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Impaired spermatogenesis in CR (A) Left: UMAP plot of all germ cells ( n = 6,290 cells, 5 samples). The curve with the arrow represents the development trajectory of germ cells from SSCs to sperm. Right: separate UMAP plot of the CR group ( n = 3) and control ( n = 2). (B) Bar plot showing the cell ratio of each germ cell subset in (A). (C) IF staining of PRM1 in tissue sections of the CR group and control. Scale bars, 20 μm (PRM1) and 100 μm (merged). Control: testis samples from patients with obstructive azoospermia. (D) GO term enrichment of SSCs in downregulated genes. The size of the dot represents the gene count. The color of the dot represents the value of −log10 p value. (E) Left: IF staining of <t>FGFR3</t> and ACTA2 in tissue sections of the CR group and control, showing the number of FGFR3+ cells significantly decreased in the CR group. Scale bar, 50 μm. Control: samples from adult males with obstructive azoospermia. Right: Quantification of the number of undifferentiated spermatogonia (FGFR3+) in a cross-section of each seminiferous tubule in different groups. Bars represent the mean with SD of 30 independent tubules in the CR group ( n = 3) and controls ( n = 3). The p value was calculated by Student’s t test. ∗∗∗∗ p < 0.0001, ∗∗ p < 0.01. (F) UMAP plot of 4 states for spermatogonia (merged SSCs and differentiating spermatogonia). Different colors represent different states. (G) Violin plots showing the expression of selected gene markers for different spermatogonium states. (H) Cell numbers of different spermatogonium states in the CR group and control. (I) The expression of classic cell-cycle-related genes in the CR group and control in different states. The color of the dot represents the average expression. (J) The expression of classic cell-cycle-related pathways in the CR group and control in different states.
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Impaired spermatogenesis in CR (A) Left: UMAP plot of all germ cells ( n = 6,290 cells, 5 samples). The curve with the arrow represents the development trajectory of germ cells from SSCs to sperm. Right: separate UMAP plot of the CR group ( n = 3) and control ( n = 2). (B) Bar plot showing the cell ratio of each germ cell subset in (A). (C) IF staining of PRM1 in tissue sections of the CR group and control. Scale bars, 20 μm (PRM1) and 100 μm (merged). Control: testis samples from patients with obstructive azoospermia. (D) GO term enrichment of SSCs in downregulated genes. The size of the dot represents the gene count. The color of the dot represents the value of −log10 p value. (E) Left: IF staining of <t>FGFR3</t> and ACTA2 in tissue sections of the CR group and control, showing the number of FGFR3+ cells significantly decreased in the CR group. Scale bar, 50 μm. Control: samples from adult males with obstructive azoospermia. Right: Quantification of the number of undifferentiated spermatogonia (FGFR3+) in a cross-section of each seminiferous tubule in different groups. Bars represent the mean with SD of 30 independent tubules in the CR group ( n = 3) and controls ( n = 3). The p value was calculated by Student’s t test. ∗∗∗∗ p < 0.0001, ∗∗ p < 0.01. (F) UMAP plot of 4 states for spermatogonia (merged SSCs and differentiating spermatogonia). Different colors represent different states. (G) Violin plots showing the expression of selected gene markers for different spermatogonium states. (H) Cell numbers of different spermatogonium states in the CR group and control. (I) The expression of classic cell-cycle-related genes in the CR group and control in different states. The color of the dot represents the average expression. (J) The expression of classic cell-cycle-related pathways in the CR group and control in different states.
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Impaired spermatogenesis in CR (A) Left: UMAP plot of all germ cells ( n = 6,290 cells, 5 samples). The curve with the arrow represents the development trajectory of germ cells from SSCs to sperm. Right: separate UMAP plot of the CR group ( n = 3) and control ( n = 2). (B) Bar plot showing the cell ratio of each germ cell subset in (A). (C) IF staining of PRM1 in tissue sections of the CR group and control. Scale bars, 20 μm (PRM1) and 100 μm (merged). Control: testis samples from patients with obstructive azoospermia. (D) GO term enrichment of SSCs in downregulated genes. The size of the dot represents the gene count. The color of the dot represents the value of −log10 p value. (E) Left: IF staining of FGFR3 and ACTA2 in tissue sections of the CR group and control, showing the number of FGFR3+ cells significantly decreased in the CR group. Scale bar, 50 μm. Control: samples from adult males with obstructive azoospermia. Right: Quantification of the number of undifferentiated spermatogonia (FGFR3+) in a cross-section of each seminiferous tubule in different groups. Bars represent the mean with SD of 30 independent tubules in the CR group ( n = 3) and controls ( n = 3). The p value was calculated by Student’s t test. ∗∗∗∗ p < 0.0001, ∗∗ p < 0.01. (F) UMAP plot of 4 states for spermatogonia (merged SSCs and differentiating spermatogonia). Different colors represent different states. (G) Violin plots showing the expression of selected gene markers for different spermatogonium states. (H) Cell numbers of different spermatogonium states in the CR group and control. (I) The expression of classic cell-cycle-related genes in the CR group and control in different states. The color of the dot represents the average expression. (J) The expression of classic cell-cycle-related pathways in the CR group and control in different states.

