imatinib hydrochloride salt  (Millipore)


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    Name:
    Imatinib
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    Catalog Number:
    cds022173
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    Structured Review

    Millipore imatinib hydrochloride salt
    Imatinib

    https://www.bioz.com/result/imatinib hydrochloride salt/product/Millipore
    Average 96 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    imatinib hydrochloride salt - by Bioz Stars, 2020-05
    96/100 stars

    Related Products / Commonly Used Together

    hydrochloric acid
    coevaporation

    Images

    1) Product Images from "Synthesis and positron emission tomography studies of carbon-11-labeled imatinib (Gleevec)"

    Article Title: Synthesis and positron emission tomography studies of carbon-11-labeled imatinib (Gleevec)

    Journal: Nuclear medicine and biology

    doi: 10.1016/j.nucmedbio.2006.11.004

    The comparison of time–activity curves of the (A) heart, (B) lungs, (C) kidneys, (D) spleen, (E) liver and (F) gallbladder before and after pretreatment with 32 mg of imatinib administration by intravenous injection. Time–activity curves
    Figure Legend Snippet: The comparison of time–activity curves of the (A) heart, (B) lungs, (C) kidneys, (D) spleen, (E) liver and (F) gallbladder before and after pretreatment with 32 mg of imatinib administration by intravenous injection. Time–activity curves

    Techniques Used: Activity Assay, Injection

    Structure of imatinib (the active ingredient of Gleevec).
    Figure Legend Snippet: Structure of imatinib (the active ingredient of Gleevec).

    Techniques Used:

    Synthetic scheme of norimatinib, imatinib and [ N - 11 C-methyl]imatinib.
    Figure Legend Snippet: Synthetic scheme of norimatinib, imatinib and [ N - 11 C-methyl]imatinib.

    Techniques Used:

    PET image of baboon brain with [ N - 11 C-methyl]imatinib. Summed frames over 90 min after the injection of 3.9 mCi of [ N - 11 ]. The anesthesia
    Figure Legend Snippet: PET image of baboon brain with [ N - 11 C-methyl]imatinib. Summed frames over 90 min after the injection of 3.9 mCi of [ N - 11 ]. The anesthesia

    Techniques Used: Positron Emission Tomography, Injection

    PET image of the torso of the anesthetized baboon with [ N - 11 C-methyl]imatinib. PET images (summation of frames over 90 min) of the baboon torso after the injection of 4.71 mCi of [ N - 11 C-methyl]imatinib showing the accumulation of carbon-11 in the heart
    Figure Legend Snippet: PET image of the torso of the anesthetized baboon with [ N - 11 C-methyl]imatinib. PET images (summation of frames over 90 min) of the baboon torso after the injection of 4.71 mCi of [ N - 11 C-methyl]imatinib showing the accumulation of carbon-11 in the heart

    Techniques Used: Positron Emission Tomography, Injection

    (A) Time–activity curve at baseline and after imatinib pretreatment for [ N - 11 C-methyl]imatinib in plasma showing the first 5 min and (B) the plasma integral over 90 min. Pretreatment delayed [ N - 11 C-methyl]imatinib peak and reduced its accumulated
    Figure Legend Snippet: (A) Time–activity curve at baseline and after imatinib pretreatment for [ N - 11 C-methyl]imatinib in plasma showing the first 5 min and (B) the plasma integral over 90 min. Pretreatment delayed [ N - 11 C-methyl]imatinib peak and reduced its accumulated

    Techniques Used: Activity Assay

    Time–activity curves for two different anesthetized baboons (A and B) that each received two injections of [ N - 11 C-methyl]imatinib in the brain through the urinary bladder.
    Figure Legend Snippet: Time–activity curves for two different anesthetized baboons (A and B) that each received two injections of [ N - 11 C-methyl]imatinib in the brain through the urinary bladder.

    Techniques Used: Activity Assay

    Related Articles

    Protease Inhibitor:

    Article Title: ABC transporter A3 facilitates lysosomal sequestration of imatinib and modulates susceptibility of chronic myeloid leukemia cell lines to this drug
    Article Snippet: .. For subcellular fractionation, cells were incubated with 2.14 μM imatinib (0.1 μ Ci [3.7 kBq]) for 2 h. After washing with ice-cold phosphate-buffered saline, cells from each cell line were harvested from three 15 cm dishes and homogenized in 0.25 M sucrose buffered with 3 mM imidazole/HCl pH 7.3, 1 mM EDTA and a 1:500 dilution of a protease inhibitor cocktail (Sigma) using five strokes of a G27 syringe. .. A post-nuclear supernatant was prepared (5 min/500 g/4°C) and 6 mL of this protein normalized post-nuclear supernatant was adjusted to a final concentration of 20% percoll solution (12 mL) in 0.25 M sucrose, 3 mM imidazole/HCl, 1 mM EDTA pH 7.3 and centrifuged for 30 min at 35,000g without brakes in a vertical tube rotor Vti 65.1 (Beckmann Instruments).

    Cell Culture:

    Article Title: Metformin Synergistically Potentiates the Antitumor Effects of Imatinib in Colorectal Cancer Cells
    Article Snippet: .. Reagents and cell culture Imatinib (also known as Gleevec) and metformin were purchased from Sigma-Aldrich (St. Louis, Mo, USA). .. Imatinib was dissolved in DMSO to a concentration of 50 mM and additionally in DMEM media to a working stock concentration of 100 μM.

    Mouse Assay:

    Article Title: c-Abl-TWIST1 Epigenetically Dysregulate Inflammatory Responses during Mycobacterial Infection by Co-Regulating Bone Morphogenesis Protein and miR27a
    Article Snippet: .. 28 days postinfection, mice were given 10 doses of Imatinib (66 mg/kg) (Calbiochem, 504595) immunoprecipitation (every 2 days) (n = 10). .. On day 56, mice were sacrificed, left lobe of the lung and whole spleen was homogenized in sterile PBS, serially diluted and plated on 7H11 agar containing OADC to quantify Mtb H37Rv CFU.

    Immunoprecipitation:

    Article Title: c-Abl-TWIST1 Epigenetically Dysregulate Inflammatory Responses during Mycobacterial Infection by Co-Regulating Bone Morphogenesis Protein and miR27a
    Article Snippet: .. 28 days postinfection, mice were given 10 doses of Imatinib (66 mg/kg) (Calbiochem, 504595) immunoprecipitation (every 2 days) (n = 10). .. On day 56, mice were sacrificed, left lobe of the lung and whole spleen was homogenized in sterile PBS, serially diluted and plated on 7H11 agar containing OADC to quantify Mtb H37Rv CFU.

    Incubation:

    Article Title: ABC transporter A3 facilitates lysosomal sequestration of imatinib and modulates susceptibility of chronic myeloid leukemia cell lines to this drug
    Article Snippet: .. For subcellular fractionation, cells were incubated with 2.14 μM imatinib (0.1 μ Ci [3.7 kBq]) for 2 h. After washing with ice-cold phosphate-buffered saline, cells from each cell line were harvested from three 15 cm dishes and homogenized in 0.25 M sucrose buffered with 3 mM imidazole/HCl pH 7.3, 1 mM EDTA and a 1:500 dilution of a protease inhibitor cocktail (Sigma) using five strokes of a G27 syringe. .. A post-nuclear supernatant was prepared (5 min/500 g/4°C) and 6 mL of this protein normalized post-nuclear supernatant was adjusted to a final concentration of 20% percoll solution (12 mL) in 0.25 M sucrose, 3 mM imidazole/HCl, 1 mM EDTA pH 7.3 and centrifuged for 30 min at 35,000g without brakes in a vertical tube rotor Vti 65.1 (Beckmann Instruments).

    other:

    Article Title: Insulin-like growth factor binding protein-3 has dual effects on gastrointestinal stromal tumor cell viability and sensitivity to the anti-tumor effects of imatinib mesylate in vitro
    Article Snippet: For drug treatment, imatinib was prepared as a 10 mM solution in sterile water and subsequently filter-sterilized using 0.45 μm filters (Millipore).

    Fractionation:

    Article Title: ABC transporter A3 facilitates lysosomal sequestration of imatinib and modulates susceptibility of chronic myeloid leukemia cell lines to this drug
    Article Snippet: .. For subcellular fractionation, cells were incubated with 2.14 μM imatinib (0.1 μ Ci [3.7 kBq]) for 2 h. After washing with ice-cold phosphate-buffered saline, cells from each cell line were harvested from three 15 cm dishes and homogenized in 0.25 M sucrose buffered with 3 mM imidazole/HCl pH 7.3, 1 mM EDTA and a 1:500 dilution of a protease inhibitor cocktail (Sigma) using five strokes of a G27 syringe. .. A post-nuclear supernatant was prepared (5 min/500 g/4°C) and 6 mL of this protein normalized post-nuclear supernatant was adjusted to a final concentration of 20% percoll solution (12 mL) in 0.25 M sucrose, 3 mM imidazole/HCl, 1 mM EDTA pH 7.3 and centrifuged for 30 min at 35,000g without brakes in a vertical tube rotor Vti 65.1 (Beckmann Instruments).

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  • 96
    Millipore imatinib hydrochloride salt
    The comparison of time–activity curves of the (A) heart, (B) lungs, (C) kidneys, (D) spleen, (E) liver and (F) gallbladder before and after pretreatment with 32 mg of <t>imatinib</t> administration by intravenous injection. Time–activity curves
    Imatinib Hydrochloride Salt, supplied by Millipore, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/imatinib hydrochloride salt/product/Millipore
    Average 96 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    imatinib hydrochloride salt - by Bioz Stars, 2020-05
    96/100 stars
      Buy from Supplier

    Image Search Results


    The comparison of time–activity curves of the (A) heart, (B) lungs, (C) kidneys, (D) spleen, (E) liver and (F) gallbladder before and after pretreatment with 32 mg of imatinib administration by intravenous injection. Time–activity curves

    Journal: Nuclear medicine and biology

    Article Title: Synthesis and positron emission tomography studies of carbon-11-labeled imatinib (Gleevec)

    doi: 10.1016/j.nucmedbio.2006.11.004

    Figure Lengend Snippet: The comparison of time–activity curves of the (A) heart, (B) lungs, (C) kidneys, (D) spleen, (E) liver and (F) gallbladder before and after pretreatment with 32 mg of imatinib administration by intravenous injection. Time–activity curves

    Article Snippet: The excess amount of hydrochloric acid was removed by coevaporation with acetonitrile to give imatinib hydrochloride salt, which was dissolved in 5 ml of sterile water and passed through a Millipore filter.

    Techniques: Activity Assay, Injection

    Structure of imatinib (the active ingredient of Gleevec).

    Journal: Nuclear medicine and biology

    Article Title: Synthesis and positron emission tomography studies of carbon-11-labeled imatinib (Gleevec)

    doi: 10.1016/j.nucmedbio.2006.11.004

    Figure Lengend Snippet: Structure of imatinib (the active ingredient of Gleevec).

    Article Snippet: The excess amount of hydrochloric acid was removed by coevaporation with acetonitrile to give imatinib hydrochloride salt, which was dissolved in 5 ml of sterile water and passed through a Millipore filter.

    Techniques:

    Synthetic scheme of norimatinib, imatinib and [ N - 11 C-methyl]imatinib.

    Journal: Nuclear medicine and biology

    Article Title: Synthesis and positron emission tomography studies of carbon-11-labeled imatinib (Gleevec)

    doi: 10.1016/j.nucmedbio.2006.11.004

    Figure Lengend Snippet: Synthetic scheme of norimatinib, imatinib and [ N - 11 C-methyl]imatinib.

    Article Snippet: The excess amount of hydrochloric acid was removed by coevaporation with acetonitrile to give imatinib hydrochloride salt, which was dissolved in 5 ml of sterile water and passed through a Millipore filter.

    Techniques:

    PET image of baboon brain with [ N - 11 C-methyl]imatinib. Summed frames over 90 min after the injection of 3.9 mCi of [ N - 11 ]. The anesthesia

    Journal: Nuclear medicine and biology

    Article Title: Synthesis and positron emission tomography studies of carbon-11-labeled imatinib (Gleevec)

    doi: 10.1016/j.nucmedbio.2006.11.004

    Figure Lengend Snippet: PET image of baboon brain with [ N - 11 C-methyl]imatinib. Summed frames over 90 min after the injection of 3.9 mCi of [ N - 11 ]. The anesthesia

    Article Snippet: The excess amount of hydrochloric acid was removed by coevaporation with acetonitrile to give imatinib hydrochloride salt, which was dissolved in 5 ml of sterile water and passed through a Millipore filter.

    Techniques: Positron Emission Tomography, Injection

    PET image of the torso of the anesthetized baboon with [ N - 11 C-methyl]imatinib. PET images (summation of frames over 90 min) of the baboon torso after the injection of 4.71 mCi of [ N - 11 C-methyl]imatinib showing the accumulation of carbon-11 in the heart

    Journal: Nuclear medicine and biology

    Article Title: Synthesis and positron emission tomography studies of carbon-11-labeled imatinib (Gleevec)

    doi: 10.1016/j.nucmedbio.2006.11.004

    Figure Lengend Snippet: PET image of the torso of the anesthetized baboon with [ N - 11 C-methyl]imatinib. PET images (summation of frames over 90 min) of the baboon torso after the injection of 4.71 mCi of [ N - 11 C-methyl]imatinib showing the accumulation of carbon-11 in the heart

    Article Snippet: The excess amount of hydrochloric acid was removed by coevaporation with acetonitrile to give imatinib hydrochloride salt, which was dissolved in 5 ml of sterile water and passed through a Millipore filter.

    Techniques: Positron Emission Tomography, Injection

    (A) Time–activity curve at baseline and after imatinib pretreatment for [ N - 11 C-methyl]imatinib in plasma showing the first 5 min and (B) the plasma integral over 90 min. Pretreatment delayed [ N - 11 C-methyl]imatinib peak and reduced its accumulated

    Journal: Nuclear medicine and biology

    Article Title: Synthesis and positron emission tomography studies of carbon-11-labeled imatinib (Gleevec)

    doi: 10.1016/j.nucmedbio.2006.11.004

    Figure Lengend Snippet: (A) Time–activity curve at baseline and after imatinib pretreatment for [ N - 11 C-methyl]imatinib in plasma showing the first 5 min and (B) the plasma integral over 90 min. Pretreatment delayed [ N - 11 C-methyl]imatinib peak and reduced its accumulated

    Article Snippet: The excess amount of hydrochloric acid was removed by coevaporation with acetonitrile to give imatinib hydrochloride salt, which was dissolved in 5 ml of sterile water and passed through a Millipore filter.

    Techniques: Activity Assay

    Time–activity curves for two different anesthetized baboons (A and B) that each received two injections of [ N - 11 C-methyl]imatinib in the brain through the urinary bladder.

    Journal: Nuclear medicine and biology

    Article Title: Synthesis and positron emission tomography studies of carbon-11-labeled imatinib (Gleevec)

    doi: 10.1016/j.nucmedbio.2006.11.004

    Figure Lengend Snippet: Time–activity curves for two different anesthetized baboons (A and B) that each received two injections of [ N - 11 C-methyl]imatinib in the brain through the urinary bladder.

    Article Snippet: The excess amount of hydrochloric acid was removed by coevaporation with acetonitrile to give imatinib hydrochloride salt, which was dissolved in 5 ml of sterile water and passed through a Millipore filter.

    Techniques: Activity Assay