kt5720  (Alomone Labs)


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    Alomone Labs kt5720
    PKA activity is required after memory retrieval at 6 but not 24 h after training for later memory expression. Six hours ( A ) or 24 h ( B ) after a single CS/US pairing (0 h), animals received a CS stimulation or no stimulation (no CS), followed 10 min later by an injection with either a PKA inhibitor <t>(KT5720)</t> or vehicle. In each group, baseline levels are defined by the mean feeding response level to the CS (line) ± SEM (gray band) of a group of animals handled in parallel ( n = 17). A , ANOVAs followed by pairwise post hoc tests reveal that the two groups ( n = 24 and 21) first tested at 6 h after training and 10 min before injection show significantly (*) elevated feeding responses to the CS compared with baseline level. At the second test, 24 h after training, one-way ANOVAs detected a source of significant difference. Of the four CS/US paired groups, only the group that received the CS at 6 h after training followed by KT5720 injection shows a feeding response to the CS that does not differ from baseline. A two-way ANOVA comparing the feeding responses to the CS of the four CS/US paired groups at 24 h detected a significant interaction of memory retrieval at 6 h and subsequent PKA inhibition. B , The two groups ( n = 17 and 20) first tested at 24 h after training and 10 min before injection show significantly (*) elevated feeding responses to the CS compared with the baseline level. At 42 h after training, one-way ANOVAs and multiple post hoc ).
    Kt5720, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 90/100, based on 11 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/kt5720/product/Alomone Labs
    Average 90 stars, based on 11 article reviews
    Price from $9.99 to $1999.99
    kt5720 - by Bioz Stars, 2022-08
    90/100 stars

    Images

    1) Product Images from "Phase-Dependent Molecular Requirements for Memory Reconsolidation: Differential Roles for Protein Synthesis and Protein Kinase A Activity"

    Article Title: Phase-Dependent Molecular Requirements for Memory Reconsolidation: Differential Roles for Protein Synthesis and Protein Kinase A Activity

    Journal: The Journal of Neuroscience

    doi: 10.1523/JNEUROSCI.0890-06.2006

    PKA activity is required after memory retrieval at 6 but not 24 h after training for later memory expression. Six hours ( A ) or 24 h ( B ) after a single CS/US pairing (0 h), animals received a CS stimulation or no stimulation (no CS), followed 10 min later by an injection with either a PKA inhibitor (KT5720) or vehicle. In each group, baseline levels are defined by the mean feeding response level to the CS (line) ± SEM (gray band) of a group of animals handled in parallel ( n = 17). A , ANOVAs followed by pairwise post hoc tests reveal that the two groups ( n = 24 and 21) first tested at 6 h after training and 10 min before injection show significantly (*) elevated feeding responses to the CS compared with baseline level. At the second test, 24 h after training, one-way ANOVAs detected a source of significant difference. Of the four CS/US paired groups, only the group that received the CS at 6 h after training followed by KT5720 injection shows a feeding response to the CS that does not differ from baseline. A two-way ANOVA comparing the feeding responses to the CS of the four CS/US paired groups at 24 h detected a significant interaction of memory retrieval at 6 h and subsequent PKA inhibition. B , The two groups ( n = 17 and 20) first tested at 24 h after training and 10 min before injection show significantly (*) elevated feeding responses to the CS compared with the baseline level. At 42 h after training, one-way ANOVAs and multiple post hoc ).
    Figure Legend Snippet: PKA activity is required after memory retrieval at 6 but not 24 h after training for later memory expression. Six hours ( A ) or 24 h ( B ) after a single CS/US pairing (0 h), animals received a CS stimulation or no stimulation (no CS), followed 10 min later by an injection with either a PKA inhibitor (KT5720) or vehicle. In each group, baseline levels are defined by the mean feeding response level to the CS (line) ± SEM (gray band) of a group of animals handled in parallel ( n = 17). A , ANOVAs followed by pairwise post hoc tests reveal that the two groups ( n = 24 and 21) first tested at 6 h after training and 10 min before injection show significantly (*) elevated feeding responses to the CS compared with baseline level. At the second test, 24 h after training, one-way ANOVAs detected a source of significant difference. Of the four CS/US paired groups, only the group that received the CS at 6 h after training followed by KT5720 injection shows a feeding response to the CS that does not differ from baseline. A two-way ANOVA comparing the feeding responses to the CS of the four CS/US paired groups at 24 h detected a significant interaction of memory retrieval at 6 h and subsequent PKA inhibition. B , The two groups ( n = 17 and 20) first tested at 24 h after training and 10 min before injection show significantly (*) elevated feeding responses to the CS compared with the baseline level. At 42 h after training, one-way ANOVAs and multiple post hoc ).

    Techniques Used: Activity Assay, Expressing, Injection, Inhibition

    2) Product Images from "Different phases of long-term memory require distinct temporal patterns of PKA activity after single-trial classical conditioning"

    Article Title: Different phases of long-term memory require distinct temporal patterns of PKA activity after single-trial classical conditioning

    Journal: Learning & Memory

    doi: 10.1101/lm.1088408

    A conserved functional PKA catalytic subunit (PKA C) is present in the Lymnaea CNS. ( A ) cAMP stimulates PKA C activity in Lymnaea nervous system extracts ( Ai ) and purified PKA fractions ( Aii ), which can be blocked by KT5720 or PKAI. The whole CNS data (mean ±SEM) come from experiments with single brains ( n = 19). *, P
    Figure Legend Snippet: A conserved functional PKA catalytic subunit (PKA C) is present in the Lymnaea CNS. ( A ) cAMP stimulates PKA C activity in Lymnaea nervous system extracts ( Ai ) and purified PKA fractions ( Aii ), which can be blocked by KT5720 or PKAI. The whole CNS data (mean ±SEM) come from experiments with single brains ( n = 19). *, P

    Techniques Used: Functional Assay, Activity Assay, Purification

    3) Product Images from "Different phases of long-term memory require distinct temporal patterns of PKA activity after single-trial classical conditioning"

    Article Title: Different phases of long-term memory require distinct temporal patterns of PKA activity after single-trial classical conditioning

    Journal: Learning & Memory

    doi: 10.1101/lm.1088408

    A conserved functional PKA catalytic subunit (PKA C) is present in the Lymnaea CNS. ( A ) cAMP stimulates PKA C activity in Lymnaea nervous system extracts ( Ai ) and purified PKA fractions ( Aii ), which can be blocked by KT5720 or PKAI. The whole CNS data (mean ±SEM) come from experiments with single brains ( n = 19). *, P
    Figure Legend Snippet: A conserved functional PKA catalytic subunit (PKA C) is present in the Lymnaea CNS. ( A ) cAMP stimulates PKA C activity in Lymnaea nervous system extracts ( Ai ) and purified PKA fractions ( Aii ), which can be blocked by KT5720 or PKAI. The whole CNS data (mean ±SEM) come from experiments with single brains ( n = 19). *, P

    Techniques Used: Functional Assay, Activity Assay, Purification

    4) Product Images from "Different phases of long-term memory require distinct temporal patterns of PKA activity after single-trial classical conditioning"

    Article Title: Different phases of long-term memory require distinct temporal patterns of PKA activity after single-trial classical conditioning

    Journal: Learning & Memory

    doi: 10.1101/lm.1088408

    A conserved functional PKA catalytic subunit (PKA C) is present in the Lymnaea CNS. ( A ) cAMP stimulates PKA C activity in Lymnaea nervous system extracts ( Ai ) and purified PKA fractions ( Aii ), which can be blocked by KT5720 or PKAI. The whole CNS data (mean ±SEM) come from experiments with single brains ( n = 19). *, P
    Figure Legend Snippet: A conserved functional PKA catalytic subunit (PKA C) is present in the Lymnaea CNS. ( A ) cAMP stimulates PKA C activity in Lymnaea nervous system extracts ( Ai ) and purified PKA fractions ( Aii ), which can be blocked by KT5720 or PKAI. The whole CNS data (mean ±SEM) come from experiments with single brains ( n = 19). *, P

    Techniques Used: Functional Assay, Activity Assay, Purification

    5) Product Images from "Different phases of long-term memory require distinct temporal patterns of PKA activity after single-trial classical conditioning"

    Article Title: Different phases of long-term memory require distinct temporal patterns of PKA activity after single-trial classical conditioning

    Journal: Learning & Memory

    doi: 10.1101/lm.1088408

    A conserved functional PKA catalytic subunit (PKA C) is present in the Lymnaea CNS. ( A ) cAMP stimulates PKA C activity in Lymnaea nervous system extracts ( Ai ) and purified PKA fractions ( Aii ), which can be blocked by KT5720 or PKAI. The whole CNS data (mean ±SEM) come from experiments with single brains ( n = 19). *, P
    Figure Legend Snippet: A conserved functional PKA catalytic subunit (PKA C) is present in the Lymnaea CNS. ( A ) cAMP stimulates PKA C activity in Lymnaea nervous system extracts ( Ai ) and purified PKA fractions ( Aii ), which can be blocked by KT5720 or PKAI. The whole CNS data (mean ±SEM) come from experiments with single brains ( n = 19). *, P

    Techniques Used: Functional Assay, Activity Assay, Purification

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    Alomone Labs kt5720
    PKA activity is required after memory retrieval at 6 but not 24 h after training for later memory expression. Six hours ( A ) or 24 h ( B ) after a single CS/US pairing (0 h), animals received a CS stimulation or no stimulation (no CS), followed 10 min later by an injection with either a PKA inhibitor <t>(KT5720)</t> or vehicle. In each group, baseline levels are defined by the mean feeding response level to the CS (line) ± SEM (gray band) of a group of animals handled in parallel ( n = 17). A , ANOVAs followed by pairwise post hoc tests reveal that the two groups ( n = 24 and 21) first tested at 6 h after training and 10 min before injection show significantly (*) elevated feeding responses to the CS compared with baseline level. At the second test, 24 h after training, one-way ANOVAs detected a source of significant difference. Of the four CS/US paired groups, only the group that received the CS at 6 h after training followed by KT5720 injection shows a feeding response to the CS that does not differ from baseline. A two-way ANOVA comparing the feeding responses to the CS of the four CS/US paired groups at 24 h detected a significant interaction of memory retrieval at 6 h and subsequent PKA inhibition. B , The two groups ( n = 17 and 20) first tested at 24 h after training and 10 min before injection show significantly (*) elevated feeding responses to the CS compared with the baseline level. At 42 h after training, one-way ANOVAs and multiple post hoc ).
    Kt5720, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/kt5720/product/Alomone Labs
    Average 90 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    kt5720 - by Bioz Stars, 2022-08
    90/100 stars
      Buy from Supplier

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    PKA activity is required after memory retrieval at 6 but not 24 h after training for later memory expression. Six hours ( A ) or 24 h ( B ) after a single CS/US pairing (0 h), animals received a CS stimulation or no stimulation (no CS), followed 10 min later by an injection with either a PKA inhibitor (KT5720) or vehicle. In each group, baseline levels are defined by the mean feeding response level to the CS (line) ± SEM (gray band) of a group of animals handled in parallel ( n = 17). A , ANOVAs followed by pairwise post hoc tests reveal that the two groups ( n = 24 and 21) first tested at 6 h after training and 10 min before injection show significantly (*) elevated feeding responses to the CS compared with baseline level. At the second test, 24 h after training, one-way ANOVAs detected a source of significant difference. Of the four CS/US paired groups, only the group that received the CS at 6 h after training followed by KT5720 injection shows a feeding response to the CS that does not differ from baseline. A two-way ANOVA comparing the feeding responses to the CS of the four CS/US paired groups at 24 h detected a significant interaction of memory retrieval at 6 h and subsequent PKA inhibition. B , The two groups ( n = 17 and 20) first tested at 24 h after training and 10 min before injection show significantly (*) elevated feeding responses to the CS compared with the baseline level. At 42 h after training, one-way ANOVAs and multiple post hoc ).

    Journal: The Journal of Neuroscience

    Article Title: Phase-Dependent Molecular Requirements for Memory Reconsolidation: Differential Roles for Protein Synthesis and Protein Kinase A Activity

    doi: 10.1523/JNEUROSCI.0890-06.2006

    Figure Lengend Snippet: PKA activity is required after memory retrieval at 6 but not 24 h after training for later memory expression. Six hours ( A ) or 24 h ( B ) after a single CS/US pairing (0 h), animals received a CS stimulation or no stimulation (no CS), followed 10 min later by an injection with either a PKA inhibitor (KT5720) or vehicle. In each group, baseline levels are defined by the mean feeding response level to the CS (line) ± SEM (gray band) of a group of animals handled in parallel ( n = 17). A , ANOVAs followed by pairwise post hoc tests reveal that the two groups ( n = 24 and 21) first tested at 6 h after training and 10 min before injection show significantly (*) elevated feeding responses to the CS compared with baseline level. At the second test, 24 h after training, one-way ANOVAs detected a source of significant difference. Of the four CS/US paired groups, only the group that received the CS at 6 h after training followed by KT5720 injection shows a feeding response to the CS that does not differ from baseline. A two-way ANOVA comparing the feeding responses to the CS of the four CS/US paired groups at 24 h detected a significant interaction of memory retrieval at 6 h and subsequent PKA inhibition. B , The two groups ( n = 17 and 20) first tested at 24 h after training and 10 min before injection show significantly (*) elevated feeding responses to the CS compared with the baseline level. At 42 h after training, one-way ANOVAs and multiple post hoc ).

    Article Snippet: The amnestic agent used was KT5720 (Alomone Labs, Jerusalem, Israel), a specific PKA inhibitor, at 10 μ m in 0.5% DMSO (final concentrations), whereas the vehicle was a mixture of saline and 0.5% DMSO.

    Techniques: Activity Assay, Expressing, Injection, Inhibition

    A conserved functional PKA catalytic subunit (PKA C) is present in the Lymnaea CNS. ( A ) cAMP stimulates PKA C activity in Lymnaea nervous system extracts ( Ai ) and purified PKA fractions ( Aii ), which can be blocked by KT5720 or PKAI. The whole CNS data (mean ±SEM) come from experiments with single brains ( n = 19). *, P

    Journal: Learning & Memory

    Article Title: Different phases of long-term memory require distinct temporal patterns of PKA activity after single-trial classical conditioning

    doi: 10.1101/lm.1088408

    Figure Lengend Snippet: A conserved functional PKA catalytic subunit (PKA C) is present in the Lymnaea CNS. ( A ) cAMP stimulates PKA C activity in Lymnaea nervous system extracts ( Ai ) and purified PKA fractions ( Aii ), which can be blocked by KT5720 or PKAI. The whole CNS data (mean ±SEM) come from experiments with single brains ( n = 19). *, P

    Article Snippet: Snails from one of the KT5720 and vehicle-injected groups each were tested at 6 h while the remaining KT5720 and vehicle-injected snails were tested at 24 h post-training for their feeding responses to the CS.

    Techniques: Functional Assay, Activity Assay, Purification