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Cell Signaling Technology Inc
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Addgene inc
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Addgene inc
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Journal: bioRxiv
Article Title: Fetal context conveys heritable protection against MLL-rearranged leukemia that depends on MLL3
doi: 10.1101/2025.03.11.642680
Figure Lengend Snippet: (A, B) Kaplan-Meier survival curves after E10.5 or P0 MLL::ENL induction using Tet-On-ME and Tet-On-ME/Nras G12D models. (C) Summary of experimental set-up for MLL::ENL induction and transplantation experiments. (D) Kaplan-Meier survival curves for recipient mice transplanted with 300,000 P0 liver cells or 500 LSK cells after MLL::ENL induction at E10.5 or P14. (E) Donor (CD45.2) leukocyte engraftment in surviving recipient mice at 8 months after transplantation. (F) Summary of experimental set-up for panels G and H, and for CITE-seq experiments in . (G) Kaplan-Meier survival curves and 16-week donor chimerism for recipient mice after MLL::ENL induction at E10.5 or P0 and transplantation at P28. (H) MLL::ENL transgene expression (counts per million; CPM) based on RNA-seq. n= 4 biological replicates per group, ***p<0.001 by one-way ANOVA with Tukey’s posthoc test. For all survival curves, group sizes and p-values are shown in the panels. p-values were calculated by the log rank test.
Article Snippet: Vav1-Cre (RRID:IMSR_JAX:008610), Rosa26 LSL-rtTA-IRES-mKate2 (RRID:IMSR_JAX:008610), Rosa26 LSL-tTA (RRID:IMSR_JAX:011008), Col1a1 TetO-H2B-GFP (RRID:IMSR_JAX:016836) and
Techniques: Transplantation Assay, Expressing, RNA Sequencing