1 −/− mouse erythrocyte pretreated with DMSO, 2 and 6 μmol l −1 S1P in normoxia and hypoxia (4% O 2 ) for 6 h. ( c ) Schematic drawing illustrates functional experiments to monitor translocalization of GAPDH from membrane isolated from human erythrocytes. Hb binding to membrane ( d ) and GAPDH release from membrane to the cytosol ( e ) in human erythrocyte membrane ghost treated with Hb and different concentrations of S1P under normoxia and hypoxia. Hb binding to membrane ( f ) and GAPDH release from membrane to the cytosol ( g ) in human erythrocyte membrane ghost treated with Hb-CO and different concentrations of S1P under normoxia and hypoxia. ( h ) Working model: hypoxia-mediated elevation of erythrocyte Sphk1 activity increases the level of S1P, which binds to deoxy-Hb and facilitates binding of deoxy-Hb to membrane and release of GAPDH; increased cytosolic GAPDH accelerates glycolysis and shifts glucose metabolism in favour of 2,3-BPG production, which in turn leads to more O 2 release to counteract tissue hypoxia. Mean±s.e.m; n =6 per group, * P <0.05 versus normoxia, ** P <0.05 versus 2 μmol l −1 or 100 nmol l −1 , Student's t -test and one-way ANOVA.

    Techniques Used: Isolation, Functional Assay, Binding Assay, Activity Assay

    agarose beads l 6101  (Echelon Biosciences)


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    Echelon Biosciences agarose beads l 6101
    Agarose Beads L 6101, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    lpa beads  (Echelon Biosciences)


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    Echelon Biosciences lpa beads
    Lpa Beads, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    lpa beads  (Echelon Biosciences)


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    Echelon Biosciences lpa beads
    Lpa Beads, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    lpa beads  (Echelon Biosciences)


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    Echelon Biosciences lpa beads
    Lpa Beads, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Echelon Biosciences lipid analogs
    Lipid Analogs, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Echelon Biosciences lysophosphatic acid beads
    ( a ) Pull-down of Hb by <t>lysophosphatic</t> acid, sphingosine and S1P beads from normal human RBC lysates. ( b ) Membrane heme concentrations in isolated Sphk1 −/− mouse erythrocyte pretreated with DMSO, 2 and 6 μmol l −1 S1P in normoxia and hypoxia (4% O 2 ) for 6 h. ( c ) Schematic drawing illustrates functional experiments to monitor translocalization of GAPDH from membrane isolated from human erythrocytes. Hb binding to membrane ( d ) and GAPDH release from membrane to the cytosol ( e ) in human erythrocyte membrane ghost treated with Hb and different concentrations of S1P under normoxia and hypoxia. Hb binding to membrane ( f ) and GAPDH release from membrane to the cytosol ( g ) in human erythrocyte membrane ghost treated with Hb-CO and different concentrations of S1P under normoxia and hypoxia. ( h ) Working model: hypoxia-mediated elevation of erythrocyte Sphk1 activity increases the level of S1P, which binds to deoxy-Hb and facilitates binding of deoxy-Hb to membrane and release of GAPDH; increased cytosolic GAPDH accelerates glycolysis and shifts glucose metabolism in favour of 2,3-BPG production, which in turn leads to more O 2 release to counteract tissue hypoxia. Mean±s.e.m; n =6 per group, * P <0.05 versus normoxia, ** P <0.05 versus 2 μmol l −1 or 100 nmol l −1 , Student's t -test and one-way ANOVA.
    Lysophosphatic Acid Beads, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/lysophosphatic acid beads/product/Echelon Biosciences
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    Echelon Biosciences agarose beads l 6101
    ( a ) Pull-down of Hb by <t>lysophosphatic</t> acid, sphingosine and S1P beads from normal human RBC lysates. ( b ) Membrane heme concentrations in isolated Sphk1 −/− mouse erythrocyte pretreated with DMSO, 2 and 6 μmol l −1 S1P in normoxia and hypoxia (4% O 2 ) for 6 h. ( c ) Schematic drawing illustrates functional experiments to monitor translocalization of GAPDH from membrane isolated from human erythrocytes. Hb binding to membrane ( d ) and GAPDH release from membrane to the cytosol ( e ) in human erythrocyte membrane ghost treated with Hb and different concentrations of S1P under normoxia and hypoxia. Hb binding to membrane ( f ) and GAPDH release from membrane to the cytosol ( g ) in human erythrocyte membrane ghost treated with Hb-CO and different concentrations of S1P under normoxia and hypoxia. ( h ) Working model: hypoxia-mediated elevation of erythrocyte Sphk1 activity increases the level of S1P, which binds to deoxy-Hb and facilitates binding of deoxy-Hb to membrane and release of GAPDH; increased cytosolic GAPDH accelerates glycolysis and shifts glucose metabolism in favour of 2,3-BPG production, which in turn leads to more O 2 release to counteract tissue hypoxia. Mean±s.e.m; n =6 per group, * P <0.05 versus normoxia, ** P <0.05 versus 2 μmol l −1 or 100 nmol l −1 , Student's t -test and one-way ANOVA.
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    https://www.bioz.com/result/agarose beads l 6101/product/Echelon Biosciences
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    Echelon Biosciences lpa beads
    ( a ) Pull-down of Hb by <t>lysophosphatic</t> acid, sphingosine and S1P beads from normal human RBC lysates. ( b ) Membrane heme concentrations in isolated Sphk1 −/− mouse erythrocyte pretreated with DMSO, 2 and 6 μmol l −1 S1P in normoxia and hypoxia (4% O 2 ) for 6 h. ( c ) Schematic drawing illustrates functional experiments to monitor translocalization of GAPDH from membrane isolated from human erythrocytes. Hb binding to membrane ( d ) and GAPDH release from membrane to the cytosol ( e ) in human erythrocyte membrane ghost treated with Hb and different concentrations of S1P under normoxia and hypoxia. Hb binding to membrane ( f ) and GAPDH release from membrane to the cytosol ( g ) in human erythrocyte membrane ghost treated with Hb-CO and different concentrations of S1P under normoxia and hypoxia. ( h ) Working model: hypoxia-mediated elevation of erythrocyte Sphk1 activity increases the level of S1P, which binds to deoxy-Hb and facilitates binding of deoxy-Hb to membrane and release of GAPDH; increased cytosolic GAPDH accelerates glycolysis and shifts glucose metabolism in favour of 2,3-BPG production, which in turn leads to more O 2 release to counteract tissue hypoxia. Mean±s.e.m; n =6 per group, * P <0.05 versus normoxia, ** P <0.05 versus 2 μmol l −1 or 100 nmol l −1 , Student's t -test and one-way ANOVA.
    Lpa Beads, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    ( a ) Pull-down of Hb by lysophosphatic acid, sphingosine and S1P beads from normal human RBC lysates. ( b ) Membrane heme concentrations in isolated Sphk1 −/− mouse erythrocyte pretreated with DMSO, 2 and 6 μmol l −1 S1P in normoxia and hypoxia (4% O 2 ) for 6 h. ( c ) Schematic drawing illustrates functional experiments to monitor translocalization of GAPDH from membrane isolated from human erythrocytes. Hb binding to membrane ( d ) and GAPDH release from membrane to the cytosol ( e ) in human erythrocyte membrane ghost treated with Hb and different concentrations of S1P under normoxia and hypoxia. Hb binding to membrane ( f ) and GAPDH release from membrane to the cytosol ( g ) in human erythrocyte membrane ghost treated with Hb-CO and different concentrations of S1P under normoxia and hypoxia. ( h ) Working model: hypoxia-mediated elevation of erythrocyte Sphk1 activity increases the level of S1P, which binds to deoxy-Hb and facilitates binding of deoxy-Hb to membrane and release of GAPDH; increased cytosolic GAPDH accelerates glycolysis and shifts glucose metabolism in favour of 2,3-BPG production, which in turn leads to more O 2 release to counteract tissue hypoxia. Mean±s.e.m; n =6 per group, * P <0.05 versus normoxia, ** P <0.05 versus 2 μmol l −1 or 100 nmol l −1 , Student's t -test and one-way ANOVA.

    Journal: Nature Communications

    Article Title: Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia

    doi: 10.1038/ncomms12086

    Figure Lengend Snippet: ( a ) Pull-down of Hb by lysophosphatic acid, sphingosine and S1P beads from normal human RBC lysates. ( b ) Membrane heme concentrations in isolated Sphk1 −/− mouse erythrocyte pretreated with DMSO, 2 and 6 μmol l −1 S1P in normoxia and hypoxia (4% O 2 ) for 6 h. ( c ) Schematic drawing illustrates functional experiments to monitor translocalization of GAPDH from membrane isolated from human erythrocytes. Hb binding to membrane ( d ) and GAPDH release from membrane to the cytosol ( e ) in human erythrocyte membrane ghost treated with Hb and different concentrations of S1P under normoxia and hypoxia. Hb binding to membrane ( f ) and GAPDH release from membrane to the cytosol ( g ) in human erythrocyte membrane ghost treated with Hb-CO and different concentrations of S1P under normoxia and hypoxia. ( h ) Working model: hypoxia-mediated elevation of erythrocyte Sphk1 activity increases the level of S1P, which binds to deoxy-Hb and facilitates binding of deoxy-Hb to membrane and release of GAPDH; increased cytosolic GAPDH accelerates glycolysis and shifts glucose metabolism in favour of 2,3-BPG production, which in turn leads to more O 2 release to counteract tissue hypoxia. Mean±s.e.m; n =6 per group, * P <0.05 versus normoxia, ** P <0.05 versus 2 μmol l −1 or 100 nmol l −1 , Student's t -test and one-way ANOVA.

    Article Snippet: Approximately 100 μl of various lipids conjugated to agarose beads including S1P-agarose beads, lysophosphatic acid beads or sphingosine beads (Echelon Biosciences Inc., Salt Lake City, UT) were washed twice with lysis buffer.

    Techniques: Isolation, Functional Assay, Binding Assay, Activity Assay