intraperitoneal atx ii  (Alomone Labs)


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    Alomone Labs intraperitoneal atx ii
    nNa v inhibition reduces LQT-associated VT. (a) Representative ECG recordings in CASQ-null mice after catecholamine challenge (black ECG) composed of epinephrine (1.5 mg/kg) and caffeine (120 mg/kg) injected intraperitoneally, which induced a narrow-QRS complex VT exhibiting beat-to-beat alternations in the polarity of QRS. Addition of <t>BayK</t> (1 mg/kg; orange ECG) or <t>ATX-II</t> (30 µg/kg; red ECG) resulted in a typical short-long-short initiating ventricular cycle leading to a wide-QRS complex polymorphic VT that resembled human TdP. A subset of mice 10 min after exposure to BayK or ATX-II and 10 min before catecholamine challenge were pretreated with either 4,9-ah-TTX (750 µg/kg; blue ECGs) or riluzole (Ril; 15 mg/kg). (b) VT incidence (%) in CASQ-null mice exposed to catecholamine challenge without (black bars) and with BayK (orange bars) or ATX-II (red bars) during Na + channel blockade with 4,9-ah-TTX or Ril (green bars). Number of mice from independent experiments is specified in the bar graph. VT was defined as three or more premature ectopies. (c) TdP-like VT incidence (%) in CASQ-null mice exposed to catecholamine challenge without (black bars) and with BayK (orange bars) or ATX-II (red bars) during Na + channel blockade with 4,9-ah-TTX or Ril (green bars). TdP-like VT was defined as three or more premature wide-QRS ectopies. Significance between the treatment groups was determined with Fisher’s exact test.
    Intraperitoneal Atx Ii, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/intraperitoneal atx ii/product/Alomone Labs
    Average 94 stars, based on 2 article reviews
    Price from $9.99 to $1999.99
    intraperitoneal atx ii - by Bioz Stars, 2022-10
    94/100 stars

    Images

    1) Product Images from "Tetrodotoxin-sensitive Navs contribute to early and delayed afterdepolarizations in long QT arrhythmia models"

    Article Title: Tetrodotoxin-sensitive Navs contribute to early and delayed afterdepolarizations in long QT arrhythmia models

    Journal: The Journal of General Physiology

    doi: 10.1085/jgp.201711909

    nNa v inhibition reduces LQT-associated VT. (a) Representative ECG recordings in CASQ-null mice after catecholamine challenge (black ECG) composed of epinephrine (1.5 mg/kg) and caffeine (120 mg/kg) injected intraperitoneally, which induced a narrow-QRS complex VT exhibiting beat-to-beat alternations in the polarity of QRS. Addition of BayK (1 mg/kg; orange ECG) or ATX-II (30 µg/kg; red ECG) resulted in a typical short-long-short initiating ventricular cycle leading to a wide-QRS complex polymorphic VT that resembled human TdP. A subset of mice 10 min after exposure to BayK or ATX-II and 10 min before catecholamine challenge were pretreated with either 4,9-ah-TTX (750 µg/kg; blue ECGs) or riluzole (Ril; 15 mg/kg). (b) VT incidence (%) in CASQ-null mice exposed to catecholamine challenge without (black bars) and with BayK (orange bars) or ATX-II (red bars) during Na + channel blockade with 4,9-ah-TTX or Ril (green bars). Number of mice from independent experiments is specified in the bar graph. VT was defined as three or more premature ectopies. (c) TdP-like VT incidence (%) in CASQ-null mice exposed to catecholamine challenge without (black bars) and with BayK (orange bars) or ATX-II (red bars) during Na + channel blockade with 4,9-ah-TTX or Ril (green bars). TdP-like VT was defined as three or more premature wide-QRS ectopies. Significance between the treatment groups was determined with Fisher’s exact test.
    Figure Legend Snippet: nNa v inhibition reduces LQT-associated VT. (a) Representative ECG recordings in CASQ-null mice after catecholamine challenge (black ECG) composed of epinephrine (1.5 mg/kg) and caffeine (120 mg/kg) injected intraperitoneally, which induced a narrow-QRS complex VT exhibiting beat-to-beat alternations in the polarity of QRS. Addition of BayK (1 mg/kg; orange ECG) or ATX-II (30 µg/kg; red ECG) resulted in a typical short-long-short initiating ventricular cycle leading to a wide-QRS complex polymorphic VT that resembled human TdP. A subset of mice 10 min after exposure to BayK or ATX-II and 10 min before catecholamine challenge were pretreated with either 4,9-ah-TTX (750 µg/kg; blue ECGs) or riluzole (Ril; 15 mg/kg). (b) VT incidence (%) in CASQ-null mice exposed to catecholamine challenge without (black bars) and with BayK (orange bars) or ATX-II (red bars) during Na + channel blockade with 4,9-ah-TTX or Ril (green bars). Number of mice from independent experiments is specified in the bar graph. VT was defined as three or more premature ectopies. (c) TdP-like VT incidence (%) in CASQ-null mice exposed to catecholamine challenge without (black bars) and with BayK (orange bars) or ATX-II (red bars) during Na + channel blockade with 4,9-ah-TTX or Ril (green bars). TdP-like VT was defined as three or more premature wide-QRS ectopies. Significance between the treatment groups was determined with Fisher’s exact test.

