genechip exon 1 0  (Thermo Fisher)


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    Name:
    GeneChip Human Gene 2 0 ST Array
    Description:
    The GeneChip Human Gene 2 0 ST Array provides the most accurate sensitive and comprehensive measurement of protein coding and long intergenic non coding RNA transcripts Comprehensive design Keeping pace with the research community s understanding of the transcriptome we have designed whole transcript arrays that include probes to measure both messenger mRNA and long intergenic non coding RNA transcripts lincRNA These whole transcript array designs provide a complete expression profile of mRNA as well as the intermediary lincRNA transcripts that impact the mRNA expression profile Research over the past 20 years has predominantly focused on protein coding messenger RNA transcripts and their role in cellular processes such as disease and development Recently researchers have identified more that 10 000 transcripts 200 bases with little or no protein coding potential Only a small fraction of these non coding RNAs has functional annotations to date However there is ample evidence that differential expression of lincRNAs plays an important role in the genesis and progression of disease and that aberrant expression of these molecules have also been linked to cancer Recent advancements in transcriptome profiling provided evidence of the association of lincRNAs in a diverse range of cellular functions • Regulation of mRNA transcription • Regulation of mRNA post transcriptional modifications • Occlusion recruitment of transcription factor binding • Activation and transportation of transcription factors • Interaction with accessory proteins • Guide protein complexes to locations in the genome Key benefits • Comprehensive coverage provides the best opportunity to discover interesting biology • 30 000 coding transcripts • 11 000 long intergenic non coding transcripts • Measure alternative splicing events transcript variants with probes designed to maximize exon coverage • Reproducible Intra lot correlation coefficient 0 99 Content profile Since the design of the Human Gene 1 0 ST Array there have been a massive number of new lincRNA that have been identified by the research community In order to provide the research community with a tool that can measure the differential expression of this exciting class of RNA transcripts we have designed the Human Gene 2 0 ST Array To supplement the lincRNA data contained in RefSeq we used sequences and transcripts from lncRNA db www lncrnadb com and Broad Institute Human Body Map lincRNAs and TUCP transcripts of uncertain coding potential catalog lincRNAs
    Catalog Number:
    902112
    Price:
    None
    Applications:
    DNA & RNA Microarray Analysis|Microarray Analysis
    Category:
    Microarrays PCR Arrays
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    Structured Review

    Thermo Fisher genechip exon 1 0
    Expression levels of the ERG gene. Right: Institute of Cancer Research: expression data from exons 4 to 11 of the ERG gene from 27 cancers determined in the current study using <t>GeneChip</t> Human Exon 1.0 ST arrays. Samples were designated as ERG rearrangement-positive
    The GeneChip Human Gene 2 0 ST Array provides the most accurate sensitive and comprehensive measurement of protein coding and long intergenic non coding RNA transcripts Comprehensive design Keeping pace with the research community s understanding of the transcriptome we have designed whole transcript arrays that include probes to measure both messenger mRNA and long intergenic non coding RNA transcripts lincRNA These whole transcript array designs provide a complete expression profile of mRNA as well as the intermediary lincRNA transcripts that impact the mRNA expression profile Research over the past 20 years has predominantly focused on protein coding messenger RNA transcripts and their role in cellular processes such as disease and development Recently researchers have identified more that 10 000 transcripts 200 bases with little or no protein coding potential Only a small fraction of these non coding RNAs has functional annotations to date However there is ample evidence that differential expression of lincRNAs plays an important role in the genesis and progression of disease and that aberrant expression of these molecules have also been linked to cancer Recent advancements in transcriptome profiling provided evidence of the association of lincRNAs in a diverse range of cellular functions • Regulation of mRNA transcription • Regulation of mRNA post transcriptional modifications • Occlusion recruitment of transcription factor binding • Activation and transportation of transcription factors • Interaction with accessory proteins • Guide protein complexes to locations in the genome Key benefits • Comprehensive coverage provides the best opportunity to discover interesting biology • 30 000 coding transcripts • 11 000 long intergenic non coding transcripts • Measure alternative splicing events transcript variants with probes designed to maximize exon coverage • Reproducible Intra lot correlation coefficient 0 99 Content profile Since the design of the Human Gene 1 0 ST Array there have been a massive number of new lincRNA that have been identified by the research community In order to provide the research community with a tool that can measure the differential expression of this exciting class of RNA transcripts we have designed the Human Gene 2 0 ST Array To supplement the lincRNA data contained in RefSeq we used sequences and transcripts from lncRNA db www lncrnadb com and Broad Institute Human Body Map lincRNAs and TUCP transcripts of uncertain coding potential catalog lincRNAs
    https://www.bioz.com/result/genechip exon 1 0/product/Thermo Fisher
    Average 93 stars, based on 3 article reviews
    Price from $9.99 to $1999.99
    genechip exon 1 0 - by Bioz Stars, 2020-08
    93/100 stars

    Images

    1) Product Images from "Detection of TMPRSS2-ERG Translocations in Human Prostate Cancer by Expression Profiling Using GeneChip Human Exon 1.0 ST Arrays"

    Article Title: Detection of TMPRSS2-ERG Translocations in Human Prostate Cancer by Expression Profiling Using GeneChip Human Exon 1.0 ST Arrays

    Journal: The Journal of Molecular Diagnostics : JMD

    doi: 10.2353/jmoldx.2008.070085

    Expression levels of the ERG gene. Right: Institute of Cancer Research: expression data from exons 4 to 11 of the ERG gene from 27 cancers determined in the current study using GeneChip Human Exon 1.0 ST arrays. Samples were designated as ERG rearrangement-positive
    Figure Legend Snippet: Expression levels of the ERG gene. Right: Institute of Cancer Research: expression data from exons 4 to 11 of the ERG gene from 27 cancers determined in the current study using GeneChip Human Exon 1.0 ST arrays. Samples were designated as ERG rearrangement-positive

    Techniques Used: Expressing

    Expression data for ERG exons 2 to 11 in prostate cancers determined using GeneChip Human Exon 1.0 ST arrays. Cancers scored as having altered ERG expression profiles based on the statistical analyses presented in are marked with an asterisk .
    Figure Legend Snippet: Expression data for ERG exons 2 to 11 in prostate cancers determined using GeneChip Human Exon 1.0 ST arrays. Cancers scored as having altered ERG expression profiles based on the statistical analyses presented in are marked with an asterisk .

    Techniques Used: Expressing

    Related Articles

    Amplification:

    Article Title: Genome-wide analysis of PDX1 target genes in human pancreatic progenitors
    Article Snippet: .. Amplified cDNA was hybridized on GeneChip™ Human Gene 2.0 ST arrays (Affymetrix, 902113). ..

    Labeling:

    Article Title: Mitotic vulnerability in triple-negative breast cancer associated with LIN9 is targetable with BET inhibitors
    Article Snippet: .. For each sample, 150 ng RNA was used to synthesize and label cDNA with biotin for hybridization to Human Gene 2.0 ST expression microarrays using the GeneChip WT Plus labeling kit and protocol, and the hybridized arrays were automatically stained and scanned with the Affymetrix standard stain and scan protocol. .. The microarray data were processed with RMA (robust multichip average algorithm) as implemented in Bioconductor package oligo ( ) where background subtraction, quantile normalization and summarization (via median-polish) was accomplished.

    Microarray:

    Article Title: Comprehensive Identification of Host Modulators of HIV-1 Replication using Multiple Orthologous RNAi Reagents
    Article Snippet: .. Microarray analysis (Affymetrix GeneChip human 2.0 ST array) was used to determine the levels of gene expression in the MAGI cells. .. The values for the probe set in the microarray were matched to the genes present in the siRNA libraries based on searching several identifiers.

    Article Title: ANXA10 induction by interaction with tumor‐associated macrophages promotes the growth of esophageal squamous cell carcinoma
    Article Snippet: .. A cDNA microarray was performed using the GeneChip Human Gene 2.0 ST Array (Affymetrix, Santa Clara, CA, USA), containing 53617 probes characterized human genes and expressed sequence tags. .. A company (Filgen, Nagoya, Japan) conducted the DNA microarray analysis.

