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Journal: Molecular Medicine Reports
Article Title: Quercetin attenuates the symptoms of osteoarthritis in vitro and in vivo by suppressing ferroptosis via activation of AMPK/Nrf2/Gpx4 signaling
doi: 10.3892/mmr.2024.13425
Figure Lengend Snippet: QCT inhibits IL-1β-induced ferroptosis in chondrocytes by activating AMPK/Nrf2/Gpx4 signaling. CHON-001 cells were treated with QCT (50 or 100 µM) for 24 h, and then exposed to IL-1β for 24 h. (A) Lipid ROS and (B) Fe 2+ levels in CHON-001 cells were evaluated using ELISAs. (C) Western blotting was used to detect p-AMPK, AMPK, Nrf2 and Gpx4 levels in CHON-001 cells. The level of p-AMPK was normalized to that of AMPK. **P<0.01 vs. control group; ## P<0.01 vs. IL-1β group. AMPK, 5′ AMP-activated protein kinase; Gpx4, glutathione peroxidase 4; Nrf2, nuclear factor erythroid 2-related factor 2; p-, phosphorylated; QCT, quercetin; ROS, reactive oxygen species.
Article Snippet: The 5′ AMP-activated
Techniques: Western Blot, Control
Journal: Molecular Medicine Reports
Article Title: Quercetin attenuates the symptoms of osteoarthritis in vitro and in vivo by suppressing ferroptosis via activation of AMPK/Nrf2/Gpx4 signaling
doi: 10.3892/mmr.2024.13425
Figure Lengend Snippet: QCT protects against IL-1β-induced chondrocyte injury in vitro by suppressing ferroptosis via the activation of AMPK/Nrf2/Gpx4 signaling. CHON-001 cells were treated with QCT (100 µM) or QCT and compound C (5 µM) for 24 h at 37°C, and then exposed to IL-1β for 24 h at 37°C. (A) Western blotting was used to detect p-AMPK, AMPK, Nrf2 and Gpx4 levels in CHON-001 cells. The level of p-AMPK was normalized to that of AMPK. (B) Western blotting was used to detect aggrecan, collagen II, MMP13 and ADAMTS5 levels in CHON-001 cells. **P<0.01 vs. control group; ## P<0.01 vs. IL-1β group; ^ P<0.05 ^^ P<0.01 vs. IL-1β + QCT group. ADAMTS5, ADAM metallopeptidase with thrombospondin type 1 motif 5; AMPK, 5′ AMP-activated protein kinase; collagen II, type II collagen; Gpx4, glutathione peroxidase 4; Nrf2, nuclear factor erythroid 2-related factor 2; p-, phosphorylated; QCT, quercetin.
Article Snippet: The 5′ AMP-activated
Techniques: In Vitro, Activation Assay, Western Blot, Control
Journal: Molecular Medicine Reports
Article Title: Quercetin attenuates the symptoms of osteoarthritis in vitro and in vivo by suppressing ferroptosis via activation of AMPK/Nrf2/Gpx4 signaling
doi: 10.3892/mmr.2024.13425
Figure Lengend Snippet: QCT ameliorates OA in mice in vivo via activation of AMPK/Nrf2/Gpx4 signaling. (A) Pathologic changes of mouse cartilage tissue were evaluated using H&E staining and safranin O/fast green assays. Immunohistochemistry was used to assess aggrecan, collagen II, MMP13 and ADAMTS5 levels in mouse cartilage tissues. Magnification, ×200. Scale bar, 100 µm. (B) Western blotting was used to detect p-AMPK, AMPK, Nrf2 and Gpx4 levels in mouse cartilage tissues. (C) The level of p-AMPK was normalized to that of AMPK and the other proteins were normalized to β-actin. (D) OARSI score in each group. **P<0.01 vs. sham group; # P<0.05, ## P<0.01 vs. OA group. ADAMTS5, ADAM metallopeptidase with thrombospondin type 1 motif 5; AMPK, 5′ AMP-activated protein kinase; collagen II, type II collagen; Gpx4, glutathione peroxidase 4; Nrf2, nuclear factor erythroid 2-related factor 2; OA, osteoarthritis; OARSI, Osteoarthritis Research Society International; p-, phosphorylated; QCT, quercetin.
Article Snippet: The 5′ AMP-activated
Techniques: In Vivo, Activation Assay, Staining, Immunohistochemistry, Western Blot