    Techniques Used: Inhibition, Mouse Assay, Injection

    2) Product Images from "Tetrodotoxin-sensitive Navs contribute to early and delayed afterdepolarizations in long QT arrhythmia models"

    Article Title: Tetrodotoxin-sensitive Navs contribute to early and delayed afterdepolarizations in long QT arrhythmia models

    Journal: The Journal of General Physiology

    doi: 10.1085/jgp.201711909

    nNa v inhibition reduces LQT-associated VT. (a) Representative ECG recordings in CASQ-null mice after catecholamine challenge (black ECG) composed of epinephrine (1.5 mg/kg) and caffeine (120 mg/kg) injected intraperitoneally, which induced a narrow-QRS complex VT exhibiting beat-to-beat alternations in the polarity of QRS. Addition of BayK (1 mg/kg; orange ECG) or ATX-II (30 µg/kg; red ECG) resulted in a typical short-long-short initiating ventricular cycle leading to a wide-QRS complex polymorphic VT that resembled human TdP. A subset of mice 10 min after exposure to BayK or ATX-II and 10 min before catecholamine challenge were pretreated with either 4,9-ah-TTX (750 µg/kg; blue ECGs) or riluzole (Ril; 15 mg/kg). (b) VT incidence (%) in CASQ-null mice exposed to catecholamine challenge without (black bars) and with BayK (orange bars) or ATX-II (red bars) during Na + channel blockade with 4,9-ah-TTX or Ril (green bars). Number of mice from independent experiments is specified in the bar graph. VT was defined as three or more premature ectopies. (c) TdP-like VT incidence (%) in CASQ-null mice exposed to catecholamine challenge without (black bars) and with BayK (orange bars) or ATX-II (red bars) during Na + channel blockade with 4,9-ah-TTX or Ril (green bars). TdP-like VT was defined as three or more premature wide-QRS ectopies. Significance between the treatment groups was determined with Fisher’s exact test.
    Figure Legend Snippet: nNa v inhibition reduces LQT-associated VT. (a) Representative ECG recordings in CASQ-null mice after catecholamine challenge (black ECG) composed of epinephrine (1.5 mg/kg) and caffeine (120 mg/kg) injected intraperitoneally, which induced a narrow-QRS complex VT exhibiting beat-to-beat alternations in the polarity of QRS. Addition of BayK (1 mg/kg; orange ECG) or ATX-II (30 µg/kg; red ECG) resulted in a typical short-long-short initiating ventricular cycle leading to a wide-QRS complex polymorphic VT that resembled human TdP. A subset of mice 10 min after exposure to BayK or ATX-II and 10 min before catecholamine challenge were pretreated with either 4,9-ah-TTX (750 µg/kg; blue ECGs) or riluzole (Ril; 15 mg/kg). (b) VT incidence (%) in CASQ-null mice exposed to catecholamine challenge without (black bars) and with BayK (orange bars) or ATX-II (red bars) during Na + channel blockade with 4,9-ah-TTX or Ril (green bars). Number of mice from independent experiments is specified in the bar graph. VT was defined as three or more premature ectopies. (c) TdP-like VT incidence (%) in CASQ-null mice exposed to catecholamine challenge without (black bars) and with BayK (orange bars) or ATX-II (red bars) during Na + channel blockade with 4,9-ah-TTX or Ril (green bars). TdP-like VT was defined as three or more premature wide-QRS ectopies. Significance between the treatment groups was determined with Fisher’s exact test.

    Techniques Used: Inhibition, Mouse Assay, Injection

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    Alomone Labs intraperitoneal atx ii
    nNa v inhibition reduces LQT-associated VT. (a) Representative ECG recordings in CASQ-null mice after catecholamine challenge (black ECG) composed of epinephrine (1.5 mg/kg) and caffeine (120 mg/kg) injected intraperitoneally, which induced a narrow-QRS complex VT exhibiting beat-to-beat alternations in the polarity of QRS. Addition of <t>BayK</t> (1 mg/kg; orange ECG) or <t>ATX-II</t> (30 µg/kg; red ECG) resulted in a typical short-long-short initiating ventricular cycle leading to a wide-QRS complex polymorphic VT that resembled human TdP. A subset of mice 10 min after exposure to BayK or ATX-II and 10 min before catecholamine challenge were pretreated with either 4,9-ah-TTX (750 µg/kg; blue ECGs) or riluzole (Ril; 15 mg/kg). (b) VT incidence (%) in CASQ-null mice exposed to catecholamine challenge without (black bars) and with BayK (orange bars) or ATX-II (red bars) during Na + channel blockade with 4,9-ah-TTX or Ril (green bars). Number of mice from independent experiments is specified in the bar graph. VT was defined as three or more premature ectopies. (c) TdP-like VT incidence (%) in CASQ-null mice exposed to catecholamine challenge without (black bars) and with BayK (orange bars) or ATX-II (red bars) during Na + channel blockade with 4,9-ah-TTX or Ril (green bars). TdP-like VT was defined as three or more premature wide-QRS ectopies. Significance between the treatment groups was determined with Fisher’s exact test.
    Intraperitoneal Atx Ii, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/intraperitoneal atx ii/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    intraperitoneal atx ii - by Bioz Stars, 2022-10
    94/100 stars
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    nNa v inhibition reduces LQT-associated VT. (a) Representative ECG recordings in CASQ-null mice after catecholamine challenge (black ECG) composed of epinephrine (1.5 mg/kg) and caffeine (120 mg/kg) injected intraperitoneally, which induced a narrow-QRS complex VT exhibiting beat-to-beat alternations in the polarity of QRS. Addition of BayK (1 mg/kg; orange ECG) or ATX-II (30 µg/kg; red ECG) resulted in a typical short-long-short initiating ventricular cycle leading to a wide-QRS complex polymorphic VT that resembled human TdP. A subset of mice 10 min after exposure to BayK or ATX-II and 10 min before catecholamine challenge were pretreated with either 4,9-ah-TTX (750 µg/kg; blue ECGs) or riluzole (Ril; 15 mg/kg). (b) VT incidence (%) in CASQ-null mice exposed to catecholamine challenge without (black bars) and with BayK (orange bars) or ATX-II (red bars) during Na + channel blockade with 4,9-ah-TTX or Ril (green bars). Number of mice from independent experiments is specified in the bar graph. VT was defined as three or more premature ectopies. (c) TdP-like VT incidence (%) in CASQ-null mice exposed to catecholamine challenge without (black bars) and with BayK (orange bars) or ATX-II (red bars) during Na + channel blockade with 4,9-ah-TTX or Ril (green bars). TdP-like VT was defined as three or more premature wide-QRS ectopies. Significance between the treatment groups was determined with Fisher’s exact test.

    Journal: The Journal of General Physiology

    Article Title: Tetrodotoxin-sensitive Navs contribute to early and delayed afterdepolarizations in long QT arrhythmia models

    doi: 10.1085/jgp.201711909

    Figure Lengend Snippet: nNa v inhibition reduces LQT-associated VT. (a) Representative ECG recordings in CASQ-null mice after catecholamine challenge (black ECG) composed of epinephrine (1.5 mg/kg) and caffeine (120 mg/kg) injected intraperitoneally, which induced a narrow-QRS complex VT exhibiting beat-to-beat alternations in the polarity of QRS. Addition of BayK (1 mg/kg; orange ECG) or ATX-II (30 µg/kg; red ECG) resulted in a typical short-long-short initiating ventricular cycle leading to a wide-QRS complex polymorphic VT that resembled human TdP. A subset of mice 10 min after exposure to BayK or ATX-II and 10 min before catecholamine challenge were pretreated with either 4,9-ah-TTX (750 µg/kg; blue ECGs) or riluzole (Ril; 15 mg/kg). (b) VT incidence (%) in CASQ-null mice exposed to catecholamine challenge without (black bars) and with BayK (orange bars) or ATX-II (red bars) during Na + channel blockade with 4,9-ah-TTX or Ril (green bars). Number of mice from independent experiments is specified in the bar graph. VT was defined as three or more premature ectopies. (c) TdP-like VT incidence (%) in CASQ-null mice exposed to catecholamine challenge without (black bars) and with BayK (orange bars) or ATX-II (red bars) during Na + channel blockade with 4,9-ah-TTX or Ril (green bars). TdP-like VT was defined as three or more premature wide-QRS ectopies. Significance between the treatment groups was determined with Fisher’s exact test.

