human recombinant vegf a (PeproTech)
96
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Name:
Recombinant Human VEGF B
Description:
VEGF B a member of the VEGF family is a potent growth and angiogenic cytokine It promotes DNA synthesis in endothelial cells helps regulate angiogenesis and vascular permeability and inhibits apoptosis in certain smooth muscle cells and neurons VEGF B is expressed in all tissues except the liver It forms cell surfaced associated disulfide linked homodimers and can form heterodimers with VEGF A There are two known isoforms formed by alternative splicing which have been designated VEGF B167 and VEGF B186 Both forms have identical amino terminal sequences encoding a cysteine knot like structural motif but differ in their carboxyl terminal domains Both VEGF B isoforms signal only through the VEGFR1 receptor Recombinant human VEGF B is a 38 0 kDa disulfide linked homodimeric protein consisting of two 167 amino acid polypeptide chains
Catalog Number:
100-20B-100UG
Price:
780.00
Category:
Recombinant Proteins
Source:
E.coli
Purity:
98.0
Quantity:
100UG
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Buy from Supplier |
Structured Review
PeproTech
human recombinant vegf a
VEGF B a member of the VEGF family is a potent growth and angiogenic cytokine It promotes DNA synthesis in endothelial cells helps regulate angiogenesis and vascular permeability and inhibits apoptosis in certain smooth muscle cells and neurons VEGF B is expressed in all tissues except the liver It forms cell surfaced associated disulfide linked homodimers and can form heterodimers with VEGF A There are two known isoforms formed by alternative splicing which have been designated VEGF B167 and VEGF B186 Both forms have identical amino terminal sequences encoding a cysteine knot like structural motif but differ in their carboxyl terminal domains Both VEGF B isoforms signal only through the VEGFR1 receptor Recombinant human VEGF B is a 38 0 kDa disulfide linked homodimeric protein consisting of two 167 amino acid polypeptide chains
https://www.bioz.com/result/human recombinant vegf a/product/PeproTech
Average 96 stars, based on 1 article reviews
Price from $9.99 to $1999.99
VEGF B a member of the VEGF family is a potent growth and angiogenic cytokine It promotes DNA synthesis in endothelial cells helps regulate angiogenesis and vascular permeability and inhibits apoptosis in certain smooth muscle cells and neurons VEGF B is expressed in all tissues except the liver It forms cell surfaced associated disulfide linked homodimers and can form heterodimers with VEGF A There are two known isoforms formed by alternative splicing which have been designated VEGF B167 and VEGF B186 Both forms have identical amino terminal sequences encoding a cysteine knot like structural motif but differ in their carboxyl terminal domains Both VEGF B isoforms signal only through the VEGFR1 receptor Recombinant human VEGF B is a 38 0 kDa disulfide linked homodimeric protein consisting of two 167 amino acid polypeptide chains
https://www.bioz.com/result/human recombinant vegf a/product/PeproTech
Average 96 stars, based on 1 article reviews
Price from $9.99 to $1999.99
human recombinant vegf a - by Bioz Stars,
2021-04
96/100 stars
Images
1) Product Images from "Does bevacizumab impact anti-EGFR therapy efficacy in metastatic colorectal cancer?"
Article Title: Does bevacizumab impact anti-EGFR therapy efficacy in metastatic colorectal cancer?
Journal: Oncotarget
doi: 10.18632/oncotarget.7008
Figure Legend Snippet: VEGFR2/Stat-3 pathway is involved in VEGF-A-induced resistance to anti-EGFR therapy ( A ) Western blot analysis performed on SW48 colon cancer cell line. Cells were stimulated with human recombinant VEGF-A (5 ng/mL) and with or without axitinib or STA-21 during 24 hours. Cetuximab was added the following day for 24 hours. α-tubulin was used as loading control (Co: Control). ( B ) Cell proliferation analyzed by crystal violet staining. Colon cancer cell lines were incubated or not with human recombinant VEGF-A (5 ng/mL) and STA-21 (10 μM) or axitinib (500 pM) were concomitantly added. Cetuximab (500μg/mL) was added the following day in culture medium and cell death was analyzed 7 days later. (* p
Techniques Used: Western Blot, Recombinant, Staining, Incubation
Figure Legend Snippet: VEGF-A is increased in patients’ serum during anti-VEGF therapy VEGF-A serum level from mCRC patients ( n = 26) treated with FOLFOX/bevacizumab chemotherapy protocol red lines) compared to patients ( n = 12) treated with chemotherapy alone (blue lines). Assays were performed before and 15 days after bevacizumab injection and analyzed by ELISA. (* p
Techniques Used: Injection, Enzyme-linked Immunosorbent Assay
Figure Legend Snippet: VEGF-A can inhibit cetuximab cytoxicity in vitro ( A ) Western Blot analysis showing VEGFR1, VEGFR2 and EGFR expression. HCS-70 was used as loading control and as a reference for EGFR quantification (a.u: arbitrary unit). ( B ) Cell proliferation analyzed by crystal violet staining. SW48, Caco-2 and Colo320 colon cancer cell lines were incubated or not with increasing dose of human recombinant VEGF-A (0,5 or 5 ng/mL). Cetuximab (500 μg/mL) was added the following day in culture medium and cell death was analyzed 7 days later. ( C ) Annexin V/7AAD staining. Cells were incubated with VEGF-A 5 ng/mL. Cetuximab 500 μg/mL was added the following day. Cell death was evaluated 24 hours after cetuximab was added, AnnexinV positive cells are in black boxes, double positive cells are in white boxes (* p
Techniques Used: In Vitro, Western Blot, Expressing, Staining, Incubation, Recombinant
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