gyki 53655  (Alomone Labs)


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    Structured Review

    Alomone Labs gyki 53655
    Different glutamate receptors mediate activation of glycinergic amacrine cells. A, Feedback IPSCs were reduced by the non-NMDAR antagonist NBQX (25 μM). B, Feedback IPSC also were reduced by the NMDAR antagonist CPP (10 μM) and eliminated by co-application with NBQX (25 μm). C, Feedback IPSCs were reduced by application of the AMPAR antagonist <t>GYKI</t> <t>53655</t> (50 μm); co-application of CPP reduced the IPSC further, but a small component remained. D, The Ca2+-permeable AMPARs antagonist philanthotoxin (PhTx) did not reduce IPSCs, but CPP and NBQX eliminated them. D, Summarized drug effects (mean ± SD) on IPSCs; ND: experiment not done. Experiments were performed in the presence of GABAR antagonists (SR95531 and TPMPA) and DHT.
    Gyki 53655, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/gyki 53655/product/Alomone Labs
    Average 85 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    gyki 53655 - by Bioz Stars, 2023-03
    85/100 stars

    Images

    1) Product Images from "DIVERSE MECHANISMS UNDERLIE GLYCINERGIC FEEDBACK TRANSMISSION ONTO ROD BIPOLAR CELLS IN RAT RETINA"

    Article Title: DIVERSE MECHANISMS UNDERLIE GLYCINERGIC FEEDBACK TRANSMISSION ONTO ROD BIPOLAR CELLS IN RAT RETINA

    Journal:

    doi: 10.1523/JNEUROSCI.0784-08.2008

    Different glutamate receptors mediate activation of glycinergic amacrine cells. A, Feedback IPSCs were reduced by the non-NMDAR antagonist NBQX (25 μM). B, Feedback IPSC also were reduced by the NMDAR antagonist CPP (10 μM) and eliminated by co-application with NBQX (25 μm). C, Feedback IPSCs were reduced by application of the AMPAR antagonist GYKI 53655 (50 μm); co-application of CPP reduced the IPSC further, but a small component remained. D, The Ca2+-permeable AMPARs antagonist philanthotoxin (PhTx) did not reduce IPSCs, but CPP and NBQX eliminated them. D, Summarized drug effects (mean ± SD) on IPSCs; ND: experiment not done. Experiments were performed in the presence of GABAR antagonists (SR95531 and TPMPA) and DHT.
    Figure Legend Snippet: Different glutamate receptors mediate activation of glycinergic amacrine cells. A, Feedback IPSCs were reduced by the non-NMDAR antagonist NBQX (25 μM). B, Feedback IPSC also were reduced by the NMDAR antagonist CPP (10 μM) and eliminated by co-application with NBQX (25 μm). C, Feedback IPSCs were reduced by application of the AMPAR antagonist GYKI 53655 (50 μm); co-application of CPP reduced the IPSC further, but a small component remained. D, The Ca2+-permeable AMPARs antagonist philanthotoxin (PhTx) did not reduce IPSCs, but CPP and NBQX eliminated them. D, Summarized drug effects (mean ± SD) on IPSCs; ND: experiment not done. Experiments were performed in the presence of GABAR antagonists (SR95531 and TPMPA) and DHT.

    Techniques Used: Activation Assay

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    Alomone Labs gyki 53655
    Different glutamate receptors mediate activation of glycinergic amacrine cells. A, Feedback IPSCs were reduced by the non-NMDAR antagonist NBQX (25 μM). B, Feedback IPSC also were reduced by the NMDAR antagonist CPP (10 μM) and eliminated by co-application with NBQX (25 μm). C, Feedback IPSCs were reduced by application of the AMPAR antagonist <t>GYKI</t> <t>53655</t> (50 μm); co-application of CPP reduced the IPSC further, but a small component remained. D, The Ca2+-permeable AMPARs antagonist philanthotoxin (PhTx) did not reduce IPSCs, but CPP and NBQX eliminated them. D, Summarized drug effects (mean ± SD) on IPSCs; ND: experiment not done. Experiments were performed in the presence of GABAR antagonists (SR95531 and TPMPA) and DHT.
    Gyki 53655, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/gyki 53655/product/Alomone Labs
    Average 85 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    gyki 53655 - by Bioz Stars, 2023-03
    85/100 stars
    		  Buy from Supplier

    Image Search Results


    Different glutamate receptors mediate activation of glycinergic amacrine cells. A, Feedback IPSCs were reduced by the non-NMDAR antagonist NBQX (25 μM). B, Feedback IPSC also were reduced by the NMDAR antagonist CPP (10 μM) and eliminated by co-application with NBQX (25 μm). C, Feedback IPSCs were reduced by application of the AMPAR antagonist GYKI 53655 (50 μm); co-application of CPP reduced the IPSC further, but a small component remained. D, The Ca2+-permeable AMPARs antagonist philanthotoxin (PhTx) did not reduce IPSCs, but CPP and NBQX eliminated them. D, Summarized drug effects (mean ± SD) on IPSCs; ND: experiment not done. Experiments were performed in the presence of GABAR antagonists (SR95531 and TPMPA) and DHT.

    Journal:

    Article Title: DIVERSE MECHANISMS UNDERLIE GLYCINERGIC FEEDBACK TRANSMISSION ONTO ROD BIPOLAR CELLS IN RAT RETINA

    doi: 10.1523/JNEUROSCI.0784-08.2008

    Figure Lengend Snippet: Different glutamate receptors mediate activation of glycinergic amacrine cells. A, Feedback IPSCs were reduced by the non-NMDAR antagonist NBQX (25 μM). B, Feedback IPSC also were reduced by the NMDAR antagonist CPP (10 μM) and eliminated by co-application with NBQX (25 μm). C, Feedback IPSCs were reduced by application of the AMPAR antagonist GYKI 53655 (50 μm); co-application of CPP reduced the IPSC further, but a small component remained. D, The Ca2+-permeable AMPARs antagonist philanthotoxin (PhTx) did not reduce IPSCs, but CPP and NBQX eliminated them. D, Summarized drug effects (mean ± SD) on IPSCs; ND: experiment not done. Experiments were performed in the presence of GABAR antagonists (SR95531 and TPMPA) and DHT.

    Article Snippet: Reagents were obtained from Sigma (St. Louis, MO) or Tocris (Ballwin, MO), except TTX (Alomone Labs, Israel), Alexa-488 (Molecular Probes, Eugene, USA), and GYKI 53655 (a gift from Dr. John Isaac).

    Techniques: Activation Assay