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Millipore herg k channel blocker
Herg K Channel Blocker, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Cayman Chemical herg channel blocker
hiPSC-CM electrophysiology data was collected (4 vs 10 days post-defrost) at baseline and after exposure to a <t>hERG</t> channel <t>blocker</t> <t>(E-4031),</t> calcium channel blocker (nifedipine), or beta-adrenergic agonist (isoproterenol). A) Percent change in the spontaneous beating rate, normalized to baseline measurement (repeated-measures) after 15-minute drug treatment. B) Representative traces of spontaneous beating after drug treatment. C-E) Percent change in the field potential duration, spike amplitude, and conduction velocity (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031 which slowed the intrinsic rate; 3 Hz for nifedipine and isoproterenol which increased the intrinsic rate). F-H) Percent change in the action potential duration at 30%, 50%, and 90% repolarization (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031; 2 Hz for nifedipine and isoproterenol). Measurements are shown as a Tukey box-and-whisker plot. Unpaired Student’s t-test, two tailed. *p<0.05, **p<0.01, ****p<0.0001. Number of replicates indicated.
Herg Channel Blocker, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/herg channel blocker/product/Cayman Chemical
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Images

1) Product Images from "hiPSC-CM Electrophysiology: Impact of Temporal Changes and Study Parameters on Experimental Reproducibility"

Article Title: hiPSC-CM Electrophysiology: Impact of Temporal Changes and Study Parameters on Experimental Reproducibility

Journal: bioRxiv

doi: 10.1101/2023.10.02.560475

hiPSC-CM electrophysiology data was collected (4 vs 10 days post-defrost) at baseline and after exposure to a hERG channel blocker (E-4031), calcium channel blocker (nifedipine), or beta-adrenergic agonist (isoproterenol). A) Percent change in the spontaneous beating rate, normalized to baseline measurement (repeated-measures) after 15-minute drug treatment. B) Representative traces of spontaneous beating after drug treatment. C-E) Percent change in the field potential duration, spike amplitude, and conduction velocity (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031 which slowed the intrinsic rate; 3 Hz for nifedipine and isoproterenol which increased the intrinsic rate). F-H) Percent change in the action potential duration at 30%, 50%, and 90% repolarization (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031; 2 Hz for nifedipine and isoproterenol). Measurements are shown as a Tukey box-and-whisker plot. Unpaired Student’s t-test, two tailed. *p<0.05, **p<0.01, ****p<0.0001. Number of replicates indicated.
Figure Legend Snippet: hiPSC-CM electrophysiology data was collected (4 vs 10 days post-defrost) at baseline and after exposure to a hERG channel blocker (E-4031), calcium channel blocker (nifedipine), or beta-adrenergic agonist (isoproterenol). A) Percent change in the spontaneous beating rate, normalized to baseline measurement (repeated-measures) after 15-minute drug treatment. B) Representative traces of spontaneous beating after drug treatment. C-E) Percent change in the field potential duration, spike amplitude, and conduction velocity (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031 which slowed the intrinsic rate; 3 Hz for nifedipine and isoproterenol which increased the intrinsic rate). F-H) Percent change in the action potential duration at 30%, 50%, and 90% repolarization (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031; 2 Hz for nifedipine and isoproterenol). Measurements are shown as a Tukey box-and-whisker plot. Unpaired Student’s t-test, two tailed. *p<0.05, **p<0.01, ****p<0.0001. Number of replicates indicated.

Techniques Used: Whisker Assay, Two Tailed Test


Structured Review

OChem Inc herg channel blocker prediction models
Herg Channel Blocker Prediction Models, supplied by OChem Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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FUJIFILM selective herg k channel blocker
Selective Herg K Channel Blocker, supplied by FUJIFILM, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Millipore herg channel blocker
Herg Channel Blocker, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Abcam herg channel blocker e 4031
Herg Channel Blocker E 4031, supplied by Abcam, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Herg Channel Blocker E 4031, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Herg K Channel Blockers, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/herg k channel blockers/product/Millipore
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Millipore herg k channel blockers
Characterization of cardiomyocytes-derived from human pluripotent stem cells (hPSC-CMs). (A) Schematic diagram of hPSC differentiation into cardiomyocytes. (B) The morphology of differentiated hPSC-CMs derived from two hPSC cell lines (hESCs: H9 and hiPSCs: CMC-11; 10 × magnification). (C) The RT-qPCR was performed to measure the expression of cardiac sarcomeric markers, cTnT, and MYH6 genes, in hPSC-CMs. The data represent the mean (±SD) of at least two independent experiments performed in triplicate. Statistical analyses were determined using paired student's t -tests, and P < 0.05 was considered as significant (*). (D) Expression of TNNT2 and ACTN2 in hPSC-CMs (hESC-CMs [upper panel] and hiPSC-CMs [lower panel]) at day 15 of differentiation were determined by flow cytometry and immunofluorescence analyses. Scale bar, 100 μm. (E) Beating cardiomyocytes were prepared for action potential (AP) recording using the patch-clamp technique in hESC-CMs and field potential (FP) recording using a multielectrode array (MEA) system in hiPSC-CMs. The hPSC-CMs were treated with 100 <t>nM</t> <t>isoprenaline</t> (β 2 -adrenergic receptor agonist), 0.3 μM and 1 μM nifedipine (L-type Ca 2+ channel blocker), and 10 nM dofetilide and 30 nM E4031 (hERG K + channel blockers).
Herg K Channel Blockers, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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herg k channel blockers - by Bioz Stars, 2024-07
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Images

1) Product Images from "Antiviral activity and safety of remdesivir against SARS-CoV-2 infection in human pluripotent stem cell-derived cardiomyocytes"

Article Title: Antiviral activity and safety of remdesivir against SARS-CoV-2 infection in human pluripotent stem cell-derived cardiomyocytes

Journal: Antiviral Research

doi: 10.1016/j.antiviral.2020.104955

Characterization of cardiomyocytes-derived from human pluripotent stem cells (hPSC-CMs). (A) Schematic diagram of hPSC differentiation into cardiomyocytes. (B) The morphology of differentiated hPSC-CMs derived from two hPSC cell lines (hESCs: H9 and hiPSCs: CMC-11; 10 × magnification). (C) The RT-qPCR was performed to measure the expression of cardiac sarcomeric markers, cTnT, and MYH6 genes, in hPSC-CMs. The data represent the mean (±SD) of at least two independent experiments performed in triplicate. Statistical analyses were determined using paired student's t -tests, and P < 0.05 was considered as significant (*). (D) Expression of TNNT2 and ACTN2 in hPSC-CMs (hESC-CMs [upper panel] and hiPSC-CMs [lower panel]) at day 15 of differentiation were determined by flow cytometry and immunofluorescence analyses. Scale bar, 100 μm. (E) Beating cardiomyocytes were prepared for action potential (AP) recording using the patch-clamp technique in hESC-CMs and field potential (FP) recording using a multielectrode array (MEA) system in hiPSC-CMs. The hPSC-CMs were treated with 100 nM isoprenaline (β 2 -adrenergic receptor agonist), 0.3 μM and 1 μM nifedipine (L-type Ca 2+ channel blocker), and 10 nM dofetilide and 30 nM E4031 (hERG K + channel blockers).
Figure Legend Snippet: Characterization of cardiomyocytes-derived from human pluripotent stem cells (hPSC-CMs). (A) Schematic diagram of hPSC differentiation into cardiomyocytes. (B) The morphology of differentiated hPSC-CMs derived from two hPSC cell lines (hESCs: H9 and hiPSCs: CMC-11; 10 × magnification). (C) The RT-qPCR was performed to measure the expression of cardiac sarcomeric markers, cTnT, and MYH6 genes, in hPSC-CMs. The data represent the mean (±SD) of at least two independent experiments performed in triplicate. Statistical analyses were determined using paired student's t -tests, and P < 0.05 was considered as significant (*). (D) Expression of TNNT2 and ACTN2 in hPSC-CMs (hESC-CMs [upper panel] and hiPSC-CMs [lower panel]) at day 15 of differentiation were determined by flow cytometry and immunofluorescence analyses. Scale bar, 100 μm. (E) Beating cardiomyocytes were prepared for action potential (AP) recording using the patch-clamp technique in hESC-CMs and field potential (FP) recording using a multielectrode array (MEA) system in hiPSC-CMs. The hPSC-CMs were treated with 100 nM isoprenaline (β 2 -adrenergic receptor agonist), 0.3 μM and 1 μM nifedipine (L-type Ca 2+ channel blocker), and 10 nM dofetilide and 30 nM E4031 (hERG K + channel blockers).

Techniques Used: Derivative Assay, Quantitative RT-PCR, Expressing, Flow Cytometry, Immunofluorescence, Patch Clamp


Structured Review

iCell Gene Therapeutics herg channel blocker
MEA based safety testing of drugs without cardiac indication using human induced pluripotent stem cell cardiomyocyte (hiPSC-CM).
Herg Channel Blocker, supplied by iCell Gene Therapeutics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/herg channel blocker/product/iCell Gene Therapeutics
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herg channel blocker - by Bioz Stars, 2024-07
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1) Product Images from "hiPSCs Derived Cardiac Cells for Drug and Toxicity Screening and Disease Modeling: What Micro- Electrode-Array Analyses Can Tell Us"

Article Title: hiPSCs Derived Cardiac Cells for Drug and Toxicity Screening and Disease Modeling: What Micro- Electrode-Array Analyses Can Tell Us

Journal: Cells

doi: 10.3390/cells8111331

MEA based safety testing of drugs without cardiac indication using human induced pluripotent stem cell cardiomyocyte (hiPSC-CM).
Figure Legend Snippet: MEA based safety testing of drugs without cardiac indication using human induced pluripotent stem cell cardiomyocyte (hiPSC-CM).

Techniques Used: Blocking Assay, Activity Assay, Patch Clamp, Derivative Assay

MEA based safety testing of drugs with cardiac indication using  hiPSC-CM.
Figure Legend Snippet: MEA based safety testing of drugs with cardiac indication using hiPSC-CM.

Techniques Used: Blocking Assay, Patch Clamp, Microelectrode Array

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    Millipore herg k channel blocker
    Herg K Channel Blocker, supplied by Millipore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    hiPSC-CM electrophysiology data was collected (4 vs 10 days post-defrost) at baseline and after exposure to a <t>hERG</t> channel <t>blocker</t> <t>(E-4031),</t> calcium channel blocker (nifedipine), or beta-adrenergic agonist (isoproterenol). A) Percent change in the spontaneous beating rate, normalized to baseline measurement (repeated-measures) after 15-minute drug treatment. B) Representative traces of spontaneous beating after drug treatment. C-E) Percent change in the field potential duration, spike amplitude, and conduction velocity (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031 which slowed the intrinsic rate; 3 Hz for nifedipine and isoproterenol which increased the intrinsic rate). F-H) Percent change in the action potential duration at 30%, 50%, and 90% repolarization (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031; 2 Hz for nifedipine and isoproterenol). Measurements are shown as a Tukey box-and-whisker plot. Unpaired Student’s t-test, two tailed. *p<0.05, **p<0.01, ****p<0.0001. Number of replicates indicated.
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    hiPSC-CM electrophysiology data was collected (4 vs 10 days post-defrost) at baseline and after exposure to a <t>hERG</t> channel <t>blocker</t> <t>(E-4031),</t> calcium channel blocker (nifedipine), or beta-adrenergic agonist (isoproterenol). A) Percent change in the spontaneous beating rate, normalized to baseline measurement (repeated-measures) after 15-minute drug treatment. B) Representative traces of spontaneous beating after drug treatment. C-E) Percent change in the field potential duration, spike amplitude, and conduction velocity (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031 which slowed the intrinsic rate; 3 Hz for nifedipine and isoproterenol which increased the intrinsic rate). F-H) Percent change in the action potential duration at 30%, 50%, and 90% repolarization (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031; 2 Hz for nifedipine and isoproterenol). Measurements are shown as a Tukey box-and-whisker plot. Unpaired Student’s t-test, two tailed. *p<0.05, **p<0.01, ****p<0.0001. Number of replicates indicated.
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    hiPSC-CM electrophysiology data was collected (4 vs 10 days post-defrost) at baseline and after exposure to a <t>hERG</t> channel <t>blocker</t> <t>(E-4031),</t> calcium channel blocker (nifedipine), or beta-adrenergic agonist (isoproterenol). A) Percent change in the spontaneous beating rate, normalized to baseline measurement (repeated-measures) after 15-minute drug treatment. B) Representative traces of spontaneous beating after drug treatment. C-E) Percent change in the field potential duration, spike amplitude, and conduction velocity (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031 which slowed the intrinsic rate; 3 Hz for nifedipine and isoproterenol which increased the intrinsic rate). F-H) Percent change in the action potential duration at 30%, 50%, and 90% repolarization (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031; 2 Hz for nifedipine and isoproterenol). Measurements are shown as a Tukey box-and-whisker plot. Unpaired Student’s t-test, two tailed. *p<0.05, **p<0.01, ****p<0.0001. Number of replicates indicated.
    Selective Herg K Channel Blocker, supplied by FUJIFILM, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    hiPSC-CM electrophysiology data was collected (4 vs 10 days post-defrost) at baseline and after exposure to a <t>hERG</t> channel <t>blocker</t> <t>(E-4031),</t> calcium channel blocker (nifedipine), or beta-adrenergic agonist (isoproterenol). A) Percent change in the spontaneous beating rate, normalized to baseline measurement (repeated-measures) after 15-minute drug treatment. B) Representative traces of spontaneous beating after drug treatment. C-E) Percent change in the field potential duration, spike amplitude, and conduction velocity (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031 which slowed the intrinsic rate; 3 Hz for nifedipine and isoproterenol which increased the intrinsic rate). F-H) Percent change in the action potential duration at 30%, 50%, and 90% repolarization (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031; 2 Hz for nifedipine and isoproterenol). Measurements are shown as a Tukey box-and-whisker plot. Unpaired Student’s t-test, two tailed. *p<0.05, **p<0.01, ****p<0.0001. Number of replicates indicated.
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    hiPSC-CM electrophysiology data was collected (4 vs 10 days post-defrost) at baseline and after exposure to a <t>hERG</t> channel <t>blocker</t> <t>(E-4031),</t> calcium channel blocker (nifedipine), or beta-adrenergic agonist (isoproterenol). A) Percent change in the spontaneous beating rate, normalized to baseline measurement (repeated-measures) after 15-minute drug treatment. B) Representative traces of spontaneous beating after drug treatment. C-E) Percent change in the field potential duration, spike amplitude, and conduction velocity (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031 which slowed the intrinsic rate; 3 Hz for nifedipine and isoproterenol which increased the intrinsic rate). F-H) Percent change in the action potential duration at 30%, 50%, and 90% repolarization (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031; 2 Hz for nifedipine and isoproterenol). Measurements are shown as a Tukey box-and-whisker plot. Unpaired Student’s t-test, two tailed. *p<0.05, **p<0.01, ****p<0.0001. Number of replicates indicated.
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    hiPSC-CM electrophysiology data was collected (4 vs 10 days post-defrost) at baseline and after exposure to a <t>hERG</t> channel <t>blocker</t> <t>(E-4031),</t> calcium channel blocker (nifedipine), or beta-adrenergic agonist (isoproterenol). A) Percent change in the spontaneous beating rate, normalized to baseline measurement (repeated-measures) after 15-minute drug treatment. B) Representative traces of spontaneous beating after drug treatment. C-E) Percent change in the field potential duration, spike amplitude, and conduction velocity (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031 which slowed the intrinsic rate; 3 Hz for nifedipine and isoproterenol which increased the intrinsic rate). F-H) Percent change in the action potential duration at 30%, 50%, and 90% repolarization (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031; 2 Hz for nifedipine and isoproterenol). Measurements are shown as a Tukey box-and-whisker plot. Unpaired Student’s t-test, two tailed. *p<0.05, **p<0.01, ****p<0.0001. Number of replicates indicated.
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    MEA based safety testing of drugs without cardiac indication using human induced pluripotent stem cell cardiomyocyte (hiPSC-CM).
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    Image Search Results


    hiPSC-CM electrophysiology data was collected (4 vs 10 days post-defrost) at baseline and after exposure to a hERG channel blocker (E-4031), calcium channel blocker (nifedipine), or beta-adrenergic agonist (isoproterenol). A) Percent change in the spontaneous beating rate, normalized to baseline measurement (repeated-measures) after 15-minute drug treatment. B) Representative traces of spontaneous beating after drug treatment. C-E) Percent change in the field potential duration, spike amplitude, and conduction velocity (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031 which slowed the intrinsic rate; 3 Hz for nifedipine and isoproterenol which increased the intrinsic rate). F-H) Percent change in the action potential duration at 30%, 50%, and 90% repolarization (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031; 2 Hz for nifedipine and isoproterenol). Measurements are shown as a Tukey box-and-whisker plot. Unpaired Student’s t-test, two tailed. *p<0.05, **p<0.01, ****p<0.0001. Number of replicates indicated.

    Journal: bioRxiv

    Article Title: hiPSC-CM Electrophysiology: Impact of Temporal Changes and Study Parameters on Experimental Reproducibility

    doi: 10.1101/2023.10.02.560475

    Figure Lengend Snippet: hiPSC-CM electrophysiology data was collected (4 vs 10 days post-defrost) at baseline and after exposure to a hERG channel blocker (E-4031), calcium channel blocker (nifedipine), or beta-adrenergic agonist (isoproterenol). A) Percent change in the spontaneous beating rate, normalized to baseline measurement (repeated-measures) after 15-minute drug treatment. B) Representative traces of spontaneous beating after drug treatment. C-E) Percent change in the field potential duration, spike amplitude, and conduction velocity (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031 which slowed the intrinsic rate; 3 Hz for nifedipine and isoproterenol which increased the intrinsic rate). F-H) Percent change in the action potential duration at 30%, 50%, and 90% repolarization (normalized to baseline measurement) after 15-minute drug treatment. hiPSC-CMs were externally paced to normalize the beating rate (1.5 Hz for E-4031; 2 Hz for nifedipine and isoproterenol). Measurements are shown as a Tukey box-and-whisker plot. Unpaired Student’s t-test, two tailed. *p<0.05, **p<0.01, ****p<0.0001. Number of replicates indicated.

    Article Snippet: A hERG channel blocker (50 nM E-4031, #15203 Cayman Chemical) was tested for its ability to prolong FPD and APD( , , ).

    Techniques: Whisker Assay, Two Tailed Test

    MEA based safety testing of drugs without cardiac indication using human induced pluripotent stem cell cardiomyocyte (hiPSC-CM).

    Journal: Cells

    Article Title: hiPSCs Derived Cardiac Cells for Drug and Toxicity Screening and Disease Modeling: What Micro- Electrode-Array Analyses Can Tell Us

    doi: 10.3390/cells8111331

    Figure Lengend Snippet: MEA based safety testing of drugs without cardiac indication using human induced pluripotent stem cell cardiomyocyte (hiPSC-CM).

    Article Snippet: Alfuzosin , Treatment of benign prostatic enlargement, a hERG-channel blocker , Clinical QT prolongation , 30 nM , hiPSC-CM iCell™ (mixture of ventricular, atrial, nodal cells) , n/a , 32 days of differentiation +15–26 days , MEA , [ , ] .

    Techniques: Blocking Assay, Activity Assay, Patch Clamp, Derivative Assay

    MEA based safety testing of drugs with cardiac indication using  hiPSC-CM.

    Journal: Cells

    Article Title: hiPSCs Derived Cardiac Cells for Drug and Toxicity Screening and Disease Modeling: What Micro- Electrode-Array Analyses Can Tell Us

    doi: 10.3390/cells8111331

    Figure Lengend Snippet: MEA based safety testing of drugs with cardiac indication using hiPSC-CM.

    Article Snippet: Alfuzosin , Treatment of benign prostatic enlargement, a hERG-channel blocker , Clinical QT prolongation , 30 nM , hiPSC-CM iCell™ (mixture of ventricular, atrial, nodal cells) , n/a , 32 days of differentiation +15–26 days , MEA , [ , ] .

    Techniques: Blocking Assay, Patch Clamp, Microelectrode Array