farnesyl s thiolodiphosphate fsdp  (Echelon Biosciences)


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    Echelon Biosciences farnesyl s thiolodiphosphate fsdp
    Farnesyl S Thiolodiphosphate Fsdp, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    farnesyl s thiolodiphosphate fsdp  (Echelon Biosciences)


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    Echelon Biosciences farnesyl s thiolodiphosphate fsdp
    Farnesyl S Thiolodiphosphate Fsdp, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    fspp  (Echelon Biosciences)


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    Echelon Biosciences fspp
    (A) Molecular structures of FPP and different FPP analogs including FPP analog 1/2/3/4, FOH, and <t>FSPP.</t> (B, C) Cytotoxic effects of different FPP analogs measured by PI signal increase under fluorescent microplate reader. Black arrows indicate the time points at which different metabolites were added. Each treatment had 3 to 4 replicates. Bars denote mean ± SEM (SEM in gray). Data are representative of at least 2 independent experiments in (B) and (C). There are no significant differences between 0 μg/mL and 15 μg/mL FPP treatments. Significant difference in 30 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 47 minutes on ( p < 0.05). Significant difference in 60 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 1 minute on ( p < 0.01). Significant difference in 120 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 1 minute on ( p < 0.001). Significant difference between 60 μg/mL FPP-Mu2 and the control shows up from 39 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu2 and the control shows up from 10 minutes on ( p < 0.01). Significant difference between 60 μg/mL FPP-Mu3 and the control shows up from 54 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu3 and the control shows up from 12 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu4 and the control shows up from 2.5 minutes on ( p < 0.01). Significant difference between 30 μg/mL FSPP and the control shows up from 43 minutes on ( p < 0.05). Significant difference between 60 μg/mL FSPP and the control shows up from 16 minutes on ( p < 0.05). Significant difference between 120 μg/mL FSPP and the control shows up from 10 minutes on ( p < 0.05). All the others show no significant difference ( p > 0.05). Two-way ANOVA analysis is used. All experiments are done with P815 cells. All the original data can be found in . FOH, farnesol; FPP, farnesyl pyrophosphate; FSPP, farnesyl S-thiolodiphosphate; PI, propidium iodide.
    Fspp, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    fspp - by Bioz Stars, 2023-02
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    1) Product Images from "Farnesyl pyrophosphate is a new danger signal inducing acute cell death"

    Article Title: Farnesyl pyrophosphate is a new danger signal inducing acute cell death

    Journal: PLoS Biology

    doi: 10.1371/journal.pbio.3001134

    (A) Molecular structures of FPP and different FPP analogs including FPP analog 1/2/3/4, FOH, and FSPP. (B, C) Cytotoxic effects of different FPP analogs measured by PI signal increase under fluorescent microplate reader. Black arrows indicate the time points at which different metabolites were added. Each treatment had 3 to 4 replicates. Bars denote mean ± SEM (SEM in gray). Data are representative of at least 2 independent experiments in (B) and (C). There are no significant differences between 0 μg/mL and 15 μg/mL FPP treatments. Significant difference in 30 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 47 minutes on ( p < 0.05). Significant difference in 60 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 1 minute on ( p < 0.01). Significant difference in 120 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 1 minute on ( p < 0.001). Significant difference between 60 μg/mL FPP-Mu2 and the control shows up from 39 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu2 and the control shows up from 10 minutes on ( p < 0.01). Significant difference between 60 μg/mL FPP-Mu3 and the control shows up from 54 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu3 and the control shows up from 12 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu4 and the control shows up from 2.5 minutes on ( p < 0.01). Significant difference between 30 μg/mL FSPP and the control shows up from 43 minutes on ( p < 0.05). Significant difference between 60 μg/mL FSPP and the control shows up from 16 minutes on ( p < 0.05). Significant difference between 120 μg/mL FSPP and the control shows up from 10 minutes on ( p < 0.05). All the others show no significant difference ( p > 0.05). Two-way ANOVA analysis is used. All experiments are done with P815 cells. All the original data can be found in . FOH, farnesol; FPP, farnesyl pyrophosphate; FSPP, farnesyl S-thiolodiphosphate; PI, propidium iodide.
    Figure Legend Snippet: (A) Molecular structures of FPP and different FPP analogs including FPP analog 1/2/3/4, FOH, and FSPP. (B, C) Cytotoxic effects of different FPP analogs measured by PI signal increase under fluorescent microplate reader. Black arrows indicate the time points at which different metabolites were added. Each treatment had 3 to 4 replicates. Bars denote mean ± SEM (SEM in gray). Data are representative of at least 2 independent experiments in (B) and (C). There are no significant differences between 0 μg/mL and 15 μg/mL FPP treatments. Significant difference in 30 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 47 minutes on ( p < 0.05). Significant difference in 60 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 1 minute on ( p < 0.01). Significant difference in 120 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 1 minute on ( p < 0.001). Significant difference between 60 μg/mL FPP-Mu2 and the control shows up from 39 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu2 and the control shows up from 10 minutes on ( p < 0.01). Significant difference between 60 μg/mL FPP-Mu3 and the control shows up from 54 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu3 and the control shows up from 12 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu4 and the control shows up from 2.5 minutes on ( p < 0.01). Significant difference between 30 μg/mL FSPP and the control shows up from 43 minutes on ( p < 0.05). Significant difference between 60 μg/mL FSPP and the control shows up from 16 minutes on ( p < 0.05). Significant difference between 120 μg/mL FSPP and the control shows up from 10 minutes on ( p < 0.05). All the others show no significant difference ( p > 0.05). Two-way ANOVA analysis is used. All experiments are done with P815 cells. All the original data can be found in . FOH, farnesol; FPP, farnesyl pyrophosphate; FSPP, farnesyl S-thiolodiphosphate; PI, propidium iodide.

    Techniques Used:

    farnesyl s thiolodiphosphate  (Echelon Biosciences)


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    Echelon Biosciences farnesyl s thiolodiphosphate
    Farnesyl S Thiolodiphosphate, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    farnesyl diphosphate 86 fpp  (Echelon Biosciences)


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    Echelon Biosciences farnesyl diphosphate 86 fpp
    Farnesyl Diphosphate 86 Fpp, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    farnesyl s thiolodiphosphate fspp  (Echelon Biosciences)


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    Echelon Biosciences farnesyl s thiolodiphosphate fspp
    Farnesyl S Thiolodiphosphate Fspp, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    standard farnesyl thiolodiphosphate  (Echelon Biosciences)


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    Echelon Biosciences standard farnesyl thiolodiphosphate
    Standard Farnesyl Thiolodiphosphate, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    farnesyl s thiolodiphosphate s fpp  (Echelon Biosciences)


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    Echelon Biosciences farnesyl s thiolodiphosphate s fpp
    Farnesyl S Thiolodiphosphate S Fpp, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    fspp  (Echelon Biosciences)


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    Echelon Biosciences fspp
    Structural comparison of <t>unliganded</t> <t>ATAS</t> (left) with the <t>ATAS-FSPP</t> complex (right) illustrating conformational changes triggered by the binding of FSPP and 3 Mg2+ ions in the active site. The aspartate-rich DDXXD metal-binding segment on helix D is red and the “NSE” metal-binding segment on helix H is orange. In the ATAS-FSPP complex, Mg2+ ions are magenta and FSPP is shown as a stick-figure. Selected secondary structure elements are labeled as discussed in the text.
    Fspp, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    1) Product Images from "Mechanistic Insights from the Binding of Substrate and Carbocation Intermediate Analogues to Aristolochene Synthase"

    Article Title: Mechanistic Insights from the Binding of Substrate and Carbocation Intermediate Analogues to Aristolochene Synthase

    Journal: Biochemistry

    doi: 10.1021/bi400691v

    Structural comparison of unliganded ATAS (left) with the ATAS-FSPP complex (right) illustrating conformational changes triggered by the binding of FSPP and 3 Mg2+ ions in the active site. The aspartate-rich DDXXD metal-binding segment on helix D is red and the “NSE” metal-binding segment on helix H is orange. In the ATAS-FSPP complex, Mg2+ ions are magenta and FSPP is shown as a stick-figure. Selected secondary structure elements are labeled as discussed in the text.
    Figure Legend Snippet: Structural comparison of unliganded ATAS (left) with the ATAS-FSPP complex (right) illustrating conformational changes triggered by the binding of FSPP and 3 Mg2+ ions in the active site. The aspartate-rich DDXXD metal-binding segment on helix D is red and the “NSE” metal-binding segment on helix H is orange. In the ATAS-FSPP complex, Mg2+ ions are magenta and FSPP is shown as a stick-figure. Selected secondary structure elements are labeled as discussed in the text.

    Techniques Used: Binding Assay, Labeling

    (a) Simulated annealing omit map of FSPP (contoured at 4.0σ) bound to monomer A in the ATAS-Mg2+3-FSPP complex. Atoms are color-coded as follows: C = yellow (protein) or gray (FSPP), O = red, N = blue, P = orange, S = yellow, Mg2+ ions = silver spheres, solvent molecules = red spheres. Metal coordination interactions are shown as red dotted lines; hydrogen bond interactions are shown as black dotted lines. Water molecule “w” is trapped in the active site along with FSPP. (b) Superposition of the ATAS-Mg2+3-FSPP complex (color-coded as in (a)) and the ATAS-Mg2+3-PPi complex (all atoms pale cyan).
    Figure Legend Snippet: (a) Simulated annealing omit map of FSPP (contoured at 4.0σ) bound to monomer A in the ATAS-Mg2+3-FSPP complex. Atoms are color-coded as follows: C = yellow (protein) or gray (FSPP), O = red, N = blue, P = orange, S = yellow, Mg2+ ions = silver spheres, solvent molecules = red spheres. Metal coordination interactions are shown as red dotted lines; hydrogen bond interactions are shown as black dotted lines. Water molecule “w” is trapped in the active site along with FSPP. (b) Superposition of the ATAS-Mg2+3-FSPP complex (color-coded as in (a)) and the ATAS-Mg2+3-PPi complex (all atoms pale cyan).

    Techniques Used:

    (a) Simulated annealing omit map of iminium cation 1 (contoured at 4.0σ) bound to monomer A in the ATAS-1 complex. Atoms are color-coded as follows: C = yellow (protein) or gray (1), O = red, N = blue, P = orange, S = yellow, Mg2+ ions = silver spheres, solvent molecules = red spheres. Metal coordination and hydrogen bond interactions are shown as red and black dotted lines, respectively. Water molecule “w” is trapped in the active site along with 1. (b) Superposition of the ATAS-1 complex (color-coded as in (a)) and the ATAS-FSPP complex (all atoms pale cyan).
    Figure Legend Snippet: (a) Simulated annealing omit map of iminium cation 1 (contoured at 4.0σ) bound to monomer A in the ATAS-1 complex. Atoms are color-coded as follows: C = yellow (protein) or gray (1), O = red, N = blue, P = orange, S = yellow, Mg2+ ions = silver spheres, solvent molecules = red spheres. Metal coordination and hydrogen bond interactions are shown as red and black dotted lines, respectively. Water molecule “w” is trapped in the active site along with 1. (b) Superposition of the ATAS-1 complex (color-coded as in (a)) and the ATAS-FSPP complex (all atoms pale cyan).

    Techniques Used:

    (a) Simulated annealing omit map of tertiary ammonium cation 3 (contoured at 3.5σ) bound to monomer B in the ATAS-3 complex. Atoms are color coded as follows: C = yellow (protein) or gray (3), O = red, N = blue, P = orange, S = yellow, Mg2+ ions = silver spheres, solvent molecules = red spheres. Metal coordination, hydrogen bond, and cation-π interactions are shown as red, black, and green dotted lines, respectively. Water molecules “w” and “ww” are trapped in the active site along with 3. (b) Superposition of the ATAS-3 complex (color coded as in (a)) with the ATAS-FSPP complex (all atoms pale cyan).
    Figure Legend Snippet: (a) Simulated annealing omit map of tertiary ammonium cation 3 (contoured at 3.5σ) bound to monomer B in the ATAS-3 complex. Atoms are color coded as follows: C = yellow (protein) or gray (3), O = red, N = blue, P = orange, S = yellow, Mg2+ ions = silver spheres, solvent molecules = red spheres. Metal coordination, hydrogen bond, and cation-π interactions are shown as red, black, and green dotted lines, respectively. Water molecules “w” and “ww” are trapped in the active site along with 3. (b) Superposition of the ATAS-3 complex (color coded as in (a)) with the ATAS-FSPP complex (all atoms pale cyan).