Journal: Cell Reports Medicine

Article Title: Decoding the pathogenesis of spermatogenic failure in cryptorchidism through single-cell transcriptomic profiling

doi: 10.1016/j.xcrm.2024.101709

Figure Lengend Snippet: Impaired spermatogenesis in CR (A) Left: UMAP plot of all germ cells ( n = 6,290 cells, 5 samples). The curve with the arrow represents the development trajectory of germ cells from SSCs to sperm. Right: separate UMAP plot of the CR group ( n = 3) and control ( n = 2). (B) Bar plot showing the cell ratio of each germ cell subset in (A). (C) IF staining of PRM1 in tissue sections of the CR group and control. Scale bars, 20 μm (PRM1) and 100 μm (merged). Control: testis samples from patients with obstructive azoospermia. (D) GO term enrichment of SSCs in downregulated genes. The size of the dot represents the gene count. The color of the dot represents the value of −log10 p value. (E) Left: IF staining of FGFR3 and ACTA2 in tissue sections of the CR group and control, showing the number of FGFR3+ cells significantly decreased in the CR group. Scale bar, 50 μm. Control: samples from adult males with obstructive azoospermia. Right: Quantification of the number of undifferentiated spermatogonia (FGFR3+) in a cross-section of each seminiferous tubule in different groups. Bars represent the mean with SD of 30 independent tubules in the CR group ( n = 3) and controls ( n = 3). The p value was calculated by Student’s t test. ∗∗∗∗ p < 0.0001, ∗∗ p < 0.01. (F) UMAP plot of 4 states for spermatogonia (merged SSCs and differentiating spermatogonia). Different colors represent different states. (G) Violin plots showing the expression of selected gene markers for different spermatogonium states. (H) Cell numbers of different spermatogonium states in the CR group and control. (I) The expression of classic cell-cycle-related genes in the CR group and control in different states. The color of the dot represents the average expression. (J) The expression of classic cell-cycle-related pathways in the CR group and control in different states.

Article Snippet: anti-FGFR3 , Santa Cruz , Cat# sc-13121; RRID: AB_627596.

Techniques: Control, Staining, Expressing

Journal: Cell Reports Medicine

Article Title: Decoding the pathogenesis of spermatogenic failure in cryptorchidism through single-cell transcriptomic profiling

doi: 10.1016/j.xcrm.2024.101709

Figure Lengend Snippet:

Article Snippet: anti-FGFR3 , Santa Cruz , Cat# sc-13121; RRID: AB_627596.

Techniques: Control, Software, Recombinant, Enzyme-linked Immunosorbent Assay