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Mimetics heparin mimetics
Heparin Mimetics, supplied by Mimetics, used in various techniques. Bioz Stars score: 91/100, based on 79 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/heparin mimetics/product/Mimetics
Average 91 stars, based on 79 article reviews
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heparin mimetics - by Bioz Stars, 2020-09
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Nuclear Magnetic Resonance:

Article Title: Heparin Mimetics: Their Therapeutic Potential
Article Snippet: .. Detailed structural studies of heparin/GAG-protein interactions using NMR spectroscopy, X-ray crystallography and molecular modelling techniques have greatly aided the design of heparin mimetics. .. However, to be effective the conditions of these in vitro binding studies should mirror, as much as possible, the conditions likely to be encountered in vivo, as the tissue microenvironment pH and cation composition may contribute to the strength of mimetic binding and position on the protein where the mimetic binds.

Binding Assay:

Article Title: Heparin Mimetics: Their Therapeutic Potential
Article Snippet: .. Heparin mimetics have potential as anti-cancer agents due to their ability to: (1) inhibit heparanase, an endoglycosidase which facilitates the spread of tumor cells; and (2) inhibit angiogenesis by binding to growth factors. ..

other:

Article Title: A novel fibroblast growth factor-1 ligand with reduced heparin binding protects the heart against ischemia-reperfusion injury in the presence of heparin co-administration
Article Snippet: Saxena K, Schieborr U, Anderka O, Duchardt-Ferner E, Elshorst B, Gande SL, Janzon J, Kudlinzki D, Sreeramulu S, Dreyer MK, Wendt KU, Herbert C, Duchaussoy P, Bianciotto M, Driguez PA, Lassalle G, Savi P, Mohammadi M, Bono F, Schwalbe H. Influence of heparin mimetics on assembly of the fgf.Fgfr4 signaling complex .

Spectroscopy:

Article Title: Heparin Mimetics: Their Therapeutic Potential
Article Snippet: .. Detailed structural studies of heparin/GAG-protein interactions using NMR spectroscopy, X-ray crystallography and molecular modelling techniques have greatly aided the design of heparin mimetics. .. However, to be effective the conditions of these in vitro binding studies should mirror, as much as possible, the conditions likely to be encountered in vivo, as the tissue microenvironment pH and cation composition may contribute to the strength of mimetic binding and position on the protein where the mimetic binds.

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  • 91
    Mimetics heparan sulfate mimetics
    Enzymatic removal of liver <t>heparan</t> sulfate releases PCSK9 and ablates its activity. a , b Infusion of heparinase I prior to the injection of PCSK9 (10 µg) completely inhibits PCSK9-induced degradation of LDLR. Western blot of representative samples is shown in a and quantification of LDLR in b (control n = 7, PCSK9 n = 6, heparinase n = 5, heparinase/PCSK9 n = 5). Heparinase treatment unmasks the antigenicity of the major liver HSPG syndecan-1 ( middle panel ). Beta-actin is used as loading control ( lower panel ). c Heparinase I treatment leads to an increase in plasma PCSK9 as measured by ELISA 15 min after injection (control n = 6, heparinase n = 6). d Western blot (representative samples) of liver syndecan-1 is used as control of heparinase injection. Beta-actin is shown as loading control. e – h Transgenic mice with constitutive expression of human heparanase ( Hpa -tg) ( n = 7) have increased plasma PCSK9 ( e ), increased liver LDLR ( f , g ), and reduced plasma cholesterol ( h ) compared to control WT mice ( n = 6). Bar graphs show mean with s.e.m. error bars. Statistical significance was evaluated using a two-tailed Student’s t -test. Supplementary Fig. 11 shows uncropped gel images
    Heparan Sulfate Mimetics, supplied by Mimetics, used in various techniques. Bioz Stars score: 91/100, based on 18 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/heparan sulfate mimetics/product/Mimetics
    Average 91 stars, based on 18 article reviews
    Price from $9.99 to $1999.99
    heparan sulfate mimetics - by Bioz Stars, 2020-09
    91/100 stars
      Buy from Supplier

    85
    Mimetics tunable heparan sulfate mimetics
    Schematic representation of the major disaccharide unit of Nodipecten nodosus <t>heparan</t> sulfate.
    Tunable Heparan Sulfate Mimetics, supplied by Mimetics, used in various techniques. Bioz Stars score: 85/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/tunable heparan sulfate mimetics/product/Mimetics
    Average 85 stars, based on 4 article reviews
    Price from $9.99 to $1999.99
    tunable heparan sulfate mimetics - by Bioz Stars, 2020-09
    85/100 stars
      Buy from Supplier

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    Enzymatic removal of liver heparan sulfate releases PCSK9 and ablates its activity. a , b Infusion of heparinase I prior to the injection of PCSK9 (10 µg) completely inhibits PCSK9-induced degradation of LDLR. Western blot of representative samples is shown in a and quantification of LDLR in b (control n = 7, PCSK9 n = 6, heparinase n = 5, heparinase/PCSK9 n = 5). Heparinase treatment unmasks the antigenicity of the major liver HSPG syndecan-1 ( middle panel ). Beta-actin is used as loading control ( lower panel ). c Heparinase I treatment leads to an increase in plasma PCSK9 as measured by ELISA 15 min after injection (control n = 6, heparinase n = 6). d Western blot (representative samples) of liver syndecan-1 is used as control of heparinase injection. Beta-actin is shown as loading control. e – h Transgenic mice with constitutive expression of human heparanase ( Hpa -tg) ( n = 7) have increased plasma PCSK9 ( e ), increased liver LDLR ( f , g ), and reduced plasma cholesterol ( h ) compared to control WT mice ( n = 6). Bar graphs show mean with s.e.m. error bars. Statistical significance was evaluated using a two-tailed Student’s t -test. Supplementary Fig. 11 shows uncropped gel images

    Journal: Nature Communications

    Article Title: Heparan sulfate proteoglycans present PCSK9 to the LDL receptor

    doi: 10.1038/s41467-017-00568-7

    Figure Lengend Snippet: Enzymatic removal of liver heparan sulfate releases PCSK9 and ablates its activity. a , b Infusion of heparinase I prior to the injection of PCSK9 (10 µg) completely inhibits PCSK9-induced degradation of LDLR. Western blot of representative samples is shown in a and quantification of LDLR in b (control n = 7, PCSK9 n = 6, heparinase n = 5, heparinase/PCSK9 n = 5). Heparinase treatment unmasks the antigenicity of the major liver HSPG syndecan-1 ( middle panel ). Beta-actin is used as loading control ( lower panel ). c Heparinase I treatment leads to an increase in plasma PCSK9 as measured by ELISA 15 min after injection (control n = 6, heparinase n = 6). d Western blot (representative samples) of liver syndecan-1 is used as control of heparinase injection. Beta-actin is shown as loading control. e – h Transgenic mice with constitutive expression of human heparanase ( Hpa -tg) ( n = 7) have increased plasma PCSK9 ( e ), increased liver LDLR ( f , g ), and reduced plasma cholesterol ( h ) compared to control WT mice ( n = 6). Bar graphs show mean with s.e.m. error bars. Statistical significance was evaluated using a two-tailed Student’s t -test. Supplementary Fig. 11 shows uncropped gel images

    Article Snippet: Our findings provide new insights into LDL biology and show that targeting PCSK9 using heparan sulfate mimetics is a potential therapeutic strategy in coronary artery disease.

    Techniques: Activity Assay, Injection, Western Blot, Enzyme-linked Immunosorbent Assay, Transgenic Assay, Mouse Assay, Expressing, Two Tailed Test

    Kinetics of mobilization of WBC, c-Kit + Lin - Sca + (KLS) hematopoietic cells and of concentrations of plasma VEGF or SDF-1 after injection of heparan sulfate mimetics. (A) Structure of the synthetic oligosaccharide mimetics of heparan sulfate EP80006 (n=1, hexa-saccharide) and EP80031 (n=2, octosaccharide). (B) Left panel: WBC concentrations in peripheral blood (PB) of C57Bl/6 mice 30 min, 1, 3 and 5 h after intravenous injection at a dose of 15 mg/kg of EP80006 and EP80031. Fifty microliters of blood were collected and peripheral blood leukocytes were counted. Data are expressed as number of cells/μL of blood (mean ± SEM, n=6, * P

    Journal: Haematologica

    Article Title: Heparan sulfate mimetics can efficiently mobilize long-term hematopoietic stem cells

    doi: 10.3324/haematol.2011.047662

    Figure Lengend Snippet: Kinetics of mobilization of WBC, c-Kit + Lin - Sca + (KLS) hematopoietic cells and of concentrations of plasma VEGF or SDF-1 after injection of heparan sulfate mimetics. (A) Structure of the synthetic oligosaccharide mimetics of heparan sulfate EP80006 (n=1, hexa-saccharide) and EP80031 (n=2, octosaccharide). (B) Left panel: WBC concentrations in peripheral blood (PB) of C57Bl/6 mice 30 min, 1, 3 and 5 h after intravenous injection at a dose of 15 mg/kg of EP80006 and EP80031. Fifty microliters of blood were collected and peripheral blood leukocytes were counted. Data are expressed as number of cells/μL of blood (mean ± SEM, n=6, * P

    Article Snippet: Heparan sulfate proteoglycans are composed of multiple forms of heparan sulfate and play a key role in the interaction between hematopoietic stem and/or progenitor cells and humoral components of the BM ECM., Exogeneous heparan sulfate could mobilize HSC, probably through titration of heparanases, endonucleases that cleave heparan sulfates, , as heparanase down-regulation is associated with HSC expansion and mobilization., In this study, we analyzed the effects of a new class of oligosaccharides, heparan sulfate mimetics, on HSC mobilization in peripheral blood.

    Techniques: Injection, Mouse Assay

    Schematic representation of the major disaccharide unit of Nodipecten nodosus heparan sulfate.

    Journal: Molecules

    Article Title: Heparan Sulfate Mimetics in Cancer Therapy: The Challenge to Define Structural Determinants and the Relevance of Targets for Optimal Activity

    doi: 10.3390/molecules23112915

    Figure Lengend Snippet: Schematic representation of the major disaccharide unit of Nodipecten nodosus heparan sulfate.

    Article Snippet: Tunable heparan sulfate mimetics for modulating chemokine activity.

    Techniques:

    Chemical structure of the synthetic heparan sulfate mimetic TD4-143-1 ( a ). Schematic representation of the synthetic heparan sulfate mimetics OTR4120 and OTR4131 ( b ).

    Journal: Molecules

    Article Title: Heparan Sulfate Mimetics in Cancer Therapy: The Challenge to Define Structural Determinants and the Relevance of Targets for Optimal Activity

    doi: 10.3390/molecules23112915

    Figure Lengend Snippet: Chemical structure of the synthetic heparan sulfate mimetic TD4-143-1 ( a ). Schematic representation of the synthetic heparan sulfate mimetics OTR4120 and OTR4131 ( b ).

    Article Snippet: Tunable heparan sulfate mimetics for modulating chemokine activity.

    Techniques: