humanized immunoglobulin ig g1 monoclonal antibody  (Genentech inc)

Journal: Frontiers in Immunology

Article Title: Precision medicine: The use of tailored therapy in primary immunodeficiencies

doi: 10.3389/fimmu.2022.1029560

Figure Lengend Snippet: Targeted treatments used in primary immunodeficiency (PID).

Article Snippet: Ustekinumab , Human immunoglobulin (Ig) G1 kappa monoclonal antibody , IL-12 and IL-23 (p40 subunit) , Binds to the p40 subunit common to IL-12 and IL-23 and prevents their interaction with the IL-12 receptor β1 subunit of the IL-12 and IL-23 receptor complexes, neutralizing human IL-12- and IL-23-mediated cell signaling, activation and cytokine production. , LAD CGD-colitis , FDA*♦ and EMA♦ ♦( IBD phenotypes ≤55 kg:260 mg 55-85Kg: 390 mg >85 mg: 520 mg).

Techniques: Activity Assay, Transduction, Recombinant, Inhibition, Binding Assay, Blocking Assay, Produced, Activation Assay, Derivative Assay, Lysis