kir 4 1  (Alomone Labs)


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    Alomone Labs kir 4 1
    Detailed view ( A ) shows basement membrane ECM molecules like laminin, entactin/nidogen-1 and collagen. Laminin interacts within the dystroglycan-dystrophin-dystrobrevin complex to ensure anchoring and stabilization of the aquaporin 4 (AQP4) water channel as well as the inwardly rectifying potassium channel Kir 4.1 in the perivascular basal lamina [  ,  ]. Detailed view ( B ) illustrates the participation of non-basement membrane ECM molecules like brevican and tenascin-R in the tripartite synapse. The tripartite synapse consists of a presynaptic and postsynaptic membrane as well as a closely apposed astrocyte process . By connection to further ECM components (hyaluronan, aggrecan, neurocan, vesican) tenascin-R and brevican form perineuronal nets (PNN). Anchored via the cell-surface glycoprotein CD44, PNNs are presumed to play a role in synapse stability and plasticity .
    Kir 4 1, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/kir 4 1/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    kir 4 1 - by Bioz Stars, 2023-02
    94/100 stars

    Images

    1) Product Images from "Astrocyte depletion alters extracellular matrix composition in the demyelinating phase of Theiler’s murine encephalomyelitis"

    Article Title: Astrocyte depletion alters extracellular matrix composition in the demyelinating phase of Theiler’s murine encephalomyelitis

    Journal: PLoS ONE

    doi: 10.1371/journal.pone.0270239

    Detailed view ( A ) shows basement membrane ECM molecules like laminin, entactin/nidogen-1 and collagen. Laminin interacts within the dystroglycan-dystrophin-dystrobrevin complex to ensure anchoring and stabilization of the aquaporin 4 (AQP4) water channel as well as the inwardly rectifying potassium channel Kir 4.1 in the perivascular basal lamina [  ,  ]. Detailed view ( B ) illustrates the participation of non-basement membrane ECM molecules like brevican and tenascin-R in the tripartite synapse. The tripartite synapse consists of a presynaptic and postsynaptic membrane as well as a closely apposed astrocyte process . By connection to further ECM components (hyaluronan, aggrecan, neurocan, vesican) tenascin-R and brevican form perineuronal nets (PNN). Anchored via the cell-surface glycoprotein CD44, PNNs are presumed to play a role in synapse stability and plasticity .
    Figure Legend Snippet: Detailed view ( A ) shows basement membrane ECM molecules like laminin, entactin/nidogen-1 and collagen. Laminin interacts within the dystroglycan-dystrophin-dystrobrevin complex to ensure anchoring and stabilization of the aquaporin 4 (AQP4) water channel as well as the inwardly rectifying potassium channel Kir 4.1 in the perivascular basal lamina [ , ]. Detailed view ( B ) illustrates the participation of non-basement membrane ECM molecules like brevican and tenascin-R in the tripartite synapse. The tripartite synapse consists of a presynaptic and postsynaptic membrane as well as a closely apposed astrocyte process . By connection to further ECM components (hyaluronan, aggrecan, neurocan, vesican) tenascin-R and brevican form perineuronal nets (PNN). Anchored via the cell-surface glycoprotein CD44, PNNs are presumed to play a role in synapse stability and plasticity .

    Techniques Used:


    Figure Legend Snippet: Primary antibodies, pretreatment and dilutions used for immunohistochemistry.

    Techniques Used: Immunohistochemistry

    Immunohistochemistry targeting Kir 4.1 potassium channels revealed a significant reduction of Kir 4.1 positive area (asterisks, A ) in the thoracic spinal cord of TMEV infected, ganciclovir treated, GFAP-transgenic (GSTG) mice compared to control animals ( B, C ). Inserts visualize in more detail the intralesional reduction of Kir 4.1 in astrocyte depleted animals ( A ) compared to the WSTP control group ( B ). For each antibody, one cross section of the thoracic spinal cord was evaluated per animal. Data are shown as scatter dot plots. The horizontal bar indicates the mean. Significant differences between GSTG and the control groups obtained by Kruskal-Wallis test followed by Mann–Whitney U post hoc tests are indicated by *, p ≤ 0.05. Bars represent 100 μm in overviews and 50 μm in the insert.
    Figure Legend Snippet: Immunohistochemistry targeting Kir 4.1 potassium channels revealed a significant reduction of Kir 4.1 positive area (asterisks, A ) in the thoracic spinal cord of TMEV infected, ganciclovir treated, GFAP-transgenic (GSTG) mice compared to control animals ( B, C ). Inserts visualize in more detail the intralesional reduction of Kir 4.1 in astrocyte depleted animals ( A ) compared to the WSTP control group ( B ). For each antibody, one cross section of the thoracic spinal cord was evaluated per animal. Data are shown as scatter dot plots. The horizontal bar indicates the mean. Significant differences between GSTG and the control groups obtained by Kruskal-Wallis test followed by Mann–Whitney U post hoc tests are indicated by *, p ≤ 0.05. Bars represent 100 μm in overviews and 50 μm in the insert.

    Techniques Used: Immunohistochemistry, Infection, Transgenic Assay, MANN-WHITNEY

    kir 4 1  (Alomone Labs)


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    Alomone Labs kir 4 1
    Detailed view ( A ) shows basement membrane ECM molecules like laminin, entactin/nidogen-1 and collagen. Laminin interacts within the dystroglycan-dystrophin-dystrobrevin complex to ensure anchoring and stabilization of the aquaporin 4 (AQP4) water channel as well as the inwardly rectifying potassium channel Kir 4.1 in the perivascular basal lamina [  ,  ]. Detailed view ( B ) illustrates the participation of non-basement membrane ECM molecules like brevican and tenascin-R in the tripartite synapse. The tripartite synapse consists of a presynaptic and postsynaptic membrane as well as a closely apposed astrocyte process . By connection to further ECM components (hyaluronan, aggrecan, neurocan, vesican) tenascin-R and brevican form perineuronal nets (PNN). Anchored via the cell-surface glycoprotein CD44, PNNs are presumed to play a role in synapse stability and plasticity .
    Kir 4 1, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/kir 4 1/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    kir 4 1 - by Bioz Stars, 2023-02
    94/100 stars

    Images

    1) Product Images from "Astrocyte depletion alters extracellular matrix composition in the demyelinating phase of Theiler’s murine encephalomyelitis"

    Article Title: Astrocyte depletion alters extracellular matrix composition in the demyelinating phase of Theiler’s murine encephalomyelitis

    Journal: PLoS ONE

    doi: 10.1371/journal.pone.0270239

    Detailed view ( A ) shows basement membrane ECM molecules like laminin, entactin/nidogen-1 and collagen. Laminin interacts within the dystroglycan-dystrophin-dystrobrevin complex to ensure anchoring and stabilization of the aquaporin 4 (AQP4) water channel as well as the inwardly rectifying potassium channel Kir 4.1 in the perivascular basal lamina [  ,  ]. Detailed view ( B ) illustrates the participation of non-basement membrane ECM molecules like brevican and tenascin-R in the tripartite synapse. The tripartite synapse consists of a presynaptic and postsynaptic membrane as well as a closely apposed astrocyte process . By connection to further ECM components (hyaluronan, aggrecan, neurocan, vesican) tenascin-R and brevican form perineuronal nets (PNN). Anchored via the cell-surface glycoprotein CD44, PNNs are presumed to play a role in synapse stability and plasticity .
    Figure Legend Snippet: Detailed view ( A ) shows basement membrane ECM molecules like laminin, entactin/nidogen-1 and collagen. Laminin interacts within the dystroglycan-dystrophin-dystrobrevin complex to ensure anchoring and stabilization of the aquaporin 4 (AQP4) water channel as well as the inwardly rectifying potassium channel Kir 4.1 in the perivascular basal lamina [ , ]. Detailed view ( B ) illustrates the participation of non-basement membrane ECM molecules like brevican and tenascin-R in the tripartite synapse. The tripartite synapse consists of a presynaptic and postsynaptic membrane as well as a closely apposed astrocyte process . By connection to further ECM components (hyaluronan, aggrecan, neurocan, vesican) tenascin-R and brevican form perineuronal nets (PNN). Anchored via the cell-surface glycoprotein CD44, PNNs are presumed to play a role in synapse stability and plasticity .

    Techniques Used:


    Figure Legend Snippet: Primary antibodies, pretreatment and dilutions used for immunohistochemistry.

    Techniques Used: Immunohistochemistry

    Immunohistochemistry targeting Kir 4.1 potassium channels revealed a significant reduction of Kir 4.1 positive area (asterisks, A ) in the thoracic spinal cord of TMEV infected, ganciclovir treated, GFAP-transgenic (GSTG) mice compared to control animals ( B, C ). Inserts visualize in more detail the intralesional reduction of Kir 4.1 in astrocyte depleted animals ( A ) compared to the WSTP control group ( B ). For each antibody, one cross section of the thoracic spinal cord was evaluated per animal. Data are shown as scatter dot plots. The horizontal bar indicates the mean. Significant differences between GSTG and the control groups obtained by Kruskal-Wallis test followed by Mann–Whitney U post hoc tests are indicated by *, p ≤ 0.05. Bars represent 100 μm in overviews and 50 μm in the insert.
    Figure Legend Snippet: Immunohistochemistry targeting Kir 4.1 potassium channels revealed a significant reduction of Kir 4.1 positive area (asterisks, A ) in the thoracic spinal cord of TMEV infected, ganciclovir treated, GFAP-transgenic (GSTG) mice compared to control animals ( B, C ). Inserts visualize in more detail the intralesional reduction of Kir 4.1 in astrocyte depleted animals ( A ) compared to the WSTP control group ( B ). For each antibody, one cross section of the thoracic spinal cord was evaluated per animal. Data are shown as scatter dot plots. The horizontal bar indicates the mean. Significant differences between GSTG and the control groups obtained by Kruskal-Wallis test followed by Mann–Whitney U post hoc tests are indicated by *, p ≤ 0.05. Bars represent 100 μm in overviews and 50 μm in the insert.

    Techniques Used: Immunohistochemistry, Infection, Transgenic Assay, MANN-WHITNEY

    kir 4 1  (Alomone Labs)


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    Alomone Labs kir 4 1
    Primary antibodies used for immunofluorescence (IF) and immunohistochemistry (IHC)
    Kir 4 1, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/kir 4 1/product/Alomone Labs
    Average 96 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    kir 4 1 - by Bioz Stars, 2023-02
    96/100 stars

    Images

    1) Product Images from "Phenotypical changes of satellite glial cells in a murine model of G M1 ‐gangliosidosis"

    Article Title: Phenotypical changes of satellite glial cells in a murine model of G M1 ‐gangliosidosis

    Journal: Journal of Cellular and Molecular Medicine

    doi: 10.1111/jcmm.17113


    Figure Legend Snippet: Primary antibodies used for immunofluorescence (IF) and immunohistochemistry (IHC)

    Techniques Used: Immunofluorescence, Immunohistochemistry

    Representative images of immunofluorescence staining of murine dorsal root ganglia (DRG) with inwardly rectifying potassium channel Kir 4.1 (green) including statistical analysis. Nuclei are counterstained with bisbenzimide (blue). (A‐D) Pictures show a high percentage of satellite glial cells (SGCs) immunopositive for the SGC‐specific marker Kir 4.1, tightly surrounding neurons at all time points investigated (2–8 months). Scale bar: 50 μm. (E) Quantification of neurons surrounded with Kir4.1‐positive SGCs indicated no significant changes of Kir 4.1 expression in Glb1 −/− mice between 2 ( n = 5 DRG for Glb1 −/− , n = 10 DRG for WT) and 8 ( n = 15 DRG for Glb1 −/− , n = 15 DRG for WT) months of age. Graphs display box and whisker plots
    Figure Legend Snippet: Representative images of immunofluorescence staining of murine dorsal root ganglia (DRG) with inwardly rectifying potassium channel Kir 4.1 (green) including statistical analysis. Nuclei are counterstained with bisbenzimide (blue). (A‐D) Pictures show a high percentage of satellite glial cells (SGCs) immunopositive for the SGC‐specific marker Kir 4.1, tightly surrounding neurons at all time points investigated (2–8 months). Scale bar: 50 μm. (E) Quantification of neurons surrounded with Kir4.1‐positive SGCs indicated no significant changes of Kir 4.1 expression in Glb1 −/− mice between 2 ( n = 5 DRG for Glb1 −/− , n = 10 DRG for WT) and 8 ( n = 15 DRG for Glb1 −/− , n = 15 DRG for WT) months of age. Graphs display box and whisker plots

    Techniques Used: Immunofluorescence, Staining, Marker, Expressing, Whisker Assay

    kir 4 1  (Alomone Labs)


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    Alomone Labs kir 4 1

    Kir 4 1, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/kir 4 1/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    kir 4 1 - by Bioz Stars, 2023-02
    94/100 stars

    Images

    1) Product Images from "Megalencephalic leukoencephalopathy with subcortical cysts is a developmental disorder of the gliovascular unit"

    Article Title: Megalencephalic leukoencephalopathy with subcortical cysts is a developmental disorder of the gliovascular unit

    Journal: eLife

    doi: 10.7554/eLife.71379


    Figure Legend Snippet:

    Techniques Used: Sequencing, Western Blot, Immunofluorescence, Transduction

    kir 4 1  (Alomone Labs)


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    Alomone Labs kir 4 1

    Kir 4 1, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/kir 4 1/product/Alomone Labs
    Average 96 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    kir 4 1 - by Bioz Stars, 2023-02
    96/100 stars

    Images

    1) Product Images from "Megalencephalic leukoencephalopathy with subcortical cysts is a developmental disorder of the gliovascular unit"

    Article Title: Megalencephalic leukoencephalopathy with subcortical cysts is a developmental disorder of the gliovascular unit

    Journal: eLife

    doi: 10.7554/eLife.71379


    Figure Legend Snippet:

    Techniques Used: Sequencing, Western Blot, Immunofluorescence, Transduction

    kir 4 1  (Alomone Labs)


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    Alomone Labs kir 4 1
    Kir 4 1, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/kir 4 1/product/Alomone Labs
    Average 96 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    kir 4 1 - by Bioz Stars, 2023-02
    96/100 stars

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    rabbit anti kir 4 1  (Alomone Labs)


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    Alomone Labs rabbit anti kir 4 1
    Rabbit Anti Kir 4 1, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rabbit anti kir 4 1/product/Alomone Labs
    Average 96 stars, based on 1 article reviews
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    96/100 stars

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    kir 4 1  (Alomone Labs)


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    Alomone Labs kir 4 1
    Primary antibodies used for immunohistochemistry (IHC) and immunofluorescence (IF)
    Kir 4 1, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/kir 4 1/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    kir 4 1 - by Bioz Stars, 2023-02
    94/100 stars

    Images

    1) Product Images from "Phenotypical peculiarities and species‐specific differences of canine and murine satellite glial cells of spinal ganglia"

    Article Title: Phenotypical peculiarities and species‐specific differences of canine and murine satellite glial cells of spinal ganglia

    Journal: Journal of Cellular and Molecular Medicine

    doi: 10.1111/jcmm.16701


    Figure Legend Snippet: Primary antibodies used for immunohistochemistry (IHC) and immunofluorescence (IF)

    Techniques Used: Immunohistochemistry, Immunofluorescence


    Figure Legend Snippet: Quantitative analysis of murine and canine spinal ganglia (SG)

    Techniques Used: Staining

    3D‐reconstructed confocal laser images of formalin‐fixed paraffin‐embedded canine spinal ganglia (A‐D): Double labelling with glutamine synthetase (GS; green; A, B) or inwardly rectifying potassium channel Kir 4.1 (green; C, D), respectively, and the neuronal marker NeuN (magenta). Nuclei are counterstained with bisbenzimide (blue). The zoomed in pictures (B, D) show that GS‐, respectively, Kir4.1‐positive satellite glial cells (SGCs) tightly envelop NeuN‐positive neurons. For GS/NeuN staining (A‐B), 32 z‐stack frames (5.2 µm total size; approx. 0.16 µm steps) and for Kir4.1/NeuN staining (C‐D), 31 z‐stack frames (5.0 µm total size; approx. 0.16 µm steps) were collected. Scale bars: 20 µm. A movie of 3D confocal reconstructions is provided in Video  ,  and Video  ,
    Figure Legend Snippet: 3D‐reconstructed confocal laser images of formalin‐fixed paraffin‐embedded canine spinal ganglia (A‐D): Double labelling with glutamine synthetase (GS; green; A, B) or inwardly rectifying potassium channel Kir 4.1 (green; C, D), respectively, and the neuronal marker NeuN (magenta). Nuclei are counterstained with bisbenzimide (blue). The zoomed in pictures (B, D) show that GS‐, respectively, Kir4.1‐positive satellite glial cells (SGCs) tightly envelop NeuN‐positive neurons. For GS/NeuN staining (A‐B), 32 z‐stack frames (5.2 µm total size; approx. 0.16 µm steps) and for Kir4.1/NeuN staining (C‐D), 31 z‐stack frames (5.0 µm total size; approx. 0.16 µm steps) were collected. Scale bars: 20 µm. A movie of 3D confocal reconstructions is provided in Video , and Video ,

    Techniques Used: Formalin-fixed Paraffin-Embedded, Marker, Staining

    3D‐reconstructed confocal laser images of formalin‐fixed paraffin‐embedded murine spinal ganglia (A‐D): Double labelling with glutamine synthetase (GS; green; A, B) or inwardly rectifying potassium channel Kir 4.1 (green; C, D), respectively, and the neuronal marker NeuN (magenta). Nuclei are counterstained with Bisbenzimide (blue). GS‐ / Kir4.1‐positive satellite glial cells (SGCs) form a tight sheath around the neuronal bodies. The zoomed in images (B, D) clearly illustrate the close contact between SGCs and neurons. For GS/NeuN staining (A‐B), 39 z‐stack frames (6.4 µm total size; approx. 0.16 µm steps) and for Kir4.1/NeuN staining (C‐D), 39 z‐stack frames (4.7 µm total size; approx. 0.12 µm steps) were obtained. Scale bars: 20 µm (A, B, C); 10 µm (D). A movie of 3D confocal reconstructions is provided in Video  ,  and Video  ,
    Figure Legend Snippet: 3D‐reconstructed confocal laser images of formalin‐fixed paraffin‐embedded murine spinal ganglia (A‐D): Double labelling with glutamine synthetase (GS; green; A, B) or inwardly rectifying potassium channel Kir 4.1 (green; C, D), respectively, and the neuronal marker NeuN (magenta). Nuclei are counterstained with Bisbenzimide (blue). GS‐ / Kir4.1‐positive satellite glial cells (SGCs) form a tight sheath around the neuronal bodies. The zoomed in images (B, D) clearly illustrate the close contact between SGCs and neurons. For GS/NeuN staining (A‐B), 39 z‐stack frames (6.4 µm total size; approx. 0.16 µm steps) and for Kir4.1/NeuN staining (C‐D), 39 z‐stack frames (4.7 µm total size; approx. 0.12 µm steps) were obtained. Scale bars: 20 µm (A, B, C); 10 µm (D). A movie of 3D confocal reconstructions is provided in Video , and Video ,

    Techniques Used: Formalin-fixed Paraffin-Embedded, Marker, Staining

    kir 4 1  (Alomone Labs)


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    Alomone Labs kir 4 1
    Primary antibodies used for immunohistochemistry (IHC) and immunofluorescence (IF)
    Kir 4 1, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/kir 4 1/product/Alomone Labs
    Average 96 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    kir 4 1 - by Bioz Stars, 2023-02
    96/100 stars

    Images

    1) Product Images from "Phenotypical peculiarities and species‐specific differences of canine and murine satellite glial cells of spinal ganglia"

    Article Title: Phenotypical peculiarities and species‐specific differences of canine and murine satellite glial cells of spinal ganglia

    Journal: Journal of Cellular and Molecular Medicine

    doi: 10.1111/jcmm.16701


    Figure Legend Snippet: Primary antibodies used for immunohistochemistry (IHC) and immunofluorescence (IF)

    Techniques Used: Immunohistochemistry, Immunofluorescence


    Figure Legend Snippet: Quantitative analysis of murine and canine spinal ganglia (SG)

    Techniques Used: Staining

    3D‐reconstructed confocal laser images of formalin‐fixed paraffin‐embedded canine spinal ganglia (A‐D): Double labelling with glutamine synthetase (GS; green; A, B) or inwardly rectifying potassium channel Kir 4.1 (green; C, D), respectively, and the neuronal marker NeuN (magenta). Nuclei are counterstained with bisbenzimide (blue). The zoomed in pictures (B, D) show that GS‐, respectively, Kir4.1‐positive satellite glial cells (SGCs) tightly envelop NeuN‐positive neurons. For GS/NeuN staining (A‐B), 32 z‐stack frames (5.2 µm total size; approx. 0.16 µm steps) and for Kir4.1/NeuN staining (C‐D), 31 z‐stack frames (5.0 µm total size; approx. 0.16 µm steps) were collected. Scale bars: 20 µm. A movie of 3D confocal reconstructions is provided in Video  ,  and Video  ,
    Figure Legend Snippet: 3D‐reconstructed confocal laser images of formalin‐fixed paraffin‐embedded canine spinal ganglia (A‐D): Double labelling with glutamine synthetase (GS; green; A, B) or inwardly rectifying potassium channel Kir 4.1 (green; C, D), respectively, and the neuronal marker NeuN (magenta). Nuclei are counterstained with bisbenzimide (blue). The zoomed in pictures (B, D) show that GS‐, respectively, Kir4.1‐positive satellite glial cells (SGCs) tightly envelop NeuN‐positive neurons. For GS/NeuN staining (A‐B), 32 z‐stack frames (5.2 µm total size; approx. 0.16 µm steps) and for Kir4.1/NeuN staining (C‐D), 31 z‐stack frames (5.0 µm total size; approx. 0.16 µm steps) were collected. Scale bars: 20 µm. A movie of 3D confocal reconstructions is provided in Video , and Video ,

    Techniques Used: Formalin-fixed Paraffin-Embedded, Marker, Staining

    3D‐reconstructed confocal laser images of formalin‐fixed paraffin‐embedded murine spinal ganglia (A‐D): Double labelling with glutamine synthetase (GS; green; A, B) or inwardly rectifying potassium channel Kir 4.1 (green; C, D), respectively, and the neuronal marker NeuN (magenta). Nuclei are counterstained with Bisbenzimide (blue). GS‐ / Kir4.1‐positive satellite glial cells (SGCs) form a tight sheath around the neuronal bodies. The zoomed in images (B, D) clearly illustrate the close contact between SGCs and neurons. For GS/NeuN staining (A‐B), 39 z‐stack frames (6.4 µm total size; approx. 0.16 µm steps) and for Kir4.1/NeuN staining (C‐D), 39 z‐stack frames (4.7 µm total size; approx. 0.12 µm steps) were obtained. Scale bars: 20 µm (A, B, C); 10 µm (D). A movie of 3D confocal reconstructions is provided in Video  ,  and Video  ,
    Figure Legend Snippet: 3D‐reconstructed confocal laser images of formalin‐fixed paraffin‐embedded murine spinal ganglia (A‐D): Double labelling with glutamine synthetase (GS; green; A, B) or inwardly rectifying potassium channel Kir 4.1 (green; C, D), respectively, and the neuronal marker NeuN (magenta). Nuclei are counterstained with Bisbenzimide (blue). GS‐ / Kir4.1‐positive satellite glial cells (SGCs) form a tight sheath around the neuronal bodies. The zoomed in images (B, D) clearly illustrate the close contact between SGCs and neurons. For GS/NeuN staining (A‐B), 39 z‐stack frames (6.4 µm total size; approx. 0.16 µm steps) and for Kir4.1/NeuN staining (C‐D), 39 z‐stack frames (4.7 µm total size; approx. 0.12 µm steps) were obtained. Scale bars: 20 µm (A, B, C); 10 µm (D). A movie of 3D confocal reconstructions is provided in Video , and Video ,

    Techniques Used: Formalin-fixed Paraffin-Embedded, Marker, Staining

    kir 4 1 ag  (Alomone Labs)


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    Alomone Labs kir 4 1 ag
    Kir 4 1 Ag, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 93 stars, based on 1 article reviews
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    93/100 stars

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    kir 4 1  (Alomone Labs)


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    Structured Review

    Alomone Labs kir 4 1
    Primary antibodies used for immunohistochemistry (IHC) and immunofluorescence (IF)
    Kir 4 1, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/kir 4 1/product/Alomone Labs
    Average 96 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    kir 4 1 - by Bioz Stars, 2023-02
    96/100 stars

    Images

    1) Product Images from "Phenotypical peculiarities and species‐specific differences of canine and murine satellite glial cells of spinal ganglia"

    Article Title: Phenotypical peculiarities and species‐specific differences of canine and murine satellite glial cells of spinal ganglia

    Journal: Journal of Cellular and Molecular Medicine

    doi: 10.1111/jcmm.16701


    Figure Legend Snippet: Primary antibodies used for immunohistochemistry (IHC) and immunofluorescence (IF)

    Techniques Used: Immunohistochemistry, Immunofluorescence


    Figure Legend Snippet: Quantitative analysis of murine and canine spinal ganglia (SG)

    Techniques Used: Staining

    3D‐reconstructed confocal laser images of formalin‐fixed paraffin‐embedded canine spinal ganglia (A‐D): Double labelling with glutamine synthetase (GS; green; A, B) or inwardly rectifying potassium channel Kir 4.1 (green; C, D), respectively, and the neuronal marker NeuN (magenta). Nuclei are counterstained with bisbenzimide (blue). The zoomed in pictures (B, D) show that GS‐, respectively, Kir4.1‐positive satellite glial cells (SGCs) tightly envelop NeuN‐positive neurons. For GS/NeuN staining (A‐B), 32 z‐stack frames (5.2 µm total size; approx. 0.16 µm steps) and for Kir4.1/NeuN staining (C‐D), 31 z‐stack frames (5.0 µm total size; approx. 0.16 µm steps) were collected. Scale bars: 20 µm. A movie of 3D confocal reconstructions is provided in Video  ,  and Video  ,
    Figure Legend Snippet: 3D‐reconstructed confocal laser images of formalin‐fixed paraffin‐embedded canine spinal ganglia (A‐D): Double labelling with glutamine synthetase (GS; green; A, B) or inwardly rectifying potassium channel Kir 4.1 (green; C, D), respectively, and the neuronal marker NeuN (magenta). Nuclei are counterstained with bisbenzimide (blue). The zoomed in pictures (B, D) show that GS‐, respectively, Kir4.1‐positive satellite glial cells (SGCs) tightly envelop NeuN‐positive neurons. For GS/NeuN staining (A‐B), 32 z‐stack frames (5.2 µm total size; approx. 0.16 µm steps) and for Kir4.1/NeuN staining (C‐D), 31 z‐stack frames (5.0 µm total size; approx. 0.16 µm steps) were collected. Scale bars: 20 µm. A movie of 3D confocal reconstructions is provided in Video , and Video ,

    Techniques Used: Formalin-fixed Paraffin-Embedded, Marker, Staining

    3D‐reconstructed confocal laser images of formalin‐fixed paraffin‐embedded murine spinal ganglia (A‐D): Double labelling with glutamine synthetase (GS; green; A, B) or inwardly rectifying potassium channel Kir 4.1 (green; C, D), respectively, and the neuronal marker NeuN (magenta). Nuclei are counterstained with Bisbenzimide (blue). GS‐ / Kir4.1‐positive satellite glial cells (SGCs) form a tight sheath around the neuronal bodies. The zoomed in images (B, D) clearly illustrate the close contact between SGCs and neurons. For GS/NeuN staining (A‐B), 39 z‐stack frames (6.4 µm total size; approx. 0.16 µm steps) and for Kir4.1/NeuN staining (C‐D), 39 z‐stack frames (4.7 µm total size; approx. 0.12 µm steps) were obtained. Scale bars: 20 µm (A, B, C); 10 µm (D). A movie of 3D confocal reconstructions is provided in Video  ,  and Video  ,
    Figure Legend Snippet: 3D‐reconstructed confocal laser images of formalin‐fixed paraffin‐embedded murine spinal ganglia (A‐D): Double labelling with glutamine synthetase (GS; green; A, B) or inwardly rectifying potassium channel Kir 4.1 (green; C, D), respectively, and the neuronal marker NeuN (magenta). Nuclei are counterstained with Bisbenzimide (blue). GS‐ / Kir4.1‐positive satellite glial cells (SGCs) form a tight sheath around the neuronal bodies. The zoomed in images (B, D) clearly illustrate the close contact between SGCs and neurons. For GS/NeuN staining (A‐B), 39 z‐stack frames (6.4 µm total size; approx. 0.16 µm steps) and for Kir4.1/NeuN staining (C‐D), 39 z‐stack frames (4.7 µm total size; approx. 0.12 µm steps) were obtained. Scale bars: 20 µm (A, B, C); 10 µm (D). A movie of 3D confocal reconstructions is provided in Video , and Video ,

    Techniques Used: Formalin-fixed Paraffin-Embedded, Marker, Staining

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    Alomone Labs kir 4 1
    Detailed view ( A ) shows basement membrane ECM molecules like laminin, entactin/nidogen-1 and collagen. Laminin interacts within the dystroglycan-dystrophin-dystrobrevin complex to ensure anchoring and stabilization of the aquaporin 4 (AQP4) water channel as well as the inwardly rectifying potassium channel Kir 4.1 in the perivascular basal lamina [  ,  ]. Detailed view ( B ) illustrates the participation of non-basement membrane ECM molecules like brevican and tenascin-R in the tripartite synapse. The tripartite synapse consists of a presynaptic and postsynaptic membrane as well as a closely apposed astrocyte process . By connection to further ECM components (hyaluronan, aggrecan, neurocan, vesican) tenascin-R and brevican form perineuronal nets (PNN). Anchored via the cell-surface glycoprotein CD44, PNNs are presumed to play a role in synapse stability and plasticity .
    Kir 4 1, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/kir 4 1/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    kir 4 1 - by Bioz Stars, 2023-02
    94/100 stars
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    96
    Alomone Labs rabbit anti kir 4 1
    Detailed view ( A ) shows basement membrane ECM molecules like laminin, entactin/nidogen-1 and collagen. Laminin interacts within the dystroglycan-dystrophin-dystrobrevin complex to ensure anchoring and stabilization of the aquaporin 4 (AQP4) water channel as well as the inwardly rectifying potassium channel Kir 4.1 in the perivascular basal lamina [  ,  ]. Detailed view ( B ) illustrates the participation of non-basement membrane ECM molecules like brevican and tenascin-R in the tripartite synapse. The tripartite synapse consists of a presynaptic and postsynaptic membrane as well as a closely apposed astrocyte process . By connection to further ECM components (hyaluronan, aggrecan, neurocan, vesican) tenascin-R and brevican form perineuronal nets (PNN). Anchored via the cell-surface glycoprotein CD44, PNNs are presumed to play a role in synapse stability and plasticity .
    Rabbit Anti Kir 4 1, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rabbit anti kir 4 1/product/Alomone Labs
    Average 96 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    rabbit anti kir 4 1 - by Bioz Stars, 2023-02
    96/100 stars
      Buy from Supplier

    93
    Alomone Labs kir 4 1 ag
    Detailed view ( A ) shows basement membrane ECM molecules like laminin, entactin/nidogen-1 and collagen. Laminin interacts within the dystroglycan-dystrophin-dystrobrevin complex to ensure anchoring and stabilization of the aquaporin 4 (AQP4) water channel as well as the inwardly rectifying potassium channel Kir 4.1 in the perivascular basal lamina [  ,  ]. Detailed view ( B ) illustrates the participation of non-basement membrane ECM molecules like brevican and tenascin-R in the tripartite synapse. The tripartite synapse consists of a presynaptic and postsynaptic membrane as well as a closely apposed astrocyte process . By connection to further ECM components (hyaluronan, aggrecan, neurocan, vesican) tenascin-R and brevican form perineuronal nets (PNN). Anchored via the cell-surface glycoprotein CD44, PNNs are presumed to play a role in synapse stability and plasticity .
    Kir 4 1 Ag, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/kir 4 1 ag/product/Alomone Labs
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    kir 4 1 ag - by Bioz Stars, 2023-02
    93/100 stars
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    Image Search Results


    Detailed view ( A ) shows basement membrane ECM molecules like laminin, entactin/nidogen-1 and collagen. Laminin interacts within the dystroglycan-dystrophin-dystrobrevin complex to ensure anchoring and stabilization of the aquaporin 4 (AQP4) water channel as well as the inwardly rectifying potassium channel Kir 4.1 in the perivascular basal lamina [  ,  ]. Detailed view ( B ) illustrates the participation of non-basement membrane ECM molecules like brevican and tenascin-R in the tripartite synapse. The tripartite synapse consists of a presynaptic and postsynaptic membrane as well as a closely apposed astrocyte process . By connection to further ECM components (hyaluronan, aggrecan, neurocan, vesican) tenascin-R and brevican form perineuronal nets (PNN). Anchored via the cell-surface glycoprotein CD44, PNNs are presumed to play a role in synapse stability and plasticity .

    Journal: PLoS ONE

    Article Title: Astrocyte depletion alters extracellular matrix composition in the demyelinating phase of Theiler’s murine encephalomyelitis

    doi: 10.1371/journal.pone.0270239

    Figure Lengend Snippet: Detailed view ( A ) shows basement membrane ECM molecules like laminin, entactin/nidogen-1 and collagen. Laminin interacts within the dystroglycan-dystrophin-dystrobrevin complex to ensure anchoring and stabilization of the aquaporin 4 (AQP4) water channel as well as the inwardly rectifying potassium channel Kir 4.1 in the perivascular basal lamina [ , ]. Detailed view ( B ) illustrates the participation of non-basement membrane ECM molecules like brevican and tenascin-R in the tripartite synapse. The tripartite synapse consists of a presynaptic and postsynaptic membrane as well as a closely apposed astrocyte process . By connection to further ECM components (hyaluronan, aggrecan, neurocan, vesican) tenascin-R and brevican form perineuronal nets (PNN). Anchored via the cell-surface glycoprotein CD44, PNNs are presumed to play a role in synapse stability and plasticity .

    Article Snippet: Kir 4.1 , microwave/citrate buffer , 1:6000 , polyclonal rabbit , Alomone labs, Jerusalem, Israel , apc 035.

    Techniques:

    Journal: PLoS ONE

    Article Title: Astrocyte depletion alters extracellular matrix composition in the demyelinating phase of Theiler’s murine encephalomyelitis

    doi: 10.1371/journal.pone.0270239

    Figure Lengend Snippet: Primary antibodies, pretreatment and dilutions used for immunohistochemistry.

    Article Snippet: Kir 4.1 , microwave/citrate buffer , 1:6000 , polyclonal rabbit , Alomone labs, Jerusalem, Israel , apc 035.

    Techniques: Immunohistochemistry

    Immunohistochemistry targeting Kir 4.1 potassium channels revealed a significant reduction of Kir 4.1 positive area (asterisks, A ) in the thoracic spinal cord of TMEV infected, ganciclovir treated, GFAP-transgenic (GSTG) mice compared to control animals ( B, C ). Inserts visualize in more detail the intralesional reduction of Kir 4.1 in astrocyte depleted animals ( A ) compared to the WSTP control group ( B ). For each antibody, one cross section of the thoracic spinal cord was evaluated per animal. Data are shown as scatter dot plots. The horizontal bar indicates the mean. Significant differences between GSTG and the control groups obtained by Kruskal-Wallis test followed by Mann–Whitney U post hoc tests are indicated by *, p ≤ 0.05. Bars represent 100 μm in overviews and 50 μm in the insert.

    Journal: PLoS ONE

    Article Title: Astrocyte depletion alters extracellular matrix composition in the demyelinating phase of Theiler’s murine encephalomyelitis

    doi: 10.1371/journal.pone.0270239

    Figure Lengend Snippet: Immunohistochemistry targeting Kir 4.1 potassium channels revealed a significant reduction of Kir 4.1 positive area (asterisks, A ) in the thoracic spinal cord of TMEV infected, ganciclovir treated, GFAP-transgenic (GSTG) mice compared to control animals ( B, C ). Inserts visualize in more detail the intralesional reduction of Kir 4.1 in astrocyte depleted animals ( A ) compared to the WSTP control group ( B ). For each antibody, one cross section of the thoracic spinal cord was evaluated per animal. Data are shown as scatter dot plots. The horizontal bar indicates the mean. Significant differences between GSTG and the control groups obtained by Kruskal-Wallis test followed by Mann–Whitney U post hoc tests are indicated by *, p ≤ 0.05. Bars represent 100 μm in overviews and 50 μm in the insert.

    Article Snippet: Kir 4.1 , microwave/citrate buffer , 1:6000 , polyclonal rabbit , Alomone labs, Jerusalem, Israel , apc 035.

    Techniques: Immunohistochemistry, Infection, Transgenic Assay, MANN-WHITNEY