Journal: Scientific Reports

Article Title: The study of tryptophol containing emulgel on fungal reduction and skin irritation

doi: 10.1038/s41598-023-46121-z

Figure Lengend Snippet: Cell viability ( a ) and cytotoxicity ( b ) of TOH-treated human foreskin fibroblasts (HFF- 1) cells at 37 °C as determined by MTT, Mitogreen, LDH, and dual AO/EB staining assays. Percentages of cell viability and cytotoxicity were shown as mean ± SD. *P < 0.05 and ****P < 0.0001 indicate significant differences compared with the control group (concentration 0). TOH Tryptophol, VOZ voriconazole.

Article Snippet: Human foreskin fibroblasts (HFF-1) cell line (ATCC #SCRC-1041™) was used to investigate cell viability and cytotoxicity after TOH treatments.

Techniques: Staining, Concentration Assay

Journal: bioRxiv

Article Title: Pyrimidine salvage in Toxoplasma gondii as a target for new treatment

doi: 10.1101/2023.11.01.565095

Figure Lengend Snippet: Effect of known anti-toxoplasma agents (A) and pyrimidine analogues (B) on intracellular tachyzoites and on uninfected HFF cells (C). Data were plotted to a log[Inhibitor] vs response sigmoid model with variable slope (A, B) or an equation for two-site competition (C) in Prims 9 to determine EC 50 values. The curves are single experiments, representative of at least 2 (pyrimethamine) or 3 (all other compounds) independent, identically-performed experiments.

Article Snippet: T. gondii tachyzoites were cultured in human foreskin fibroblasts (HFF), sourced from ATCC (SCRC-1041).

Techniques: Analogues

Journal: bioRxiv

Article Title: Pyrimidine salvage in Toxoplasma gondii as a target for new treatment

doi: 10.1101/2023.11.01.565095

Figure Lengend Snippet:

Article Snippet: T. gondii tachyzoites were cultured in human foreskin fibroblasts (HFF), sourced from ATCC (SCRC-1041).

Techniques: In Vitro