    Techniques Used:

    (a) Simulated annealing omit map of tertiary ammonium cation 4 (contoured at 3.0σ) bound to monomer A in the ATAS-4 complex. Atoms are color-coded as follows: C = yellow (protein) or gray (4), O = red, N = blue, P = orange, S = yellow, Mg2+ ions = silver spheres, solvent molecules = red spheres. Metal coordination, hydrogen bond, and cation-π interactions are shown as red, black, and green dotted lines, respectively. Water molecule “w” is trapped in the active site along with 4. (b) Superposition of the ATAS-4 complex (color coded as in (a)) with the ATAS-FSPP complex (all atoms pale cyan).
    Figure Legend Snippet: (a) Simulated annealing omit map of tertiary ammonium cation 4 (contoured at 3.0σ) bound to monomer A in the ATAS-4 complex. Atoms are color-coded as follows: C = yellow (protein) or gray (4), O = red, N = blue, P = orange, S = yellow, Mg2+ ions = silver spheres, solvent molecules = red spheres. Metal coordination, hydrogen bond, and cation-π interactions are shown as red, black, and green dotted lines, respectively. Water molecule “w” is trapped in the active site along with 4. (b) Superposition of the ATAS-4 complex (color coded as in (a)) with the ATAS-FSPP complex (all atoms pale cyan).

    Techniques Used:

    farnesyl s thiolodiphosphate  (Echelon Biosciences)


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    Echelon Biosciences farnesyl s thiolodiphosphate
    Farnesyl S Thiolodiphosphate, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    farnesyl s thiolodiphosphate  (Echelon Biosciences)


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    Echelon Biosciences farnesyl s thiolodiphosphate
    Farnesyl S Thiolodiphosphate, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Echelon Biosciences farnesyl s thiolodiphosphate fsdp
    Farnesyl S Thiolodiphosphate Fsdp, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Echelon Biosciences fspp
    (A) Molecular structures of FPP and different FPP analogs including FPP analog 1/2/3/4, FOH, and <t>FSPP.</t> (B, C) Cytotoxic effects of different FPP analogs measured by PI signal increase under fluorescent microplate reader. Black arrows indicate the time points at which different metabolites were added. Each treatment had 3 to 4 replicates. Bars denote mean ± SEM (SEM in gray). Data are representative of at least 2 independent experiments in (B) and (C). There are no significant differences between 0 μg/mL and 15 μg/mL FPP treatments. Significant difference in 30 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 47 minutes on ( p < 0.05). Significant difference in 60 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 1 minute on ( p < 0.01). Significant difference in 120 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 1 minute on ( p < 0.001). Significant difference between 60 μg/mL FPP-Mu2 and the control shows up from 39 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu2 and the control shows up from 10 minutes on ( p < 0.01). Significant difference between 60 μg/mL FPP-Mu3 and the control shows up from 54 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu3 and the control shows up from 12 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu4 and the control shows up from 2.5 minutes on ( p < 0.01). Significant difference between 30 μg/mL FSPP and the control shows up from 43 minutes on ( p < 0.05). Significant difference between 60 μg/mL FSPP and the control shows up from 16 minutes on ( p < 0.05). Significant difference between 120 μg/mL FSPP and the control shows up from 10 minutes on ( p < 0.05). All the others show no significant difference ( p > 0.05). Two-way ANOVA analysis is used. All experiments are done with P815 cells. All the original data can be found in . FOH, farnesol; FPP, farnesyl pyrophosphate; FSPP, farnesyl S-thiolodiphosphate; PI, propidium iodide.
    Fspp, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Echelon Biosciences farnesyl s thiolodiphosphate
    (A) Molecular structures of FPP and different FPP analogs including FPP analog 1/2/3/4, FOH, and <t>FSPP.</t> (B, C) Cytotoxic effects of different FPP analogs measured by PI signal increase under fluorescent microplate reader. Black arrows indicate the time points at which different metabolites were added. Each treatment had 3 to 4 replicates. Bars denote mean ± SEM (SEM in gray). Data are representative of at least 2 independent experiments in (B) and (C). There are no significant differences between 0 μg/mL and 15 μg/mL FPP treatments. Significant difference in 30 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 47 minutes on ( p < 0.05). Significant difference in 60 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 1 minute on ( p < 0.01). Significant difference in 120 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 1 minute on ( p < 0.001). Significant difference between 60 μg/mL FPP-Mu2 and the control shows up from 39 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu2 and the control shows up from 10 minutes on ( p < 0.01). Significant difference between 60 μg/mL FPP-Mu3 and the control shows up from 54 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu3 and the control shows up from 12 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu4 and the control shows up from 2.5 minutes on ( p < 0.01). Significant difference between 30 μg/mL FSPP and the control shows up from 43 minutes on ( p < 0.05). Significant difference between 60 μg/mL FSPP and the control shows up from 16 minutes on ( p < 0.05). Significant difference between 120 μg/mL FSPP and the control shows up from 10 minutes on ( p < 0.05). All the others show no significant difference ( p > 0.05). Two-way ANOVA analysis is used. All experiments are done with P815 cells. All the original data can be found in . FOH, farnesol; FPP, farnesyl pyrophosphate; FSPP, farnesyl S-thiolodiphosphate; PI, propidium iodide.
    Farnesyl S Thiolodiphosphate, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Echelon Biosciences farnesyl diphosphate 86 fpp
    (A) Molecular structures of FPP and different FPP analogs including FPP analog 1/2/3/4, FOH, and <t>FSPP.</t> (B, C) Cytotoxic effects of different FPP analogs measured by PI signal increase under fluorescent microplate reader. Black arrows indicate the time points at which different metabolites were added. Each treatment had 3 to 4 replicates. Bars denote mean ± SEM (SEM in gray). Data are representative of at least 2 independent experiments in (B) and (C). There are no significant differences between 0 μg/mL and 15 μg/mL FPP treatments. Significant difference in 30 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 47 minutes on ( p < 0.05). Significant difference in 60 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 1 minute on ( p < 0.01). Significant difference in 120 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 1 minute on ( p < 0.001). Significant difference between 60 μg/mL FPP-Mu2 and the control shows up from 39 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu2 and the control shows up from 10 minutes on ( p < 0.01). Significant difference between 60 μg/mL FPP-Mu3 and the control shows up from 54 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu3 and the control shows up from 12 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu4 and the control shows up from 2.5 minutes on ( p < 0.01). Significant difference between 30 μg/mL FSPP and the control shows up from 43 minutes on ( p < 0.05). Significant difference between 60 μg/mL FSPP and the control shows up from 16 minutes on ( p < 0.05). Significant difference between 120 μg/mL FSPP and the control shows up from 10 minutes on ( p < 0.05). All the others show no significant difference ( p > 0.05). Two-way ANOVA analysis is used. All experiments are done with P815 cells. All the original data can be found in . FOH, farnesol; FPP, farnesyl pyrophosphate; FSPP, farnesyl S-thiolodiphosphate; PI, propidium iodide.
    Farnesyl Diphosphate 86 Fpp, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/farnesyl diphosphate 86 fpp/product/Echelon Biosciences
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    Echelon Biosciences farnesyl s thiolodiphosphate fspp
    (A) Molecular structures of FPP and different FPP analogs including FPP analog 1/2/3/4, FOH, and <t>FSPP.</t> (B, C) Cytotoxic effects of different FPP analogs measured by PI signal increase under fluorescent microplate reader. Black arrows indicate the time points at which different metabolites were added. Each treatment had 3 to 4 replicates. Bars denote mean ± SEM (SEM in gray). Data are representative of at least 2 independent experiments in (B) and (C). There are no significant differences between 0 μg/mL and 15 μg/mL FPP treatments. Significant difference in 30 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 47 minutes on ( p < 0.05). Significant difference in 60 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 1 minute on ( p < 0.01). Significant difference in 120 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 1 minute on ( p < 0.001). Significant difference between 60 μg/mL FPP-Mu2 and the control shows up from 39 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu2 and the control shows up from 10 minutes on ( p < 0.01). Significant difference between 60 μg/mL FPP-Mu3 and the control shows up from 54 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu3 and the control shows up from 12 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu4 and the control shows up from 2.5 minutes on ( p < 0.01). Significant difference between 30 μg/mL FSPP and the control shows up from 43 minutes on ( p < 0.05). Significant difference between 60 μg/mL FSPP and the control shows up from 16 minutes on ( p < 0.05). Significant difference between 120 μg/mL FSPP and the control shows up from 10 minutes on ( p < 0.05). All the others show no significant difference ( p > 0.05). Two-way ANOVA analysis is used. All experiments are done with P815 cells. All the original data can be found in . FOH, farnesol; FPP, farnesyl pyrophosphate; FSPP, farnesyl S-thiolodiphosphate; PI, propidium iodide.
    Farnesyl S Thiolodiphosphate Fspp, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/farnesyl s thiolodiphosphate fspp/product/Echelon Biosciences
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    Echelon Biosciences standard farnesyl thiolodiphosphate
    (A) Molecular structures of FPP and different FPP analogs including FPP analog 1/2/3/4, FOH, and <t>FSPP.</t> (B, C) Cytotoxic effects of different FPP analogs measured by PI signal increase under fluorescent microplate reader. Black arrows indicate the time points at which different metabolites were added. Each treatment had 3 to 4 replicates. Bars denote mean ± SEM (SEM in gray). Data are representative of at least 2 independent experiments in (B) and (C). There are no significant differences between 0 μg/mL and 15 μg/mL FPP treatments. Significant difference in 30 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 47 minutes on ( p < 0.05). Significant difference in 60 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 1 minute on ( p < 0.01). Significant difference in 120 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 1 minute on ( p < 0.001). Significant difference between 60 μg/mL FPP-Mu2 and the control shows up from 39 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu2 and the control shows up from 10 minutes on ( p < 0.01). Significant difference between 60 μg/mL FPP-Mu3 and the control shows up from 54 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu3 and the control shows up from 12 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu4 and the control shows up from 2.5 minutes on ( p < 0.01). Significant difference between 30 μg/mL FSPP and the control shows up from 43 minutes on ( p < 0.05). Significant difference between 60 μg/mL FSPP and the control shows up from 16 minutes on ( p < 0.05). Significant difference between 120 μg/mL FSPP and the control shows up from 10 minutes on ( p < 0.05). All the others show no significant difference ( p > 0.05). Two-way ANOVA analysis is used. All experiments are done with P815 cells. All the original data can be found in . FOH, farnesol; FPP, farnesyl pyrophosphate; FSPP, farnesyl S-thiolodiphosphate; PI, propidium iodide.
    Standard Farnesyl Thiolodiphosphate, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Echelon Biosciences farnesyl s thiolodiphosphate s fpp
    (A) Molecular structures of FPP and different FPP analogs including FPP analog 1/2/3/4, FOH, and <t>FSPP.</t> (B, C) Cytotoxic effects of different FPP analogs measured by PI signal increase under fluorescent microplate reader. Black arrows indicate the time points at which different metabolites were added. Each treatment had 3 to 4 replicates. Bars denote mean ± SEM (SEM in gray). Data are representative of at least 2 independent experiments in (B) and (C). There are no significant differences between 0 μg/mL and 15 μg/mL FPP treatments. Significant difference in 30 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 47 minutes on ( p < 0.05). Significant difference in 60 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 1 minute on ( p < 0.01). Significant difference in 120 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 1 minute on ( p < 0.001). Significant difference between 60 μg/mL FPP-Mu2 and the control shows up from 39 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu2 and the control shows up from 10 minutes on ( p < 0.01). Significant difference between 60 μg/mL FPP-Mu3 and the control shows up from 54 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu3 and the control shows up from 12 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu4 and the control shows up from 2.5 minutes on ( p < 0.01). Significant difference between 30 μg/mL FSPP and the control shows up from 43 minutes on ( p < 0.05). Significant difference between 60 μg/mL FSPP and the control shows up from 16 minutes on ( p < 0.05). Significant difference between 120 μg/mL FSPP and the control shows up from 10 minutes on ( p < 0.05). All the others show no significant difference ( p > 0.05). Two-way ANOVA analysis is used. All experiments are done with P815 cells. All the original data can be found in . FOH, farnesol; FPP, farnesyl pyrophosphate; FSPP, farnesyl S-thiolodiphosphate; PI, propidium iodide.
    Farnesyl S Thiolodiphosphate S Fpp, supplied by Echelon Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    (A) Molecular structures of FPP and different FPP analogs including FPP analog 1/2/3/4, FOH, and FSPP. (B, C) Cytotoxic effects of different FPP analogs measured by PI signal increase under fluorescent microplate reader. Black arrows indicate the time points at which different metabolites were added. Each treatment had 3 to 4 replicates. Bars denote mean ± SEM (SEM in gray). Data are representative of at least 2 independent experiments in (B) and (C). There are no significant differences between 0 μg/mL and 15 μg/mL FPP treatments. Significant difference in 30 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 47 minutes on ( p < 0.05). Significant difference in 60 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 1 minute on ( p < 0.01). Significant difference in 120 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 1 minute on ( p < 0.001). Significant difference between 60 μg/mL FPP-Mu2 and the control shows up from 39 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu2 and the control shows up from 10 minutes on ( p < 0.01). Significant difference between 60 μg/mL FPP-Mu3 and the control shows up from 54 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu3 and the control shows up from 12 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu4 and the control shows up from 2.5 minutes on ( p < 0.01). Significant difference between 30 μg/mL FSPP and the control shows up from 43 minutes on ( p < 0.05). Significant difference between 60 μg/mL FSPP and the control shows up from 16 minutes on ( p < 0.05). Significant difference between 120 μg/mL FSPP and the control shows up from 10 minutes on ( p < 0.05). All the others show no significant difference ( p > 0.05). Two-way ANOVA analysis is used. All experiments are done with P815 cells. All the original data can be found in . FOH, farnesol; FPP, farnesyl pyrophosphate; FSPP, farnesyl S-thiolodiphosphate; PI, propidium iodide.

    Journal: PLoS Biology

    Article Title: Farnesyl pyrophosphate is a new danger signal inducing acute cell death

    doi: 10.1371/journal.pbio.3001134

    Figure Lengend Snippet: (A) Molecular structures of FPP and different FPP analogs including FPP analog 1/2/3/4, FOH, and FSPP. (B, C) Cytotoxic effects of different FPP analogs measured by PI signal increase under fluorescent microplate reader. Black arrows indicate the time points at which different metabolites were added. Each treatment had 3 to 4 replicates. Bars denote mean ± SEM (SEM in gray). Data are representative of at least 2 independent experiments in (B) and (C). There are no significant differences between 0 μg/mL and 15 μg/mL FPP treatments. Significant difference in 30 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 47 minutes on ( p < 0.05). Significant difference in 60 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 1 minute on ( p < 0.01). Significant difference in 120 μg/mL FPP group compared to the 0 μg/mL FPP group shows up from 1 minute on ( p < 0.001). Significant difference between 60 μg/mL FPP-Mu2 and the control shows up from 39 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu2 and the control shows up from 10 minutes on ( p < 0.01). Significant difference between 60 μg/mL FPP-Mu3 and the control shows up from 54 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu3 and the control shows up from 12 minutes on ( p < 0.05). Significant difference between 120 μg/mL FPP-Mu4 and the control shows up from 2.5 minutes on ( p < 0.01). Significant difference between 30 μg/mL FSPP and the control shows up from 43 minutes on ( p < 0.05). Significant difference between 60 μg/mL FSPP and the control shows up from 16 minutes on ( p < 0.05). Significant difference between 120 μg/mL FSPP and the control shows up from 10 minutes on ( p < 0.05). All the others show no significant difference ( p > 0.05). Two-way ANOVA analysis is used. All experiments are done with P815 cells. All the original data can be found in . FOH, farnesol; FPP, farnesyl pyrophosphate; FSPP, farnesyl S-thiolodiphosphate; PI, propidium iodide.

    Article Snippet: FPP analogs FOH was purchased from Sigma (#F203) and FSPP from Echelon Bioscience (Salt Lake City, USA, #I-S150).

    Techniques: