Journal: Frontiers in Immunology

Article Title: Precision medicine: The use of tailored therapy in primary immunodeficiencies

doi: 10.3389/fimmu.2022.1029560

Figure Lengend Snippet: Targeted treatments used in primary immunodeficiency (PID).

Article Snippet: Ustekinumab , Human immunoglobulin (Ig) G1 kappa monoclonal antibody , IL-12 and IL-23 (p40 subunit) , Binds to the p40 subunit common to IL-12 and IL-23 and prevents their interaction with the IL-12 receptor β1 subunit of the IL-12 and IL-23 receptor complexes, neutralizing human IL-12- and IL-23-mediated cell signaling, activation and cytokine production. , LAD CGD-colitis , FDA*♦ and EMA♦ ♦( IBD phenotypes ≤55 kg:260 mg 55-85Kg: 390 mg >85 mg: 520 mg).

Techniques: Activity Assay, Transduction, Recombinant, Inhibition, Binding Assay, Blocking Assay, Produced, Activation Assay, Derivative Assay, Lysis

Journal: Cancers

Article Title: FDA-Approved Drugs for Hematological Malignancies—The Last Decade Review

doi: 10.3390/cancers14010087

Figure Lengend Snippet: Features of the monoclonal antibody drugs approved by the Food and Drug Administration (FDA) from 2011 to 2021. The order of drugs is tabulated in order of most recent to oldest registration date.

Article Snippet: 9 , Daratumumab , DARZALEX Janssen Biotech, Inc., Horsham, PA, USA , FDA: 16 November 2015 EMA: 20 May 2016 , Humanized immunoglobulin G1 kappa (IgG1 κ) monoclonal antibody , CD38 3 , Intravenous , Multiple Myeloma , Infusion-related reactions, lymphopenia, neutropenia, thrombocytopenia, anemia , [ , ] .

Techniques: Infection