    Generated:

    Article Title: Medulloblastoma subgroups remain stable across primary and metastatic compartments
    Article Snippet: .. Whole genome expression was generated using the Affymetrix GeneChip Human Gene 2.0 ST Array. .. Samples were normalized using RMA as part of the R/Bioconductor oligo package (version 1.26.6) [ ].

    Expressing:

    Article Title: Comprehensive Identification of Host Modulators of HIV-1 Replication using Multiple Orthologous RNAi Reagents
    Article Snippet: .. Microarray analysis (Affymetrix GeneChip human 2.0 ST array) was used to determine the levels of gene expression in the MAGI cells. .. The values for the probe set in the microarray were matched to the genes present in the siRNA libraries based on searching several identifiers.

    Article Title: Medulloblastoma subgroups remain stable across primary and metastatic compartments
    Article Snippet: .. Whole genome expression was generated using the Affymetrix GeneChip Human Gene 2.0 ST Array. .. Samples were normalized using RMA as part of the R/Bioconductor oligo package (version 1.26.6) [ ].

    Article Title: Mitotic vulnerability in triple-negative breast cancer associated with LIN9 is targetable with BET inhibitors
    Article Snippet: .. For each sample, 150 ng RNA was used to synthesize and label cDNA with biotin for hybridization to Human Gene 2.0 ST expression microarrays using the GeneChip WT Plus labeling kit and protocol, and the hybridized arrays were automatically stained and scanned with the Affymetrix standard stain and scan protocol. .. The microarray data were processed with RMA (robust multichip average algorithm) as implemented in Bioconductor package oligo ( ) where background subtraction, quantile normalization and summarization (via median-polish) was accomplished.

    Article Title: Comprehensive Survey of SNPs in the Affymetrix Exon Array Using the 1000 Genomes Dataset
    Article Snippet: .. In contrast, Spielman and co-workers used the Affymetrix GeneChip Human Genome Focus array to measure and compare the expression of ∼8,000 genes between the CEU and ASN samples. .. Taking advantage of the Affymetrix GeneChip Human Exon 1.0ST array (exon array), which was designed to interrogate the entire length of the gene and not just the 3′ end characteristic of conventional oligonucleotide arrays, Zhang et al . measured and compared ∼18,000 gene-level transcript clusters and ∼1.4 million exon-level probesets between the CEU and YRI samples.

    Sequencing:

    Article Title: ANXA10 induction by interaction with tumor‐associated macrophages promotes the growth of esophageal squamous cell carcinoma
    Article Snippet: .. A cDNA microarray was performed using the GeneChip Human Gene 2.0 ST Array (Affymetrix, Santa Clara, CA, USA), containing 53617 probes characterized human genes and expressed sequence tags. .. A company (Filgen, Nagoya, Japan) conducted the DNA microarray analysis.

    Staining:

    Article Title: Mitotic vulnerability in triple-negative breast cancer associated with LIN9 is targetable with BET inhibitors
    Article Snippet: .. For each sample, 150 ng RNA was used to synthesize and label cDNA with biotin for hybridization to Human Gene 2.0 ST expression microarrays using the GeneChip WT Plus labeling kit and protocol, and the hybridized arrays were automatically stained and scanned with the Affymetrix standard stain and scan protocol. .. The microarray data were processed with RMA (robust multichip average algorithm) as implemented in Bioconductor package oligo ( ) where background subtraction, quantile normalization and summarization (via median-polish) was accomplished.

    Hybridization:

    Article Title: Mitotic vulnerability in triple-negative breast cancer associated with LIN9 is targetable with BET inhibitors
    Article Snippet: .. For each sample, 150 ng RNA was used to synthesize and label cDNA with biotin for hybridization to Human Gene 2.0 ST expression microarrays using the GeneChip WT Plus labeling kit and protocol, and the hybridized arrays were automatically stained and scanned with the Affymetrix standard stain and scan protocol. .. The microarray data were processed with RMA (robust multichip average algorithm) as implemented in Bioconductor package oligo ( ) where background subtraction, quantile normalization and summarization (via median-polish) was accomplished.

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