dtx  (Alomone Labs)


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    Structured Review

    Alomone Labs dtx
    Dtx, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/dtx/product/Alomone Labs
    Average 94 stars, based on 7 article reviews
    Price from $9.99 to $1999.99
    dtx - by Bioz Stars, 2022-08
    94/100 stars

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    Alomone Labs dtx i
    An I D -like current activated from the resting membrane potential is blocked by low doses of 4-AP A , firing response upon injection of a steady inward current (0.1 nA for 800 ms) from a resting membrane potential of -61 mV. Notice the afterhyperpolarisation at the end of the pulse. B , increasing the stimulation intensity (0.2 nA) produced in the same neurone repetitive firing with strong adaptation followed by a prominent afterhyperpolarisation. C , upon membrane hyperpolarisation (-68 mV), the same neurone responded to a current step of 0.2 nA with a reduced number of spikes and with a larger delay in the appearance of the first action potential. Insets in A - C represent the same traces on an expanded time scale. D , mean delay to the appearance of the first spike from the resting membrane potential (control, ctl, -56 ± 1 mV; n = 12) and from a more hyperpolarised membrane potential (hyper, -66 ± 1 mV). E and F , voltage responses to a 0.2 nA current step in control conditions ( E ) and in the presence of 4-AP ( F ) for a different neurone. G , mean delay to the generation of the first spike in control conditions and in the presence of 4-AP ( n = 14). H and I , firing responses to a 0.2 nA current step in control conditions ( H ) and in the presence of <t>DTX-I</t> (DTX, I ; scale bar as in E and F ). J , mean delay to the first spike appearance in control conditions and in the presence of DTX-I ( n = 4). * P
    Dtx I, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/dtx i/product/Alomone Labs
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    dtx i - by Bioz Stars, 2022-08
    94/100 stars
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    An I D -like current activated from the resting membrane potential is blocked by low doses of 4-AP A , firing response upon injection of a steady inward current (0.1 nA for 800 ms) from a resting membrane potential of -61 mV. Notice the afterhyperpolarisation at the end of the pulse. B , increasing the stimulation intensity (0.2 nA) produced in the same neurone repetitive firing with strong adaptation followed by a prominent afterhyperpolarisation. C , upon membrane hyperpolarisation (-68 mV), the same neurone responded to a current step of 0.2 nA with a reduced number of spikes and with a larger delay in the appearance of the first action potential. Insets in A - C represent the same traces on an expanded time scale. D , mean delay to the appearance of the first spike from the resting membrane potential (control, ctl, -56 ± 1 mV; n = 12) and from a more hyperpolarised membrane potential (hyper, -66 ± 1 mV). E and F , voltage responses to a 0.2 nA current step in control conditions ( E ) and in the presence of 4-AP ( F ) for a different neurone. G , mean delay to the generation of the first spike in control conditions and in the presence of 4-AP ( n = 14). H and I , firing responses to a 0.2 nA current step in control conditions ( H ) and in the presence of DTX-I (DTX, I ; scale bar as in E and F ). J , mean delay to the first spike appearance in control conditions and in the presence of DTX-I ( n = 4). * P

    Journal: The Journal of Physiology

    Article Title: An Id-like current that is downregulated by Ca2+ modulates information coding at CA3-CA3 synapses in the rat hippocampus

    doi: 10.1113/jphysiol.2003.051045

    Figure Lengend Snippet: An I D -like current activated from the resting membrane potential is blocked by low doses of 4-AP A , firing response upon injection of a steady inward current (0.1 nA for 800 ms) from a resting membrane potential of -61 mV. Notice the afterhyperpolarisation at the end of the pulse. B , increasing the stimulation intensity (0.2 nA) produced in the same neurone repetitive firing with strong adaptation followed by a prominent afterhyperpolarisation. C , upon membrane hyperpolarisation (-68 mV), the same neurone responded to a current step of 0.2 nA with a reduced number of spikes and with a larger delay in the appearance of the first action potential. Insets in A - C represent the same traces on an expanded time scale. D , mean delay to the appearance of the first spike from the resting membrane potential (control, ctl, -56 ± 1 mV; n = 12) and from a more hyperpolarised membrane potential (hyper, -66 ± 1 mV). E and F , voltage responses to a 0.2 nA current step in control conditions ( E ) and in the presence of 4-AP ( F ) for a different neurone. G , mean delay to the generation of the first spike in control conditions and in the presence of 4-AP ( n = 14). H and I , firing responses to a 0.2 nA current step in control conditions ( H ) and in the presence of DTX-I (DTX, I ; scale bar as in E and F ). J , mean delay to the first spike appearance in control conditions and in the presence of DTX-I ( n = 4). * P

    Article Snippet: The following drugs were used: 4-AP (Sigma); DTX-I (Alomone Labs, Jerusalem, Israel); DL-2-amino-5-phosphonopentaoic acid (D-AP5), 6,7-dinitroquinoxaline-2,3-dione (DNQX), bicuculline and CGP 55845 (all purchased from Tocris Cookson, Bristol, UK).

    Techniques: Injection, Mass Spectrometry, Produced, CTL Assay

    GABAergic inputs enhance excitability at E14 but are inhibitory at E18 in NM neurons. A , Neurons held in whole-cell current clamp were stimulated with depolarizing current pulses of variable amplitude. GABAergic synaptic stimulation was performed with a bipolar electrode in the presence of bath-applied DNQX and AP5. B , Under control conditions, GPSPs summated with current pulses in E14 neurons to induce spiking, but shunted current pulses at E18 to prevent spiking (left column; stimulus artifacts reduced for clarity). Addition of DTX-I to the bath (right column) induced summation between GPSP and current pulses in neurons of both ages. C , Rheobase during a GPSP was subtracted from the control condition for E14 ( n = 6) and E18 ( n = 7) neurons. All E14 neurons ( n = 6) exhibit negative changes in rheobase, indicating enhancement of excitability. This effect was significantly enhanced by addition of DTX-I (* p

    Journal: The Journal of Neuroscience

    Article Title: A Developmental Switch to GABAergic Inhibition Dependent on Increases in Kv1-Type K+ Currents

    doi: 10.1523/JNEUROSCI.5266-06.2007

    Figure Lengend Snippet: GABAergic inputs enhance excitability at E14 but are inhibitory at E18 in NM neurons. A , Neurons held in whole-cell current clamp were stimulated with depolarizing current pulses of variable amplitude. GABAergic synaptic stimulation was performed with a bipolar electrode in the presence of bath-applied DNQX and AP5. B , Under control conditions, GPSPs summated with current pulses in E14 neurons to induce spiking, but shunted current pulses at E18 to prevent spiking (left column; stimulus artifacts reduced for clarity). Addition of DTX-I to the bath (right column) induced summation between GPSP and current pulses in neurons of both ages. C , Rheobase during a GPSP was subtracted from the control condition for E14 ( n = 6) and E18 ( n = 7) neurons. All E14 neurons ( n = 6) exhibit negative changes in rheobase, indicating enhancement of excitability. This effect was significantly enhanced by addition of DTX-I (* p

    Article Snippet: TTX and DTX-I were obtained from Alomone Labs (Jerusalem, Israel).

    Techniques: