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Qiagen
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Qiagen
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Qiagen
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Waters Corporation
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WiCell Research Institute Inc
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Thermo Fisher
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Waters Corporation
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Journal: Molecular Medicine
Article Title: Integrative analysis of gene expression and histone modifications for DES , DSP , GJA1 and SMOC2 in adipose tissue reveals potential relationship to cardiometabolic health
doi: 10.1186/s10020-025-01391-3
Figure Lengend Snippet: Depot-specific expression of cardiac-related genes in the in-house cohort. A IGV browser view of the ATAC-seq and RNA-seq data showing differential accessibility and gene expression along the studied genes loci in both SAT (blue) and OVAT (red) samples. B Barplots showing relative expression levels of DES , DSP , GJA1 , and SMOC2 in paired subcutaneous adipose tissue (SAT) and omental visceral adipose tissue (OVAT) samples from 78 patients. Data are presented as mean ± standard deviation. A paired t-test was used to assess statistical significance between depots
Article Snippet: All TaqMan assays were commercially sourced (
Techniques: Expressing, RNA Sequencing, Gene Expression, Standard Deviation
Journal: Molecular Medicine
Article Title: Integrative analysis of gene expression and histone modifications for DES , DSP , GJA1 and SMOC2 in adipose tissue reveals potential relationship to cardiometabolic health
doi: 10.1186/s10020-025-01391-3
Figure Lengend Snippet: Depot-specific expression of cardiac-related genes in independent human cohorts. Gene expression comparisons of the DES , DSP , GJA1 , and SMOC2 between OVAT and SAT within ( A ) the cross-sectional cohort (no obesity: N = 31; obesity: N = 1.449), ( B ) the two-step bariatric surgery cohort (pre and post-surgery: N = 65) and within ( C ) the metabolically healthy versus unhealthy obesity cohort (insulin sensitive: N = 31, insulin resistant: N = 42) of LOBB. Gene expression data are based on TMM-normalized RNA sequencing data, adjusted for sex and age. Statistical significance was assessed using Wilcoxon pairwise comparisons with Bonferroni correction
Article Snippet: All TaqMan assays were commercially sourced (
Techniques: Expressing, Gene Expression, Metabolic Labelling, RNA Sequencing
Journal: Molecular Medicine
Article Title: Integrative analysis of gene expression and histone modifications for DES , DSP , GJA1 and SMOC2 in adipose tissue reveals potential relationship to cardiometabolic health
doi: 10.1186/s10020-025-01391-3
Figure Lengend Snippet: Correlation of cardiac-related genes expression with clinical and metabolic parameters. A Heatmap showing bivariate Spearman rank correlation between clinical variables and relative expression of DES, DSP, GJA1 and SMOC2 in SAT and OVAT. Only statistically significant correlations (p < 0.05) are annotated with corresponding r values. Hierarchical clustering was applied to both genes and clinical traits to identify patterns of association. Colour scale represents correlation strength and direction (red = positive, blue = negative). B Scatter plots depicting individual linear regression models for selected gene-clinical trait associations, adjusted for age, sex, and BMI. The β coefficient and p-value for each association are shown. All models demonstrate significant associations ( p < 0.05)
Article Snippet: All TaqMan assays were commercially sourced (
Techniques: Expressing