    Article Snippet: Briefly, after baseline recording (5 min), a subset of animals received either intraperitoneal ATX-II (30 µg/kg; Alomone Labs) or BayK (1 mg/kg; Tocris).

    Techniques: Inhibition, Mouse Assay, Injection

    nNa v inhibition reduces LQT-associated VT. (a) Representative ECG recordings in CASQ-null mice after catecholamine challenge (black ECG) composed of epinephrine (1.5 mg/kg) and caffeine (120 mg/kg) injected intraperitoneally, which induced a narrow-QRS complex VT exhibiting beat-to-beat alternations in the polarity of QRS. Addition of BayK (1 mg/kg; orange ECG) or ATX-II (30 µg/kg; red ECG) resulted in a typical short-long-short initiating ventricular cycle leading to a wide-QRS complex polymorphic VT that resembled human TdP. A subset of mice 10 min after exposure to BayK or ATX-II and 10 min before catecholamine challenge were pretreated with either 4,9-ah-TTX (750 µg/kg; blue ECGs) or riluzole (Ril; 15 mg/kg). (b) VT incidence (%) in CASQ-null mice exposed to catecholamine challenge without (black bars) and with BayK (orange bars) or ATX-II (red bars) during Na + channel blockade with 4,9-ah-TTX or Ril (green bars). Number of mice from independent experiments is specified in the bar graph. VT was defined as three or more premature ectopies. (c) TdP-like VT incidence (%) in CASQ-null mice exposed to catecholamine challenge without (black bars) and with BayK (orange bars) or ATX-II (red bars) during Na + channel blockade with 4,9-ah-TTX or Ril (green bars). TdP-like VT was defined as three or more premature wide-QRS ectopies. Significance between the treatment groups was determined with Fisher’s exact test.

    Journal: The Journal of General Physiology

    Article Title: Tetrodotoxin-sensitive Navs contribute to early and delayed afterdepolarizations in long QT arrhythmia models

    doi: 10.1085/jgp.201711909

    Figure Lengend Snippet: nNa v inhibition reduces LQT-associated VT. (a) Representative ECG recordings in CASQ-null mice after catecholamine challenge (black ECG) composed of epinephrine (1.5 mg/kg) and caffeine (120 mg/kg) injected intraperitoneally, which induced a narrow-QRS complex VT exhibiting beat-to-beat alternations in the polarity of QRS. Addition of BayK (1 mg/kg; orange ECG) or ATX-II (30 µg/kg; red ECG) resulted in a typical short-long-short initiating ventricular cycle leading to a wide-QRS complex polymorphic VT that resembled human TdP. A subset of mice 10 min after exposure to BayK or ATX-II and 10 min before catecholamine challenge were pretreated with either 4,9-ah-TTX (750 µg/kg; blue ECGs) or riluzole (Ril; 15 mg/kg). (b) VT incidence (%) in CASQ-null mice exposed to catecholamine challenge without (black bars) and with BayK (orange bars) or ATX-II (red bars) during Na + channel blockade with 4,9-ah-TTX or Ril (green bars). Number of mice from independent experiments is specified in the bar graph. VT was defined as three or more premature ectopies. (c) TdP-like VT incidence (%) in CASQ-null mice exposed to catecholamine challenge without (black bars) and with BayK (orange bars) or ATX-II (red bars) during Na + channel blockade with 4,9-ah-TTX or Ril (green bars). TdP-like VT was defined as three or more premature wide-QRS ectopies. Significance between the treatment groups was determined with Fisher’s exact test.

    Article Snippet: Briefly, after baseline recording (5 min), a subset of animals received either intraperitoneal ATX-II (30 µg/kg; Alomone Labs) or BayK (1 mg/kg; Tocris).

    Techniques: Inhibition, Mouse Assay, Injection