Premature Activation of Immune Transcription Programs in Autoimmune-Predisposed Mouse Embryonic Stem Cells and Blastocysts International Journal of Molecular Sciences, 2020 Aug 11

"Genome-wide transcriptomic and proteomic analyses of autoimmune-prone ES cell lines: ( a ) heatmap shows clustering of differentially expressing genes identified in mRNA-Seq for NOD, B6, V6.5 and NZB ES cell lines, color scale bar shows expression level relative to average; ( b ) venn diagrams show overlap of genes with similar expression levels (left) and protein expression (right) in NOD and B6 ES cells; ( c ) volcano plot shows significantly increased protein expression in NOD (red dots, right) and in B6 (red dots, left) ES cells. ( d ) <t>Ingenuity</t> <t>pathway</t> <t>analysis</t> shows majority of proteins in the inflammation pathway are up-regulated (red) with 2-fold or more up-regulation and FDR < 0.05. ( e ) Ingenuity canonical pathways that are enriched in genes that are up-regulated in NOD ES cells. "