Journal: Translational and Clinical Pharmacology

Article Title: Clinical pharmacology and therapeutics in South Korea: 30 years with the Korean Society of Clinical Pharmacology and Therapeutics

doi: 10.12793/tcp.2024.32.e12

Figure Lengend Snippet: The list of domestic new drug approvals contributed by Korean Society of Clinical Pharmacology and Therapeutics

Article Snippet: ZEMIGLO TAB , LG Life Sciences, Ltd. , Gemigliptin , Anti-diabetics , 12.06.27 , FIH study, drug-drug interaction study, bioequivalence study, special population study (renal impairment), food effect study, etc. [ ] .

Techniques: Recombinant, Purification

Journal: Heliyon

Article Title: Improvement effect of gemigliptin on salivary gland dysfunction in exogenous methylglyoxal-injected rats

doi: 10.1016/j.heliyon.2024.e29362

Figure Lengend Snippet: Animal experimental groups.

Article Snippet: After reaching 70 % confluency, the cells were treated with various concentrations of gemigliptin (0, 2.5, 5, 10, 25, 50, and 100 μM; LG Life Sciences, Seoul, Korea), aminoguanidine (AG; 0, 2.5, 5, 10, 25, 50, and 100 μM; Sigma Aldrich, Louis, MO, USA), and MGO (0, 50, 100, 200, 300, 400, 500, and 600 μM; Sigma Aldrich) for 24 h, following the group conditions.

Techniques: Injection

Journal: Heliyon

Article Title: Improvement effect of gemigliptin on salivary gland dysfunction in exogenous methylglyoxal-injected rats

doi: 10.1016/j.heliyon.2024.e29362

Figure Lengend Snippet: Effects of gemigliptin (GG) on methylglyoxal (MGO)-treated immortalized human salivary gland acinar cells (SGACs). (A) Effects of 24-h treatment with methylglyoxal (MGO) on the viability of SGACs. (B) Cell viability of SGACs treated with GG and aminoguanidine (AG) for 24 h. (C) Effects of gemigliptin and AG on the viability of immortalized human SGACs treated with MGO for 24 h. (D) Glucagon-like peptide 1 (GLP-1) levels in SGACs treated with different concentrations of gemigliptin and AG. All data are presented as the mean ± standard error of the mean (n = 5). *p < 0.05.

Article Snippet: After reaching 70 % confluency, the cells were treated with various concentrations of gemigliptin (0, 2.5, 5, 10, 25, 50, and 100 μM; LG Life Sciences, Seoul, Korea), aminoguanidine (AG; 0, 2.5, 5, 10, 25, 50, and 100 μM; Sigma Aldrich, Louis, MO, USA), and MGO (0, 50, 100, 200, 300, 400, 500, and 600 μM; Sigma Aldrich) for 24 h, following the group conditions.

Techniques:

Journal: Scientific Reports

Article Title: In-lab synthesized turn-off fluorescence sensor for estimation of Gemigliptin and Rosuvastatin polypill appraised by Spider diagram, AGREE and whiteness metrics

doi: 10.1038/s41598-024-53203-z

Figure Lengend Snippet: Chemical structures of ( A ) Gemigliptin, ( B ) Rosuvastatin, and ( C ) Fluorescence sensor.

Article Snippet: Gemigliptin (GEM) (CAS Number: 911637-19-9) was purchased from Shanghai Jinhe Biotechnology Co. Ltd, China.

Techniques: Fluorescence

Journal: Scientific Reports

Article Title: In-lab synthesized turn-off fluorescence sensor for estimation of Gemigliptin and Rosuvastatin polypill appraised by Spider diagram, AGREE and whiteness metrics

doi: 10.1038/s41598-024-53203-z

Figure Lengend Snippet: ( A ) Excitation and emission spectra of the fluorescence sensor, and Fluorescence titration spectra of sensor 3 with different concentrations of ( B ) Gemigliptin (0.2–2 μg/mL) and ( C ) Rosuvastatin (0.1–1 μg/mL) in deionized water at 25 °C (λ ex = 226 nm, and λ em = 406 nm).

Article Snippet: Gemigliptin (GEM) (CAS Number: 911637-19-9) was purchased from Shanghai Jinhe Biotechnology Co. Ltd, China.

Techniques: Fluorescence, Titration

Journal: Scientific Reports

Article Title: In-lab synthesized turn-off fluorescence sensor for estimation of Gemigliptin and Rosuvastatin polypill appraised by Spider diagram, AGREE and whiteness metrics

doi: 10.1038/s41598-024-53203-z

Figure Lengend Snippet: Stern–Volmer plot for the interaction of ( A ) Gemigliptin and ( B ) Rosuvastatin with the fluorescence sensor at different temperatures.

Article Snippet: Gemigliptin (GEM) (CAS Number: 911637-19-9) was purchased from Shanghai Jinhe Biotechnology Co. Ltd, China.

Techniques: Fluorescence

Journal: Scientific Reports

Article Title: In-lab synthesized turn-off fluorescence sensor for estimation of Gemigliptin and Rosuvastatin polypill appraised by Spider diagram, AGREE and whiteness metrics

doi: 10.1038/s41598-024-53203-z

Figure Lengend Snippet: Selectivity and specificity of sensor 3 in the presence of 10 μg/mL of each interference analyte (co-administered drugs, excipients, and serum albumin), Gemigliptin (0.75 μg/mL), and Rosuvastatin (0.65 μg/mL).

Article Snippet: Gemigliptin (GEM) (CAS Number: 911637-19-9) was purchased from Shanghai Jinhe Biotechnology Co. Ltd, China.

Techniques:

Journal: Pharmaceutics

Article Title: Evaluation of the Drug-Induced Liver Injury Potential of Saxagliptin through Reactive Metabolite Identification in Rats

doi: 10.3390/pharmaceutics16010106

Figure Lengend Snippet: Chemical structures of five dipeptidyl peptidase-4 inhibitors: vildagliptin ( a ), saxagliptin ( b ), trelagliptin ( c ), linagliptin ( d ), and gemigliptin ( e ).

Article Snippet: Saxagliptin, trelagliptin, and gemigliptin ( ) were purchased from AdooQ Bioscience (>98%, Irvine, CA, USA); linagliptin and 5-hydroxysaxagliptin from Toronto Research Chemicals (Toronto, Canada); ammonium acetate (99.99%), β-nicotinamide adenine dinucleotide phosphate sodium salt hydrate (NADP + ), dimethyl sulfoxide (DMSO, >99.7%), glucose-6-phosphate (G6P), glucose-6-phosphate dehydrogenase (G6PD), L-cysteine, magnesium chloride, reduced glutathione (GSH, ≥99%), 3′-phosphoadenosine-5′-phosphosulfate (PAPS), potassium phosphate, uridine diphosphate glucuronic acid (UDPGA, >98%), and vildagliptin from Sigma-Aldrich (St. Louis, MO, USA); and rat liver microsomes (RLM, R1000) from XenoTech (Lenexa, KS, USA).

Techniques: