farnesyl s thiolodiphosphate fsdp (Echelon Biosciences)


Structured Review
Farnesyl S Thiolodiphosphate Fsdp, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/farnesyl s thiolodiphosphate fsdp/product/Echelon Biosciences
Average 94 stars, based on 1 article reviews
Price from $9.99 to $1999.99
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farnesyl s thiolodiphosphate fsdp (Echelon Biosciences)


Structured Review
Farnesyl S Thiolodiphosphate Fsdp, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/farnesyl s thiolodiphosphate fsdp/product/Echelon Biosciences
Average 94 stars, based on 1 article reviews
Price from $9.99 to $1999.99
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fspp (Echelon Biosciences)


Structured Review

Fspp, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/fspp/product/Echelon Biosciences
Average 94 stars, based on 1 article reviews
Price from $9.99 to $1999.99
Images
1) Product Images from "Farnesyl pyrophosphate is a new danger signal inducing acute cell death"
Article Title: Farnesyl pyrophosphate is a new danger signal inducing acute cell death
Journal: PLoS Biology
doi: 10.1371/journal.pbio.3001134

Figure Legend Snippet: (A) Molecular structures of FPP and different FPP analogs including FPP analog 1/2/3/4, FOH, and FSPP. (B, C) Cytotoxic effects of different FPP analogs measured by PI signal increase under fluorescent microplate reader. Black arrows indicate the time points at which different metabolites were added. Each treatment had 3 to 4 replicates. Bars denote mean ± SEM (SEM in gray). Data are representative of at least 2 independent experiments in (B) and (C). There are no significant differences between 0 μg/mL and 15 μg/mL FPP treatments. Significant difference in 30 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 47 minutes on ( p < 0.05). Significant difference in 60 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 1 minute on ( p < 0.01). Significant difference in 120 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 1 minute on ( p < 0.001). Significant difference between 60 μg/mL FPP-Mu2 and the control shows up from 39 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu2 and the control shows up from 10 minutes on ( p < 0.01). Significant difference between 60 μg/mL FPP-Mu3 and the control shows up from 54 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu3 and the control shows up from 12 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu4 and the control shows up from 2.5 minutes on ( p < 0.01). Significant difference between 30 μg/mL FSPP and the control shows up from 43 minutes on ( p < 0.05). Significant difference between 60 μg/mL FSPP and the control shows up from 16 minutes on ( p < 0.05). Significant difference between 120 μg/mL FSPP and the control shows up from 10 minutes on ( p < 0.05). All the others show no significant difference ( p > 0.05). Two-way ANOVA analysis is used. All experiments are done with P815 cells. All the original data can be found in . FOH, farnesol; FPP, farnesyl pyrophosphate; FSPP, farnesyl S-thiolodiphosphate; PI, propidium iodide.
Techniques Used:
farnesyl s thiolodiphosphate (Echelon Biosciences)


Structured Review
Farnesyl S Thiolodiphosphate, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/farnesyl s thiolodiphosphate/product/Echelon Biosciences
Average 94 stars, based on 1 article reviews
Price from $9.99 to $1999.99
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farnesyl diphosphate 86 fpp (Echelon Biosciences)


Structured Review
Farnesyl Diphosphate 86 Fpp, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/farnesyl diphosphate 86 fpp/product/Echelon Biosciences
Average 94 stars, based on 1 article reviews
Price from $9.99 to $1999.99
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farnesyl s thiolodiphosphate fspp (Echelon Biosciences)


Structured Review
Farnesyl S Thiolodiphosphate Fspp, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/farnesyl s thiolodiphosphate fspp/product/Echelon Biosciences
Average 94 stars, based on 1 article reviews
Price from $9.99 to $1999.99
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standard farnesyl thiolodiphosphate (Echelon Biosciences)


Structured Review
Standard Farnesyl Thiolodiphosphate, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/standard farnesyl thiolodiphosphate/product/Echelon Biosciences
Average 94 stars, based on 1 article reviews
Price from $9.99 to $1999.99
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farnesyl s thiolodiphosphate s fpp (Echelon Biosciences)


Structured Review
Farnesyl S Thiolodiphosphate S Fpp, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/farnesyl s thiolodiphosphate s fpp/product/Echelon Biosciences
Average 94 stars, based on 1 article reviews
Price from $9.99 to $1999.99
Images
fspp (Echelon Biosciences)


Structured Review

Fspp, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/fspp/product/Echelon Biosciences
Average 94 stars, based on 1 article reviews
Price from $9.99 to $1999.99
Images
1) Product Images from "Mechanistic Insights from the Binding of Substrate and Carbocation Intermediate Analogues to Aristolochene Synthase"
Article Title: Mechanistic Insights from the Binding of Substrate and Carbocation Intermediate Analogues to Aristolochene Synthase
Journal: Biochemistry
doi: 10.1021/bi400691v

Figure Legend Snippet: Structural comparison of unliganded ATAS (left) with the ATAS-FSPP complex (right) illustrating conformational changes triggered by the binding of FSPP and 3 Mg2+ ions in the active site. The aspartate-rich DDXXD metal-binding segment on helix D is red and the “NSE” metal-binding segment on helix H is orange. In the ATAS-FSPP complex, Mg2+ ions are magenta and FSPP is shown as a stick-figure. Selected secondary structure elements are labeled as discussed in the text.
Techniques Used: Binding Assay, Labeling

Figure Legend Snippet: (a) Simulated annealing omit map of FSPP (contoured at 4.0σ) bound to monomer A in the ATAS-Mg2+3-FSPP complex. Atoms are color-coded as follows: C = yellow (protein) or gray (FSPP), O = red, N = blue, P = orange, S = yellow, Mg2+ ions = silver spheres, solvent molecules = red spheres. Metal coordination interactions are shown as red dotted lines; hydrogen bond interactions are shown as black dotted lines. Water molecule “w” is trapped in the active site along with FSPP. (b) Superposition of the ATAS-Mg2+3-FSPP complex (color-coded as in (a)) and the ATAS-Mg2+3-PPi complex (all atoms pale cyan).
Techniques Used:

Figure Legend Snippet: (a) Simulated annealing omit map of iminium cation 1 (contoured at 4.0σ) bound to monomer A in the ATAS-1 complex. Atoms are color-coded as follows: C = yellow (protein) or gray (1), O = red, N = blue, P = orange, S = yellow, Mg2+ ions = silver spheres, solvent molecules = red spheres. Metal coordination and hydrogen bond interactions are shown as red and black dotted lines, respectively. Water molecule “w” is trapped in the active site along with 1. (b) Superposition of the ATAS-1 complex (color-coded as in (a)) and the ATAS-FSPP complex (all atoms pale cyan).
Techniques Used:

Figure Legend Snippet: (a) Simulated annealing omit map of tertiary ammonium cation 3 (contoured at 3.5σ) bound to monomer B in the ATAS-3 complex. Atoms are color coded as follows: C = yellow (protein) or gray (3), O = red, N = blue, P = orange, S = yellow, Mg2+ ions = silver spheres, solvent molecules = red spheres. Metal coordination, hydrogen bond, and cation-π interactions are shown as red, black, and green dotted lines, respectively. Water molecules “w” and “ww” are trapped in the active site along with 3. (b) Superposition of the ATAS-3 complex (color coded as in (a)) with the ATAS-FSPP complex (all atoms pale cyan).
Techniques Used:

Figure Legend Snippet: (a) Simulated annealing omit map of tertiary ammonium cation 4 (contoured at 3.0σ) bound to monomer A in the ATAS-4 complex. Atoms are color-coded as follows: C = yellow (protein) or gray (4), O = red, N = blue, P = orange, S = yellow, Mg2+ ions = silver spheres, solvent molecules = red spheres. Metal coordination, hydrogen bond, and cation-π interactions are shown as red, black, and green dotted lines, respectively. Water molecule “w” is trapped in the active site along with 4. (b) Superposition of the ATAS-4 complex (color coded as in (a)) with the ATAS-FSPP complex (all atoms pale cyan).
Techniques Used:
farnesyl s thiolodiphosphate (Echelon Biosciences)


Structured Review
Farnesyl S Thiolodiphosphate, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/farnesyl s thiolodiphosphate/product/Echelon Biosciences
Average 94 stars, based on 1 article reviews
Price from $9.99 to $1999.99
Images
farnesyl s thiolodiphosphate (Echelon Biosciences)


Structured Review
Farnesyl S Thiolodiphosphate, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/farnesyl s thiolodiphosphate/product/Echelon Biosciences
Average 94 stars, based on 1 article reviews
Price from $9.99 to $1999.99